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Matches 1 - 50 out of 20,302

Document Document Title
WO/2024/112731A1
Flavone, quinolinone, quinazolinone, and aurone derivatives are disclosed. The compounds have a structure according to formula I or formula II, or a pharmaceutically acceptable salt, hydrate, stereoisomer, or tautomer thereof. The compou...  
WO/2024/109233A1
Provided in the present disclosure are a pyrimidoaromatic compound with a structure as shown in formula I', and a preparation method therefor and the use thereof. The compound has a significant inhibitory effect on the activities of KRAS...  
WO/2024/110381A1
It is provided an ionizable lipid of formula (I) or a pharmaceutically acceptable salt thereof, or a stereoisomer of any one of them; a lipid nanoparticle comprising the ionizable lipid, particularly, as an encapsulation agent, optionall...  
WO/2024/104464A1
The present invention provides a compound represented by formula (I), and a tautomer, stereoisomer, hydrate, solvate, pharmaceutically acceptable salt or prodrug thereof. The compound has a good Nav1.8 inhibitory effect.  
WO/2024/104954A1
The present invention relates to substituted cycloalkyloxyphenyluracils of general formula (I) or salts thereof, wherein the radicals in general formula (I) correspond to the definitions given in the description, and to the use thereof a...  
WO/2024/105364A1
The present invention relates to compounds of formula (I). The compounds may be used to inhibit Cdc-Like Kinases, and thereby treat cancer, inflammatory disease, neurodegenerative disease, infection, tendinopathy, Duchenne muscular dystr...  
WO/2024/106438A1
The present invention provides a superior novel pest control agent for agriculture and horticulture. The present invention pertains to: compounds represented by general formula [I] (each symbol is as described in the description) or salt...  
WO/2024/106781A1
The present invention relates to a novel lipid compound and a lipid nanoparticle (LNP) composition containing same. The lipid compound according to the present invention can either directly or indirectly bind to and surround an active su...  
WO/2024/104956A1
The present invention relates to substituted cycloalkylsulfanylphenyluracils of general formula (I) or their salts, (I), wherein the groups in general formula (I) are as defined in the description, and to their use as herbicides, in part...  
WO/2024/104952A1
The present invention relates to substituted cyclopropyloxyphenyluracils of general formula (I) or salts thereof, wherein the radicals in general formula (I) correspond to the definitions given in the description, and to the use thereof ...  
WO/2024/102177A1
Disclosed herein are methods of treating brain cancer in a subject, such as glioblastoma, comprising administering inhibitors of synaptic signaling to the subject.  
WO/2024/101336A1
One embodiment of the present invention provides a compound, or a pharmaceutically acceptable salt thereof, capable of suppressing the splicing anomalies that are a factor in the onset or progression of disease. This disclosure relates t...  
WO/2024/100679A1
A stable, sterile, ready-to-use aqueous pharmaceutical formulation comprising flucytosine or its pharmaceutically acceptable salts and pharmaceutically acceptable excipients in flexible plastic container for intravenous and intraperitone...  
WO/2024/099437A1
Provided are certain PI3K inhibitors, pharmaceutical compositions thereof, and methods of use thereof.  
WO/2024/102455A1
Non-covalent inhibitors of coronavirus main protease and pharmaceutical formulations thereof are disclosed. The compounds and pharmaceutical formulations disclosed herein can be used to treat or prevent coronavirus infection, especially ...  
WO/2024/099168A1
Disclosed is a 2,4,5-trisubstituted pyrimidine compound having a structure as represented by the formula (I) compound, an isotope labeled compound, or an optical isomer, a geometric isomer, a tautomer or an isomer mixture thereof, or a p...  
WO/2024/095296A1
The present invention relates to solvent free compositions, more particularly, compositions containing self-emulsifying amorphous solid dispersion resulting in pharmaceutical compositions with enhanced solubility and thereby enhanced bio...  
WO/2024/094190A1
The present invention relates to use of compounds of formula I and formula II, and specifically relates to use of compound A1-A52, B1-B5, or C1-C36 in the preparation of a drug for treating and/or preventing an inflammatory or immune dis...  
WO/2024/092895A1
Disclosed is a method for preparing 2,4,5-triamino-6-hydroxypyrimidine sulfate by means of a micro-channel reaction. Specifically, 2,4-diamino-6-hydroxypyrimidine is taken as a raw material, and after a cyclization reaction at a proper s...  
WO/2024/095268A1
Methods for treating or reducing inflammation, in is in a site or an organ excluding the central nervous system of a subject in need thereof, by administering a pharmaceutical composition comprising the translocator protein ligand 2-C1-M...  
WO/2024/097219A1
The disclosure relates to method for treating, among other things, NF1 or conditions resulting from NF1 function loss the method comprising administering a therapeutically effective amount of (i) a single selective RXR agonist; or (ii) t...  
WO/2024/091498A1
Disclosed are compounds that are parathyroid hormone receptor 1 agonists, and methods useful for preventing or treating osteoporosis, fracture, osteomalacia, arthritis, thrombocytopenia, hypoparathyroidism, hyperphosphatemia or tumoral c...  
WO/2024/091450A1
The present disclosure relates to compounds for treating cancer. The compounds may prevent conversion of non-stem cancer cells into cancer-initiating cells caused by radiation treatment.  
WO/2024/091024A1
The present specification relates to a compound of chemical formula 1 and an organic light-emitting device comprising same.  
WO/2024/089683A1
Anticancer conjugates combining a DNA methylation agent and an anticancer drug are provided herein, as well as uses of the same in cancer treatment.  
