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Matches 601 - 650 out of 3,013

Document Document Title
WO/1999/052560A1
Synthetic comb copolymers which elicit controlled cellular response, methods of applying these polymers to various surfaces, and methods of using the polymers for modifying biomaterial surfaces, in tissue engineering applications and as ...  
WO/1999/052574A1
The present invention relates to new biopolymer resistant coatings for materials that come in contact with such molecules in solution. Additionally, the present invention discloses a process for the fabrication of these coatings, under m...  
WO/1999/051571A1
The present invention is directed to aminoguanidine and alkoxyguanidine compounds, including compounds of Formula (I), wherein X is O or NH, L is -O- or -SO¿2?-, and R?1¿-R?4¿, R?9¿-R?19¿, R?a¿, R?b¿, R?c¿, Y, Z, n and m are set ...  
WO/1999/051168A1
A composite graft (10) for a fluid-carrying vessel in a living body, comprising: an inner vessel (12) comprising a biologic collagenic material that has been stabilized, an outer member (14) surrounding at least a segment of the inner ve...  
WO/1999/049907A1
Medical devices are provided, at least part of the surface of which a protein having the activity of Protein C or Activated Protein C is directly or indirectly attached. The devices of the invention may be vascular prostheses such as ste...  
WO/1999/047176A2
A reagent and related method for use in passivating a biomaterial surface, the reagent including a latent reactive group and a bifunctional aliphatic acid (e.g., fatty acid), in combination with a spacer group linking the latent reactive...  
WO/1999/045970A1
Compositions and methods for use with substrates which are useful in the sustained delivery of bioeffecting agents are described. The compositions of the invention include a multicomponent complex which attaches a bioeffecting agent to a...  
WO/1999/043728A1
The present invention is directed to novel compounds with a high degree of haemocompatibility constituted by a polyurethane covalently bound to sulphated hyaluronic acid or to its sulphated derivatives, suitable for the preparation of bi...  
WO/1999/043688A1
A photoactivatable nucleic acid derivative composition in which one or more photoreactive group(s) are bound to a natural or synthetic nucleic acid. The photoreactive groups can be bound to the nucleic acid before, during or after its fo...  
WO/1999/040874A1
The present invention provides a lumen support stent (20) for use in an artery or any body lumen. The stent is formed from a plurality of ladder elements (32) having elongated ribs (28) bowed to define a circumferential arc of the tubula...  
WO/1999/038547A2
Enhanced biocompatibility coatings for medical implants and acute exposure medical devices are disclosed in conjunction with methods for their production and use. The biocompatible coatings are particularly advantageous when used in conj...  
WO/1999/034763A2
Thiram (tetramethylthiuram disulfide) is shown to inhibit angiogenesis and/or inflammation and to be useful in the treatment of angiogenesis-dependent disorders, including neoplasms, and in the inhibition, treatment and alleviation of in...  
WO/1999/034784A2
Disulfiram (tetraethylthiuram disulfide) is shown to inhibit angiogenesis and to be useful in the treatment of angiogenesis-dependent disorders, including neoplasms, and to prevent cell hyperproliferation and formation of clots along or ...  
WO/1999/033499A2
A method for making a medical device having at least one biomolecule immobilized on a substrate surface is provided. The method may include oxidizing a 2-aminoalcohol moiety with a periodate to form an aldehyde-functional material; combi...  
WO/1999/032080A2
Disclosed is a method for immobilizing the thrombogenic inhibitor hirudine on polymer surfaces of extracorporeal and/or intracorporeal medical objects by direct interaction or via appropriate spacer systems between functional groups of t...  
WO/1999/027976A1
Process for the preparation of polymer materials with high compatibility with organic fluids and tissues comprising a basic polymer to which it is covalently bonded molecules of a polysaccharide comprising disaccharide repetitive unities...  
WO/1999/027968A2
A method for making a medical device having at least one glycoprotein and/or glycopeptide immobilized on a substrate surface is provided. The method may include oxidizing 1,2 dihydroxy moieties with a periodate to form an aldehyde-functi...  
WO/1999/026983A1
The present invention is related to heparin-like compounds characterized by their capacity of inhibiting collagen-induced platelet aggregation in flowing whole blood and their use for prophylactic treatment of arterial thrombosis associa...  
WO/1999/024106A1
A drug-infusing device is implanted into a body cavity such as a bladder. The device is implanted in an uninflated, low profile state. After insertion into the body cavity, the device is filled with a substance, such as a drug, and assum...  
WO/1999/019381A1
A medical material composed of a poly(alkyl aryl ether)sulfone copolymer (A) and a thermoplastic polymer (B), such as cellulose triacetate, and being used in contact with the blood, wherein the concentration of the copolymer (A) is at le...  
WO/1999/016477A2
The invention relates to a radioactively marked antithrombogenic polymer and the use thereof as a component of therapeutic devices for preventing excessive cell proliferation or scarring. The invention also relates to devices which conta...  
WO/1999/016475A2
A hemocompatible composition comprising a polymer containing at least one pharmacologic material other than heparin chemically bonded to a polymer backbone or a polymer containing heparin and at least one other pharmacologic material, bo...  
WO/1999/008717A2
A polybifunctional reagent having a polymeric backbone, one or more pendent photoreactive moieties, and two or more pendent bioactive groups. The reagent can be activated to form a bulk material or can be brought into contact with the su...  
WO/1999/001089A1
Coated implantable prosthetic devices are disclosed. The device is a prosthetic having a gold layer on the surface to which bioactive molecules are attached through a gold-sulfhydryl bond. The devices are easy and convenient to prepare. ...  
