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WO/2024/073359A1 |
The present disclosure provides hydrophobically-modified biopolymers, including hydrophobically-modified chitosans, which comprise benzenediol groups, optionally where a portion are oxidized to the corresponding quinone. The biopolymers ...
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WO/2023/244605A1 |
A library of copolymers for use as broad-spectrum antibiotics is provided where each copolymer includes three distinct acrylamide-based monomers: (1) a cationic monomer to attract the polymer selectively to bacterial surfaces; (2) a hydr...
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WO/2023/239711A1 |
Provided is a bovine intestinal heparin chemically modified with a 1-(3-dimethylaminopropyl)-3-ethylurea (EDU)-amide having anti-factor IIA activity is about 20 to about 30 lU/mg, wherein the modified bovine intestinal heparin exhibits b...
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WO/2023/186794A1 |
The present invention relates to an inverse opal (IOPAL) hydrogel formed with poly(ethylene)glycol (PEG) covalently bonded to heparin (Hep). The invention also relates to the use of said hydrogel as well as to the procedure, based in the...
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WO/2023/162926A1 |
This medical coating agent comprises a polymer including a structural unit (A) derived from an ethylenic unsaturated monomer having a urea bond. The polymer contained in the medical coating agent satisfies Condition (i) in a case where a...
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WO/2023/129866A1 |
In a method of integrating an active pharmaceutical ingredient (API) with a thermoplastic polymer, the thermoplastic polymer and API are into a first feed port of a multi-screw extruder or the thermoplastic polymer is fed into the first ...
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WO/2023/119704A1 |
[Problem] To provide a curable calcium phosphate composition that is suitably used as a biological bone reinforcement treatment and can impart a calcium phosphate cured body exhibiting both a high level of strength and absorbability into...
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WO/2023/068375A1 |
The present invention provides a resin composition to which proteins do not adhere easily and, therefore, which is suitable for manufacturing an article that comes in contact with proteins, said resin composition containing a vinyl chlor...
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WO/2023/059649A1 |
An example medical device includes a vascular device, such as a catheter, and an anti-thrombogenic coating on a surface of the vascular device, such as a surface likely to contact blood. The anti-thrombogenic coating includes one or more...
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WO/2023/054500A1 |
This medical coating agent contains a polymer having a structural unit (A) derived from an ethylenic unsaturated monomer having an urethane bond. The polymer contained in the medical coating agent satisfies condition (i) in a case where ...
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WO/2023/054499A1 |
This medical coating agent contains a polymer including a structural unit (A) derived from an ethylenically unsaturated monomer having a urethane bond. In a DSC curve obtained by including water into the polymer and increasing the temper...
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WO/2023/046044A1 |
The present application relates to a modified polymer membrane material having a surface composite grafted phosphorylcholine and heparin anticoagulant coating. A preparation method for the modified polymer membrane material comprises the...
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WO/2023/035046A1 |
Provided is a method of coating a substrate with a hyperbranched polyglycerol. The hyperbranched polyglycerol is formed by activating the surface of the substrate followed by polymerisation of monomers of glycidol, or derivatives thereof...
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WO/2023/006858A1 |
The invention relates to a combination product comprising, as active substances, at least grapefruit seed extract, vitamin C, vitamin D3 and zinc in dry form to help maintain the body's natural defenses, protect cells from oxidative stre...
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WO/2023/278225A1 |
A device for obtaining a blood sample may include a holder for receiving a sample source, the holder having an actuation portion and a port; a blood collector attachment removably connected to the holder; and a collection container remov...
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WO/2022/254943A1 |
Provided is an absorbent article having improved menstrual blood absorbency.　This absorbent article for absorbing menstrual blood has a functional substance that has the function of impeding factors that affect blood coagulation.
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WO/2022/253780A1 |
A coating for a medical device is described. The coating comprises: a base layer comprising a protein; and a polymer layer disposed on the base layer. The polymer layer comprises a polymer having a plurality of hemocompatible groups. Eac...
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WO/2022/167447A9 |
The invention relates to a medicinal product, at least parts of the medicinal product being coated and the coating comprising a functional layer and the functional layer containing saccharides and peptide sequences with integrin-binding ...
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WO/2022/240919A1 |
A system is provided for generating plasma within narrow diameter tubes, e.g., tubes with an inner diameter of less than 1 millimeter. The system may comprise the tube, a nozzle connected to at least one end of the tube configured to sup...
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WO/2022/207703A1 |
Provided is a process for the preparation of a silicone or fluorosilicone-coated solid substrate, which process comprises the following steps a) providing a solid substrate having at least one surface to be coated, b) bringing the surfac...
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WO/2022/210938A1 |
The present invention provides: a composition for medical use, the composition being capable of providing the surface of a medical instrument or the like with biocompatibility; an application of this composition for medical use; and the ...
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WO/2022/210759A1 |
[Problem] The present invention addresses the problem of providing a surface treatment agent that has high hydrophilicity and is superior in antithrombogenicity, and consequently biocompatibility, relative to conventional medical materia...
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WO/2022/191637A1 |
The present invention relates to a method for grafting a surface of a medical device by using quaternized trimethylamine. A catheter onto which quaternized trimethylamine has been grafted allows for the reduction of thrombus production. ...
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WO/2022/182971A1 |
Medical articles formed from a polyurethane-based resin including an ionically-charged modifier provide enhanced properties. The polyurethane-based resin is a reaction product of ingredients comprising: a diisocyanate; a diol chain exten...
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WO/2022/182978A1 |
Medical articles formed from a polyurethane-based resin including an ionically-charged modifier provide enhanced properties. The polyurethane-based resin is a reaction product of ingredients comprising: a diisocyanate; a diol chain exten...
