Title:
COMPOSITION FOR PREVENTING, AMELIORATING, OR TREATING ALZHEIMER'S DISEASE CONTAINING AS ACTIVE INGREDIENT VITIS VINIFERA STEM EXTRACT OR COMPOUND ISOLATED THEREFROM
Document Type and Number:
WIPO Patent Application WO/2024/096280
Kind Code:
A1
Abstract:
The present invention relates to a composition for preventing, ameliorating, or treating Alzheimer's disease, comprising, as active ingredients, a Vitis vinifera stem extract and a compound isolated therefrom. The active ingredient of the present invention, the Vitis vinifera stem extract or vitisin A, may inhibit infection caused by herpes simplex virus and have an excellent inhibitory effect on Alzheimer's disease triggers in the brain tissue of an animal model infected with herpes simplex virus, and thus the composition of the present invention can be useful as a therapeutic agent for Alzheimer's disease, a health functional food or feed additive for preventing or ameliorating Alzheimer's disease.
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Inventors:
CHOI JANG GI (KR)
KWON EUN-BIN (KR)
KIM YOUNG SOO (KR)
LI WEI (KR)
KIM BUYUN (KR)
GO YOUNGHOON (KR)
CHOI CHUNWHAN (KR)
KWON EUN-BIN (KR)
KIM YOUNG SOO (KR)
LI WEI (KR)
KIM BUYUN (KR)
GO YOUNGHOON (KR)
CHOI CHUNWHAN (KR)
Application Number:
PCT/KR2023/012385
Publication Date:
May 10, 2024
Filing Date:
August 22, 2023
Export Citation:
Assignee:
KOREA INST ORIENTAL MEDICINE (KR)
GYEONGGIDO BUSINESS ＆ SCIENCE ACCELERATOR (KR)
GYEONGGIDO BUSINESS ＆ SCIENCE ACCELERATOR (KR)
International Classes:
A61K36/87; A23K10/30; A23K20/121; A23L33/10; A23L33/105; A61K31/343; A61P25/28
Foreign References:
| KR100791862B1 | 2008-01-07 |
Other References:
CHOI, Y.H.; YOO, M.Y.; CHOI, C.W.; CHA, M.R.; YON, G.H.; KWON, D.Y.; KIM, Y.S.; PARK, W.K.; RYU, S.Y.*: "A new specific BACE-1 inhibitor from the Stembark extract of Vitis vinifera", MEDICINAL & AROMATIC PLANTS ABSTRACTS, SCIENTIFIC PUBLISHERS, SCIENTIFIC PUBLISHERS, NEW DELHI - INDIA, vol. 31, no. 5, 1 October 2009 (2009-10-01), Scientific Publishers, New Delhi - India , XP018026633, ISSN: 0250-4367
LIH-GEENG CHEN: "Vitisin A, a Resveratrol Tetramer, Improves Scopolamine-Induced Impaired Learning and Memory Functions in Amnesiac ICR Mice", BIOMEDICINES, MDPI, BASEL, vol. 10, no. 2, Basel , pages 273, XP093166335, ISSN: 2227-9059, DOI: 10.3390/biomedicines10020273
CARLA ZANNELLA: "Antiviral Activity of Vitis vinifera Leaf Extract against SARS-CoV-2 and HSV-1", VIRUSES, MDPI, CH, vol. 13, no. 7, CH , pages 1263, XP093166336, ISSN: 1999-4915, DOI: 10.3390/v13071263
RUTH F. ITZHAKI: "Overwhelming Evidence for a Major Role for Herpes Simplex Virus Type 1 (HSV1) in Alzheimer’s Disease (AD); Underwhelming Evidence against", VACCINES, M D P I AG, CH, vol. 9, no. 6, CH , pages 679, XP093166338, ISSN: 2076-393X, DOI: 10.3390/vaccines9060679
LIH-GEENG CHEN: "Vitisin A, a Resveratrol Tetramer, Improves Scopolamine-Induced Impaired Learning and Memory Functions in Amnesiac ICR Mice", BIOMEDICINES, MDPI, BASEL, vol. 10, no. 2, Basel , pages 273, XP093166335, ISSN: 2227-9059, DOI: 10.3390/biomedicines10020273
CARLA ZANNELLA: "Antiviral Activity of Vitis vinifera Leaf Extract against SARS-CoV-2 and HSV-1", VIRUSES, MDPI, CH, vol. 13, no. 7, CH , pages 1263, XP093166336, ISSN: 1999-4915, DOI: 10.3390/v13071263
RUTH F. ITZHAKI: "Overwhelming Evidence for a Major Role for Herpes Simplex Virus Type 1 (HSV1) in Alzheimer’s Disease (AD); Underwhelming Evidence against", VACCINES, M D P I AG, CH, vol. 9, no. 6, CH , pages 679, XP093166338, ISSN: 2076-393X, DOI: 10.3390/vaccines9060679
Attorney, Agent or Firm:
CHOI, Kyu Whan (KR)
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