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Matches 51 - 100 out of 26,569

Document Document Title
WO/2020/128529A1
The present invention relates to therapeutic compositions comprising a HSD11B1 inhibitor for use in the prevention, management and/or treatment of sarcopenia or a sarcopenic disease or disorder in individuals who are sensitive to insulin...  
WO/2020/131998A1
The present disclosure provides a method to treat or ameliorate vascular malformations, developmental abnormalities of one or more types of blood or lymphatic vessels. These are rare disorders with life-long risk of high morbidity includ...  
WO/2020/132647A1
The present disclosure provides compositions and methods for increasing the activity of an annexin protein to treat a cellular membrane injury in a patient in need thereof.  
WO/2020/130594A1
The present invention relates to a human Lefty A protein variant with improved productivity and stability, a fusion protein comprising the protein variant, and a composition for preventing and/or treating neuromuscular disease comprising...  
WO/2020/127929A1
The invention relates to a synthetic or recombinant collagen peptide for use in a method for the treatment of the human or animal body by therapy, the peptide having a molecular weight in a range of 0.18 to 10.0 kDa, particularly 0.18 to...  
WO/2020/128528A1
The present invention relates to therapeutic compositions comprising a p38 MARK inhibitor for use in the prevention, management and/or treatment of sarcopenia or a sarcopenic disease or disorder, and particularly in individuals who are s...  
WO/2020/130146A1
The present invention relates to an agent for improving the quality of muscles which contains one or more selected from the group consisting of isoleucine, glycine, and cysteine. The present invention can provide an agent which can preve...  
WO/2020/117706A1
The present disclosure features useful compositions and methods to treat repeat expansion disorders, e.g., in a subject in need thereof. In some aspects, the compositions and methods described herein are useful in the treatment of disord...  
WO/2020/115501A1
Provided are USP19 inhibitors, methods of treating obesity, metabolic syndrome and/or diabetes using the USP19 inhibitor compounds, as well as those compounds for use in methods of treating obesity, metabolic syndrome and/or diabetes. Al...  
WO/2020/115500A1
Provided are USP19 inhibitors, methods of treating obesity, metabolic syndrome and/or diabetes using the USP19 inhibitor compounds, as well as those compounds for use in methods of treating obesity, metabolic syndrome and/or diabetes. Al...  
WO/2020/117161A1
The present invention relates to a pharmaceutical combination comprising dimethyl fumarate and at least one muscle relaxant agent.  
WO/2020/107229A1
A traditional Chinese medicine composition, a preparation method therefor and an application thereof; the traditional Chinese medicine composition is prepared from the traditional Chinese medicinal raw materials in the following proporti...  
WO/2020/106724A1
The disclosure provides methods of treating myasthenia gravis (MG) in a pediatric subject in need thereof by administering to the subject a substance that specifically binds complement component 5 (C5). In some embodiments, the substance...  
WO/2020/101585A1
The invention relates to a pharmaceutical composition for oral administration comprising phenyramidol or a pharmaceutically acceptable salt thereof, wherein pharmaceutical composition composed of final blend with a specified particle siz...  
WO/2020/097266A1
Substituted pyridazinone compounds, conjugates, and pharmaceutical compositions for use in the treatment of neuromuscular diseases, such as Duchenne Muscular Dystrophy (DMD), are disclosed herein. The disclosed compounds are useful, amon...  
WO/2020/097258A1
Substituted pyridazinone compounds, conjugates, and pharmaceutical compositions for use in the treatment of neuromuscular diseases, such as Duchenne Muscular Dystrophy (DMD), are disclosed herein. The disclosed compounds are useful, amon...  
WO/2020/096127A1
The present invention relates to a pharmaceutical composition and a cosmetic composition comprising hydrolyzed sponge, acetyl glucosamine, and dimethyl sulfone for preventing or treating arthralgia or myalgia and to a method for preventi...  
WO/2020/096441A1
The present invention relates to a pharmaceutical composition which comprises the synergistic combination of a selective inhibitor of cyclooxygenase II, such as the active ingredient: celecoxib and its pharmaceutically acceptable salts, ...  
WO/2020/097002A1
This invention relates to polynucleotides comprising optimized FIG4 open reading frame (ORF) sequences, vectors comprising the same, and methods of using the same for delivery of the ORF to a cell or a subject and to treat disorders asso...  
WO/2020/097265A1
Substituted pyridazinone compounds, conjugates, and pharmaceutical compositions for use in the treatment of neuromuscular diseases, such as Duchenne Muscular Dystrophy (DMD), are disclosed herein. The disclosed compounds are useful, amon...  
WO/2019/246125A8
Products and methods for treating dystroglycanopathies and laminin-deficient muscular dystrophies are provided. In the methods, a protein including a linker domain, such as the heparin-binding domain of Heparin-Binding Epidermal Growth F...  
WO/2020/096660A1
Methods and egg yolk powder containing compositions for improving skeletal muscle protein fractional synthetic rate (FSR) in mammals and inhibiting or reversing sarcopenia are provided.  
WO/2020/094555A1
Compositions may be used for a variety of therapeutic applications, including treating and/or preventing a disease or disorder related to reduced or inadequate mitochondrial activity, such as aging or stress, diabetes, obesity, and neuro...  
WO/2020/087428A1
A multifunctional healthcare pillow filled with traditional Chinese medicine. Said healthcare pillow has a convex shape, the outermost layer is a dense coarse sheet, a traditional Chinese medicine insert is provided in the coarse sheet, ...  
WO/2020/091463A1
The present invention relates to a pharmaceutical composition for preventing or treating tendinopathy, comprising isolated mitochondria as an effective component. The pharmaceutical composition of the present invention, comprising isolat...  
