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Matches 1 - 50 out of 4,938

Document Document Title
WO/2019/009604A2
The present invention relates to a superparamagnetic gold nanoparticle cluster-protein nanoparticle fusion body for magnetic resonance imaging and magnetic thermotherapy. According to the present invention, a superparamagnetic gold nanop...  
WO/2019/008040A1
The invention relates to methods for treating tumors. In particular, the invention provides novel use of nanoparticles in combination with ionizing radiations for treating tumors, wherein the combined effect of nanoparticles induces sene...  
WO/2019/006248A1
The present disclosure relates to noninvasive methods for detecting liver fibrosis. Disclosed herein are noninvasive liver fibrosis detection methods that use Doppler Ultrasound devices and a physics-based machine learning method. Furthe...  
WO/2019/002940A1
Various approaches for disrupting target tissue for treatment include identifying a target volume of the target tissue; causing disruption of the target tissue in a region corresponding to the target volume so as to increase tissue perme...  
WO/2019/004669A2
The present invention relates to a microbubble-nanoparticle complex which can be simultaneously used as an ultrasound contrast agent, a photodynamic therapeutic agent, and a chemical drug therapeutic agent, and which can selectively tran...  
WO/2019/002947A1
Various approaches for enhancing treatment of target tissue using a source of focused ultrasound while limiting damage to non-target tissue include selecting a frequency of ultrasound waves transmitted from the source of focused ultrasou...  
WO/2019/003202A1
A method of obtaining, from a target compound, a radioisotope of a target element comprised in the target compound includes irradiating the target compound with high energy photon irradiation (gamma irradiation). Thereby the target eleme...  
WO/2019/002943A1
Various approaches for computationally generating a protocol for treatment of one or more target BBB regions within a tissue region of interest using a source of focused ultrasound include specifying (i) settings of sonication parameters...  
WO/2019/002177A1
The present invention relates to conjugate complexes, comprising at least one biological entity, at least one cargo moiety, and at least one effector moiety that is capable of converting, degrading, and/or modifying a given medium, where...  
WO/2019/003155A1
The invention discloses pharmaceutical compositions comprising a conjugate of a porphyrin (e.g., PpIX) and a recombinant protein. The pharmaceutical compositions of the invention may be used in photodynamic therapy. The invention also re...  
WO/2018/234509A1
The invention relates to a dissolution chamber (10) for use with a catheter for dissolving and preparing an aqueous solution of a water-soluble photosensitizing agent for installation into the bladder, e.g. for use in photodynamic diagno...  
WO/2018/234586A1
The present invention relates to a sensitizer-peptide conjugate for use in the treatment of cancer. In particular, the present invention relates to a sensitizer-peptide conjugate for use in the treatment of melanoma. The use of such sens...  
WO/2018/229134A1
There is provided tinostamustine or a pharmaceutically acceptable salt thereof for use in the treatment of ovarian cancer in a patient in need thereof.  
WO/2018/229133A1
There is provided tinostamustine or a pharmaceutically acceptable salt thereof for use in the treatment of sarcomain a patient in need thereof.  
WO/2018/222339A1
A carrier device and methods of use, for implanting in biological tissue and releasing a medical payload in the biological tissue according to remote ultrasound trigger pulses. The carrier device includes at least one internal resonant e...  
WO/2018/222778A1
Prostate-specific membrane antigen targeted high-affinity agents for endoradiotherapy of prostate cancer are disclosed.  
WO/2018/222340A1
A carrier device and methods of use are described. The device and methods are directed toward implanting in biological tissue and optionally for propelling in a biological tissue and for releasing a medical payload in a biological tissue...  
WO/2018/220376A1
The invention relates to microbubble complexes for use in methods of sonodynamic therapy which comprise a microbubble attached to or otherwise associated with one or more linking groups, each linking group being bound to at least one son...  
WO/2018/212649A1
The present invention is in the field of a kit of parts comprising a radionuclide and a therapeutic compound, a medic ament comprising said kit of parts, and a method of treating disease by administering said kit of parts, in particular ...  
WO/2018/209359A1
A method for the systemic delivery of a polypeptide within a subject is provided by creating genetically modified skin cells via topical introduction of a genetically engineered virus which delivers a nucleic acid encoding a therapeutic ...  
WO/2018/203083A2
The invention provides CaO2 nanoparticles having a p H-responsive coating for use in a method of adjuvant therapy of hypoxic tumour cells or tissues. The nanoparticles find particular use in enhancing cancer therapies that depend on oxyg...  
WO/2018/201257A1
The present technology generally relates to products, devices, methods and systems for healing of wounds or for wound-treatment therapies. More particularly, but not by way of limitation, the present technology relates an absorbent produ...  
WO/2018/203083A3
The invention provides CaO2 nanoparticles having a p H-responsive coating for use in a method of adjuvant therapy of hypoxic tumour cells or tissues. The nanoparticles find particular use in enhancing cancer therapies that depend on oxyg...  
WO/2018/200713A1
The present invention provides universal immunotherapy compositions useful for targeted treatment of cancers. The present invention utilizes in its various aspects, bifunctional compounds or complexes that contain at least two domains. O...  
WO/2018/197451A1
A neutron activator for neutron activation of a material, the neutron activator being configured to produce neutrons from an interaction with a proton beam (7), the neutron activator comprising: - a neutron source comprising a metallic t...  
WO/2018/200462A1
The present invention is directed to a composition suitable for forming an implanted light activated drug depot, methods of making the composition, and methods and systems for using the composition. The composition comprises a plurality ...  
