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Matches 101 - 150 out of 20,908

Document Document Title
WO/2016/031987A1
A compound represented by any of formulas (Ia)-(Ic) or formula (II), or a pharmaceutically acceptable salt thereof. (In the formulas, R1, R2, R3, R4a, R4c, R5, R15, ring A, X1, and X2 are as defined in the specification.)  
WO/2016/031264A1
The present invention addresses the problem of providing a new therapeutic strategy for an ailment wherein skeletal muscle loss is the main cause or partial cause of the ailment. Provided is a skeletal muscle bulking agent containing mec...  
WO/2016/028971A1
The present invention provides compounds of Formula (I) or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This inven...  
WO/2016/028894A1
Uridine triacetate or other uridine prodrugs are used to treat genetic glycosylation disorders by administering them in an amount sufficient to raise plasma uridine in the to a level greater than 30 micromolar. They can be administered a...  
WO/2016/027225A1
A pharmaceutical composition or dietary supplement having a muscle-relaxant and anti¬ inflammatory activity is described, which is effective in the treatment of muscle, bone, articular and tendon pathologies, comprising, as active ingre...  
WO/2016/027225A8
A pharmaceutical composition or dietary supplement having a muscle-relaxant and anti¬ inflammatory activity is described, which is effective in the treatment of muscle, bone, articular and tendon pathologies, comprising, as active ingre...  
WO/2016/025339A3
The present invention relates to the delivery of oligomers for treating patients with a 5' mutation in their DMD gene other than a DMD exon 2 duplication. The invention provides methods and materials for activating an internal ribosome e...  
WO/2016/016507A1
The invention relates to a method for diagnosing fibromyalgia using microRNAs. The invention provides a method for molecular diagnosis of fibromyalgia patients, based on analysing the possible alteration of the levels of certain microRNA...  
WO/2016/017767A1
Provided are: a novel Sirtuin-1 activator; and a preparation for preventing the occurrence of oxidative stress-induced cellular senescence, which contains the Sirtuin-1 activator. The present invention provides: a Sirtuin-1 activator whi...  
WO/2016/012398A1
The present invention relates to a novel pharmaceutical composition comprising zaitoprofen or a pharmaceutically acceptable salt thereof in combination with muscle relaxants with anti-inflammatory, analgesic and myorelaxant activity.  
WO/2016/008034A1
This invention relates to a method of increasing energy available to skeletal muscle cells comprising administering to the cells an effective amount of Tenurin C-terminal Associated Peptide (TCAP). The invention provides the use of TCAP ...  
WO/2016/008966A1
The present invention relates to methods for treating neuromuscular junction-related diseases. In particular, the present invention relates to a method of treating a neuromuscular junction-related disease in a subject in need thereof com...  
WO/2016/011420A1
This invention provides methods, compounds and compositions for the treatment of musculoskeletal disease, muscle dysfunction, muscle-wasting disease or disorder, including hereditary myopathy, neuromuscular disease, muscular dystrophy, m...  
WO/2016/011348A1
Potent modulators of RNA function can be assembled in cellulo by using the cell as a reaction vessel and a disease-causing RNA as a catalyst. When designing small molecule effectors of function, a balance between permeability and potency...  
WO/2016/011019A1
The present invention provides small-molecule inhibitors of BMP signaling and compositions and methods for inhibiting BMP signaling. These compounds and compositions may be used to modulate cell growth, differentiation, proliferation, an...  
WO/2016/005527A1
The present invention relates to a method of treatment of movement disorders, comprising administering to a patient in need thereof an effective amount of befiradol, where in the administering step provides an average patient's maximum p...  
WO/2016/004882A1
Provided herein are aromatic heterocyclic derivatives or a stereoisomer, a tautomer, an N-oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof used for treating Alzheimer's disease. Also provided herein...  
WO/2016/006996A1
The present invention relates to a therapeutic tape comprising stretchable base cloth formed from the material of a kinesiology tape; an adhesive layer provided on one side of the base cloth; and a composition of non-steroidal anti- infl...  
WO/2016/001762A1
The present disclosure relates to the use of the non-toxic proteolytic C fragment of tetanus toxin and plasmids encoding such protein fragment to increase muscle mass and/or muscle strength in a subject in need thereof. As such, methods ...  
WO/2016/002948A1
The purpose of the present invention is to provide a lysophosphatidylserine derivative or salt thereof. The present invention provides a lysophosphatidylserine derivative or salt thereof, and a pharmaceutical composition or lysophosphati...  
WO/2015/199169A1
Provided is a composition that includes: a tea extract or a catechin; and a citrus fruit extract or a flavanone, or a glucoside thereof.  
WO/2015/197503A1
The present invention provides compounds of formula (I) wherein A, Xl, X2, R1, R2, R3, R4and R5are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture...  
WO/2015/194520A1
Provided is a drug that provides highly efficient exon skipping. The present invention provides an antisense oligomer having at least two unit oligomers linked that target arrays that are do not continue on from or overlap with each othe...  
WO/2015/188943A1
This invention relates to novel uses of recombinant clostridial neurotoxins exhibiting decreased duration of effect, in particular uses for the treatment of patients having experienced muscle-related disorders and/or injuries.  
