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Patent Searching and Data


Matches 701 - 750 out of 15,683

Document Document Title
WO/2009/025149A1
The object is to identify a receptor for ADNF to elucidate a specific signaling pathway of the anti-ALS activity of ADNF, and to provide a screening system for identifying a compound capable of binding to the ADNF receptor or a compound ...  
WO/2009/025091A1
Disclosed is a novel therapeutic agent for fibromyalgia. A pharmaceutical composition comprising tizanidine as an active ingredient can be used as a therapeutic agent for fibromyalgia. The pharmaceutical composition can ameliorate a pain...  
WO/2009/021750A3
There are disclosed compounds of Formula (1). Pharmaceutical compositions containing the compounds are also provided. Methods of treatment of Duchenne muscular dystrophy, Becker muscular dystrophy and cachexia using the compounds and com...  
WO/2009/021747A3
There are provided compounds of Formula (I) wherein three of A1, A2, A3, and A4 represent CH and one of A1, A2, A3, and A4 represents CR1; R1 represents SO2R2 or NHCOR2 wherein R2 represents C1-C6 alkyl optionally substituted by one or m...  
WO/2009/021747A2
There are provided compounds of Formula (I) wherein three of A1, A2, A3, and A4 represent CH and one of A1, A2, A3, and A4 represents CR1; R1 represents SO2R2 or NHCOR2 wherein R2 represents C1-C6 alkyl optionally substituted by one or m...  
WO/2009/022687A1
Disclosed is a compound represented by the following general formula (I). (I) (In the formula, R1 represents a hydrogen atom or the like; R2 and R3 independently represent a hydrogen atom, an optionally oxidized C1-C4 alkyl group or an o...  
WO/2009/019027A1
Myogenesis in mammals can be promoted by a prenatal administration of 25-hydroxy vitamin D3 (25-OH D3). The 25-OH D3 can be administered to the pregnant mother, and the amount of muscle tissue in the offspring is increased relative to co...  
WO/2009/019505A3
Combinations comprising (or consisting essentially of) one or more compounds of the formula (I) or (II) with one or more ancillary compounds, to processes for preparing the combinations, and to various therapeutic uses of the combination...  
WO/2009/019505A2
Combinations comprising (or consisting essentially of) one or more compounds of the formula (I) or (II) with one or more ancillary compounds, to processes for preparing the combinations, and to various therapeutic uses of the combination...  
WO/2009/019815A1
Disclosed is a novel compound having excellent γ-secretase inhibitory activity and specifically inhibiting production of Aβ. Specifically disclosed is a compound represented by the formula (1) below or a pharmaceutically acceptable sal...  
WO/2009/016326A2
The present invention relates to a composition comprising: a first adeno-associated viral (AAV) vector comprising: i) a 5'ITR (Inverted Terminal Repeat) sequence of AAV; ii) a portion of gene placed under the control of a promoter; iii) ...  
WO/2009/013477A1
Compounds of general formula (I), wherein X1, X2, X3, R1, R2, R3, Y and Z are as defined herein are useful for the treatment and prevention of Duchenne muscular dystrophy, Becker muscular dystrophy and cachexia.  
WO/2009/013335A1
Compounds of formula (I) in free or salt or solvate form, where R1, R2 and R5 have the meanings as indicated in the specification, are useful for treating diseases mediated by the ALK-5 and/or ALK-4 receptor. Pharmaceutical compositions ...  
WO/2009/014127A1
Disclosed is a composition for the prevention or treatment of a disease associated with the production of an autoantibody. Specifically disclosed is a composition for the prevention or treatment of a disease associated with the productio...  
WO/2009/008529A1
It is intended to provide an antibody which binds specifically to an abnormal aggregate of TDP-43 protein. It is also intended to provide a drug for detecting a TDP-43 proteinopathy lesion which contains this antibody, a method of detect...  
