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Matches 1 - 50 out of 477,863

Document Document Title
WO/2018/187572A1
Disclosed are methods of treating or preventing infection in a mammal in need thereof, by administering the following compound, or related compounds, to a mammal, as well as cosmeceutical preparations and methods of using the same to inf...  
WO/2018/187503A1
Methods of improving neurodegenerative disease with CCR3 modulating agents are provided. The methods include administering a therapeutically effective amount of the CCR3 modulating agent to the subject, with a concomitant improvement in ...  
WO/2018/185270A1
The invention relates to inhibitors of microRNAs 19a and 19b and their use for treating or preventing conditions or diseases which are associated with bone loss, in particular osteoporosis and osteogenesis imperfect (01). The inhibitors ...  
WO/2018/187285A1
The invention is directed to a synthetic particle antibody comprising a bi-functional particle framework, such as for example and not limitation, a Janus micro- or nanoparticle, wherein one side of the bi-functional particle comprises ta...  
WO/2018/186487A1
Provided is adenosine as a substance that induces attracting behavior and food searching behavior of fish. Also provided is a novel adenosine receptor as a receptor for adenosine.  
WO/2018/187551A1
Disclosed is a salt prepared from the STAT3 inhibitor known as 2-hydroxy-4-[[2-[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino] benzoic acid and 2-amino-2-(hydroxymethyl)-1,3-propanediol. The salt is soluble in water and stable for extended...  
WO/2018/187484A1
Provided herein are, inter alia, methods of treating a cancer tumor in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of an adenosine A2A receptor antagonist, wherein the ...  
WO/2018/185685A1
The present invention relates to a topical pharmaceutical composition comprising: at least two pharmaceutical agents selected from the group consisting of pentamidine isethionate, ketoconazole and miltefosine; an agent for boosting skin ...  
WO/2018/187374A1
Compositions and methods are presently disclosed that provide improved efficiacy for the treatment of cancer. In particular, 3-O-ribose monoester derivatives of adenosine triphosphate are observed to have vastly superior efficiacy over a...  
WO/2018/186327A1
The present invention provides a conjugated linoleic acid containing c9, t11 conjugated linoleic acids, wherein a mass ratio of total t10, c12 conjugated linoleic acids to total c9, t11 conjugated linoleic acids is below 0.25.  
WO/2018/187485A1
The present disclosure provides methods, pharmaceutical compositions, dosing regimens, and kits comprising a DNA damaging agent and an inhibitor of the Janus kinase 2-signal transducer and activator of transcription 5 (JAK2-STAT5) pathwa...  
WO/2018/185557A1
The present invention relates to the treatment of Streptococcal infections for the treatment of psoriasis via the administration of the antibiotic compounds vancomycin, rifamixin, metronidazole, ceftriaxone, rifabutin, clofazimine, clari...  
WO/2018/185098A1
The present invention relates to a pharmaceutical combination comprising: (a) a PPAR agonist; (b) a p38 kinase inhibitor; and optionally (c) one or more pharmaceutically acceptable diluents, excipients or carriers for use in a method of ...  
WO/2018/187804A1
The present invention relates to processes for preparing compounds of Formula (I) and compounds of Formula (II) or a pharmaceutically acceptable salt or solvate thereof. These compounds and pharmaceutical compositions are useful as FXR o...  
WO/2018/187414A1
The present disclosure provides compounds and methods for inhibiting mTORC2, as well as methods for treating cancers such as glioblastoma.  
WO/2018/187698A2
Disclosed are combination therapies including administration of Caspase-1 dependent anticancer agents and PGE2 antagonists, and the use of such therapies in the treatment of cell proliferative diseases.  
WO/2018/186060A1
The present invention provides: (A) a composition comprising a moisturizing component which can be easily used with a polyhydric alcohol in combination, and a polyhydric alcohol; (B) a moisturizing agent which can improve moisturizing pr...  
WO/2018/185135A1
The invention describes anti-cancer therapies comprising using an MDM2 inhibitor in combination with a PD-1 antagonist and a LAG-3 antagonist, each as described herein.  
WO/2018/187623A1
The present invention provides crystalline forms of compound of formula (la) and processes of making the crystalline forms. Also provided are compositions comprising the crystalline forms and crystalline forms for treating or preventing ...  
WO/2018/186523A1
The present invention relates to a composition which is for preventing or treating breast cancer and includes salidroside and betulin as active ingredients. The composition according to the present invention including a mixture in which ...  
WO/2018/187508A1
Provided herein are, inter alia, methods of treating cancer by administering to a subject a therapeutically effective amount of an adenosine -A2A (A2A) receptor antagonist, or a combination of an adenosine -A2A (A2A) receptor antagonist,...  
WO/2018/186866A1
The present invention generally relates to sustained release 4-aminopyridine tablets, which include a core and a coating. The sustained release tablets of the invention are generally suitable for once daily oral administration for the tr...  
WO/2018/185664A1
The present invention relates to solvates of eluxadoline, processes for their preparation, pharmaceutical compositions comprising these solvates, and their use for the treatment of irritable bowel syndrome with diarrhea (IBS-D).  
WO/2018/184585A1
The present invention provides a compound for inhibiting IDO, a manufacturing method and a use thereof. The compound has a general structural formula of (I), wherein (II) is selected from a cis-isomer, a trans-isomer, or a mixture of cis...  
WO/2018/187509A1
Disclosed herein, inter alia, compounds of formula (I) and methods of use thereof for the modulation of CCR4 activity.  
WO/2018/186775A1
The invention relates to 4-((2-(6-(4-methylpiperazine- 1-carbonyl)naphthalen-2-yl)ethyl)amino)quinazoline-6-carboni trile salts which exhibit the properties of an inhibitor of cyclin-dependent kinase CDK8/CDK19. The invention also relate...  
