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WO/2023/212416A1 |
Disclosed herein are various bioreactor devices that mimic the mammalian joint. The bioreactor device includes a series of bioreactor chambers that contain different components of the joint, such as bone, cartilage, synovium, and ligamen...
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WO/2023/205854A1 |
The present invention relates to biocompatible hydrogels, in particular, biocompatible hydrogels for delivering a cell to a subject, wherein the hydrogel comprising a scaffold and an oxygen carrier.
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WO/2023/211909A1 |
Compositions for local delivery of a drug to an intracranial region, such as brain tissue or a brain tumor. Methods for locally delivering drug or therapy to an intracranial region. Compositions may include a hydrogel in which a chemothe...
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WO/2023/208968A1 |
The present invention relates to a guided bone regeneration device that is intended for the reconstruction of a buccal bone defect and is composed of an optionally micro-perforated smooth wall which is made of titanium and has a shape th...
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WO/2023/204122A1 |
[Problem] The purpose of the present invention is to provide a method for producing a hydroxyl-group- and (meth)acryl-group-containing siloxane at high purity and high yield. [Solution] The present invention provides a method for purifyi...
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WO/2023/205265A1 |
The present disclosure provides improved polymer compositions, such as GelMA polymer compositions. In certain embodiments, the improved polymer compositions can be used for delivering one or more therapeutic agents, such as cells, to a t...
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WO/2023/205051A1 |
Compositions, methods, and applications for single component systems for the formation of in situ hydrogels are described. The single component systems are effective for forming stable, single solutions containing precursors providing bo...
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WO/2023/205370A1 |
Disclosed herein are apparatuses comprising one or more channels defining a luminal space, wherein the luminal space is defined by an inner wall of fibrous basement membrane material, as well as methods of their manufacture and use.
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WO/2023/204434A1 |
According to the present invention, a decellularized tissue supplement is prepared by: a preparation step for preparing tissue of a non-human mammal; a pretreatment step for pretreating the tissue; a first inactivation step for inactivat...
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WO/2023/204424A1 |
The present invention relates to a technology relating to an implant abutment and, more specifically, to an implant abutment absorbing external shock and a manufacturing method thereof, wherein when an implant abutment made of titanium (...
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WO/2023/205141A1 |
Disclosed are compositions and kits useful for bone repair and reconstruction of bone defects such as bone voids and fractures. The compositions can include two reactive components that when mixed together form a polythiourethane that cu...
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WO/2023/205519A1 |
A method for producing a microfluidic device, the method comprising: producing a first housing portion and a second housing portion; securing the second housing portion to the first housing portion; enclosing a three-dimensional biomater...
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WO/2023/204749A1 |
A method of forming a cross-linked hydrogel, comprising to provide a) a polymer composition comprising polymer molecules provided with thiol-containing moieties, wherein the one or more thiol groups of a thiol-containing moiety are prote...
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WO/2023/205163A1 |
Disclosed herein are systems and methods for coating an implant with a therapeutic agent in a sterile clinical setting. The systems and methods disclosed herein can provide for coating implants or other prosthetic components with one or ...
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WO/2023/205127A1 |
In an embodiment, the present disclosure pertains to a multi-network hydrogel composed of a first network, a second network, and a third network. In some embodiments, the first network, the second network, and the third network form a po...
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WO/2023/203235A1 |
Provided is a composite material used for promoting innervation, osteogenesis and angiogenesis.
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WO/2023/204435A1 |
A decellularized mammal-derived tissue matrix according to the present invention is prepared through: a preparation step of preparing tissues of a mammal that excludes humans; a pretreatment step of pre-treating the tissues; a primary in...
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WO/2023/201397A1 |
Disclosed herein is a bioactive polymer for forming a tissue scaffold, the polymer comprising a first monomer for binding water, a second monomer for imparting mechanical properties to the scaffold; optionally, a third monomer for bindin...
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WO/2023/201684A1 |
The present application provides a porous material and a preparation method therefor, a current collector, a secondary battery and a device. The porous material has pores having a first pore diameter and pores having a second pore diamet...
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WO/2023/199586A1 |
An artificial skin (1) comprises a collagen layer (2), which is mainly composed of collagen, and a silicone layer (3), which is mainly composed of silicone and covers one surface of the collagen layer (2). Of the collagen layer (2) and t...
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WO/2023/198555A1 |
There is provided an object, wherein there are particles on the surface of the object, wherein the amount of particles is in the interval 0.041 - 6 μg/cm2, wherein the particles comprise palladium in an amount corresponding to 0.02 - 2 ...
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WO/2023/200847A1 |
Anti-biofilm osseointegrating and/or tissue-integrating implantable biomaterial devices that optionally can elute therapeutic ions such as magnesium, silver, copper and/or zinc. In certain embodiments, the devices are subjected to a surf...
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WO/2023/200731A1 |
A method for 3D printing a patient-specific bone implant having variable density, in various aspects, comprises: (1) providing a thermoplastic polymer composition comprising: (A) between about 20% and about 50% bioactive agent by weight;...
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WO/2023/199814A1 |
The present invention addresses the problem of providing a method for producing an octacalcium phosphate molded article compounded with a biocompatible polymer. Provided is a method for producing an octacalcium phosphate molded article...
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WO/2023/200098A1 |
The present invention relates to an artificial structure for preventing or treating lymphedema and a construction method therefor. According to the artificial structure for preventing or treating lymphedema and the construction method th...
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WO/2023/197881A1 |
The present invention relates to a nanotube capable of promoting selective nerve self-repair. The nanotube comprises a hollow nanotube body and a slidable cover plate. The side wall of the nanotube body is provided with a side wall openi...
