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Matches 1 - 50 out of 464,799

Document Document Title
WO/2018/011094A1
The present invention relates to a compound of the general formula (1), wherein the pyranose ring is alpha-D-galactopyranose, A is selected from (2), and (3). The compound of formula (1) is suitable for use in a method for treating a dis...  
WO/2018/011808A1
The present invention provides self-emulsifying, high concentration and high dose cannabinoid compositions and formulations, to improve administration of cannabinoids and standardized marijuana extracts to patients.  
WO/2018/010441A1
Provided are a series of Chinese medicine healthcare preparations for slimming and weight loss prepared from basic active pharmaceutical ingredients consisting of rose flower, soybean protein isolate, konjac flour, soybean oligosaccharid...  
WO/2018/011286A1
The current invention relates to a method of separating polyunsaturated fatty acids containing lipids from a lipids containing biomass.  
WO/2018/010674A1
Provided are an organic selenium compound, a preparation method thereof, a pharmaceutical composition comprising the same, and a use thereof. The organic selenium compound has a structure represented by formula (I): Ar1-A-C(M)-Se-Ar 2 (I...  
WO/2018/012772A1
The present invention relates to a wound treatment composition containing as an active ingredient an uldavioside A compound separated from an Ulmus davidiana Planch. extract. The uldavioside A compound shows excellent efficacy for wound ...  
WO/2018/012157A1
The present invention provides an agent which contains an orotic acid derivative having excellent physiological activity and has high solubility in a solvent. The agent according to the present invention is a melanin production inhibitor...  
WO/2018/010856A1
New compounds of formula (I) are provided,wherein: X is CH or N, preferably CH; n is 1-5, preferably 1-2; m is 0-5, preferably 1-2; and, when m is 2-5, two of the R2 radicals taken together with two adjacent carbons of the benzene ring c...  
WO/2018/011628A1
Provided herein are heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds that are useful for inhibiting plasma kallikrein. Furthermore, the subject compounds and compositions are useful for the trea...  
WO/2018/010202A1
A targeted delivery system for a hydrophobic antitumor drug, referring to conjugates of E-selectin polypeptide ligand-polyethylene glycol-antitumor drug connected by different link bridges and containing disulfide bonds. The synthesis of...  
WO/2018/013328A1
Provided is a decarboxylatmg carboxylic acids of cannabinoids in hemp extract or hemp biomass in which the hemp extract or hemp biomass is heated to a temperature of 40° C to 100° C in the presence of one or more divalent or monovalent...  
WO/2018/010965A1
Embodiments of the invention are directed to new equatorially modified polymer linked multimers of guanosine-3', 5'-cyclic monophosphate (cGMP) analogues that inhibit the cGMP-signaling system. The invention is also directed to related m...  
WO/2018/011569A1
The present invention relates to compounds that are useful as inhibitors of the activity of Wee-1 kinase. The present invention also relates to pharmaceutical compositions comprising these compounds and to methods of using these compound...  
WO/2018/012773A1
The present invention relates to an anti-inflammatory composition containing as an active ingredient an uldavioside A compound separated from an Ulmus davidiana Planch. extract. More particularly, the uldavioside A compound shows an anti...  
WO/2018/011162A1
The present invention relates to compounds of the formula (I), or pharmaceutically acceptable salts, enantiomer or diastereomer thereof, wherein R1 to R3 are as described above. The compounds may be useful for the treatment or prophylaxi...  
WO/2018/011164A1
The present invention relates to a compound of formula (I) wherein R1 is phenyl, lower alkyl, C3-6-cycloalkyl, -CH2-C3-6-cycloalkyl or bridged C4-6-cycloalkyl, substituted by one, two or three halogen atoms, or by lower alkyl or lower al...  
WO/2018/011351A2
The present invention refers to inhibitors of native, non-mutated KRAS for use in preventing and/or treating malignant melanoma and/or hepatocellular carcinoma. In addition, a KRAS inhibitor is combined with an inhibitor of another facto...  
WO/2018/013873A1
The present invention relates to pharmaceutical compositions comprising combinations of amino acids, vitamins, and minerals, which prevent the occurrence of adverse effects associated with prolonged use of glucocorticoids (GCs), especial...  
WO/2018/013655A1
Solid state forms of Crisaborole and salts thereof, processes for preparation thereof and pharmaceutical compositions thereof are disclosed.  
WO/2018/013918A2
The disclosure provides compositions and methods for treating diseases associated with expression of an antigen or for treating or prevent cytokine release syndrome, e.g., by administering a CAR therapy with a kinase inhibitor, e.g., JAK...  
WO/2018/011192A1
The present invention relates to a composition comprising at least one poloxamer compound for use in the treatment of a fistula in an individual.  
WO/2018/012516A1
The present invention provides particles having an average particle diameter of 5 μm or less that contain pirfenidone and a lipid, especially magnesium stearate, and a powdered formulation containing these particles and a carrier.  
WO/2018/011811A2
A pharmaceutical composition and a method of treating, reducing or preventing vascular, cardiovascular arterial or valve calcification in a subject in need comprising administering to the subject an effective amount of an agent that prev...  
WO/2018/013597A1
The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.  
WO/2018/011181A1
Provided herewith is a pharmaceutical composition comprising, separately or together, a pulsatile release component comprising levodopa and a DOPA decarboxylase inhibitor for the management of OFF-time episodes in patients with Parkinson...  
WO/2018/012683A1
The present invention relates to an adjuvant usable in cancer treatment using a cell therapeutic agent and to a method using the same. According to the present invention, a deterioration in activity of effector cells administered for tre...  
