Login| Sign Up| Help| Contact|

Patent Searching and Data


Matches 701 - 750 out of 18,374

Document Document Title
WO/2010/080581A2  
WO/2010/081070A2
The invention relates to novel crystalline forms of (2RS)-1 -(4-ethylphenyl)-2-methyl-3- piperidin-1-yl-propan-1-one. The preparation and characterization of the novel crystalline forms according to various embodiments of the invention i...  
WO/2010/081070A3
The invention relates to novel crystalline forms of (2RS)-1 -(4-ethylphenyl)-2-methyl-3- piperidin-1-yl-propan-1-one. The preparation and characterization of the novel crystalline forms according to various embodiments of the invention i...  
WO/2010/080455A1
This invention relates to a hydrochloride, malafe, oxalate and tartrate salt forms of 1-(4- { 1-[(E)-4-cyclohexyl-3-trifluoromethyl-benzyloxyimino]-ethyl} -2-ethyl-benzyI)-azetidine- 3-carboxylic acid (Compound I), to pharmaceutical comp...  
WO/2010/079668A1
Disclosed is a compound represented by general formula (I) or a pharmacologically acceptable salt thereof. (In the formula, R1, R2, R2', R4, R5, R6, R7, R8 and R8' each represents a hydrogen atom or the like; and R3 represents a hydrogen...  
WO/2010/075611A1
A composition comprising a proanthocyanidin, a proteolytic enzyme and a substance derived from Aloe Vera and/or from a plant of the Agave species, the composition being free of papain. Use of the composition for improving athletic perfor...  
WO/2010/077686A1
Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorder...  
WO/2010/074284A1
By searching for a number of various compounds having an activity of inhibiting IL-12/IL-23 production, provided are a medicinal composition and a drug for treating or preventing a disease relating to the hyperproduction of IL-12/IL-23, ...  
WO/2010/075263A3
Compounds and methods for enhancing erythropoiesis are disclosed. The compound comprises a chemical structure of the formula (I) indicated below, in which R is a glycosyl group. In addition to having an erythropoiesis effect, the compoun...  
WO/2010/073531A1
Provided is a muscle-building agent comprising a whey protein hydrolyzate having a muscle increasing effect which is highly safe, an aqueous solution of which is highly transparent and which can be used in various products without limita...  
WO/2010/075287A3
The present invention relates generally to alkyne containing pharmaceutical agents, and in particular, to phenylethynyl-thiophene based metalloprotease inhibitor compounds. More particularly, the present invention provides a new class of...  
WO/2010/075263A2
Compounds and methods for enhancing erythropoiesis are disclosed. The compound comprises a chemical structure of the formula (I) indicated below, in which R is a glycosyl group. In addition to having an erythropoiesis effect, the compoun...  
WO/2010/075287A2
The present invention relates generally to alkyne containing pharmaceutical agents, and in particular, to phenylethynyl-thiophene based metalloprotease inhibitor compounds. More particularly, the present invention provides a new class of...  
WO/2010/071794A1
This invention relates to a novel crystalline form (Form A) of 1-(4-{1-[(E)-4-cyclohexyl-3-trifluoromethyl-benzyloxyimino]- ethyl}-2-ethyl-benzyl)-azetidine-3-carboxylic acid (Compound I), to pharmaceutical compositions comprising this c...  
WO/2010/069684A1
Compounds of formula (I): wherein R1, R2, X1, and X2 are as defined herein, are useful for the treatment or prophylaxis of conditions such as Duchenne muscular dystrophy, Becker muscular dystrophy, and cachexia.  
WO/2010/069949A1
The invention provides compounds of Formula (I) for the treatment of multiple sclerosis and other diseases.  
WO/2010/070094A1
Description of antigen binding proteins, such as antibodies, which bind to myostatin, polynucleotides encoding such antigen binding proteins, pharmaceutical compositions comprising said antigen binding proteins and methods of manufacture...  
WO/2010/068264A2
The invention provides method and composition for alleviating one or more symptoms associated with a medical condition mediated by one or more of a cyclooxygenase, a pro- inflammatory cytokine, and a pro-inflammatory enzyme. The method i...  
WO/2010/068264A3
The invention provides method and composition for alleviating one or more symptoms associated with a medical condition mediated by one or more of a cyclooxygenase, a pro- inflammatory cytokine, and a pro-inflammatory enzyme. The method i...  
WO/2010/064248A3
Use of an agent which upregulates an activity or amount of miRNA-9 or miRNA-9* is disclosed for the preparation of a medicament for the treatment of a motor neuron disease (MND).  
WO/2010/064597A1
A compound represented by formula (I) or a salt thereof. In formula (I), the symbols are as defined in the description.  
WO/2010/064707A1
Disclosed is a compound which has an excellent S1P1 agonistic activity and is particularly useful as an active ingredient for a prophylactic and/or therapeutic agent for diseases induced by undesirable lymphocyte infiltration or diseases...  
WO/2010/064248A2
Use of an agent which upregulates an activity or amount of miRNA-9 or miRNA-9* is disclosed for the preparation of a medicament for the treatment of a motor neuron disease (MND).  
WO/2010/058846A1
Disclosed is a 4,6-diaminonicotinamide compound which is useful as an active ingredient for a pharmaceutical composition, in particular, a pharmaceutical composition for treatment of diseases caused by undesirable and/or abnormal cytokin...  
WO/2010/057833A1
Compounds of formula (I): wherein R1, R2, R3, L1, L2, and Y are as defined herein, are useful for the treatment or prophylaxis of conditions such as Duchenne muscular dystrophy, Becker muscular dystrophy, and cachexia.  
WO/2010/052563A2
The invention provides compositions and methods for ameliorating symptoms associated with hyperglycemia by administering a Zn-α2-glycoprotein or a functional fragment thereof, methods of decreasing plasma insulin levels, methods of incr...  
WO/2010/053182A1
