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WO/2024/108145A2 |
The present disclosure relates to development of methods for quantitative detection of genomic rearrangement. In particular, as described in greater detail below, some embodiments of the disclosure provide methods which involve tagmentat...
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WO/2024/104914A1 |
A method of quantifying RNA capping efficiency, the method comprising: (a) providing a sample of capped RNA; (b) contacting the capped RNA with a nuclease, wherein the nuclease is a protein, thereby hydrolysing the RNA to produce hydroly...
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WO/2024/105057A1 |
The present application relates to multiplex digital polymerase chain reaction assays (dPCR assays), methods and systems in which Target Sequences are characterized by a combination of at least two colors (color-combination approach). Th...
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WO/2024/107494A1 |
The present invention relates to the field of cancer. More specifically, the present invention provides compositions and methods useful for treating patients having a HOXB13 genetic variant. In a specific embodiment, a method for identif...
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WO/2024/106442A1 |
A method for evaluating filtration condition(s), the method including: under conditions where cell growth is suppressed, feeding a culture fluid containing cells from a culture tank 11 containing the culture fluid to a porous membrane 12...
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WO/2024/104130A1 |
A whole genome molecular marker development method utilizing degenerate primer amplification. Provided is a whole genome molecular marker detection method, which comprises: using a random degenerate primer, performing thermal asymmetric ...
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WO/2024/107023A1 |
The present invention relates to a method for detection or activity measurement of cell-based botulinum toxin and, more particularly, to a recombinant cell in which a gene construct consisting of a recombinant fluorescent protein coding ...
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WO/2024/108068A2 |
Method of evaluating a virus-producing cell on a microfluidic device is described therein. The method comprises culturing the virus-producing cell thereby producing a viral particle in a chamber of the microfluidic device; and evaluating...
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WO/2024/107982A1 |
One or more techniques for optimizing cancer classification based on covariate characteristics is disclosed. In a first approach, an analytics system may determine separate cutoff thresholds for positively detecting disease signal for di...
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WO/2024/105670A1 |
Disclosed are non-invasive methods for genotyping a fetus, comprising the analysis of sequencing data of maternal cell-free DNA (cfDNA), and parental (maternal and optionally paternal) genomic DNA (gDNA) from a pair parenting the fetus. ...
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WO/2024/103471A1 |
Provided are a LAMP reaction reagent for detecting Vibrio parahaemolyticus and/or Vibrio vulnificus and use thereof. The LAMP reaction reagent comprises a LAMP primer pair for detecting Vibrio parahaemolyticus and/or Vibrio vulnificus, p...
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WO/2024/108191A1 |
A method is provided for predicting whether a melanoma patient has a single lymph node metastasis or multiple metastases. RNA data can be received from tumor-involved lymph nodes of patients confirmed to have single or multiple metastase...
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WO/2024/106826A1 |
The present invention relates to a method and apparatus for processing K-mer gene data for PCR by using reference sequence data and cross-validation of target and non-target species. The method, performed by a gene processing apparatus, ...
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WO/2024/105671A1 |
Disclosed are non-invasive methods for genotyping a fetus, comprising the analysis of sequencing data of maternal cell-free DNA (cfDNA), and parental (maternal and optionally paternal) genomic DNA (gDNA) from a pair parenting the fetus. ...
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WO/2024/106444A1 |
The present invention provides a drug which can improve the implantation rate of an embryo and can be used in combination with an existing drug used in the treatment of infertility, a screening method by which such a drug can be reliably...
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WO/2024/106669A1 |
The present invention relates to a composition for improving skin wrinkles and a method for providing information for selecting a personalized substance for improving skin wrinkles, comprising the step of identifying a base of a polymorp...
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WO/2024/106289A1 |
In a DNA-dependent DNA polymerase having 5'-3'exonuclease activity, it was not possible to specifically amplify only mutant DNA having a sequence partially different from the sequence of a target DNA. The purpose of the present invention...
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WO/2024/106231A1 |
A three-dimensional image (D2) of a blastocyst stage embryo is first acquired by optical coherence tomography. A parameter (P) representing at least any one of the following is then calculated based on the three-dimensional image (D2): v...
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WO/2024/107430A1 |
The present application describes methods for assaying activity of an enzyme by using a donor substrate, a labeling substrate, and a liquid chromatography column.
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WO/2024/105132A1 |
The present disclosure provides for, among other things, methods and systems for detecting, diagnosing, predicting, monitoring, screening for, staging, and/or providing survival prognosis for advanced adenoma and/or colorectal cancer usi...
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WO/2024/104396A1 |
A detection method for analyzing the family proportion of the microRNA (miRNA) subtype in a sample. The method comprises carrying out high-throughput sequencing of sample RNAs, and then calculating the family proportion of the miRNA subt...
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WO/2024/107887A1 |
The present disclosure relates in some aspects to methods and compositions for assessing performance of in situ analyte detection and/or platforms (e.g., methods, assays, workflows, and/or instruments for in situ analyte detection and/or...
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WO/2024/107916A1 |
The technology described herein is directed to compositions and methods for isolating and analyzing biological nanoparticles, e.g., extracellular vesicles.
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WO/2024/108005A2 |
A non-contact sample holder for use with an optical detection system provides for the insertion of sample collection vessels into a housing to block out ambient light, and for optical inspection using an optical detection system without ...
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WO/2024/105001A1 |
A method is provided for sequencing of target genetic sequences (910) of a plurality of cells (700, 908) comprising the following steps: providing droplets (702, 906), each droplet including at least one cell (700, 908) of the plurality ...
