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Matches 1 - 50 out of 80,907

Document Document Title
WO/2018/012582A1
Provided is a blood amino acid level elevation promoter which contains a whey protein hydrolysate as an active ingredient. The elevation of a blood amino acid level in a subject can be promoted by feeding the promoter to the subject.  
WO/2018/012157A1
The present invention provides an agent which contains an orotic acid derivative having excellent physiological activity and has high solubility in a solvent. The agent according to the present invention is a melanin production inhibitor...  
WO/2018/013655A1
Solid state forms of Crisaborole and salts thereof, processes for preparation thereof and pharmaceutical compositions thereof are disclosed.  
WO/2018/011192A1
The present invention relates to a composition comprising at least one poloxamer compound for use in the treatment of a fistula in an individual.  
WO/2018/011201A1
The present invention relates to a compound according to general formula (I) wherein X represents N or CH; R1 is -CN, (C1-C6)alkyl, (C3-C7)cycloalkyl, (3-7 membered)heterocycloalkyl, (5-6 membered)heteroaryl, (C3-C7)cycloalkyl(C1-C4)alky...  
WO/2018/013732A1
A non-irritation, non-blurring, photostable ophthalmic sunscreen composition contains at least one of the following: bemotrizinol; bisoctrizole; tris-biphenyl triazine; and/or octyl methoxycinnamate. A liquid vehicle base is then a remai...  
WO/2018/013546A1
The invention includes methods for modulating a reaction dependent on a blue light-dependent protein interaction between a CRY protein and a CRY-signaling protein. The method comprises combining a CRY protein and a CRY-signaling protein ...  
WO/2018/011375A1
The present invention relates to compounds of the following general formula (I) or (II) or a pharmaceutically acceptable salt and/or solvate thereof, for use in the prevention and/or the treatment of disorders associated to the inflammat...  
WO/2018/013870A1
Provided herein are combinations of (a) ceftibuten or a pharmaceutically acceptable salt thereof, or a hydrate of the foregoing; and (b) clavulanic acid, or a pharmaceutically acceptable salt thereof for use in a method of treating or pr...  
WO/2018/011382A1
The present invention relates to the field of skin and/or hair repair, for therapeutic and cosmetic purposes. It more specifically relates to an agent stimulating the 5- hydroxytryptamine 1B receptor, for use for boosting skin and/or hai...  
WO/2018/011416A1
The invention relates to a uronic acid monomer for use in a method for treating Alzheimer's disease, cancer, disorders caused by oxidative stress, a viral disease, migraine, or diabetes, wherein the uronic acid monomer is β-D-mannuronic...  
WO/2018/014016A1
Substance P analogs are useful for treating and protecting against exposure to ionizing radiation such as acute radiation syndrome, chronic radiation syndrome and the like. The active agents can be administered via inhalation therapy, in...  
WO/2018/007957A1
The present invention refers to novel thiazolo[5,4-d]pyrimidine derivatives that are inverse agonists of the adenosine A2A receptor, to a process for their preparation, to the pharmaceutical compositions containing them and to their use ...  
WO/2018/009417A1
Disclosed herein are small molecule calpain modulator compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to macrocyclic α-keto amide derivatives and their use as therapeutic agents.  
WO/2018/009113A1
It is disclosed a skin treatment composition comprising an emulsion, which comprises a continuous phase and a dispersed phase. The continuous phase comprises cellulose derivatives (CD), and nanocellulose, preferably cellulose nanocrystal...  
WO/2018/008749A1
A nucleic acid which can inhibit expression of the MEX3B gene with low cytotoxicity as a side effect, an MEX3B gene expression inhibitor which contains said nucleic acid, a method for inhibiting MEX3B gene expression, and a prophylactic ...  
WO/2018/000060A1
The present invention relates to an anti-acne sunscreen composition comprising a specific combination of components, namely a mixture of drometrizole trisiloxane and terephthalylidene dicamphor sulfonic acid as sunscreens, a mixture of s...  
