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Matches 1 - 50 out of 45,628

Document Document Title
WO/2018/130537A1
The present invention is directed to cell-protective, in particular, cardio- and renal-protective organic compounds, preferably to organic compounds that inhibit substrate phosphorylation by the G-protein-coupled receptor kinase 2 (GRK2,...  
WO/2018/130207A1
The present invention pertains to the field of pharmaceutical chemicals, and discloses a 4,4-diphenyl piperidine compound or a pharmaceutically acceptable salt thereof, a pharmaceutical composition using the same, and a use thereof. Spec...  
WO/2018/130213A1
Disclosed are an imidazopyrazine compound, a preparation method therefor and use thereof. Specifically, disclosed are a compound having a structure as represented by formula (I), a pharmaceutically acceptable salt, a stereoisomer or a pr...  
WO/2018/130107A1
A vaccaria segetalis polysaccharide hydrolysate and medical application thereof. The vaccaria segetalis polysaccharide hydrolysate is obtained by hydrolyzing vaccaria segetalis seed polysaccharide, and the molecular weight is 1.7-50 kDa....  
WO/2018/132268A1
The present disclosure provides pharmaceutical agents, including those of the formula:(I) wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such pharmaceu...  
WO/2018/129479A1
Methods of treating or ameliorating urinary tract infection (UTI), including complicated urinary tract infection (cUTI) and acute pyelonephritis (AP), comprising administering a composition comprising a cyclic boronic acid ester vaborbac...  
WO/2018/127469A1
The present invention relates to IL-8 inhibitor compounds for use in the treatment of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and benign prostatic hyperplasia.  
WO/2018/123507A1
The present invention addresses the problem of providing a combination therapy which is effective in a cancer immunotherapy. The problem can be solved by providing an anti-tumor agent which contains DNA encoding WT1 protein and DNA encod...  
WO/2018/126016A1
The innovation is directed to a method for treating a CCR5 and/or CCR2 mediated disease such as nonalcoholic steatohepatitis (NASH) comprising administering an effective amount of a C-C Chemokine receptor 5 (CCR5) antagonist (e.g., marav...  
WO/2018/124179A1
The present invention provides a compound represented by general formula (I) (in the formula, X is as described in the description and claims) or a pharmacologically acceptable salt thereof, and provides a pharmaceutical composition cont...  
WO/2018/125983A1
The present invention is related to a compound represented by the following structural formula: The present invention is also related a method of treating a subject with a disease which can be ameliorated by inhibition of aminocarboxymuc...  
WO/2018/123968A1
In the present invention, mesenchymal stem cells cultured in a serum-free medium are used to provide a repair agent for repairing tissue damage in a living body and a method for producing said repair agent.  
WO/2018/125916A1
Disclosed herein are complexes of gadolinium metal, ligand and meglumine that are substantially free of non-aqueous solvents. In particular, solvent-free complexes of 1) gadopentetate dimeglumine and 2) gadoterate meglumine are disclosed...  
WO/2018/123908A1
[Problem] An objective of the present invention is to provide a novel composition that can inhibit the activity of PDE5. [Solution] A composition for inhibiting phosphodiesterase-5 activity, the composition comprising a processed product...  
WO/2018/123925A1
The purpose of the present invention is to establish a molecular therapy for Alport's syndrome. Provided are the following: a 15 to 30 base-long oligonucleotide formed of a nucleotide sequence complimentary to cDNA of COL4A5 gene, the ol...  
WO/2018/116197A1
The present invention relates to an anhydrous pharmaceutical composition comprising an anti-inflammatory ingredient selected from among the arylpropionic acid derivatives, an antispasmodic agent from the triphenol family, and an efferves...  
WO/2018/113094A1
Disclosed is the use of a fullerene structure in the preparation of a drug for treating diabetes and complications thereof. The fullerene structure comprises at least one effective ingredient selected from the group consisting of an oil-...  
WO/2018/117253A1
Provided are: a nucleic acid having an activity of inhibiting the expression of complement factor B; a medicinal composition comprising the nucleic acid; and a prophylactic or therapeutic agent, said agent comprising the nucleic acid, fo...  
WO/2018/117166A1
The present invention addresses the problem of providing: a novel thiazole derivative or a pharmacologically acceptable salt thereof; a pharmaceutical composition which contains the thiazole derivative or a pharmacologically acceptable s...  
WO/2018/116238A1
The present invention relates to a composition comprising a mixture of at least three plant extracts and at least one monosaccharide for use in the therapeutic or preventive treatment of the symptoms of pathologies and/or disorders cause...  
WO/2018/107700A1
A method for preventing and/or treating renal tissue injury of a subject, comprising administering an effective amount of plasminogen to a subject. The subject is at the risk of suffering renal tissue injury, is suspected to suffer renal...  
WO/2018/107984A1
The present invention discloses a polypeptide containing a T helper cell epitope (Th epitope), which can serve as an immunostimulant of a B cell epitope or a peptide hapten of a target antigen. The invention also discloses a polypeptide ...  
WO/2018/107699A1
A method for preventing and/or treating drug-induced renal tissue injury and related diseases thereof of a subject, comprising administering an effective amount of plasminogen to a subject. Also provided are a drug, a pharmaceutical comp...  
WO/2018/107695A1
A method for preventing and treating kidney fibrosis, comprising administering an effective amount of plasminogen to a subject.  
WO/2018/109646A1
The present invention relates to a compound which is (R)-3-(1,4- dimethyl-1 H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3- dihydropyrido[2,3-f][l,4]oxazepin-4(5H)-yl)methyl)-4-methylp henyl) propanoic acid (I), or a pharmaceutica...  