WO/2015/188944A1
This invention relates to novel uses of recombinant clostridial neurotoxins exhibiting decreased duration of effect, in particular uses for the treatment of patients having experienced tendon-related disorders and/or injuries.  
WO/2015/191827A1
A method for reducing muscle damage and/or oxidative stress in active mammals as disclosed. In one embodiment, the mammals are administered a carnitine supplement. The L-carnitine supplement may be administered without any other pharmace...  
WO/2015/190643A1
The present invention relates to a composition for promoting the differentiation of myoblasts, the composition containing butylpyridinium, a derivative thereof, or a pharmaceutically acceptable salt thereof; a pharmaceutical composition ...  
WO/2015/189534A1
The invention relates to the use of compounds which inhibit VAP-1 /SSAO activity for the treatment of muscular dystrophy. The invention also relates to combined preparations comprising compounds which inhibit VAP-1 /SSAO activity, and th...  
WO/2015/188942A1
This invention relates to novel uses of recombinant clostridial neurotoxins exhibiting decreased duration of effect, in particular uses for the treatment of patients suffering from a limited range of muscle extension, in particular from ...  
WO/2015/188945A1
This invention relates to novel uses of recombinant clostridial neurotoxins exhibiting decreased duration of effect, in particular uses for the treatment of different forms of back pain, in particular recurrent low back pain.  
WO/2015/187977A1
The present invention relates to follistatin-Fc fusion proteins that have effects in the tissue of administration (such as an injected muscle), rather than systemic effects. The Fc domain results in dimerization of the follistatin-Fc fus...  
WO/2015/186068A1
Provided herein are crystalline beta-D-nicotinamide riboside chloride compositions and methods of preparation and use thereof. Also provided are related pharmaceutical compositions and methods of use thereof. The crystalline beta-D-nicot...  
WO/2015/186906A1
The present invention relates to: a composition for alleviating or treating a tendon or ligament disease, containing autologous and allogeneic adipose-derived mesenchymal stem cells; a preparation method therefor; and a method for treati...  
WO/2015/184528A1
The present invention relates to botulinum toxins for use in the treatment of paratonia. In particular, the present invention relates to the treatment of paratonia by local administration of a botulinum toxin to a muscle of a patient.  
WO/2015/184260A2  
WO/2015/184003A1
Methods for the safe administration of imidazole or imidazolium compounds, and conditions that may be treated by these methods, are described herein.  
WO/2015/184279A1
A method is provided for treating a Mendelian disorder of the epigenetic machinery (e.g., Kabuki syndrome) in a subject in need thereof. In particular, the method comprises administering to the subject a ketogenic composition in an amoun...  
WO/2015/177469A1
The present invention relates to chemical compounds and the therapeutic use thereof, in particular for improving muscular quality in mammals. More particularly, the invention enables improvement of muscular quality in sarcopenic mammals ...  
WO/2015/178404A1
The present invention addresses the problem of discovering a carotenoid compound exhibiting excellent water solubility. Provided is a carotenoid derivative represented by general formula (I) [in general formula (I): X represents a carbon...  
WO/2015/179125A1
Methods are disclosed for treating multiple sclerosis comprising administering an agent that reduces expression and/or activity of Allograft inflammatory factor- 1 (Aif-1) in a subject and for screening for such agents.  
WO/2015/173684A1
This invention relates to a novel crystalline form of 6-[(4R)-4-methyl-1, 1-dioxido- 1,2,6-thiadiazinan-2-yl]isoquinoline-1-carbonitrile which is useful as a selective androgen receptor modulator (SARM), and to compositions thereof and s...  
WO/2015/172207A1
The present invention relates to methods for culturing and generation of mesodermal progenitor cells, more particularly methods to produce mesodermal progenitor cells, starting from pluripotent stem cells. The invention relates to method...  
WO/2015/173181A1
The present invention provides compounds of formula (I) wherein A, R1, R2 and R3 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compou...  
WO/2015/170683A1
The objective of the present invention is to provide: an NOX inhibitor and an NFκB inhibitor, each having excellent activity; and a prophylactic or therapeutic agent for diseases associated with NOX or NFκB, which utilizes the NOX inhi...  
WO/2015/165279A1
Provided are new polyfluoro-substituted pyrazolopyrimidine compounds or salts represented by formulae (I) to (IX), a preparation method therefor, and a method for using said compounds and a preparation thereof to treat and inhibit autoim...  
WO/2015/166887A1
 The purpose of the present invention is to provide a novel muscle atrophy inhibitor containing an ingredient that can be taken safely over an extended period of time. It was discovered that a glycoside of quercetin, which is a type of...  
WO/2015/160793A1
Provided are novel biocompatible copolymers, compositions comprising the copolymers, and methods of using the copolymers. The copolymers are non-toxic and typically have an LCST below 37°C. Compositions comprising the copolymers can be ...  
WO/2015/158740A1
The present invention relates to compositions and methods for treating myotonic dystrophy.  
WO/2015/158836A1
The invention relates to a Mangifera (Mango) Indica preparation as Sirtuin 1 activating agent for in vivo and in vitro applications. The preparation may be used to reduce the risk of developping obesity, type II diabetes, elevated blood ...  
WO/2015/158365A1
The present invention relates to compositions and methods for treating myotonic dystrophy.  

Matches 101 - 150 out of 20,908