WO/2018/187473A1
Methods of improving visual endpoints related to retina-associated disease with CCR3 modulating agents are provided. An example of such an endpoint is visual acuity. Retina-associated diseases upon which visual acuity and other visual en...  
WO/2018/185175A1
The present invention relates to a pharmaceutical composition comprising a therapeutically effective dose of Lenvatinib mesylate having sodium wherein the weight ratio of Lenvatinib mesylate to sodium carbonates ranges from 1: 1.5 to 1:5.  
WO/2018/187636A1
This disclosure provides cell surface anchoring antigen conjugates, formulations comprising cell surface anchoring antigen conjugates, and methods of using the same for treating cancer.  
WO/2018/186725A1
The present invention relates to a composition containing a photosensitizer-metal nanosheet complex for photodynamic treatment or diagnosis. The utilization of a folic acid-loaded metal nanosheet of the present invention can effectively ...  
WO/2018/185406A1
This syringe (1) comprises: - a syringe body (2), intended to receive a product for injection; - gripping wings (4), arranged at one end (21) of the syringe body (2); - a piston rod (5), mounted so as to be able to slide inside the syrin...  
WO/2018/185078A1
The present invention concerns a novel pharmaceutical composition comprising doxycycline for topical application, in particular to the eye and eyelids. The invention also concerns this topical composition for the use of same in the treat...  
WO/2018/187590A1
This disclosure provides improved Iipid-based compositions, including lipid nanoparticle compositions, and methods of use thereof for delivering nucleic acids in vivo. These compositions have reduced immune activation resulting in accele...  
WO/2018/185408A1
The present invention relates to a new use of pullulan or a derivative thereof in combination with a polysaccharide selected from hyaluronic acid, a salt or derivative thereof, alginic acid, a salt or derivative thereof, and a mixture of...  
WO/2018/187506A1
Described herein are compounds, including pharmaceutically acceptable salts, solvates, metabolites, prodrugs thereof, methods of making such compounds, pharmaceutical compositions comprising such compounds, and methods of using such comp...  
WO/2018/184561A1
Disclosed in the present invention are compounds having an aldolase selective inhibiting activity, a preparation method therefor, a pharmaceutical composition comprising the compounds, and uses of the compounds in preparation of drugs fo...  
WO/2018/185788A1
The present invention relates to an ophthalmic solution comprising (i) bimatoprost or its pharmaceutically acceptable salt in an amount ranging from about 0.005 % to 0.015 % weight by volume; (ii) a biguanide compound in an amount rangin...  
WO/2018/187643A1
The present disclosure is directed to a crystalline, hydrated form of afatinib dimaleate having about 2 to 3 molecules of water, designated as Form Z, a pharmaceutical composition comprising the form, its method of use for treating a pat...  
WO/2018/185735A1
The present invention relates to anti-microbial agents (AMA) having bacteriostatic and/or bactericidal properties, compositions and combinations comprising an AMA, and the use of such compositions, combinations and/or AMAs for use in inh...  
WO/2018/187728A1
his invention relates to methods of preparing nanotherapeutic compounds and compositions comprising nanotherapeutic compounds. The nanotherapeutic compounds prepared according to the methods provided herein are useful for the treatment o...  
WO/2018/184274A1
Provided in the present application are a compound for enhancing the spatial coupling of endothelial ion channel complex TRPV4-KCa2.3 and antihypertensive applications of the compound.  
WO/2018/185711A1
The present invention relates to solvates of eluxadoline, processes for their preparation, pharmaceutical compositions comprising these solvates, and their use for the treatment of irritable bowel syndrome with diarrhea (IBS-D).  
WO/2018/187519A1
The invention provides compositions and methods for treating cancers comprising administering a combination of antineoplastic agents, wherein the combination comprises taxane derivative chemotherapeutics and one or more nucleic acid mole...  
WO/2018/185030A1
The present invention relates to the treatment of type 2 inflammation. Based on the role of ILC2 in the induction of airway inflammation, the inventors investigate whether ILC2 could be influenced by sex hormones. In this study (effected...  
WO/2018/187187A1
A deuterated compound having the structure of Formula I: or a pharmaceutically acceptable salt, solvate, or prodrug thereof; or a salt of a prodrug thereof; or a hydrate or polymorph thereof; wherein Y1, Y2, Y3, Y4, Y5, Y6, Y7, Y8, Y9, Y...  
WO/2018/185783A1
The present invention provides a single pot process for the synthesis of 19-Norethisterone of Formula (I), comprising contacting 19-Norandostene-3,17-dione of Formula–II with a first base, an organic gas/solution and an acid to obtain ...  
WO/2018/185516A1
The invention relates to methods for treating cardiovascular toxicity induced by anti-cancer and anti-angiogenic compound. The inventors explored the cardiotoxicity induced by the antiangiogenic therapy, sunitinib, in the mouse heart. Th...  
WO/2018/185266A1
The invention relates to compounds of formula: wherein R1 to R7 are as defined in the description. These compounds are useful as inhibitors of the YAP/TAZ-TEAD interaction.  
WO/2018/186441A1
The present invention provides a risperidone-containing patch endowed with both excellent drug releasability and patch physical properties. Specifically, the present invention provides a medical patch that includes risperidone or a pharm...  
WO/2018/184115A1
Compounds comprising quinazolinone derivatives and methods of identification and use of imaging agents. The compounds have the general formula I: wherein R2 is selected from halogen, halosubstituted alkyl, alkyl, hydroxyl-alkyl, and amin...  

Matches 1 - 50 out of 477,863