WO/2018/109647A1
The present invention relates to bisaryl amide analogs, pharmaceutical compositions containing them and their use as NRF2 activators. In particular, the invention relates to bisaryl heterocycles of Formula (I).  
WO/2018/106566A1
Provided herein are methods for the treatment of polycystic kidney disease, including autosomal dominant polycystic kidney disease, using modified oligonucleotides targeted to miR-17.  
WO/2018/104877A1
The invention describes compositions containing Boswellia sacra and formulations thereof in the form of soft capsules useful for the treatment of benign prostatic hyperplasia.  
WO/2018/106568A1
Provided herein are methods for the treatment of polycystic kidney disease, including autosomal dominant polycystic kidney disease, using modified oligonucleotides targeted to miR-17.  
WO/2018/106845A1
Compositions of glycan polymers and methods of making and manufacturing the same are described herein. Also provided are methods of treating a disease or disorder with a glycan polymer preparation.  
WO/2018/100290A1
The invention relates to a compound of formula (I) in which R' and R'' are independently selected from: a hydrogen; the halogens; the alkyls, preferably with 1, 2 or 3 carbon atoms; and a –CO-R1 function in which R1 is an alkyl prefera...  
WO/2018/101481A1
[Problem] To provide a steroid-containing cell preparation exhibiting high therapeutic effects on diseases associated with cartilage tissue as a treatment target. [Solution] The present invention provides a prophylactic or therapeutic ag...  
WO/2018/100533A1
The invention relates to compositions for vaginal or, alternatively, oral administration and to the use of such compositions for stabilizing the vaginal, or, alternatively, the intestinal acidity and establishing favorable conditions for...  
WO/2018/097294A1
The present invention pertains to a therapeutic drug or prophylactic drug for diabetic nephropathy, said drug comprising a compound represented by formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient.  
WO/2018/094974A1
A pharmaceutical composition for treating ischemic stroke and a preparation method and use thereof. The active pharmaceutical ingredients of the pharmaceutical composition include: 0.05-20 parts by weight of NADPH, and 10-100 parts by we...  
WO/2018/096159A1
The invention relates to compounds of formula (I) and pharmaceutically acceptable salts thereof. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula (I) as well as pharmace...  
WO/2018/097308A1
The present invention pertains to: a ligand-binding molecule, the ligand binding activity of which is reduced by cleavage of a cleavage site thereof; a production method for the ligand-binding molecule; a complex formed of the ligand-bin...  
WO/2018/095067A1
A pirfenidone polyvinyl alcohol (PVA) hydrogel and a preparation method therefor. The preparation method comprises the following steps: dissolving pirfenidone in ethanol to form a saturated solution; mixing and dissolving with a polyviny...  
WO/2018/094221A1
This document relates to materials and methods for treating fibrillary glomerulonephritis (e.g., non-amyloid fibrillary glomerulonephritis) and/or a complication associated with fibrillary glomerulonephritis (e.g., high blood pressure, p...  
WO/2018/092045A1
Methods of treating the signs and symptoms of Benign Prostatic Hyperplasia (BPH) in a subject by administering at least one tetrahydrocyclopenta[b] indole compound are disclosed. Also disclosed are methods of treating the signs and sympt...  
WO/2018/093569A1
Disclosed are compounds of Formula (I) or a salt thereof, wherein R1 is (II) or (III); each W is independently NR1b or O; Z is a bond or CHR1d; and R1, R2, Rd, R3, L1, L2, R1a, R1b, R1c, and n are define herein. Also disclosed are method...  
WO/2018/094387A1
Methods are provided for preventing, reducing, and/or treating contrast-induced acute kidney injury which include administering an inhibitor of fatty acid oxidation to a patient in need thereof. Also provided are methods involving use of...  
WO/2018/093569A4
Disclosed are compounds of Formula (I) or a salt thereof, wherein R1 is (II) or (III); each W is independently NR1b or O; Z is a bond or CHR1d; and R1, R2, Rd, R3, L1, L2, R1a, R1b, R1c, and n are define herein. Also disclosed are method...  
WO/2018/091950A1
A process of producing a herbal medicine for diseases / illnesses namely Kidney disease, Diabetes, Hemorrhoids, Hypertensions, Cirrhosis, and entrails diseases. This certain medicine is a composition of plants, plant parts and plant extr...  
WO/2018/087132A1
The present invention relates to methods for treating or preventing chronic kidney disease and cardiovascular disease in patients with chronic kidney disease comprising administering empagliflozin to the patient.  
WO/2018/089902A1
The disclosure relates to diaminothiazole derivatives of formula (I) where the variables are as defined herein, pharmaceutical compositions containing such compounds, and methods for the use of such compounds and compositions for the tre...  
WO/2018/086501A1
A novel ironing moxibustion apparatus combining moxibustion and ironing methods. Before and after use, the variation value of a grease parameter in a grease-containing Artemisia vulgaris product is less than 50% (0.5), wherein a grease c...  
WO/2018/087202A1
The present invention relates to the use of compounds or pharmaceutical compositions comprising the same for use in the prophylaxis and/or treatment of alopecia areata, vitiligo, cutaneous lupus, lupus nephritis, giant cell arteritis, sa...  
WO/2018/089539A1
The present invention provides methods of treating or preventing Alport syndrome in a patients in need thereof using bardoxolone methyl or analogs thereof, and/or improving the kidney function of patients who have been diagnosed with Alp...  
WO/2018/079832A1
The present invention addresses the problem of providing an agent for reducing uremic substances in the blood which has an action of effectively lowering (reducing) the concentration of uremic substances in the blood, and a prophylactic ...  

Matches 1 - 50 out of 45,628