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WO/2012/060707 |
The invention is directed to a method for preparing a microsphere comprising a lanthanide metal phosphate complex, a microsphere, a powder comprising a number of the microspheres, a suspension comprising the microsphere or the powder, th...
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WO/2012/054997 |
The present invention relates to a method for labelling with radionuclides murine or human, monoclonal or polyclonal anti-tumour necrosis factor antibodies, to a reagent for in vivo and/or in vitro diagnosis on the basis of murine or hum...
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WO/2012/054998 |
The present invention relates to a method for labelling somatostatin analogues with radionuclides, to a reagent for in vivo or in vitro diagnosis on the basis of somatostatin analogues labelled with radionuclides, to the diagnostic use t...
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WO/2012/055992 |
The invention relates to a method for improving stability of radiopharmaceutical precursors, and in particular protected amino acid derivatives which are used as precursors for production of radiolabelled amino acids for use in in vivo i...
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WO/2012/057312 |
One of the purposes of the present invention is to provide a probe for imaging a protein having a β-sheet structure for the purpose of diagnosing conformation diseases, particularly diseases in which the accumulation of tau protein in t...
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WO/2012/051170 |
Methods for detecting or ruling out a meningioma in a patient using a phenylbenzothiazole derivative or a stilbene derivative or a biphenylalkyne derivative, and a medical imaging technique such as positron emission tomography / computed...
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WO/2012/049624 |
Described is a pretargeting method, and related kits, for targeted medical imaging and/or therapeutics, wherein use is made of abiotic reactive chemical groups that exhibit bio-orthogonal reactivity towards each other. The invention invo...
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WO/2012/047317 |
Provided are isolated antibodies, and fragments and derivatives thereof, which bind to tumor antigens. Also provided are compositions and delivery agents that include the disclosed antibodies and fragments and derivatives thereof; cells ...
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WO/2012/047354 |
An environmentally sensitive membrane binding polypeptide, pH (low) -sensitive membrane peptide (pHLIP) has improved insertion kinetics balanced with solubility to selectively target acidic tissues.
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WO/2012/041953 |
The present invention provides a method useful in the diagnosis and monitoring of cancer wherein there is an abnormal expression of PBR. The method of the invention is particularly useful in evaluating the severity of the cancer, e.g. PB...
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WO/2012/040824 |
The present invention relates to isolated or purified antibodies or fragments thereof specific for CEACAM6 and their use as therapeutic or diagnostic tools. Specifically, the present invention is directed to antibodies or fragments there...
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WO/2012/041862 |
The present invention relates to radiopharmaceutical imaging in vivo of apoptosis. The invention provides imaging agents which target apoptotic cells via selective binding to the aminophospholipid phosphatidylethanolamine (PE), which is ...
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WO/2012/037648 |
An isolated conformational isomer of a bifunctional chelating agent of the formula (1) wherein the variables Q1 and Q2 are as defined in the description of the present application. Also described is a complex of the above chelating agent...
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WO/2012/038532 |
The present invention provides a method useful in the diagnosis and/or monitoring of mood disorders wherein there is an abnormal expression of PBR. The method of the invention is useful in the differential diagnosis of said mood disorder...
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WO/2012/039908 |
This invention provides a combination of a gene and isotope therapy that is applied to a cancerous tissue to selectively kill that associated cancer cells with minimal negative effects on surrounding non-cancerous cells. Functionally, th...
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WO/2012/031457 |
A medicine delayed release vascular embolization gel used for treating tumor, conducting angiography and preventing hemorrhea. The gel is made by coating and loading drugs with pharmaceutical carriers, wherein the drugs can be anti-tumor...
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WO/2012/032043 |
A radiopharmaceutical composition that comprises a radioactive isotope of lead (212Pb) combination with a pharmaceutical or an antibody or antibody fragment and a chelating agent. These compositions are especially useful in the imaging a...
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WO/2012/032029 |
The invention generally relates to the preparation of 18F-!abeled radiopharmaceuticals. In particular, this invention relates to the advanced processes for an efficient eiution of [18F]fluoride trapped in a cartridge filled with quaterna...
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WO/2012/027570 |
Engineered multivalent and multispecific binding proteins, methods of making, and their uses in the prevention, diagnosis, and/or treatment of disease are provided.
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WO/2012/027527 |
A microreactor for preparing a radiolabeled complex or a biomolecule conjugate comprises a microchannel for fluid flow, where the microchannel comprises a mixing portion comprising one or more passive mixing elements, and a reservoir for...
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WO/2012/025464 |
This invention relates to deuterated tyrosine derivatives labeled with 18 F or 19 F, methods of preparing such compounds, compositions comprising such compounds, kits thereof and uses of such compounds, compositions or kits for imaging p...
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WO/2012/024519 |
The present invention relates to compositions and methods of inhibiting stem cell binding to organs and tissues, including the blocking of stem cell binding to germinal centers present in lymph tissue. Disclosed are compositions and meth...
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WO/2012/022812 |
The present invention provides novel in vivo imaging agents useful for detecting the presence of mycobacteria using in vivo imaging methods. Also provided by the present invention is a precursor compound useful in the synthesis of the in...
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WO/2012/024604 |
The present invention provides novel high-valent palladium complexes. The complexes typically include multi-dentate ligands that stabilize the octahedral coordination sphere of the palladium(IV) atom. These complexes are useful in fluori...
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WO/2012/022676 |
The present invention relates to imaging agent compositions comprising radiolabelled c-Met binding peptides suitable for positron emission tomography (PET) imaging in vivo. The c-Met binding peptides are labelled with the radioisotope 18...