WO/2018/013519A1
The present disclosure relates to a method for treating diabetic macular edema (DME) and/or retinal vein occlusion (RVO) comprising administering to the retina of a patient in need thereof an effective amount of a caspase-9 signaling pat...  
WO/2018/013617A2
Cellular solids combine the properties of the solid material that forms the cell walls and edges with the properties of the matter that fills the cells. This results in unique properties that are superior to the properties of the single-...  
WO/2018/013420A1
A method of treating an MS patient with homosalate, octyl salicylate, or a combination is disclosed.  
WO/2018/013770A1
Disclosed are compounds of Formula (I) to (IV): [INSERT CHEMICAL STRUCTURE HERE] or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate or prodrug thereof. Also disclosed are methods of using such compounds as PAR4 inhibi...  
WO/2018/013983A1
A composition for weight loss comprising at least 8% total chalcones comprising 4-hydroxyderricin and xanthoangelol and coumarins. A composition for reduction of visceral fat comprising at least 8% total chalcones comprising 4-hydroxyder...  
WO/2018/011470A1
The present invention relates to the field of non-smokable products, more specifically snuff type compositions. Specifically, the invention relates to a snuff-type composition, wherein said snuff-type composition comprises nicotine and l...  
WO/2018/010702A1
Disclosed are a nicotinic acid or isonicotinic acid compound and a use thereof. The compound is the compound shown in formula I, or a pharmaceutically acceptable salt, ester or solvate thereof. Efficacy tests demonstrate that the nicotin...  
WO/2018/013774A1
Disclosed are compounds of Formula (I) to (VIII): (I) (II) (III) (IV) (V) (VI) (VII) (VIII); or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate or prodrug thereof, wherein R3 is a bicyclic heteroaryl group substituted...  
WO/2018/011201A1
The present invention relates to a compound according to general formula (I) wherein X represents N or CH; R1 is -CN, (C1-C6)alkyl, (C3-C7)cycloalkyl, (3-7 membered)heterocycloalkyl, (5-6 membered)heteroaryl, (C3-C7)cycloalkyl(C1-C4)alky...  
WO/2018/011160A1
The present invention relates to compounds of the formula (I) or pharmaceutically acceptable salts, enantiomer or diastereomer thereof, wherein R1 to R4 are as described above. The compounds may be useful for the treatment or prophylaxis...  
WO/2018/011100A1
The present invention relates to compounds of the formula (I), or pharmaceutically acceptable salts, enantiomer or diastereomer thereof, wherein R1 to R5 are as described above. The compounds may be useful for the treatment or prophylaxi...  
WO/2018/012829A1
The present invention relates to a continuous manufacturing method of polymer microspheres and an apparatus for the continuous manufacture of polymer microspheres for carrying out the manufacturing method.  
WO/2018/010622A1
Provided are a preparation method for a crystalline form of the compound represented by formula (A), as well as a method for preparation thereof, a composition thereof, and an application thereof in preparing an angiotensin II receptor a...  
WO/2018/011040A1
This invention relates to PLGA microparticles loaded with a fluoroquinolone with high mucosal permeability, the method of preparation thereof and applications thereof.  
WO/2018/013862A1
Provided herein are compositions and methods for the treatment of a hematological malignancy. Also disclosed herein are compositions and methods for the treatment of Ewings Sarcoma. Said compositions comprise isoform selective pyrrolo-py...  
WO/2018/011520A1
The subject matter of the present invention is, according to a first aspect, a dressing comprising an interface layer, characterised in that said interface layer comprises a weave coated with an elastomeric matrix comprising metformin, t...  
WO/2018/013625A1
This invention relates to deuterated forms of miconazole and pharmaceutically acceptable salts thereof. This invention also provides pharmaceutical compositions comprising a compound of this invention and a pharmaceutically acceptable ca...  
WO/2018/010656A1
A pyrrolidine derivative serving as a PPAR agonist, and applications thereof in treating diseases of pathways related to a PPAR receptor, such as nonalcoholic steatohepatitis, complication fibrosis, insulin resistance, primary biliary ch...  
WO/2018/011093A1
The present invention relates to a compound of the general formula (1). The compound of formula (1) is suitable for use in a method for treating a disorder relating to the binding of a galectin, such as galectin-1 to a ligand in a mammal...  
WO/2018/013890A1
In this study, we capitalized on the antimicrobial property and low oral bioavailability of known salicylanilide anthelmintics (closantel, rafoxanide, niclosamide, oxyclozanide) to target the gut pathogen. The anthelmintics displayed exc...  
WO/2018/011578A1
This invention relates to a process for the preparation of Form B of 3-[5-amino-4-(3- cyanobenzoyl)-pyrazol-1-yl]-N-cyclopropyl-4-methylbenzamide. Also disclosed herein is Form B of 3-[5-amino-4-(3-cyanobenzoyl)-pyrazol-1-yl]-N-cyclopro...  
WO/2018/013771A1
Extended release, abuse deterrent dosage forms in which the active ingredient consists essentially of hydrocodone are disclosed, wherein administration of the dosage form to a subject in at least one dose per day over multiple days does ...  
WO/2018/013509A1
The present invention relates to compositions and methods for diagnosing and treating arrhythmias. In particular, the present invention provides IL-18 markers and uses thereof.  
WO/2018/011414A1
Derivatives of 1,2,4-Triazolo-[3,4-b]-1,3,4-thiadiazoles according to formula (I), processes for their production, pharmaceutical compositions containing them and their use in the treatment of cancer.  

Matches 1 - 50 out of 464,799