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WO/2022/250147A1 |
This transplant material is to be used in kidney xenotransplantation to a primate and contains a kidney anlage with bladder attached without including any blood vessels derived from a pig embryo.
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WO/2022/251793A1 |
Biodegradable orthopedic implants and coatings for the implants are provided. The implant can include a Mg alloy and a coating, where the coating includes silk fibroin. The coating can be anticorrosive and can include a first layer compr...
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WO/2022/243379A1 |
The present invention relates to the use of compounds as primers in a polymerisable thiol-ene-based composition for improving adhesion of the composition on a substrate to be coated, which compounds comprise, for each molecule, at least ...
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WO/2022/243319A1 |
The invention relates to a device and a method for decellularising and/or purifying tissue. The aim of the invention is to eliminate the existing disadvantages according to the prior art and to decellularise and purify allografts and xen...
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WO/2022/246319A1 |
Nitric oxide releasing particles, coatings, tapes, monoliths, and sprayable formulations for reducing the normal foreign body response (FBR) to implanted materials, enhancing wound healing, and/or increasing vascularization. The particle...
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WO/2022/241852A1 |
A preparation method for a bioactive substance coated polyester mesh layer scaffold, which comprises the following steps: forming a mesh layer from a polyester material by means of spun bonding and reinforcement; washing and drying the m...
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WO/2022/242414A1 |
The present application relates to an anti-cancer bionic bone material which can significantly inhibit the activity of osteosarcoma cells. The bionic bone material has good biodegradability and biocompatibility and can be used as a carri...
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WO/2022/245657A1 |
A mixture (30) is formed into a fiber (40). The mixture includes a polymer (26), and an additive molecule (20) that includes one or more fluorinated end-groups (24). The fiber is incorporated into a fabric or textile (60). Other methods ...
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WO/2022/245932A1 |
Methods of producing hybrid fibrous scaffolds are provided. The methods include dissolving a polymer, such as polydioxanone, in a solution, such as 1,1, 1,3,3, 3-hexafluoro-2- propanol (HFP), to form a polymer-containing solution. The me...
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WO/2022/243246A1 |
A corrosion resistant coating for substrates susceptible to corrosion in essentially saline environments, optionally, in vivo environments, is provided. The coating is provided as a nanolaminate structure comprising a plurality of deposi...
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WO/2022/246454A1 |
Disclosed herein are implant materials comprising a shape memory polymer having a first shape and a second shape. The shape memory polymer can comprise at least one monomer unit of glycerol and at least one monomer unit of dodecanedioate...
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WO/2022/243823A1 |
The present invention relates to a system for slowing, inhibiting or blocking the activity of nerves and neuronal structures, useful for research purposes and for medical use by injection or surgical implantation in patients in need ther...
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WO/2022/242413A1 |
The present invention relates to a bionic bone material and a preparation method therefor. The biomimetic bone material of the present invention is obtained by depositing a calcium-containing inorganic salt, a phosphate, etc. in an inorg...
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WO/2022/243567A1 |
The present invention relates to the field of bioresorbable crosslinked materials. More specifically, the present invention pertains to a combination comprising a polyester having a crystalline backbone and at least one end-capping group...
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WO/2022/238441A1 |
The present invention relates to polymeric compounds of glucuronic acid having phenolic hydroxyl moieties (herein after designated by PGU-Ph) and more particularly to a method of hydrogelation of such compounds. The present invention als...
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WO/2022/237002A1 |
Disclosed are a gel microsphere-based 3D printing bio-ink and an application thereof. The 3D printing bio-ink is formed from cross-linked, cell-loaded gel microspheres, or is obtained by mixing cross-linked, cell-loaded gel microspheres ...
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WO/2022/240866A1 |
A method of immobilizing extracellular vesicles in an extracellular matrix material provides for improved extracellular vesicle retention in vitro and in vivo. Extracellular matrix materials, such as collagen, are functionalized with che...
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WO/2022/241255A1 |
Contact lens delivery systems containing ocular therapeutic agent(s) within a crosslinked polymeric silicone hydrogel matrix with macromolecular memory sites to release the ocular therapeutic agent(s) from the hydrogel matrix over time a...
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WO/2022/238718A1 |
The invention relates to an osteoconductive implant material composition comprising or consisting of: (A) calcium phosphate pellets and/or calcium phosphate-encapsulating pellets, wherein the calcium hosphate-encapsulating pellets compri...
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WO/2022/237901A1 |
Provided herein are hyaluronic acid compositions comprising hyaluronic acid or modified hyaluronic acid or crosslinked hyaluronic acid and slowly resorbable particles, spheres and granules. Also provided are methods for augmenting soft t...
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WO/2022/240739A1 |
Absorbable 3D printed implants can be used to reconstruct the nipple with regenerated tissue resulting in improved aesthetic satisfaction. The implants are formed from parallel planes of filaments that are offset and bonded to each other...
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WO/2022/240657A1 |
A flat self-curling rollable composite sheet membrane, and methods for preparing such membranes. The sheet membrane includes a flat layer of collagen and a bioactive agent, such as a calcium phosphate-based mineral. The flat layer self-c...
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WO/2022/241425A1 |
A heart valve model includes a parametric leaflet model representing geometries of a heart valve constructed based on at least one landmark point associated with the heart valve. The heart valve model includes a ray casted anatomical str...
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WO/2022/239633A1 |
The present invention provides a complex which can be used for a shape memory member that can be driven by local heating by means of the application of an electric current. A complex according to one embodiment of the present invention c...
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WO/2022/237900A1 |
Proived herein are derivatized or rapidly polymerizing collagen compositions for tissue augmentation containing non-resorbable or slowly resorbable polymers. Also provided are methods for the preparation of the compositions, and methods ...