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WO/2024/104511A1 |
Provided is use of Flibanserin in the preparation of a drug for treating androgenic alopecia. Experimental results show that Flibanserin inhibits the proliferation of Lncap cells, reverses androgen-mediated androgenic alopecia damage, an...
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WO/2024/104129A1 |
Provided are a method for enriching a part of a genome and related use. The method for enriching a part of the genome comprises: using a sequence-specific primer and an arbitrary degenerate primer for pairing, and performing thermal asym...
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WO/2024/107948A1 |
A process for determining an extent of a central nervous system (CNS) specific neurological condition in a subject including collecting a biological sample of biofluid from the subject and measuring a quantity of a first biomarker, or me...
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WO/2024/108016A2 |
Provided herein are compositions, systems, and methods comprising effector proteins (e.g., CRISPR-associated (Cas) proteins), and uses thereof. Various compositions, systems, and methods of the present disclosure may leverage the activit...
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WO/2024/105378A1 |
The invention relates to nucleic acid detection, and particularly, although not exclusively, to electrochemical methods for detecting target nucleic acid sequences in a sample obtained from a subject. The nucleic acid detection methods o...
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WO/2024/104216A1 |
A method for processing a mixture of DNA and RNA. The method involves digesting in advance a portion of the DNA in a sample mixture of DNA and RNA, thereby effectively improving the detection rate of RNA in a combined library of DNA and ...
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WO/2024/105058A1 |
The present application relates to multiplex polymerase chain reaction (PCR) assays, methods and systems in which Target Sequences are detected by using mediator probes and complementary single stranded fluorescent reporter complexes, pr...
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WO/2024/106109A1 |
The preset invention pertains to a method, a reagent, and a kit which are for detecting genes. Specifically, the present invention pertains to a method, a reagent, and a kit which are for detecting genes by means of a single-base extensi...
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WO/2024/106507A1 |
The present invention provides a dry composition for nucleic acid amplification uses, which contains a polymer containing a constituent unit derived from a monomer represented by formula (1) (wherein the definitions for symbols are as de...
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WO/2024/107614A1 |
A microRNA sensing platform is disclosed that is sensitive, accurate, easy to use, affordable, and that does not require expensive equipment on the part of the end-user. The sensing system can be used as a sensitive and accurate miRNA pr...
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WO/2024/107641A1 |
Provided herein are compositions, systems, kits, and methods for treating a patient with cancer (e.g., Ewing's Sarcoma) by treating the patient with at least one of the following compositions: a) a composition comprising at least a porti...
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WO/2024/106448A1 |
The nucleic acid construct according to the present invention has such a structure that a protein can be expressed by the occurrence of at least two times of a recombinant reaction by single-strand annealing (SSA), is useful for the diag...
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WO/2024/105108A1 |
The present invention provides methods for inducing a formula-fed infant's gut microbiome trajectory to converge with that of a reference gut microbiome trajectory obtained from human milk-fed infants, the methods comprising administerin...
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WO/2024/106568A1 |
The present invention relates to a novel recombinant nucleic acid molecule where a bioluminescence enzyme gene is linked to downstream of the transposable element in an inverted direction with being disrupted by an artificial intron. Thi...
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WO/2024/106651A1 |
The present invention relates to a low-dose radiation specific DNA methylation biomarker composition and uses thereof, and relates to use for diagnosing low-dose radiation exposure by using low-dose-radiation-induced DNA methylation chan...
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WO/2024/107832A2 |
The present disclosure provides a regimen for treating a subject suffering from hematological cancer by administering an effective amount of Talabostat or a pharmaceutically acceptable salt thereof on days 1-3, 8-10, 15-17 and 22-24 in o...
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WO/2024/105220A1 |
The present invention relates to the field of genomics. The invention relates more particularly to new microsatellite markers and their uses, in particular for determining the microsatellite status of a tumor, in particular of a tumor fr...
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WO/2024/107441A1 |
Embodiments of the present disclosure pertain to methods of assessing glioma in a subject by (1) receiving a plurality of measured biomarker levels of the subject; and (2) assessing glioma in the subject based on the measured biomarker l...
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WO/2024/108111A1 |
The present disclosure relates to detecting one or more types of urological cancer in a biological sample from a subject. In particular, the present disclosure provides compositions and methods for detecting the presence or absence of on...
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WO/2024/103184A1 |
Provided are improved methods for prognosing a clinical outcome in a subject or diagnosing the subject with high-risk or stable smoldering multiple myeloma (SMM), comprising determining a 3D telomeres organization signature of a test sam...
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WO/2024/107932A1 |
A method any system for performing optical PCR. The method includes binding nucleic acids in a sample fluid bind to a solid-phase substrate. The method also includes flowing the sample fluid in a fluid conduit to a trapping site. The tra...
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WO/2024/108156A2 |
Aspects of the disclosure relate to methods, systems, and computer-readable storage media, that are useful for characterizing subjects having cancer. The disclosure is based, in part, on methods for immunoprofiling a cancer subject and t...
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WO/2024/106930A1 |
The present invention relates to a method for detecting an analyte by using an oligonucleotide with a hairpin structure so as to amplify nucleic acids without temperature change.
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WO/2024/106421A1 |
The present invention addresses the problem of providing a method for collecting miRNA with high yield. The aforementioned problem is solved by a method for collecting miRNA from a liquid specimen collected from a subject, said method in...
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WO/2024/105485A1 |
The diagnostic dental device is for detecting the presence of microbes in an oral cavity. It includes a polymeric tray configured to receive one or more tooth of a subject. The dental device further includes an indicator composition disp...
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