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Matches 451 - 500 out of 5,981

Document Document Title
WO/2011/010682
Disclosed is a sterol derivative, which has an effect of promoting the proliferation of nerve stem cells, or a pharmaceutically acceptable salt of the same. Specifically disclosed is a sterol derivative represented by general formula (I)...  
WO/2011/011252
Nutritional compositions and methods of using the nutritional compositions with exercise to attenuate the loss of functional status are provided. In a general embodiment, the present disclosure provides a nutritional composition includin...  
WO/2011/009075
The present disclosure provides biologically active deuterated 2,4-pyrimidinediamine compounds and prodrugs thereof, compositions comprising the deuterated compounds, intermediates and methods for synthesizing the deuterated compounds an...  
WO/2011/007794
The present invention is directed to improve the usefulness of zeolite and sericite in various medical fields. To achieve this purpose, a composition for medical or medical assisting uses, which contains zeolite and sericite, is provided...  
WO/2011/007866
Disclosed are an agent which is capable of correcting splicing disorders of myotonic dystrophy, and a use of the agent. Specifically disclosed is an agent for treatment of myotonic dystrophy, which contains a compound the medicinal effec...  
WO/2011/003129
The present invention relates to a method for slowing the development of mammalian organ, tissue and cellular damage and death by using a persistent sodium current blocker (or a pharmaceutically acceptable salt or derivative thereof). Th...  
WO/2011/004911
Provided is a method of producing a skeletal muscle progenitor cell using a pluripotent stem cell, particularly an iPS cell, the method comprising the step 1) of culturing a pluripotent stem cell under serum-free conditions, and in the p...  
WO/2011/002525
The present invention relates to methods and agents useful for treating muscular dystrophy. Methods and agents for treating various physiological and pathological features associated with muscular dystrophy are also provided.  
WO/2011/002520
Componds and pharmaceutical compositions are provided that inhibit the activity of poly ADP- ribose synthetase (PARP). Such compounds are useful in the treatment of various diseases, conditions and injuries such as stroke, myocardial inf...  
WO/2011/002520
Componds and pharmaceutical compositions are provided that inhibit the activity of poly ADP- ribose synthetase (PARP). Such compounds are useful in the treatment of various diseases, conditions and injuries such as stroke, myocardial inf...  
WO/2010/151042
The present invention relates to a composition which contains Schizandra chinensis Baillon and Chaenomeles sinensis extracts as active ingredients for alleviating muscle fatigue and muscle pain or for enhancing exercise capability. The c...  
WO/2010/151840
This invention relates to botulinum toxin formulations that are stabilized without the use of any proteinaceous excipients. The invention also relates to methods of preparing and using such botulinum toxin formulations.  
WO/2010/151042
The present invention relates to a composition which contains Schizandra chinensis Baillon and Chaenomeles sinensis extracts as active ingredients for alleviating muscle fatigue and muscle pain or for enhancing exercise capability. The c...  
WO/2010/148010
The present invention provides chimeric polypeptides comprising myotubularin 1 (MTM1) polypeptides and an internalising moiety, wherein, the moiety can be an antibody, and is preferably monoclonal antibody 3E10, a functional variant or a...  
WO/2010/147226
Provided is a compound having a serotonin 5-HT2c receptor activating action, useful for lower urinary tract conditions, obesity and cancer. A compound represented by the formula (I0): wherein each symbol is as defined in the specificatio...  
WO/2010/146622
Provided are drugs, external preparations and cosmetics having an effect of inhibiting NFAT signal, an effect of inhibiting calcineurin and an effect of promoting hair growth. An NFAT signal inhibitor which comprises as the active ingred...  
WO/2010/140685
Disclosed is an amplifier for hematopoietic stem cells and/or hematopoietic progenitor cells which is useful for treating various diseases and for improving the efficiency of transferring a gene into hematopoietic stem cells in gene ther...  
WO/2010/136508
The present invention describes an antigen-binding construct comprising a first agent which binds to a stem cell specific marker molecule and a second agent which binds to a tissue specific marker molecule. In particular, the invention d...  
WO/2010/137349
Disclosed is a compound which enhances the activity of neurotrophic factors and exerts a protective action on nerve cells. Specifically disclosed is a compound represented by formula (I), a pharmaceutically acceptable salt thereof or a s...  
WO/2010/137350
Disclosed is a compound which enhances the activity of neurotrophic factors and exerts a protective action on nerve cells. Specifically disclosed is a compound represented by formula (Ia) or (Ib), a pharmaceutically acceptable salt there...  
WO/2010/138670
Disclosed herein are thiocolchicine derivatives suitable for use as muscle relaxants, methods of making the derivatives, and compositions comprising the derivatives.  
WO/2010/136508
The present invention describes an antigen-binding construct comprising a first agent which binds to a stem cell specific marker molecule and a second agent which binds to a tissue specific marker molecule. In particular, the invention d...  
WO/2010/138670
Disclosed herein are thiocolchicine derivatives suitable for use as muscle relaxants, methods of making the derivatives, and compositions comprising the derivatives.  
WO/2010/137351
The present invention relates to aryl substituted carboxamide derivatives of formula (I) or a pharmaceutically acceptable salt thereof, which have blocking activities of T-type calcium channels or voltage gated sodium channels as the tet...  