WO/2020/091036A1
Provided is an edaravone suspension for oral administration that has excellent bioavailability. It is expected that burden on ALS patients and care workers can be reduced thereby.  
WO/2020/089325A1
The current invention provides splice-switching compounds with improved characteristics that enhance clinical applicability preferably for treating, ameliorating, preventing, and/or delaying neuromuscular disorders, more specifically DMD.  
WO/2020/089260A1
The present invention relates to antisense oligonucleotides (oligomers) complementary to nucleic acids encoding mammalian T cell-restricted intracellular antigen-1 (TIA1), in particular antisense oligonucleotides targeting TIA1 pre-mRNA ...  
WO/2020/084488A1
A conjugate of oligonucleotides and bile acid derivatives having the structure (I), (II) or (III), pharmaceutical compositions thereof, and uses thereof are described.  
WO/2020/086728A1
In one aspect, compounds of Formula A, or a pharmaceutically acceptable salt thereof, are featured (Formula A) or a pharmaceutically acceptable salt thereof, wherein the variables shown in Formula A can be as defined anywhere herein.  
WO/2020/086733A1
Described herein are methods and compositions comprising nicotinamide riboside and alpha-ketoglutarate for treating frailty, for maintaining health, and for re-growing hair.  
WO/2020/086890A1
The invention provides novel co-crystals of epicatechin with a carboxy-N-heterocyclic co-crystal former such as trigonelline or proline and their pharmaceutical compositions. Methods of preparing the co-crystals and methods of using them...  
WO/2020/082435A1
A preparation method for a cisatracurium besilate injection without preservatives. Each 1000 ml of the injection contains the following components by weight: 2-10 g of cisatracurium besilate and a proper amount of benzenesulfonic acid. T...  
WO/2020/086732A1
In one aspect, compounds of Formula AA, or a pharmaceutically acceptable salt thereof, are featured or a pharmaceutically acceptable salt thereof, wherein the variables shown in Formula A can be as defined anywhere herein.  
WO/2019/190175A9
The present invention relates to a method for differentiating motor neurons from tonsil-derived mesenchymal stem cells, and a cell therapy agent using same. The differentiation method of the present invention exhibits high differentiatio...  
WO/2020/079203A1
The present invention relates to a process for the preparation of 7-(4,7-diazaspiro[2.5]octan-7-yl)-2-(2,8-dimethylimidazo[1,2 -b]pyridazin-6-yl)pyrido[1,2-a]pyrimidin-4-one useful as pharmaceutically active compounds.  
WO/2020/080641A1
The present invention relates to a composition for preventing or treating AMPK-related diseases, comprising a Gynostemma longipes VK1 extract or a compound isolated therefrom as an active ingredient. It is found that the Gynostemma longi...  
WO/2020/079299A1
Microspheres for the treatment of musculoskeletal and vascular skin or dermatological disorders. The present invention relates to microspheres which are formed by a core comprising a triblock copolymer non-ionic surfactant, a halogenated...  
WO/2020/078445A1
A pharmaceutical combination or a pharmaceutical composition for the treatment of fibrotic diseases, and a use for said pharmaceutical combination or pharmaceutical composition in the preparation of drugs for preventing and/or treating f...  
WO/2020/077412A1
The present disclosure relates to methods of administering a gene therapy construct comprising RNA interference (RNAi) reagents, such as short hairpin microRNA (shmiR), in combination with PABPN1 replacement reagents, such as polynucleot...  
WO/2020/075845A1
[Problem] To provide a potential candidate for preventing or treating diseases or disorders that are related to glucose metabolism by discovering a substance that can induce the expression of a GLUT family. [Solution] Through several asp...  
WO/2020/074952A1
Provided are a pharmaceutical composition comprising zinc, leucine, and omega-3 fatty acids, formulated for oral delivery; a kit comprising the pharmaceutical composition; and methods of promoting recovery of pelvic floor muscles in a po...  
WO/2020/070236A1
The invention provides a VMAT2 blocking compound for use in a method of treating a subject suffering from a movement disorder; which method comprises administering to the subject a therapeutically effective amount of the VMAT2 blocking c...  
WO/2020/070506A1
The present invention provides a compound for use in preventing or treating overtraining in a subject, wherein the compound is selected from (i) (R)-3-hydroxybutyrate; (ii) an ester of (R)-3-hydroxybutyrate; and (iii) an oligomer obtaina...  
WO/2020/072997A1
Methods and compositions for relieving general and chronic fatigue, restoring energy, rejuvenating sore muscles, and relieving associated pain by administering a composition including caffeine, and a cannabis component having one or more...  
WO/2020/072574A1
Processes for production of a composition containing active follistatin via spray/heat drying of a biological source containing follistatin as well as compositions containing this active follistatin and methods for use in increasing musc...  
WO/2020/063976A1
Provided are a fused heterocyclic biaryl benzyl alcohol compound, a preparation method, and use. The fused heterocyclic biaryl benzyl alcohol compound is as represented by formula (IA), has good inhibition activity for a BRD enzyme, and ...  
WO/2020/063178A1
A gene editing composition or kit used for in vivo gene therapy, comprising: 1) sgRNA that is linked to a nucleic acid molecule of a binding protein and that targets a target mutant gene, or a coding sequence thereof, 2) a template nucle...  
WO/2020/067435A1
The purpose of the present invention is to provide: a method for producing a high-quality graft from differentiation-induced cells derived from a pluripotent stem cell; a graft produced by using the method; and a method for treating a di...  
WO/2020/039088A3
The present invention comprises novel aromatic molecules, which can be used in the treatment of pathological conditions, such as cancer, skin diseases, muscle disorders, and immune system-related disorders such as disorders of the haemat...  

Matches 51 - 100 out of 26,569