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WO/2012/022932 |
The present invention relates to a new synthetic process in which an alkyne and an azide react to form a radioisotopic bioconjugate construct. The reaction is particularly useful for producing compounds for use in imaging and radiotherap...
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WO/2012/024196 |
A bio compatible free radical suspension comprising of oxygen and electronically modified reaction intermediates, where a fluorocarbon is used as an inert medium for stabilization of reaction intermediates. A stabilized bio compatible el...
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WO/2012/021045 |
The present invention relates to a sentinel lymph node marker comprising albumin to which a radioactive isotope, one or more dyes selected from near-infrared ray absorbing dyes, and a visible ray absorbing dye are coupled, a preparation ...
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WO/2012/021882 |
A formulation for stabilizing a radiopharmaceutical. The formulation includes a radiopharmaceutical (or a pharmaceutically acceptable salt thereof), a gas which has oxygen, a stabilizer, and a solvent.
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WO/2012/021045 |
The present invention relates to a sentinel lymph node marker comprising albumin to which a radioactive isotope, one or more dyes selected from near-infrared ray absorbing dyes, and a visible ray absorbing dye are coupled, a preparation ...
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WO/2012/018790 |
Engineered multivalent and multispecific binding proteins, methods of making, and their uses in the prevention, diagnosis, and/or treatment of disease are provided.
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WO/2012/017891 |
The present invention relates to: a pyridyl benzofuran derivative; and a composition for diagnosing amyloid-related diseases, which contains the derivative.
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WO/2012/017103 |
The invention relates to novel compounds such as succinimidyl ester of the Zn(ll) dithiocarbamate of isonipecotic acid and succinimidyl ester of Zn(ll) of dithiocarbamate of nipecotic acid; to the methods for preparing same, causing any ...
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WO/2012/018389 |
The present disclosure relates to various embodiments associated with artificial cells, particularly artificial antigen presenting cells, methods of making the same, methods of administering the same, computer systems relating thereto, c...
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WO/2012/016050 |
This invention relates to methods of treating KRAS-mutant cancers by administering a composition comprising Midostaurin (PKC-412), and methods for increasing the sensitivity of colorectal cancers to radiation, e.g., using Midostaurin (PK...
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WO/2012/013701 |
The present invention relates to 99mTc-maraciclatide radiopharmaceutical compositions, which are stabilised with a radioprotectant. Also described are kits for the preparation of the radiopharmaceutical compositions, as well as methods o...
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WO/2012/012282 |
This invention relates to synthetic bifunctional compounds comprising a first rho-associated kinase (ROCK) inhibiting compound and a second pharmaceutically active compound with complementary activity; the first and the second compounds ...
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WO/2012/009080 |
The present invention provides for a biocompatible drug delivery device for the targeted treatment of cancer that is implantable within the tumorous cells of a patient. In one embodiment, the device comprises two polarizable elements mec...
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WO/2012/009080 |
The present invention provides for a biocompatible drug delivery device for the targeted treatment of cancer that is implantable within the tumorous cells of a patient. In one embodiment, the device comprises two polarizable elements mec...
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WO/2012/006038 |
According to an illustrative embodiment, provided herein are paramagnetic chemical exchange saturation transfer MRI contrast agents having a tetraazacyclododecane ligand and a paramagnetic ion that provides a ratiometric imaging measurem...
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WO/2012/006038 |
According to an illustrative embodiment, provided herein are paramagnetic chemical exchange saturation transfer MRI contrast agents having a tetraazacyclododecane ligand and a paramagnetic ion that provides a ratiometric imaging measurem...
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WO/2012/000843 |
There is described the use of a peptide (1) for the preparation of an agent for detecting an antigen (4) which (a) includes an amino acid sequence of a paratope (7) of an antibody (6) which is directed against the antigen (4), b) binds s...
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WO/2012/000749 |
The use of a peptide (1) for producing an agent for detecting a tumour (18) which expresses a peptide transporter (PEPT) (4) is described. The peptide binds (1) to the pepetide transporter (PEPT) (4) and has an 11C carbon atom on the car...
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WO/2012/002388 |
Disclosed is a drug delivery agent which, in a living body, can selectively deliver a medicinal agent that can detect or treat specifically a lymph node, particularly a sentinel lymph node, in which a cancer cell is likely to become meta...
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WO/2012/000764 |
The use of a peptide (1) for producing an agent for detecting a tumour (18) which expresses a bombesin receptor (4) is described. The peptide (1) binds to the bombesin receptor (4) and has an 11C carbon atom. Also described is a radiopha...
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WO/2012/000861 |
There is described the use of an aptamer (1) for the preparation of an agent for detecting a diseased tissue (18). The aptamer (1) binds to the diseased tissue (18) and is coupled to an amino acid (2) which, in turn, includes an 11C carb...
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WO/2012/000763 |
The invention relates to the use of a peptide (1) for producing an agent for detecting a diseased tissue (18) that expresses an insulin-like growth factor receptor (IGF receptor) (4). The peptide (1) bonds to the IGF receptor (4) and has...
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WO/2012/000841 |
There is described the use of a peptide (1) for the preparation of an agent for detecting an antibody (4), where the peptide (1) binds to a paratope (5) of the antibody (4) and includes an 11C carbon atom. Also provided is a radiopharmac...
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WO/2012/000863 |
There are described a complex (1) and its use for the preparation of an agent for detecting a diseased tissue (18). The complex (1) has the formula I: A - V - B, where A represents an aptamer (2), V is absent or represents a linker molec...
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WO/2012/000781 |
200922936 foreign-countries version 18 abstract 11C-labelled peptide for detecting a tumour which expresses a somatostatin receptor. The use of a peptide (1) for the preparation of an agent for detecting a tumour (18) which expresses a s...
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