WO/1999/001167A1
A process for modifying a surface of an article that includes treating a surface with a solution that includes an organic solvent, and the reaction product of a substantially water insoluble polymer and a polyalkylene imine to form a mod...  
WO/1999/000070A1
The preparation and use of medical devices are described. A thiol group agent is loaded onto a medical device such as a stent or a catheter. Preferably, the loading is accomplished onto a polymeric surface (22) that had been activated by...  
WO/1998/058680A2
The invention relates to stents consisting of a base body coated with a carrier polymer linked to perfluoroalkyl chains which protrude from the stent surface like a brush. The invention also relates to a method for producing said stents ...  
WO/1998/058690A2
The adherent coating of the invention comprises a stabilizing polymer together with an active agent (a hydrophilic polymer and/or a bioactive agent) in a layer bonded to the surface of a medical device. This invention encompasses the coa...  
WO/1998/057680A2
A device useful for localized delivery of a therapeutic material is provided. The device includes a structure including a porous material; and a water-insoluble salt of a therapeutic material dispersed in the porous material. The water-i...  
WO/1998/057679A1
Antithrombic medical material having on its surface a film made from a graft copolymer produced by grafting a quaternary ammonium monomer and a hydrophilic monomer onto a hydrophobic polymer, characterized in that an anticoagulant such a...  
WO/1998/057671A2
A medical device is described which has on a surface thereof a bio-compatible coating. This bio-compatible coating is formed from a composition which includes an aqueous emulsion or dispersion of a polycarbonate-polyurethane composition ...  
WO/1998/055128A1
A process for forming a surface modification on a polymer substrate and polymer substrates having such surface modifications. The process comprises the steps of: absorbing a swelling monomer into the polymer substrate for a period of tim...  
WO/1998/055162A2
A metal, glass or ceramics surface is treated to enhance its compatibility with biological material such as blood or blood related products. Treatment involves covalently bonding to the surface by means of a catalyst functional molecules...  
WO/1998/052623A1
Ion-implanted protein-coated occlusion coils are described which have essentially the same dimensions as untreated coils and exhibit altered surface properties, e.g., thrombogenicity, endothelial cellular migration and adhesion, relative...  
WO/1998/050086A2
A medical device comprising a biomaterial formed from a polymer comprising urethane groups and saturated linear polyethylene moieties.  
WO/1998/049206A1
A polymer, possibly fabricated as part of a medical device or as part of a medical prostheses (such as a contact lens) is functionalised to facilitate the introduction of functional groups, such as biomedical species including heparin. T...  
WO/1998/046659A1
Biocompatible polyurethanes or polyurethane ureas having phosphorylcholine structures represented by general formula (1) in the side chain; and antithrombotic medical devices made by using them. In said formula, R?1� is C�1?-C�20?a...  
WO/1998/046351A1
The present invention relates to a high density tethered polymer surface material comprising two regions: (1) a polymer shell characterized by an optimal surface concentration of aldehyde, hydroxyl or sulfhydryl groups; and (2) polymer c...  
WO/1998/046288A1
Methods for binding heparin to biological or synthetic materials which are to be implanted within a mammalian body. In instances where connective tissue proteins or other components of the material having adequate carboxyl groups present...  
WO/1998/045335A1
The present invention is directed to novel sulphated compounds of hyaluronic acid and derivatives thereof, optionally salified, wherein the glucosamines are partially N-sulphated or partially N-sulphated and partially or totally O-sulpha...  
WO/1998/040112A1
There is described a bio-compatible aqueous slurry for forming a fluid-tight barrier on a surface of a porous implantable article. This aqueous slurry includes a self-aggregating protein comminutate having a substantially uniform particl...  
WO/1998/034959A1
A method of inhibiting thrombin generation and complement activation is inhibited by using a dermatan disulfate having at least 2 sulfate groups per disaccharide obtained by chemical sulfation of native dermatan sulfate. The resulting de...  
WO/1998/025544A1
A tissue graft construct and method for repairing the inner linings of damaged or diseased vertebrate vessels are described. The method comprises the steps of positioning a tissue graft construct within a blood vessel at a site in need o...  
WO/1998/025654A1
The present invention provides a method for improving the biocompatibility of devices, especially medical devices which are invasively present within a patient's body and the improved medical device. The present invention particularly re...  
WO/1998/025545A1
A graft construct and method for repairing the inner linings of damaged or diseased vessels is described. The method comprises the steps of positioning a graft construct within a blood vessel at a site in need of repair. The graft constr...  
WO/1998/023228A1
The invention relates to a directional drug delivery stent which includes an elongated or tubular member having a cavity containing a biologically active agent. In one embodiment, the active agent is diffused from the reservoir directly ...  
WO/1998/023565A2
Aminoguanidine and alkoxyguanidine compounds, including compounds of formula $i((I)) wherein X is O or NR?9� and R?1�-R?4�, R?6�-R?9�, R?11�, R?12�, R?a�, R?b�, R?c�, Y, Z, n and m are set forth in the specification, ...  
WO/1998/023306A1
Disclosed are bio-active coating compositions for polymeric substrates. In particular, a bio-active coating is described which is the reaction product formed by providing a polymer backbone with at least one free isocyanate group, wherei...  
WO/1998/023308A1
A medical device having a bio-active coating is prepared by providing a polymeric substrate having hydroxyl and/or amine functionality on a surface thereof and applying the bio-active coating to the surface. The bio-active coating is the...  
WO/1998/023307A1
A bio-active coating composition is described which is the reaction product of two different reactions. The first reaction includes reacting a bio-compatible polymer backbone having $g(a),$g(b)-unsaturated carbonyl functionality with a h...  

Matches 601 - 650 out of 3,013