WO/2018/192405A1
Provided is a target polypeptide compound having dual targets, comprising a TATE cyclic peptide structure, an RGD cyclic peptide structure, and a NOTA chelating group. The TATE cyclic peptide structure, the RGD cyclic peptide structure, ...  
WO/2018/193958A1
[Problem] The present invention addresses the problem of enhancing the photodynamic effect in ALA-PDT and ALA-PDD. [Solution] Provided is a pharmaceutical pertaining to a combination of an ALA and a dynamin inhibitor.  
WO/2018/194823A1
Methods and devices are disclosed for non-invasive optogenetic stimulation of autonomic efferent fibers to regulate glucose metabolism in the liver and brown adipose tissue and to treat metabolic disorders.  
WO/2018/191316A1
Provided are sulfur- or heavy atom-containing silica or aluminosilica nanoparticles. A nanoparticle can have at least one dye molecule covalently bonded to the silica or aluminosilica matrix of the silica or aluminosilica nanoparticle, r...  
WO/2018/191363A8
Some embodiments of the present disclosure are directed to methods and compositions for the treatment of tumors, using a combination of immunotherapeutic agents and tumor-targeting viral capsid protein assemblages comprising anti-cancer ...  
WO/2018/191363A1
Some embodiments of the present disclosure are directed to methods and compositions for the treatment of tumors, using a combination of immunotherapeutic agents and tumor-targeting viral capsid protein assemblages comprising anti-cancer ...  
WO/2018/186725A1
The present invention relates to a composition containing a photosensitizer-metal nanosheet complex for photodynamic treatment or diagnosis. The utilization of a folic acid-loaded metal nanosheet of the present invention can effectively ...  
WO/2018/176699A1
A conjugated polymer nanometer probe comprising: a fluorescent conjugated polymer; a surface ligand; a target molecule; and a near-infrared fluorescent dye; and may also comprise magnetic resonance contrast agents with gadolinium. The pr...  
WO/2018/178213A1
A method for the surface-modification of metal nanoparticles, which functionalised metal nanoparticles can be encapsulated in a biocompatible polymer, and to which a binding agent can be conjugated is disclosed. The disclosure further re...  
WO/2018/175790A1
Methods are provided for using anti-CD47 mAbs as therapeutics for the prevention and treatment of solid and hematological cancers, with other anti-cancer agents, more specifically, chemotherapeutic agents, which include but are not limit...  
WO/2018/171882A1
The present invention relates to nanoparticles which are doped with Gd 3+ so they are capable of emitting UV-radiation but also paramagnetic and detectably by MR techniques.  
WO/2018/167618A1
Compositions and their use are described for delivery of drugs to desired tissues via a light responsive quantum dot (QD) drug delivery system (QD-DDS). The QD-DDS comprises water soluble QD nanoparticles loaded with drug molecules that ...  
WO/2018/169440A1
The invention relates to the field of radiotherapyand, more specifically, to production of a radiopharmaceutical for treating preferably cancers. The method provided comprises the use of mono isotopic element Be-9 irradiated with quanta ...  
WO/2018/167149A1
The present invention relates to a method for irradiating a population of mammalian cells comprising at least one target mammalian cell with electron beams and/or X-rays, characterized in that: (i) a composition comprising a population o...  
WO/2018/164493A1
The present invention relates to a bubble volume control method and a bubble volume controlling apparatus wherein the volume of a bubble is adjusted using a method to increase and decrease the volume of the bubbles by radiating in the di...  
WO/2018/158314A1
Disclosed is (a) an antibody or an antigen-binding portion thereof that specifically binds to and inhibits Programmed Death-1 (PD-1) and/or an antibody or an antigen–binding protein portion thereof that specifically binds to and inhibi...  
WO/2018/161080A1
An embolic agent and a piezoelectric substance are mixed together. The mixture can be delivered to a tumor or other object by a non-invasive method. The embolic agent prevents movement of the piezoelectric substance from the target locat...  
WO/2018/156815A1
Provided are conjugates, e.g., dual conjugates, compositions and methods for use in photoimmunotherapy, such as photoimmunotherapy induced by activation of a phthalocyanine dye in the dual conjugate. In some embodiments, the dual conjuga...  
WO/2018/154566A1
Apparatus and methods are described for use with a heating device (26) configured to heat at least a portion of a subject's body. A nanoparticle (22) is configured to be administered to the subject, the nanoparticle including at least on...  
WO/2018/156787A1
The invention relates to the application of photon energy to energize dental materials to enhance their physical handling characteristics, efficacy, ability to be delivered, reactivity, polymerization, and/or post-cure mechanical propert...  
WO/2018/156807A1
A method for improving healing of a wound includes delivering an activating agent to the wound and irradiating the wound with an electromagnetic radiation source. The method also includes activating the activating agent, in response to t...  
WO/2018/150266A1
This invention concerns magnetic nanoparticles for use in a magnetic hyperthermia therapeutic treatment, prophylactic treatment or diagnosis method, wherein the magnetic nanoparticles are administered to a body part of an individual and ...  
WO/2018/145208A1
The present technology relates to a method for modulating in situ production of energy by a biological tissue comprising stimulating the biological tissue by exposing said biological tissue to a photostimulated biophotonic composition fo...  
WO/2018/148596A1
A patch for treating vascular ulcers caused by excessive enzymatic activity may include a substrate configured to span a vascular ulcer as well as a linking material that is disposed relative to the substrate and has an affinity for an e...  

Matches 1 - 50 out of 4,938