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Matches 1 - 50 out of 482,207

Document Document Title
WO/2019/008520A1
The present invention relates to a process for preparing the Alectinib or a pharmaceutically acceptable salt thereof using lesser reaction steps and also eliminating expensive and time- consuming column chromatography. The invention also...  
WO/2019/008029A1
The present invention relates to compounds of formula (I): wherein Q is O or S, R1 is a 6-membered heteroaryl group containing at least one nitrogen atom in the 6-membered ring structure, wherein R1 may optionally be substituted, and R2 ...  
WO/2019/009663A1
The present invention relates to a composition for preventing and ameliorating athlete's foot. More specifically, the present invention relates to a cosmetic or pharmaceutical composition for preventing and ameliorating athlete's foot, w...  
WO/2019/007991A1
The present disclosure relates to a MTMR2-S polypeptide, or a nucleic acid sequence producing or encoding said MTMR2-S polypeptide, for a use in the treatment of a disease or disorder associated with MTM1 mutation or deficiency. The pres...  
WO/2019/010491A1
Disclosed are compositions and methods for screening drugs that treat neurodegenerative disorders and methods of treating neurodegenerative orders with combinations of said drugs.  
WO/2019/009438A1
The present invention provides a novel immune checkpoint inhibitor which has not been reported before. Provided is an immune checkpoint inhibitor which is characterized by including, as an active ingredient, a plant fermentation produc...  
WO/2019/009739A1
The invention relates to application of totarol for production of a preparation for treatment of vaginal mucous membrane inflammations of bacterial origin, for alleviation of symptoms in such a treatment, and for prophylaxis and preventi...  
WO/2019/010447A1
The invention provides compositions and methods for administering a therapeutic agent to a patient, such as pharmaceutical compositions containing a blood product and a therapeutic agent selected from an anthracycline anti-cancer agent (...  
WO/2019/008507A1
The invention is directed to substituted azetidine derivatives. Specifically, the invention is directed to compounds according Formula I: (I) wherein C, D, L1,L2,L3,R1, R2, R4, R5, R6, z2, z4, z5, and z6are as defined herein; and salts t...  
WO/2019/010482A1
Compositions and methods of modulating cervical ripening including initiating cervical ripening and/or inducing labor as well inhibiting preterm cervical ripening and/or preterm birth in a female in need thereof can include at least one ...  
WO/2019/007710A1
The invention relates to myobacterium tuberculosis-thioredoxin reductase inhibitors, processes for the preparation thereof, drugs containing said compounds, and the use of said compounds for manufacturing drugs.  
WO/2019/009354A1
The purpose of the present invention is to provide a composition for amelioration of dysuria, containing, in addition to a natural substance such as nobiletin which is a prior art, a component derived from a natural substance that is sim...  
WO/2019/009298A1
According to the present invention, a nucleic acid medicine, which has a higher effect of inhibiting α-synuclein expression and sustains this effect for a longer period of time, can be provided. The oligonucleotide according to the pres...  
WO/2019/007443A1
Disclosed are a dezocine analogue ester-containing sustained-release suspension and a preparation method therefor. An injectable oleaginous additive and an excipient are selected to act as a pharmaceutical sustained-release reservoir, an...  
WO/2019/008034A1
The present invention relates to crystalline forms of N-[1-(5-cyano-pyridin-2-ylmethyl)-1H- pyrazol-3-yl]-2-[4-(1-trifluoromethyl-cyclopropyl)-phenyl]-a cetamide, pharmaceutical compositions comprising said crystalline forms and their us...  
WO/2019/008102A1
A human milk fortifier composition comprising one or more human milk oligosaccharide. Said human milk fortifier composition may be tailored to fortify the breastmilk of a multiparous woman.  
WO/2019/007317A1
A solid dispersion, a method for preparing same, and a solid preparation comprising the solid dispersion. The solid dispersion contains (R)-4-amino-1-(1-(but-2-ynylacyl)pyrrolidin-3-yl)-3-(4-(2,6- difluorophenoxy)phenyl)-1,6-dihydro-7H-p...  
WO/2019/008506A1
The invention is directed to substituted bridged cycloalkane derivatives. Specifically, the invention is directed to compounds according to Formula (I) wherein X, a, b, C, D, L2, L3, Y1, Y2, R2, R4, R5, R6, z2, z4, z5, and z6 are as defi...  
WO/2019/008178A1
A composition comprising a cannabinoid, in particular a phytocannabinoid or a synthetic cannabinoid, where the cannabinoid is stabilised against oxidation and/or photochemical degradation, characterized in that the composition comprises ...  
WO/2019/007356A1
There is provided topical pharmaceutical formulations comprising montelukast,or a pharmaceutical acceptable salt of solvate thereof,as well as combination products comprising(a)at least one mussel adhesive protein or a derivative...  
WO/2019/008537A1
There is provided a medical compound comprising a synthetic flavone derivative, according to the formula (I) with allotment in position C-3 of a group as shown below: Formula (I) wherein at least two of R2-R6 a re H, and the remaining ar...  
WO/2019/007441A1
Disclosed are a sustained release suspension containing dezocine analogue ester and a preparation method therefor. According to the present invention, an injectable oily auxiliary material which may pharmaceutically serve as a sustained-...  
WO/2019/007003A1
The present invention discloses a pyrazolo[3,4-d]pyrimidine derivative as shown by formula (I). The compound provided by the present invention has a significant effect on inhibiting growth of tumor cells, can be used for preventing and/o...  
WO/2019/010295A1
The present invention provides compounds of Formula (I) or a subgeneric structure or species thereof, or a pharmaceutically acceptable salt, ester, solvate, and/or prodrug thereof, and methods and compositions for treating or amelioratin...  