A kynurenine production inhibitor or the like, which contains a nitrogen-containing heterocyclic compound represented by formula (I). (In the formula, R50 and R51 may be the same or different and each represents a hydrogen atom or the l...  
WO/2010/052563A3
The invention provides compositions and methods for ameliorating symptoms associated with hyperglycemia by administering a Zn-α2-glycoprotein or a functional fragment thereof, methods of decreasing plasma insulin levels, methods of incr...  
WO/2010/050168A1
A mixture of valine, isoleucine and leucine, which is excellently reduced in bitterness, while having an improved dissolution rate. Specifically disclosed are a solid solution of three kinds of amino acids, namely valine, isoleucine and ...  
WO/2010/050802A2
The invention relates a method wherein a molecule is used for inducing and/or promoting skipping of at least one of exon 43, exon 46, exons 50-53 of the DMD pre- mRNA in a patient, preferably in an isolated cell of a patient, the method ...  
WO/2010/050445A1
A compound having an ACC inhibitory effect and useful for prevention/treatment of adiposis, diabetes, hypertension, hyperlipemia, heart failure, diabetic complication, metabolic syndrome, sarcopenia, cancer and the like. The compound ha...  
WO/2010/050802A3
The invention relates a method wherein a molecule is used for inducing and/or promoting skipping of at least one of exon 43, exon 46, exons 50-53 of the DMD pre- mRNA in a patient, preferably in an isolated cell of a patient, the method ...  
WO/2010/044894A1
A chimeric polypeptide comprising: (i) an MBNL (muscleblind-like) polypeptide and (ii) a targeting moiety which targets muscle cells (such as an antibody or a protein that acts via an equilibrative nucleoside transporter (ENT2) pathway)....  
WO/2010/043010A1
The present invention relates to N-acyl hydrazine compounds capable of promoting vascular smooth muscle relaxation by activation of the biosynthesis of nitric oxide (NO) and having the general formula (I), and to the method for producing...  
WO/2010/041681A1
Provided is a novel compound which is a sominone derivative represented by formula (1) or a salt thereof and which is useful as an agent for the prevention and treatment of neurological disease.  
WO/2010/039823A2
Described herein vise compositions comprising decellularized cardiac extracellular matrix and therapeutic uses thereof Methods for treating. repairing or regenerating defective, diseased damaged or ischemic cells, tissues or organs in ar...  
WO/2010/039823A3
Described herein are compositions comprising decellularized cardiac extracellular matrix and therapeutic uses thereof. Methods for treating, repairing or regenerating defective, diseased, damaged or ischemic cells, tissues or organs in a...  
WO/2010/039823A8
Described herein are compositions comprising decellularized cardiac extracellular matrix and therapeutic uses thereof. Methods for treating, repairing or regenerating defective, diseased, damaged or ischemic cells, tissues or organs in a...  
WO/2010/035769A1
The amino acid sequences for a variable region and a constant region in TOCILIZUMAB, which is a humanized anti-IL-6 receptor IgG1 antibody, are modified so as to improve the pharmacokinetics of TOCILIZUMAB while enhancing the antigen-neu...  
WO/2010/035806A1
A solid preparation which contains a compound (I) or a salt thereof, a pH adjuster and a calcium antagonist, while having excellent dissolvability and stability.  
WO/2010/031190A1
This application relates to a serum-free culture medium that enables the proliferation of cell of the myogenic lineage while maintaining their ability to differentiate into functional muscle cells. Also contemplated herewith are method o...  
WO/2010/028981A1
The invention is concerned with novel benzimidazole derivatives of Formula (I) wherein A, n and R1 to R7 are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds...  
WO/2010/027002A1
Disclosed is a compound represented by formula (I) or a pharmaceutically acceptable salt thereof, which can inhibit the activity of PI3K to regulate many biological processes including the growth, differentiation, survival, proliferation...  
WO/2010/024258A1
Disclosed is a compound which can inhibit the activity of PI3K to regulate many biological processes such as growth, differentiation, survival, proliferation, migration and metabolism of cells, and is therefore useful for the prevention/...  
WO/2010/021064A1
Provided are a therapeutic agent for fibromyalgia syndrome and a therapeutic agent for pain due to vascular smooth muscle spasm. The therapeutic agent for fibromyalgia syndrome or therapeutic agent for pain due to vascular smooth muscle ...  
WO/2010/020432A3
Compounds of formula (I): wherein R1, L2, R2, L3, R3, L4 and R4 are as defined herein, upregulate endogenous utrophin in predictive screens, and thus, are useful for the treatment or prophylaxis of conditions such as Duchenne muscular dy...  
WO/2010/019911A2
The present invention includes compositions and methods for inhibiting kinase activity to protect against neurodegeneration including diseases such as Alzheimer's disease, Parkinson's disease, or Huntington's disease, and conditions such...  
WO/2010/018856A1
Disclosed is a prophylactic/ameliorating or therapeutic agent for CB receptor-related diseases, which comprises at least one member selected from the group consisting of ω3PUFAs and pharmaceutically acceptable salts and esters thereof a...  
WO/2010/019911A3
The present invention includes compositions and methods for inhibiting kinase activity to protect against neurodegeneration including diseases such as Alzheimer's disease, Parkinson's disease, or Huntington's disease, and conditions such...  
WO/2010/018280A1
The present invention relates to the use of P2X7 receptor antagonists capable of crossing the hematoencephalic barrier and pharmaceutically-acceptable vehicles, in addition to pharmaceutical compositions thereof, to produce medicaments i...  

Matches 701 - 750 out of 18,374