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WO/2013/051479 |
[Problem] To provide a composition for forming a coating film that effectively inhibits the adhesion of cells such as platelets and a biomaterial such as a protein. [Solution] The invention provides an adhesion inhibitor, for cells and a...
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WO/2013/049068 |
Methods of covalently attaching heparin to a membrane comprising plasma treating the membrane to produce an amino-functionalized membrane; and reacting the amino-functionalized membrane with heparin under conditions in which heparin beco...
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WO/2013/047527 |
The present invention provides a substrate for ligand immobilization, which comprises a water-insoluble carrier and a copolymer represented by general formula (1) bound to at least the surface of the water-insoluble carrier. [In general ...
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WO/2013/038901 |
[Problem] To provide a novel organic silicon compound that can be used for a silane coupling agent. [Solution] This organic silicon compound is represented by formula (1). (In the formula: A- represents formula (2) or formula (3); E repr...
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WO/2013/031459 |
Provided is a medical instrument, the surface of which exhibits lubricity and/or antithrombotic properties when wet. A medical instrument of the present invention comprises a base layer and a hydrophilic layer that is supported on at lea...
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WO/2013/033023 |
A bio-compatible lumen bearing device such as a catheter formed of a polymeric material having a titanium surface bonded to the underlying exposed catheter surface. The titanium surface is employed in patients to improve bio-compatibilit...
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WO/2013/027556 |
Provided is an antithrombogenic material that has excellent anticoagulation activity and is capable of forming a stable coating layer on a substrate by a simple and mild coating process. The antithrombogenic material comprises a copolyme...
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WO/2013/027579 |
[Problem] The present invention provides a medical tube which mainly comprises a thermoplastic resin, has a heparinized blood contact surface, and in which quality defects due to clouding and oil defects are reduced. [Solution] The prese...
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WO/2013/028725 |
An apparatus and method provides a drug layer formed on a surface region of a medical device, the drug layer comprised of a drug deposition and a carbonized or densified layer formed from the drug deposition by irradiation on an outer su...
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WO/2013/028761 |
A method of modifying the surface of a medical device to release a drug in a controlled way by providing a barrier layer on the surface of one or more drug coatings. The barrier layer consists of modified drug material converted to a bar...
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WO/2013/015419 |
A blood container (10) for use in a centrifuge is characterized by the provision of a container body (11) comprising a hard resin and is further characterized in that the tensile strength of said container body (11) is 10 to 80 MPa. Part...
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WO/2012/176861 |
The purpose of the invention is to provide a medical supply wherein a compound that is capable of interfering with the blood coagulation reaction, both during the step of primary hemostasis in which platelets participate and the step of ...
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WO/2012/160053 |
The present invention relates to a layer composite comprising a bonding layer and a hydrophilic topcoat joined thereto, where the bonding layer comprises a polyurethane urea which can be obtained by reaction of at least the following com...
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WO/2012/123384 |
There is described inter alia a device having a surface comprising a layered coating wherein the outer coating layer comprises a plurality of cationic hyperbranched polymer molecules characterized by having (i) a core moiety of molecular...
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WO/2012/116250 |
The invention generally relates to functional polymers and hydrogels. More particularly, the invention provides versatile monomers and polymers with well-defined functionalities, e.g., polycarbonates and poly(ester-carbonates), compositi...
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WO/2012/106707 |
Embodiments of the invention are based on the fermentation of bacteria to produce nano-cellulose in oxygen permeable tubular bioreactors. The resulting hydrogel non-hollow fiber can be stretched and dewatered to form strong, stiff yet fl...
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WO/2012/106707 |
Embodiments of the invention are based on the fermentation of bacteria to produce nano-cellulose in oxygen permeable tubular bioreactors. The resulting hydrogel non-hollow fiber can be stretched and dewatered to form strong, stiff yet fl...
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WO/2012/100100 |
A self-healing, scratch resistant slippery surface that is manufactured by wicking a chemically-inert, high-density liquid coating over a roughened solid surface featuring micro and nanoscale topographies is described. Such a slippery su...
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WO/2012/091028 |
The invention addresses the problem of providing a medical material and a hemoperfusion machine of high anti-thrombotic properties and safety. The machine is obtained by incorporating a medical material, wherein: a hydrophilic copolymer ...
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WO/2012/090553 |
The present invention relates to a tubular structure coating composition containing silk fibroin and polyurethane resin.
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WO/2012/017337 |
The present invention relates to a functionalized semi-permeable membrane composed of a porous biocompatible support pretreated so as to increase the surface energy thereof and characterized in that it comprises at least two layers, each...
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WO/2012/001532 |
A medical device includes a substrate having at least a portion thereof functionalized with at least one reactive member and a chemotactic agent functionalized with at least one complementary reactive member, wherein the at least one rea...
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WO/2011/146292 |
Medical delivery devices include a needle and a flexible compressible impermeable tube attached to the needle. The compressible tube has an open interior channel. The device is adapted to releasably hold a length of a medical implant in ...
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WO/2011/131887 |
The present invention relates to a method for manufacturing a hemocompatible material comprising a synthetic substrate and animal biological tissue, according to which said animal biological tissue is dehydrated and adhered to said synth...
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WO/2011/118818 |
Disclosed is a novel amidine derivative that exhibits activated blood coagulation factor X inhibitory activity, a method for producing the same, a production intermediate thereof, and a pharmaceutical composition containing said amidine ...