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WO/2023/199855A1 |
The purpose of the present invention is to provide: a copolymer that can impart excellent biocompatibility to the surface of a medical device by a simple process and enables the biocompatibility to be kept for a long period of time; a me...
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WO/2023/197248A1 |
The present invention belongs to the technical field of cell biology. Disclosed are a biological agent, use of a QF-1 compound in the preparation of a biological agent for promoting adipogenic differentiation of mesenchymal stem cells an...
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WO/2023/197419A1 |
An injectable hyaluronic acid microsphere, a preparation method therefor and use thereof. The method comprises: adding cross-linked hyaluronic acid into an aqueous solvent to prepare a first liquid phase, the concentration of the cross-l...
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WO/2023/199794A1 |
A cervical stenosis prevention device (1) comprises: a composite thread portion (2) that is formed by twisting a membrane-like dried vitrigel body and includes a thread-like core material; and a fixing part (3) that is used for indwellin...
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WO/2022/159878A9 |
The present disclosure provides compositions and methods related to the delivery of therapeutic medicines to the heart for treating a cardiac injury, such as those that occur due to a myocardial infarction (MI). In particular, the presen...
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WO/2023/196970A1 |
Compositions are disclosed herein that include an extracellular matrix (ECM) hydrogel and matrix bound nanovesicles (MBV). These compositions provide a synergistic effect and are of use for treating subjects.
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WO/2023/195790A1 |
The present invention relates to a biomaterial for tissue repair comprising a compound of the pyridine series as an active ingredient and a method for manufacturing same, wherein the compound of the pyridine series has excellent biocompa...
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WO/2023/195633A1 |
The present invention relates to decellularized acellular dermal tissue prepared using supercritical fluid extraction. More specifically, the present invention relates to an acellular dermal tissue having an improved level of extracellul...
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WO/2023/196422A1 |
A dehydrated, partially perforated, placental tissue allograft that can be used in the treatment of wounds. Specifically, the dehydrated, partially perforated placental allograft has the property of being able to be cleaned during proces...
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WO/2023/196367A1 |
An implant including a shell and a plurality of position-stabilizing wells is described. The position-stabilizing wells are defined by an opening at least one-half (0.5) millimeters across. The position-stabilizing wells allow the ingrow...
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WO/2023/196443A1 |
A nerve regeneration system includes a nerve guide having a proximal end and a distal end. The system includes nerve growth factor configured to enhance the growth of axons and associated nerve tissue. The nerve growth factor has a first...
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WO/2023/196312A1 |
Embodiments of the present disclosure are directed to radiopaque polymer formulations comprising thermoplastic polymer and a filler. The filler comprises 25 wt% to 45 wt% of tungsten and 35 wt% to 55 wt% of barium sulfate.
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WO/2023/195514A1 |
The present invention improves the physical properties of a polymer that includes an alkoxy alkyl (meth)acrylate as a principal structural unit to achieve a polymer that has physical properties that are very similar to a biological subst...
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WO/2023/194445A1 |
The present invention relates to a method for the production of a biomimetic model of non-melanoma skin cancer comprising a hydrogel and at least a cell population comprising squamous carcinoma keratinocyte cells. Uses of said skin model...
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WO/2023/196852A1 |
A jammed gel bioink comprises a self-assembling peptide solution comprising a self-assembling peptide, and a cell solution comprising living cells and a cell culture medium. The self-assembling peptide solution is extruded to form an obj...
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WO/2023/194992A1 |
A method of manufacturing a retinal graft. The method includes: (a) preparing a scaffold material solution; (b) air-drying the scaffold material solution, to form a thin scaffold layer; (c) crosslinking the thin scaffold layer; (d) rehyd...
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WO/2023/194333A1 |
The invention described herein relates to a novel non-naturally occurring, elastomeric animal-free recombinant fusion biopolymers produced in plants through transient expression. More specifically, the present invention describes polynuc...
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WO/2023/195397A1 |
An artificial blood vessel according to the present invention has a predetermined fibrous structure woven by warps 1 and wefts 2, wherein at least one among the warps 1 and the wefts 2 are constituted by a multi-filament fiber including ...
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WO/2023/192339A1 |
Embodiments relate to granular hydrogel bioinks with preserved interconnected porosity for extrusion bioprinting and methods of use and making thereof. The granular hydrogel bioinks comprise hydrogel particles and materials/methods to re...
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WO/2023/190762A1 |
This design device (100) comprises: a beam generation unit (152) for repeatedly generating a plurality of new beams branching from a node at the distal end of an existing beam, while changing at least one of the beam length, number of br...
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WO/2023/192344A1 |
Embodiments relate to a device and/or method for vascularization, which can also be used to enhance regenerating tissues. The method comprises inducing surgical micropuncture, in which small perforations are created using a microscale ne...
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WO/2023/191144A1 |
The present invention relates to a method for manufacturing a separable ceramic dental implant and, more specifically, to a method for manufacturing a separable ceramic dental implant, the method comprising: injection molding a ceramic d...
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WO/2023/191273A1 |
The present invention relates to a polymer scaffold for prosthesis manufactured of a biodegradable polymer material for stabilization and regeneration of a diseased part and to a method for manufacturing same. The purpose of the present ...
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WO/2023/191272A1 |
The present invention is to provide a polymer scaffold for prosthesis, which is an insertion-type support, and a manufacturing method thereof. The polymer scaffold for prosthesis comprises: two outer sheets made of a biodegradable synthe...
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