WO/2009/008727A2
The invention provides conjugates, comprising an organ, tissue or tumor cell homing molecule linked to a moiety. Such a moiety can be, for example, an oligonucleotide, small interfering RNA, gene, virus, protein, pharmaceutical or detect...  
WO/2009/008727A3
The invention provides conjugates, comprising an organ, tissue or tumor cell homing molecule linked to a moiety. Such a moiety can be, for example, an oligonucleotide, small interfering RNA, gene, virus, protein, pharmaceutical or detect...  
WO/2009/008725A2
The invention provides conjugates, comprising an organ, tissue or tumor cell homing molecule linked to a moiety. Such a moiety can be, for example, an oligonucleotide, small interfering RNA, gene, virus, protein, pharmaceutical or detect...  
WO/2009/008725A3
The invention provides conjugates, comprising an organ, tissue or tumor cell homing molecule linked to a moiety. Such a moiety can be, for example, an oligonucleotide, small interfering RNA, gene, virus, protein, pharmaceutical or detect...  
WO/2009/004146A2
The invention relates to products having formula (I), in which A represents one of the following three rings: ring a, ring b, ring c and W represents hydrogen or -(C1-C4)alkyl, -(C1-C4)alkenyl, -CO-(C1-C3)alkyl, - CO-(C1-C3)alkenyl, -CO-...  
WO/2009/005033A1
It is intended to provide a substance which can be used as an active ingredient for improving dysfunction due to neuropathy. An agent for improving dysfunction due to neuropathy of the invention as a means for resolution is characterized...  
WO/2009/001915A1
Disclosed is a novel substituted imidazole compound having excellent renin inhibitory activity, which is sufficiently practical for use as a pharmaceutical product. Specifically disclosed is a compound represented by the formula (I) belo...  
WO/2008/155390A3
This invention relates to the use of inhibitors of sirtuins and/or AMPK for the preparation of a medicament for the treatment of polyalanine diseases, in particular oculopharyngeal musculardystrophy (OPMD). The invention also relates to ...  
WO/2008/156685A3
The invention relates to tendon stem cells useful for treating a variety of diseases and condition, including tendon repair and attachment of tendon to bone. The invention is also directed to treatment and/or inhibition of bone formation...  
WO/2008/156513A3
Disclosed herein are compositions and methods for the treatment of skeletal muscle and/or the protection of skeletal muscle against injury. The adenosine A3 receptor has been identified as a new therapeutic target for the treatment of sk...  
WO/2008/156418A1
The present invention relates to methods for screening or diagnosis of Postpolio Syndrome (PPS) in subjects, for determining the stage or severity of PPS, for identifying subjects at risk of developing PPS, or for monitoring the effect o...  
WO/2008/156685A2
The invention relates to tendon stem cells useful for treating a variety of diseases and condition, including tendon repair and attachment of tendon to bone. The invention is also directed to treatment and/or inhibition of bone formation...  
WO/2008/156513A9
Disclosed herein are compositions and methods for the treatment of skeletal muscle and/or the protection of skeletal muscle against injury. The adenosine A3 receptor has been identified as a new therapeutic target for the treatment of sk...  
WO/2008/155390A2
This invention relates to the use of inhibitors of sirtuins and/or AMPK for the preparation of a medicament for the treatment of polyalanine diseases, in particular oculopharyngeal musculardystrophy (OPMD). The invention also relates to ...  
WO/2008/156513A2
Disclosed herein are compositions and methods for the treatment of skeletal muscle and/or the protection of skeletal muscle against injury. The adenosine A3 receptor has been identified as a new therapeutic target for the treatment of sk...  
WO/2008/149177A2
Novel marine lipid compositions comprising triglycerides and omega-3 rich phospholipids are described. The compositions are characterized by providing highly bioavailable omega- 3, increased tissue incorporation of omega-3 and reduced co...  
WO/2008/150477A3
The invention relates to compositions and methods for treating kidney and muscle dysfunction that involves use of therapeutic amounts of N-acetyl mannosamine.  