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WO/2022/240725A1 |
Absorbable implants can be used to reconstruct the nipple with regenerated tissue resulting in improved aesthetic satisfaction. The implants are particularly suitable for use in plastic surgery procedures, for example, to reconstruct the...
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WO/2022/239868A1 |
The purpose of the present invention is to provide a method for producing retinal system cells or retinal tissue, in which method the proportion of non-target cells is reduced when pluripotent stem cell differentiation is induced. The me...
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WO/2022/237224A1 |
The present invention provides a recombinant human type XVII collagen, the collagen consisting of an amino acid sequence shown represented by (A)n or comprising the amino acid sequence represented by (A)n, wherein A is a sequence shown i...
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WO/2022/235756A1 |
Provided are thiol-ene polymer networks which can reduce the ROS species that contribute to delayed bone healing and fusion. Furthermore, patients that suffer from neuropathic comorbidities such as diabetes suffer from a diminished heali...
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WO/2022/236125A1 |
The present disclosure provides reinforced hydrogel structures, methods of reinforcing hydrogel structures, and methods of treating ischemic disorders using the reinforced hydrogel structures.
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WO/2022/234444A1 |
The present disclosure provides multivalent cation alginate (e.g., calcium alginate) string wound filler compositions suitable for negative pressure wound therapy. In particular, wound filler compositions are well-suited to filling in co...
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WO/2022/234644A1 |
An amnion drying device 1 dries an amnion 11 as a result of disposing the amnion 11 inside a treatment tank 10, heating the amnion 11, and reducing the pressure inside the treatment tank 10, wherein said amnion drying device comprises a ...
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WO/2022/236103A1 |
Embodiments of the present disclosure include methods of simultaneously manufacturing two or more hydrogel constructs (e.g., tubular hydrogel constructs). In some embodiments, the method comprises one or more of the following steps: prov...
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WO/2022/233680A1 |
The invention relates to a method for producing vascularized biological tissue, having the steps of producing a network structure made of a plurality of interconnected filaments (11) of a support polymer, coating the network structure wi...
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WO/2022/236061A1 |
Embodiments of this disclosure relate to bioinks and bioink compositions. These bioinks may be 3D printed into a hydrogel. The printed hydrogel may support primary cell and induced pluripotent stem cell attachment, proliferation, and spr...
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WO/2022/235781A1 |
An aerosol containing fine droplets, the droplets separately or together containing a first component comprising an aqueous preparation of a transition metal or compound thereof and a second component which is an aqueous preparation cont...
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WO/2022/236266A1 |
Bioink formulations including an ionically crosslinkable polymer; the ionically crosslinkable polymer includes a plurality of ionically crosslinkable groups, preferably, anionic functional groups. Also provided are bioink formulation kit...
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WO/2022/234843A1 |
The present invention provides a drug kit for rebuilding a damaged neural pathway, wherein the drug kit comprises a first formulation comprising axonal elongation-inducing protein, nucleic acid encoding said protein, or a vector that exp...
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WO/2022/235741A1 |
Hydrogel-coated orthopedic implants with surfaces that mimic the mechanical and tribological properties of cartilage, and bases that enable integration with bone for long-term fixation, and methods of forming them.
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WO/2022/236119A1 |
The systems and methods of the present disclosure can be used to generate systems and models that are physiologically relevant to the human and animal system. These physiological conditions can be designed to mimic the actual human condi...
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WO/2022/236116A1 |
Provided herein are methods which alter the mechanical and biological properties of polymeric materials. Also provided are compositions comprising the polymeric materials having said properties.
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WO/2022/226590A1 |
The subject invention relates generally to the repair of severed or damaged nerve and/or epineurium in a patient in need of such treatment. In particular, the present invention provides devices and methods of repairing severed or damaged...
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WO/2022/229053A1 |
An implantable device (300, 400, 500, 600, 820, 830, 840, 860) for providing a therapeutic agent (101) includes a container (102, 202, 702, 811, 821, 831, 841, 861) configured to contain multiple cells (103) capable of producing the ther...
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WO/2022/229058A1 |
An implantable device (100, 200, 300, 400, 500, 600, 700, 810, 820, 830, 840, 850, 860) for providing a therapeutic agent (101) includes a container (102, 202, 702, 811, 821, 831, 841, 851, 861) configured to contain multiple cells (103)...
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WO/2022/231904A1 |
A bioactive suspension derived from freshly disaggregated tissue is provided, as well as related methods of formulation and use. The bioactive suspension may comprise a cell-free supernate derived from epidermal and dermal tissue that ha...
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WO/2022/232389A1 |
A ligament repair device and method is particularly suited to the demands of UCL repair using a scaffold device for surgical implantation across a torn ligament section. The implantable device includes an encapsulation of a therapeutic e...
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WO/2022/232639A1 |
Disclosed are intervertebral disc implants utilizing self-healing polymers. Preferred embodiments include a resilient body configured to be, when implanted, positioned between an endplate of a superior vertebral body of an intervertebral...
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WO/2022/229915A1 |
The present disclosure relates to a fluid gel support medium for embedded printing wherein the fluid gel support medium comprises 1 to 4 wt.% of negatively charged cellulose nanocrystals; and at least 0.5 mM of a cation; wherein the flui...
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WO/2022/229653A1 |
The invention provides a decellularized tissue hydrogel cross-linked with a polyphenol, and a method of preparing a cross-linked decellularized tissue hydrogel, the method comprising the steps of: a) providing at least one decellularized...
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WO/2022/226650A1 |
Disclosed herein are hydrogel precursor solutions, hydrogels, and methods of preparation and uses of the same. The hydrogels may be gelled at room temperature, in the absence of added light or heat, to yield ultra-strong hydrogel fibers ...
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