WO/2024/087265A1
A protein inhibitor, a reagent set, and a use thereof. The protein inhibitor is an inhibitor for inhibiting a CILK1 protein; the protein inhibitor is CILK1-C28 or CILK1-C30; the use of the protein inhibitor is to apply the protein inhibi...  
WO/2024/083256A1
Provided in the present invention are a pan-KRAS degrading agent, and a preparation method therefor and the use thereof. Specifically, disclosed in the present invention are a small molecule compound for targeted degradation of the pan-K...  
WO/2024/086789A2
The disclosure is directed to compounds of Formula (I). Pharmaceutical compositions comprising compounds of Formula (I), as well as methods of their use and preparation, are also described.  
WO/2024/086347A1
This disclosure features methods for the rational design of Cereblon-based molecular glue degraders. Also featured are methods for the rational and modular design of MGDs. The methods include selecting a plurality of organic moieties, al...  
WO/2024/083258A1
Disclosed in the present invention are a KRAS G12C degradation agent, and a preparation method and use therefor. The KRAS G12C degradation agent in the present invention is a compound as shown in formula I or I', and/or a stereoisomer, e...  
WO/2024/085676A1
The present invention relates to a novel organic compound and an organic electroluminescent device using same, and, more specifically, to an organic compound having excellent electron injection and transport ability and thermal stability...  
WO/2024/078372A1
Provided are a heterocyclic substituted phenol derivative, a preparation method therefor, and a use thereof. Specifically, provided are compounds of formulas (I-1), (II-1B), (III), and (IV), stereoisomers thereof, pharmaceutically accept...  
WO/2024/078906A1
The present invention relates to substituted N-phenyluracils of general formula (I) or salts thereof (formula I), wherein the radicals in general formula (I) correspond to the definitions given in the description, and to the use thereof ...  
WO/2024/079128A1
The invention relates to compounds and their therapeutic use, said compounds having the formula (I): wherein, for example,  Z is representing a (II)  X is representing a NR5R6 group wherein R5 and R6 are hydrogen,  R1 is represe...  
WO/2024/081904A1
This disclosure provides compounds of Formula (I), Formula (II), Formula (III), and pharmaceutically acceptable salts of any of the foregoing, that inhibit PI3Kα. These compounds are useful for treating diseases such as cancer in a subj...  
WO/2024/078555A1
The present invention relates to the field of drugs, and specifically, the present invention relates to a pyrimidopyridine compound, and a pharmaceutical composition and use thereof. Specifically, the present invention relates to a compo...  
WO/2024/080844A1
The present disclosure relates to a novel pyrimidine derivative, a solvate or stereoisomer thereof, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition including any of the foregoing as an active ingredient, t...  
WO/2024/077085A1
The present disclosure describes methods of treating a condition comprising administering a compound that inhibits PLA2G7. The present disclosure describes methods of treating a condition comprising administering a compound that inhibits...  
WO/2024/075825A1
The present invention addresses the problem of providing a novel compound that has an OX2R agonist activity. The present invention pertains to a cyclopentane compound represented by formula (I) or a pharmacologically acceptable salt th...  
WO/2024/074577A1
The present disclosure relates to methods of preparing a compound of Formula (IX): (IX); or a pharmaceutically acceptable salt thereof. The present disclosure also relates to compounds being prepared by the methods, the pharmaceutical co...  
WO/2024/074538A1
The present disclosure relates to morphic forms of Compound A. The present disclosure also relates to processes for the preparation of the morphic forms of Compound A, the pharmaceutical compositions comprising the morphic forms, and the...  
WO/2024/067626A1
A composite, comprising: 3-hydroxybutyric acid; and one or more of potassium 3-hydroxybutyrate, or calcium 3-hydroxybutyrate, or magnesium 3-hydroxybutyrate. A composite, wherein the anion comprises 3-hydroxyvaleric acid, and the cation ...  
WO/2024/069507A1
This invention relates to novel processes for synthesizing N-(3-(6-Amino-5-(2-(N- methylacrylamido)ethoxy)pyrimidin-4-yl)-5-fluoro-2-methylphe nyl)-4-cyclopropyl-2-fluorobenzamide and to intermediates which are used in such processes.  
WO/2024/067560A1
Disclosed in the present invention are a sulfonamide compound and the medical use thereof as a STING inhibitor, specifically, a compound as represented by formula (I) or a pharmaceutically acceptable salt or ester or solvate thereof, whi...  
WO/2024/073426A1
Provided dihydroquinazolinone and azadihydroquinazolinone compounds for treating cardiac indications such as hypertrophic cardiomyopathy and diastolic dysfunction.  
WO/2024/073502A1
The present disclosure relates to novel compounds that inhibit glucose-induced degradation-deficient (GID) E3 ligase, pharmaceutical compositions containing such compounds, and their use in prevention and treatment of cancer and related ...  
WO/2024/072930A1
D3R selective partial agonists and their use in treating substance use disorders alone or in combination with affective disorders are disclosed. These substance use disorders include psychostimulant use disorder (PSUD). Compounds include...  
WO/2024/064091A1
This present invention relates to compounds of Formula I that feature the inhibition of protein tyrosine kinases (PTKs), including EGFR mutants, their pharmaceutical compositions that comprising a therapeutically effective amount of the ...  
WO/2024/064024A1
The present invention relates to ((4-oxo-3,4-dihydroquinazolin-8-yl)methyl)amine derivatives of formula (I) as well as to said compounds for use as P13K inhibitors in methods of treatment of cancer.  
WO/2024/064214A2
The present disclosure provides methods of preparing substituted cyclopropane compounds.  

Matches 1 - 50 out of 20,302