WO/2018/000067A1
The present invention generally belongs to the technological field of the pharmaceutical industry and relates more specifically to one or more second use compositions for the treatment of melasma, in particular in cases of melasma identi...  
WO/2018/000727A1
A compound preparation for treating contact dermatitis and a preparation method therefor. The compound preparation comprises the follow main raw materials: Cortex dictamni, radix sophorae flavescentis, propolis, Coptis chinensis, Aloe, l...  
WO/2018/001392A1
A preparation containing the mycoparasitic microorganism Pythium oligandrum for the treatment of dermatophytoses and yeast infections on the skin and mucous membranes obtained from a dry mixture containing 0.1 to 99.9 % weight mycoparasi...  
WO/2018/003962A1
2- (Piperidin-1-yl) pyrimidin-4 (3H) -ones characterized by having a 1,8-diazaspiro [4.5] deca-3-ene, 1-oxa-8-azaspiro [4.5] deca-3-ene, 2,8-diazaspiro [4.5] deca-3-ene, 2-oxa-8-azaspiro [4.5] deca-3-ene, 2,9-diazaspiro [5.5] undeca-3-en...  
WO/2018/006101A1
A topical skin preparation configured for the treatment of psoriasis, is provided. The preparation includes a pharmaceutically effective amount of clobetasol propionate and other preparation components which work in synergy to significan...  
WO/2018/005695A1
The disclosure relates to the use of neurokinin-1 (NK-1) antagonists, such as serlopitant, in treating acute or chronic pruritus associated with a variety of medical conditions, including dermatitis/eczema, psoriasis, prurigo, urticaria,...  
WO/2018/001287A1
Provided in the present invention is a use of methyl 4-[9-(6-aminopuryl)]-2(s)-hydroxybutyrate in the preparation of a medicament for treating psoriasis and vitiligo. More specifically, the present invention uses mice whose psoriasis is ...  
WO/2018/003531A1
The present invention provides a pyrroloquinone quinone monosodium having a structure represented by formula (1).  
WO/2018/005774A1
The present invention generally relates to the treatment of vitiligo with a composition comprising pyruvic acid and/or a pyruvate salt. The composition may be formulated for application to the skin of a subject, for instance, as a gel, l...  
WO/2018/000093A1
A composition for facilitating eyelash and/or eyebrow growth which includes at least forskolin derived exclusively from coleus forskohlii and at least one keratmocyte growth stimulator. In some embodiments, the keratinocyte growth stimul...  
WO/2018/003867A1
The present invention provides a method for producing a compound represented by formula (I), which comprises a step for obtaining a compound represented by formula (I) by reacting a compound represented by formula (II) and an alkali meta...  
WO/2018/002338A1
The present invention relates to a Silybum marianum (L.) Gaertn. extract comprising less than0.2% by weight of silymarin with respect to the weight of the dry extract, as well as pharmaceutical and cosmetic compositions containing same, ...  
WO/2018/003583A1
The purpose of the present disclosure is to provide a heat sensitive sheet having an excellent wearing feeling both in an initial state and in use. This heat sensitive sheet has the following configuration. This heat sensitive sheet (1) ...  
WO/2018/003035A1
Provided is a novel Sirtuin 1 activator. The present invention provides a Sirtuin 1 activator characterized by comprising enmeisou (Isodon japonicus Hara) plant matter or a solvent extract thereof.  
WO/2018/003850A1
The present invention provides a topical composition that has excellent stability and usability. Prepared is a topical composition containing: (A) at least one member selected from the group consisting of ascorbic acid and salts thereof;...  
WO/2018/003997A1
The present invention addresses the problem of providing a safe and easy-to-prepare cell preparation for prevention and/or treatment of organ fibrosis such as liver fibrosis. Provided is a cell preparation for prevention and/or treatment...  
WO/2018/004467A1
Disclosed herein are pharmaceutical compositions comprising at least one polycationic aliphatic amine, in particular spermidine, spermine or a combination thereof. The compositions can further comprise one or more selected from decarboxy...  