WO/2019/007789A1
The present invention relates to topical compositions comprising erythrulose and hydroxyacetophenone as well as the use thereof for the prevention and/or treatment of ailments associated with Malassezia yeast, Propionibacterium acnes as ...  
WO/2019/008144A1
The present invention relates to the use of a liquid aqueous solution of edaravone in the treatment of an oxidative stress-mediated neurodegenerative disorder in a human patient, said treatment comprising at least once daily oral adminis...  
WO/2019/007696A1
The present invention discloses compounds according to Formula (I) Wherein R1, R2, L, A1, A2, A3, Cy and the subscript n are as defined herein. The present invention relates to antagonists compounds of sphingosine 1-phosphate (SIP) recep...  
WO/2019/007740A1
The present invention relates to compressed tablets comprising 3-nitrooxypropanol or derivatives thereof and a gluten as well as to the production of such tablets.  
WO/2019/009693A1
The present invention relates to the use of the compound Cur-[G-2]-OH as a sensitiser in a wide range of multiresistant tumors, particularly glioblastoma, which are characterised by the overexpression of the Nrf2 pathway.  
WO/2019/009528A2
The present invention relates to a preparation comprising uniform granules prepared by using mirabegron, a polyethylene oxide, and a silicate compound, and to a method for preparing the same. It was found that when mirabegron and a polye...  
WO/2019/010445A1
Water-in-hydrocarbon emulsions, preferably comprising a fluorinated or perfluorinated hydrocarbon continuous phase, a discontinuous aqueous phase, and a surfactant or mixture of surfactants. The emulsions contain pharmacologically active...  
WO/2019/007418A1
The present invention relates to the technical field of pharmacy, and specifically relates to a compound as represented by formula (I), and a pharmaceutically acceptable salt, an ester or stereoisomers thereof. R1, X1, X2, M, Ar, ring A,...  
WO/2019/008426A1
The present invention relates to novel composition of oral dosage forms of enzalutamide with pharmaceutically acceptable excipients and method of manufacturing thereof. The invention provides economical and advanced dosage form.  
WO/2019/010490A1
Provided herein are synthetic bioconjugates comprising collagen-binding peptides covalently bound to chemically modified glycan backbones, compositions containing the same, and uses thereof.  
WO/2019/010230A1
The present disclosure relates generally to compositions and formulations of active agents for improved delivery of the active agents, methods of making such compositions or formulations, and methods of use thereof. Also described herein...  
WO/2019/010301A1
The present invention provides a method of protecting the heart from damage, by administering to a patient at risk of such damage, a pharmaceutically effective amount of a composition which inhibits the interaction of RSK3 and mAKAPβ, o...  
WO/2019/007415A1
Disclosed are a furan-naphthoquinone-based sulfoximine derivative as shown in formula (I), a pharmaceutical composition containing the derivative and the use of the derivative as an STAT3 inhibitor.  
WO/2019/009265A1
The present invention addresses the problem of providing a medicine with which it is possible to simply treat and/or prevent retinal degenerative diseases associated with photoreceptor degeneration, including retinitis pigmentosa. The so...  
WO/2019/007321A1
Disclosed in the present invention are an indoleamine-2,3-dioxygenase inhibitor compound, a preparation method therefor, and an application thereof. The indoleamine-2,3-dioxygenase inhibitor compound provided by the present invention is ...  
WO/2019/009645A1
The present invention relates to a skin whitening composition. The skin whitening composition according to the present invention inhibits the expression of a melanogenesis-related protein and suppresses the activity of tyrosinase even in...  
WO/2019/009627A1
The present invention relates to a skin whitening composition. The skin whitening composition according to the present invention inhibits the expression of a melanogenesis-related protein and suppresses the activity of tyrosinase even in...  
WO/2019/009606A1
The present invention relates to microRNA having effects of preventing, treating, and ameliorating dermatitis and, more specifically, to a pharmaceutical composition containing miR-4507 microRNA as an active ingredient for prevention or ...  
WO/2019/009412A1
The present invention addresses the problem of providing a novel compound having high LSD1 inhibitory activity, high selectivity for LSD1 inhibition, and/or having useful therapeutic effects for various diseases. One embodiment of the pr...  
WO/2019/010226A1
Pharmacological compositions of single-stranded antisense miR-214 oligonucleotides that are chemically modified to increase their efficacy for intracolonic (enema) administration to treat Ulcerative Colitis (UC) or proctitis provide a an...  
WO/2019/010419A1
A method for purification and separation of cannabinoids, such as cannabidiol and tetrahydrocannabinol, e.g., from the dried hemp and cannabis leaves can use a continuous simulated moving bed process and a combination of one or more of a...  
WO/2019/010418A1
The present invention provides constructs that can be used for delivering therapeutic and/or diagnostic agents to a subject's tissue or organ. In certain embodiments, the invention provides a doubly ultrasound-voltage-activated imaging a...  
WO/2019/008152A1
The present invention provides novel compounds of formula (I) that are useful as inhibitors of the PD-l/PD-Ll protein/protein interaction. The compounds may be used in the treatment of cancer, infectious diseases and neurodegenerative di...  
WO/2019/007790A1
The present invention relates to the use of erythrulose as antimicrobial agent as well as to composition comprising said agent.  
WO/2019/010298A1
Disclosed is a compound of formula (I) in which a, R1- R5 and X1 are as described herein. Also disclosed are a pharmaceutical composition containing the compound and a method of using the compound for treating cancer, such as renal cancer.  
WO/2019/008516A2
Provided are methods and compositions for treating cancer. An embodiment of a method includes administering an effective amount of at least one dihydropyridine, such as lercanidipine, manidipine, nitrendipine, nicardipine, nisoldipine, a...  

Matches 1 - 50 out of 482,207