WO/2008/149177A3
Novel marine lipid compositions comprising triglycerides and omega-3 rich phospholipids are described. The compositions are characterized by providing highly bioavailable omega- 3, increased tissue incorporation of omega-3 and reduced co...  
WO/2008/150477A2
The invention relates to compositions and methods for treating kidney and muscle dysfunction that involves use of therapeutic amounts of N-acetyl mannosamine.  
WO/2008/148867A3
The present invention relates to quinoxaline compound of the formula (I): wherein R1 is carbocyclyl or heterocyclyl, either of which is optionally substituted with 1, 2, 3, 4 or 5 R; R2 is caryl or heterocyclyl, either of which is option...  
WO/2008/148867A2
The present invention relates to quinoxaline compound of the formula (I): wherein R1 is carbocyclyl or heterocyclyl, either of which is optionally substituted with 1, 2, 3, 4 or 5 R; R2 is caryl or heterocyclyl, either of which is option...  
WO/2008/150525A1
The invention provides anti-Notch 1 NRR antibodies, and compositions comprising and methods of using these antibodies.  
WO/2008/138943A3
The invention relates to the use of sirtuin inhibitors for reducing TNF-alpha production by cells and organisms. The invention also concerns prophylactic and therapeutic applications of sirtuin inhibitors in TNF-alpha mediated pathologie...  
WO/2008/138115A8
A nutritional composition comprising at least L-carnitine fumarate, red wine extract, and saw palmetto extract is provided to maintain skeletal muscle androgen receptivity, via simultaneous increase in the availability of androgen recept...  
WO/2008/138943A2
The invention relates to the use of sirtuin inhibitors for reducing TNF-alpha production by cells and organisms. The invention also concerns prophylactic and therapeutic applications of sirtuin inhibitors in TNF-alpha mediated pathologie...  
WO/2008/140782A3
Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases associated with the proteasome. The peptide-based compounds ...  
WO/2008/140782A2
Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases associated with the proteasome. The peptide-based compounds ...  
WO/2008/138115A1
A nutritional composition comprising at least L-carnitine fumarate, red wine extract, and saw palmetto extract is provided to maintain skeletal muscle androgen receptivity, via simultaneous increase in the availability of androgen recept...  
WO/2008/135661A3
The invention relates to the use of L-citrulline of the formula (I) for preparing a cosmetic composition, a food or nutraceutic composition or a pharmaceutical composition for treating diseases related to an increase in protein carbonyla...  
WO/2008/134844A1
The present invention relates to compositions and methods for improving skeletal muscle protein metabolism through encouraging skeletal muscle protein synthesis, reducing skeletal muscle protein degradation, and attenuating inflammatory ...  
WO/2008/135661A2
The invention relates to the use of L-citrulline of the formula (I) for preparing a cosmetic composition, a food or nutraceutic composition or a pharmaceutical composition for treating diseases related to an increase in protein carbonyla...  
WO/2008/131941A1
The present invention relates to a method of treating a movement disorder in a patient, the method comprising administering a medicament comprising an effective amount of chemodenervating agent to said patient, wherein said patient is su...  
WO/2008/133132A1
Disclosed is a method for improving the activity of a reactive oxygen species (ROS)-scavenging enzyme, which has a mechanism of action based on scientific grounds, is highly safe, is inexpensive, and is widely applicable. An organism hav...  
WO/2008/126693A1
It is intended to provide a remedy and a diagnostic for a brain disease typified by cerebral infarction. Namely, a remedy for a mitochondrial dysfunction brain disease characterized by comprising a combination of (A) a δ-aminolevulinic ...  
WO/2008/122098A1
The biological function of skeletal muscle precursor cells in the repair and growth of skeletal muscle in response to exercise is promoted by providing a supplemental composition comprising at least creatine and fucoidin to reinforce bio...  

Matches 701 - 750 out of 15,683