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Matches 1 - 50 out of 171,151

Document Document Title
WO/2018/012582A1
Provided is a blood amino acid level elevation promoter which contains a whey protein hydrolysate as an active ingredient. The elevation of a blood amino acid level in a subject can be promoted by feeding the promoter to the subject.  
WO/2018/011803A1
Peptides derived from NKp44 protein, chimeric peptides, nucleotides encoding same and pharmaceutical compositions comprising same, are provided. Further, methods of extending the biological half-life of a protein of interest are provided.  
WO/2018/013585A1
Thymus modulating compositions and methods are disclosed.  
WO/2018/013855A2
The invention provides methods and dose escalation regimens for administering IL-15 to a patient in need thereof.  
WO/2018/011302A1
The present invention relates to a method or process of producing a glycoprotein that interacts with, or acts as an agonist to, the erythropoietin receptor (EpoR), which glycoprotein has modified efficacy, wherein the method or process c...  
WO/2018/011811A2
A pharmaceutical composition and a method of treating, reducing or preventing vascular, cardiovascular arterial or valve calcification in a subject in need comprising administering to the subject an effective amount of an agent that prev...  
WO/2018/014017A1
Substance P analogs are useful for treating and protecting against pulmonary fibrosis and related diseases and conditions. The active agents can be administered via inhalation therapy, intravenously, intramuscularly, sublingually, or by ...  
WO/2018/013775A2
This disclosure relates to purified and recombinant granulins, fusions, or variants and vectors encoding the same. In certain embodiments, this disclosure relates to uses of these granulins or vectors, alone or in combination, in the tre...  
WO/2018/010053A1
A method for preparing an antitumor drug, comprising the following steps: (1) adding a polymer tetrazole derivative and a crosslinking agent containing methacrylate group to water or a buffer to obtain a carrier solution having a concent...  
WO/2018/013509A1
The present invention relates to compositions and methods for diagnosing and treating arrhythmias. In particular, the present invention provides IL-18 markers and uses thereof.  
WO/2018/012936A1
The present invention relates to a nanoperforator comprising a lipid-bilayer nanodisc and a membrane-structured protein surrounding the nanodisc and to a pharmaceutical composition comprising the nanoperforator as an active ingredient fo...  
WO/2018/013589A1
Ex vivo cultures of cells having thymic function and methods of use and methods of making are disclosed.  
WO/2018/012570A1
The purpose of the present invention is to provide a vaccinia virus which expresses a foreign gene and is capable of killing cancer cells, and a medicine for cancer treatment which comprises the vaccinia virus. The present invention rela...  
WO/2018/013803A1
The present invention provides a compound or a pharmaceutically acceptable salt of the Formula : X1 I V X2 S L D V P I G L L Q I L X3 E Q E K Q E K E K Q Q A K* T N A X4 I L A Q V-NH2 wherein the X1 denotes that the I residue is modified...  
WO/2018/010476A1
Provided are a glycopeptides based derivative represented by the general formula (I) and a pharmaceutically acceptable salt thereof. R1 is H, 2-alkylamine-ethyl group, a substituted benzyl group, a substituted phenylpropionyl group or a ...  
WO/2018/013546A1
The invention includes methods for modulating a reaction dependent on a blue light-dependent protein interaction between a CRY protein and a CRY-signaling protein. The method comprises combining a CRY protein and a CRY-signaling protein ...  
WO/2018/010475A1
A glycopeptide derivative represented by the general formula (I) and a pharmaceutically acceptable salt thereof, R1 is H, 2-alkylamine-ethyl, a substituted benzyl group, a substituted phenylpropionyl group, or a linear acyl group contain...  
WO/2018/013720A1
The present disclosure relates to modulation of protein expression.  
WO/2018/012736A1
The preset invention relates to cartilage regeneration using a combination of IL-8 and a bone marrow concentrate and, more specifically, provides: a composition for cartilage regeneration comprising IL-8 and a bone marrow concentrate as ...  
WO/2018/013013A1
´╗┐The invention relates to molecular biology, biotechnology, medicine, veterinary science. A group of inventions is proposed: a fusion protein comprising a ligand to MATN1 protein, and a growth factor of EGF, TGF, FGF, IGF, the construc...  
WO/2018/013907A1
The present invention relates to a screening method to identify mucus- penetrating compounds. In certain aspects, the present invention relates to mucus- penetrating peptides and constructs comprising an agent, such as a therapeutic agen...  
WO/2018/013783A1
The disclosure provides compounds of Formula (I), wherein X, Y, and Z are defined herein. The disclosure also provides particles comprising one or more compounds described herein, compositions comprising one or more compounds or particle...  
WO/2018/013142A1
Compositions and methods for topical treatment of hair loss in otherwise normal skin that is affected by alopecia are presented. Such compositions include defensins in concentrations that are below those that exhibit antimicrobial activi...  
WO/2018/013939A1
ProTGFB1-GARP complex-selective antibodies, polynucleotides capable of encoding the proTGFB1-GARP complex-selective antibodies or antigen-binding fragments, cells expressing proTGFB1-GARP complex-selective antibodies or antigen-binding f...  
WO/2018/013053A1
The invention relates to an ELABELA polypeptide or nucleic acid for use in the treatment, alleviation or prophylaxis of pre-eclampsia in an individual. In another aspect of the invention, there is provided a method of diagnosing or detec...  