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WO/2022/157345A1 |
The present invention is directed to materials compatible with blood, implantable devices comprising said material, methods of preparation of such material and medical devices coated therewith and uses thereof for anti-thrombotic and/or ...
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WO/2022/135878A1 |
The invention relates to an intravascular implant, in particular a stent, comprising a lattice structure made of lattice elements, which delimit lattice openings and have a superelastic structural material, in particular an alloy having ...
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WO/2022/135453A1 |
Provided are an enzyme-modified anticoagulant valve and a manufacturing method therefor. The manufacturing method is: (1) placing a bioprosthetic valve material in a mixture of a polyphenol compound and a soluble metal salt for a reactio...
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WO/2022/121912A1 |
A biovalve crosslinking method for improving mechanical and anticoagulation properties, a biovalve material and an application thereof, relating to the technical field of biomedical materials. In the biovalve crosslinking method, a bioma...
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WO/2022/126021A1 |
Described are methods for embedding one or more therapeutic agents into vascular grafts and other scaffold-based devices, and methods of implanting vascular grafts comprising tubular scaffolds into subjects. The tubular scaffolds compris...
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WO/2022/113019A1 |
The object of the invention is a membrane made of an organic material with pore-forming, anti-inflammatory and anticoagulant properties, characterized in that it has the form of a flat film or a hollow fiber tube and is made of an organi...
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WO/2022/113015A1 |
The object of the invention is an organic material with blowing, anti-inflammatory and anticoagulant properties characterized in that it comprises a base polymeric material and an active admixture in the form of albumin or argatroban or ...
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WO/2022/083759A1 |
The present invention relates to the technical field of biomedical materials. Disclosed are an anticoagulation and anticalcification artificial heart valve material, a preparation method therefor, and an application thereof. The anticoag...
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WO/2022/083758A1 |
Disclosed are an anticoagulant artificial heart valve material, a preparation method therefor and use thereof, which belong to the technical field of biomedical materials. The anticoagulant artificial heart valve material comprises a bio...
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WO/2022/061430A1 |
The invention relates to a non-polymeric, biocompatible, expandable intravascular or organic prosthetic device (50, 51) for releasing multiple drugs (33), by extrinsic factors, such as precursor drugs (36), released via organic implants,...
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WO/2022/028395A1 |
Disclosed are an anticoagulant intravascular stent cover film and a preparation method therefor. Silkworm silk is divided into two groups, wherein one of the groups is twisted and combined to obtain a silk thread group, and the other gro...
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WO/2022/028396A1 |
Disclosed are a silk anticoagulant vascular stent cover film and a preparation method therefor. Silkworm silk is divided into two groups, wherein one group is twisted and combined to obtain a silk thread group, and the other group is a s...
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WO/2022/026415A1 |
A method of reducing or delaying the onset of fatty liver disease in a subject comprises enterally administering at least one human milk oligosaccharide (HMO) to a subject in need thereof in an amount effective to reduce hepatic lipid ac...
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WO/2022/026800A2 |
The present invention provides mannose-binding lectin (MBL)-based compositions, and methods of using the MBL-based compositions in the reduction of unintended platelet activation, such as during a medical procedure.
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WO/2022/021363A1 |
The present invention relates to a coating composition, a hydrogel coating and a preparation method therefor, and a coated product. The coating composition comprises the following components in parts by weight: 2-100 parts of polyethylen...
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WO/2022/019297A1 |
A first problem to be addressed by the present invention is to provide an antithrombotic sheet for cell adhesion, which exhibits excellent antithrombotic properties and cell adhesion properties. A second problem to be addressed by the pr...
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WO/2021/256725A1 |
The present invention relates to artificial blood vessels with thrombolytic activity and a preparation method therefor, in which the artificial blood vessels with fucoidan bound thereto can prevent neointimal hyperplasia and thrombokines...
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WO/2021/254347A1 |
The present invention provides a valve material having a long-acting antithrombosis property and a preparation method therefor. The preparation method therefor comprises the following steps: performing glutaraldehyde cross-linking treatm...
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WO/2021/254346A1 |
The present invention provides a valve material having synergistic anti-coagulation and anti-calcification functions and a preparation method therefor. The preparation method comprises the following steps: performing glutaraldehyde cross...
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WO/2021/251712A1 |
The present invention relates to a stent for drug delivery and a manufacturing method therefor, the stent being inserted into a narrowed area in the body in which stenosis symptoms are observed or predicted, so as to prevent stenosis of ...
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WO/2021/247692A1 |
A prosthetic venous valve includes an expanding anchoring frame, a valve seat at the middle portion of the anchoring frame, a ball disposed within the lumen of the anchoring frame and having an outer diameter, and least one ball retentio...
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WO/2021/242783A1 |
Devices, systems, and methods are provided including a structure having one or more surfaces configured for internal use within a patient's body and one or more therapeutic compositions comprising one or more active substances including ...
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WO/2021/239080A1 |
Disclosed are a biological heart valve with both anticoagulation and anti-calcification properties, and a preparation method therefor. The specific process of the method comprises: using glutaraldehyde to conduct a cross-linking treatmen...
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WO/2021/213516A1 |
An anticoagulation and anticalcification biological material, and a preparation method therefor. The preparation method comprises the following steps: introducing, on biological tissue, an active group capable of causing polymerization r...
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WO/2021/212787A1 |
An artificial bioprosthetic valve and a preparation method therefor. The artificial bioprosthetic valve comprises a support and a functional biological tissue material attached to the support. The functional biological tissue material is...
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