WO/2010/132982
It is reported herein that certain muscle diseases and conditions, including forms of muscular dystrophy, are characterized by impaired insulin-dependent signaling in the muscle tissue, in essence, a form of insulin resistance. The prese...  
WO/2010/134047
The present invention relates to a pharmaceutical solution comprising isotretinoin or salts thereof. The present invention further relates to the processes for preparing such compositions.  
WO/2010/131382
Disclosed is a muscle repair promoter for local administration, which comprises a granulocyte-colony stimulating factor (G-CSF) as an active ingredient. The muscle repair promoter can exhibit the efficacy thereof at a small dose particul...  
WO/2010/130799
The present invention relates to a batch method for impregnating a nonporous polymer pharmaceutical carrier with an active substance, characterised in that said method includes the following consecutive steps: a) mixing the active substa...  
WO/2010/131712
Disclosed are a therapeutic pharmaceutical agent for diseases associated with the decrease in the function of GNE protein, a food composition, and a food additive. The therapeutic pharmaceutical agent is characterized by comprising a com...  
WO/2010/130799
The present invention relates to a batch method for impregnating a nonporous polymer pharmaceutical carrier with an active substance, characterised in that said method includes the following consecutive steps: a) mixing the active substa...  
WO/2010/129406
The present invention relates to use of the interaction of myostatin with the activin type II receptors, and more specifically to use of soluble ACVR2 to increase muscle growth in a subject. As such, methods of increasing muscle mass in ...  
WO/2010/129273
The present invention relates to the use of butaclamol and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases.  
WO/2010/128243
The present invention relates to a method for preparing a concentrated spinach extract in a liquid or dry form and having a polyphenol titer greater than or equal to 50%, including a step of purifying a raw spinach extract in a liquid fo...  
WO/2010/129273
The present invention relates to the use of butaclamol and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases.  
WO/2010/129406
The present invention relates to use of the interaction of myostatin with the activin type II receptors, and more specifically to use of soluble ACVR2 to increase muscle growth in a subject. As such, methods of increasing muscle mass in ...  
WO/2010/125271
The invention relates to a gas mixture that contains nitrous oxide (N2O) for use as a breathable drug for the treatment of chronic pain in a mammal, in particular a pain from neuropathic, iatrogenic, dysfunctional or inflammatory origin,...  
WO/2010/124365
There are provided compositions and methods for modulating stem cell division decisions, in particular, division symmetry. It has been demonstrated that wnt7a acts through frizzled-7 receptor expressed on the surface of adult stem cells,...  
WO/2010/125799
Disclosed is a compound represented by formula (I), which inhibits the action of PI3K, controls a number of biological processes, such as the growth, differentiation, survival, proliferation, migration and metabolism of cells, and, there...  
WO/2010/126167
Disclosed are: a compound represented by formula (I), or a salt, solvate or physiologically functional derivative thereof; and a pharmaceutical composition comprising the compound or the salt, solvate or physiologically functional deriva...  
WO/2010/124520
The pharmaceutical compositions for treating abnormal energy metabolism, comprising a) medicines for promoting oxidation of fatty acid or derivatives thereof, particularly levocarnitine, and b) medicines for promoting oxidation of glucos...  
WO/2010/126104
Disclosed is a novel pyridazinone compound having an activity of inhibiting P2X7 receptor that is a kind of purine receptor, which is useful in preventing, treating or ameliorating diseases relating to inflammation or immunity. Specifica...  
WO/2010/125348
The present invention provides a means for prevention and treatment of sarcopenia by administration of a substance that both reduces the sensibility of beta-adrenergic receptors and of 5-HT1a receptors. (S)-pindolol, (S)-propanol, tertat...  
WO/2010/121324
The present invention relates to methods for producing particles of metaxalone using dry milling processes as well as compositions comprising metaxalone, medicaments produced using metaxalone in particulate form and/or compositions, and ...  
WO/2010/123243
The present invention relates to a composition containing a testis extract for treating or preventing diseases. More particularly, a testis extract, which is a natural substance obtained by separating sex hormones containing anabolic ste...  
WO/2010/123243
The present invention relates to a composition containing a testis extract for treating or preventing diseases. More particularly, a testis extract, which is a natural substance obtained by separating sex hormones containing anabolic ste...  
WO/2010/118675
The present invention reveals a new use of neferine. Neferine regulates M8 and V1 subtype of transient receptor potential ion channel (TRPM8 and TRPV1), respectively, in mammals, including humans, and can be used for preparing medicament...  
WO/2010/121225
The invention provides methods for the treatment or amelioration of disorders associated with undesired activity of protein kinase CK2, using compounds of Formula (I) that are potent, selective inhibitors of CK2, and pharmaceutical compo...  
WO/2010/119875
Disclosed is a fused pyrrolopyridine derivative which is useful as an active ingredient for a pharmaceutical composition, in particular a pharmaceutical composition for prevention or treatment of diseases that are caused by undesirable c...  
WO/2010/118699
High purified (2β,3α,5α,16β,17β) -2-(4-morpholinyl)-16-(1-pyrrolidinyl)-androstane-3,17-diol (formula III) or composition containing it and their use in preparing rocuronium bromide (formula I) are disclosed.  
WO/2010/121225
The invention provides methods for the treatment or amelioration of disorders associated with undesired activity of protein kinase CK2, using compounds of Formula (I) that are potent, selective inhibitors of CK2, and pharmaceutical compo...  

Matches 451 - 500 out of 5,981