WO/2018/005193A1
Bifunctional compounds that increase uric acid excretion and reduce uric acid production, and monofunctional compounds that either increase uric acid excretion or reduce uric acid production. Methods of using these compounds for reducing...  
WO/2017/223273A1
In certain aspects, described herein are methods, bacteria, and compositions for the reduction of the amount, activity and/or proliferation of colonic group 3 innate lymphoid cells (ILC3s) and for the treatment and/or prevention of disea...  
WO/2017/220049A2
Disclosed is a formulation treating scalding, said formulation comprising the following components by gram: 10-30 grams of jujube tree bark, 10-50 grams of clarified pennisetum centrasiaticum water, 1-10 grams of tea leaf powder, 1-10 gr...  
WO/2017/219580A1
Provided is a skin care gel containing natural extracts, comprising (in parts by weight): 20-30 parts of a carbomer gel, 4-5 parts of glycerin, 2-3 parts of hyaluronic acid, 10-20 parts of distilled water, 0.1-0.2 parts of a Blumea megac...  
WO/2017/220563A1
The invention refers to the useof extracts of Deschampsia antarctica (EDA) for counteracting the human skin barrier damage caused by environmental aggressions and for preventing and/or ameliorating disorders related to an impaired barrie...  
WO/2017/219935A1
The present invention discloses a biaryl urea RORγt inhibitor, and specifically relates to a biaryl urea derivative, as represented by formula I, with an RORγt inhibiting activity, and a manufacturing method thereof, and a pharmaceutic...  
WO/2017/221008A1
The invention relates to compounds of general formula (I): wherein R1, R2, R3, R10 and X- are as defined herein. The compounds are inhibitors of the epithelial sodium channel (ENaC) and are useful for the treatment or prevention respirat...  
WO/2017/220048A2
Disclosed is a formulation treating scalding, reducing inflammation and relieving pain, said formulation comprising an external application formulation and an oral formulation. The external application formulation comprises a paste formu...  
WO/2017/221142A1
The present disclosure relates to a Wingless-type (wnt) inhibitor of formula (I) for use in the treatment of fibrosis and some fibrosis mediated disorders such as stiff skin syndrome and systemic sclerosis. The present disclosure also pr...  
WO/2017/219081A1
This invention relates to peptides and their use for modulating sodium channels. More particularly, the present invention relates to peptides from the venom of the tarantula Pamphobeteus nigricolor and their use in methods of inhibiting ...  
WO/2017/222946A1
Disclosed are inhibitors of adenylyl cyclase of Formula (I) having variables as described, as well as methods of synthesis thereof, pharmaceutical compositions thereof, and methods of treatment of various diseases using the pharmaceutica...  
WO/2017/220369A1
The present invention provides an isolated monoclonal antibody or an antigen portion thereof which: a) binds to Mac-1, b) specifically inhibits the interaction of CD40L with activated Mac-1 and c) does not induce integrin outside-in sign...  
WO/2017/223245A1
Methods for treating a wound are provided herein. Such methods include a step of contacting the wound with an effective amount of a BRAF inhibitor. In some aspects, BRAF inhibitors may be part of a pharmaceutical composition. In such cas...  
WO/2017/220525A1
The present invention is directed to the direct application of beneficial or probiotic bacteria to the skin for maintenance of a healthy skin microbiota and to help restore an unbalanced skin microbiota. The application is based on the u...  
WO/2017/221973A1
Provided is a method for improving the retention properties of a compound in the skin, which is effective for prevention of aging or improvement of the skin. An external preparation for the skin in an oil-gel form according to the presen...  
WO/2017/219839A1
Disclosed is an anti-acne traditional Chinese medicinal ointment, comprising the following ingredients: an aloe water extract; a ginseng water extract; a honeysuckle water extract; a wild chrysanthemum water extract; a dandelion water ex...  

Matches 1 - 50 out of 80,907