WO/2018/012901A1
The present invention relates to a pharmaceutical composition for cell protection containing cyclo histidine-proline (cyclo His-Pro, CHP) as an active ingredient. The pharmaceutical composition for cell protection containing cyclo histid...  
WO/2018/013568A1
The present invention includes a composition and method for the treatment of an eye disease comprising a therapeutically effective amount of an autophagy stimulator that treats or slows the progression of the eye disease by enhancing or ...  
WO/2018/014016A1
Substance P analogs are useful for treating and protecting against exposure to ionizing radiation such as acute radiation syndrome, chronic radiation syndrome and the like. The active agents can be administered via inhalation therapy, in...  
WO/2018/013936A1
In some aspects, the disclosure relates to GDF/BMP antagonists and methods of using GDF/BMP antagonists to treat, prevent, or reduce the progression rate and/or severity of pulmonary hypertension (PH), particularly treating, preventing o...  
WO/2018/013993A1
Described herein are methods for selecting lymphocytes for adoptive cell therapy based on P-glycoprotein expression and compositions comprising same.  
WO/2018/012778A1
The present invention relates to a conjugate for photodynamic diagnosis or treatment in which a peptide binds with a photosensitizer via an intracellularly degradable linkage, and to a composition for photodynamic diagnosis or treatment ...  
WO/2018/013897A1
Provided herein are methods for producing stimulated populations of regulatory B cells comprising treating an isolated population of B cells with stimulatory agents, such as CpG oligonucleotides, BCR ligation, and CD40 ligand. Also provi...  
WO/2018/012935A1
The present invention relates to a pharmaceutical composition for preventing or treating cancer, comprising keratin. The composition increases the expression of various genes associated with apoptosis, inhibits the expression of genes as...  
WO/2018/006750A1
Provided is a secretory protein sDSS1 of a higher primate. The protein can be detected in human blood serum and cerebrospinal fluid. The sDSS1 protein can bind, under non-enzymatic conditions, with an oxidized protein to form a polymer, ...  
WO/2018/007597A1
The invention features soluble fibroblast growth factorreceptor3 (sFGFR3) polypeptides. The invention also features methods of using sFGFR3 polypeptides to treat skeletal growth retardation disorders, such as achondroplasia.  
WO/2018/006667A1
Disclosed are antihypertensive peptides and antihypertensive proteins and a use thereof. The amino acid sequences of the antihypertensive peptides are respectively TTW, VHW and KAKW, and the amino acid sequences of the antihypertensive p...  
WO/2018/008772A1
The present invention relates to a cancer treatment composition for inhibiting angiogenesis, and a preparation method therefor. An angiogenesis inhibitor according to the present invention is a cancer treatment composition containing a f...  
WO/2018/008932A1
The present invention provides a composition for inhibiting the survival or growth of a tubercle bacillus, containing a material which induces the polarization of a macrophage into an MI macrophage, and a method for inhibiting the surviv...  
WO/2018/007601A1
The present invention relates to clinically relevant dosing regimens of prophylactic subcutaneously administered long-acting factor IX (i.e., human FIX fused to human albumin) in human patients.  
WO/2018/009832A1
This document relates to materials and methods for controlling ligand gated ion channel (LGIC) activity. For example, modified LGICs including at least one LGIC subunit having a modified ligand binding domain (LBD) and/or a modified ion ...  
WO/2018/008729A1
The present invention addresses the problem of providing a therapeutic agent for ischemic diseases, which exhibits a tissue-protecting effect against tissue injuries associated with ischemia. The therapeutic agent according to the presen...  
WO/2018/009534A1
The presently disclosed subject matter provides compositions and methods comprising improvements of a CRISPR system (e.g. CRISPR associated (Cas) 9 (CRISPR-Cas9, non-Cas9 CRISPR systems). Such compositions may comprise modifications to t...  
WO/2018/009624A1
The present invention discloses heterodimers comprising endoglin-Fc and ALK1-Fc, or heterodimers comprising endoglin-Fc and ALK2-Fc. The Fc domains can include amino acid mutations that promote heterodimer formation. In certain aspects, ...  
WO/2018/007530A1
The invention relates to aptamers which specifically bind to fibrinogen and their use in the purification of said protein.  
WO/2018/009628A1
A method of screening is provided including providing a combination of a plurality of proliferating cell types wherein each proliferating cell type has a unique associated barcode within its genome that is different from other proliferat...  
WO/2018/009921A1
The present invention provides fusion proteins comprising leptin and a second protein. The presence of the second protein provides increased biological activity and/or increased half-life in vivo. The present invention also provides huma...  
WO/2018/009457A1
Compositions and methods for using actin-based peptides to modulate cellular bioactivity, including modulation of cellular susceptibility to intracellular pathogens, such as bacteria and viruses.  
WO/2018/009903A2
Provided herein are Clostridial Botulinum neurotoxin (BoNT) polypeptides of a novel serotype (BoNT/X) and methods of making and using the BoNT polypeptides, e.g., in therapeutic applications.  
WO/2018/007767A1
The invention relates to a composition comprising stable fibrinogen in liquid form.  
WO/2018/008902A1
The present invention relates to a psoriasis-induced animal model and a use thereof and, more particularly, to: a psoriasis-induced animal model transformed such that a Pellino homolog 1 (Peli1) gene is overexpressed according to the adm...  

Matches 1 - 50 out of 171,151