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WO/2011/118818 |
Disclosed is a novel amidine derivative that exhibits activated blood coagulation factor X inhibitory activity, a method for producing the same, a production intermediate thereof, and a pharmaceutical composition containing said amidine ...
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WO/2011/110684 |
There is describedinter alia a medical device having a surface which comprises a coating layer, said coating layer being a biocompatible composition comprising an anti-coagulant entity capable of interacting with mammalian blood to preve...
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WO/2011/103486 |
A vena cava filter catheter includes a catheter having a lumen disposed therethrough and at least one strand of biocompatible wire. The at least one strand has a first state in which the at least one strand has an elongate geometry suita...
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WO/2011/103486 |
A vena cava filter catheter includes a catheter having a lumen disposed therethrough and at least one strand of biocompatible wire. The at least one strand has a first state in which the at least one strand has an elongate geometry suita...
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WO/2011/093932 |
The present invention describes the design and development of new fibrinogen and fibrinogen derived products with significantly reduced binding to bacteria while retaining normal physiological functions by using modified fibrinogen amino...
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WO/2011/093932 |
The present invention describes the design and development of new fibrinogen and fibrinogen derived products with significantly reduced binding to bacteria while retaining normal physiological functions by using modified fibrinogen amino...
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WO/2011/083815 |
Disclosed is a method for coating the inner surface of a medical tube made from poly(vinyl chloride) and containing a plasticizer with an anti-thrombotic material comprising a specific (meth)acrylate copolymer, whereby the anti-thromboti...
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WO/2011/083154 |
The present invention relates to a dry powder fibrin sealant which comprises a mixture of fibrinogen and thrombin for use in surgery, trauma and other wounds or injuries. It further relates to novel formulations comprising said dry powde...
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WO/2011/083815 |
Disclosed is a method for coating the inner surface of a medical tube made from poly(vinyl chloride) and containing a plasticizer with an anti-thrombotic material comprising a specific (meth)acrylate copolymer, whereby the anti-thromboti...
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WO/2011/078208 |
Provided is a hydrophilic polymer compound which is capable of interfering with blood coagulation in both the primary hemostasis step wherein platelets participate and the blood clot formation step wherein blood coagulation factor partic...
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WO/2011/063940 |
The present disclosure relates to a continuous process for selectively modifying the lumen surface of a hollow fiber membrane using a plasma, an apparatus for carrying out the process and to hollow fiber membranes obtainable by the proce...
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WO/2011/060554 |
The present description relates to a presolidified implant composition, a method for its preparation, and a use of said implant composition for repairing tissue of a patient wherein the implant comprises a blood component, a salt and a p...
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WO/2011/060066 |
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WO/2011/059123 |
The present invention relates to a heparin compound bound to an adhesive material, a preparation method thereof, a solid surface coating agent containing the same as an active ingredient, and a coating method of a solid surface using the...
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WO/2011/006507 |
The present invention relates to preparation of a polymer coating comprising or consisting of polymer chains comprising or consisting of units of 2-methoxyethyl acrylate synthesized by Surface-Initiated Atom Transfer Radical Polymerizati...
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WO/2011/006507 |
The present invention relates to preparation of a polymer coating comprising or consisting of polymer chains comprising or consisting of units of 2-methoxyethyl acrylate synthesized by Surface-Initiated Atom Transfer Radical Polymerizati...
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WO/2010/150874 |
A surgery instrument which can be used for both general surgery and endoscopic surgery and consists of a material having not only liquid-absorbing properties and liquid-retaining properties but also excellent liquid removal properties. T...
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WO/2010/123465 |
The subject of the invention is a method for the treatment of biomedical implants for the improvement of antithrombogenic properties thereof. The mentioned biomedical implants are cardiovascular implants, especially artificial blood vess...
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WO/2010/123465 |
The subject of the invention is a method for the treatment of biomedical implants for the improvement of antithrombogenic properties thereof. The mentioned biomedical implants are cardiovascular implants, especially artificial blood vess...
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WO/2010/118335 |
Methods for protecting biomaterĪals comprise attaching CD47 or Ig domain thereof to the surface of the biomaterial, thereby inhibiting or reducing immune cell attachment and/or immune cell-mediated damage to the biomaterial. Also provid...
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WO/2010/113632 |
Disclosed is a surface-treating agent characterized by comprising a copolymer composed of, as monomer components, a monomer (A) having a hydrophilic functional group and represented by formula (1) or (2),a monomer (B) having a basic func...
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WO/2010/101722 |
A polymer comprising a phosphoryl choline moiety(ies), a composition comprising the polymer and optionally a bioactive agent, an implantable device such as a DES or a non-implantable device such as an angioplasty balloon comprising there...
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WO/2010/090097 |
Disclosed is an antibacterial catheter (1) which is characterized by comprising a tube-shaped main body (2) composed of a polymer material containing an antibacterial agent (3), wherein the antibacterial agent (3) is localized in the vic...
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WO/2010/057142 |
The present invention provides compositions and methods for the production of silk fibroin matrices surface-PEGylated on one or more surfaces. Such surface-PEGylated silk fibroin matrices can be used in biomedical applications, such as a...
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WO/2010/057142 |
The present invention provides compositions and methods for the production of silk fibroin matrices surface-PEGylated on one or more surfaces. Such surface-PEGylated silk fibroin matrices can be used in biomedical applications, such as a...
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