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Matches 401 - 450 out of 15,685

Document Document Title
WO/2011/097500A3
The invention provides methods for preventing loss and augmenting regeneration of skeletal muscle by decreasing the activity of the TWEAK/Fn14 system.  
WO/2011/096484A1
A read through inducer for an immature termination codon formed by a nonsense mutation, which comprises a compound represented by structure formula (A); and a therapeutic agent for nonsense-mutation-type genetic diseases, which comprises...  
WO/2011/097456A2
The present invention provides methods and compositions for enhanced transduction of an adeno-associated virus (AAV) vector comprising a heterologous nucleic acid of interest wherein the AAV vector genome is oversized relative to a wild ...  
WO/2011/096377A1
Disclosed is a novel low molecular weight compound that has an immunosuppressive effect. Specifically disclosed is a compound represented by general formula (I) or a pharmacologically acceptable salt thereof. (In the formula, substituent...  
WO/2011/097500A2
The invention provides methods for preventing loss and augmenting regeneration of skeletal muscle by decreasing the activity of the TWEAK/Fn14 system.  
WO/2011/090062A1
Disclosed are a piperazine compound represented by formula (1) and a salt thereof. (In the formula, X represents CH or a N atom, R1 represents a C1-6 alkyl group; R2 represents any of a C1-6 alkyl group optionally having a substituted ba...  
WO/2011/081173A1
A tetracyclic compound represented by formula (I) (wherein Q represents -O- or the like; X represents CH or the like; R1 represents a lower alkyl group or the like; R2 and R3 independently represent a hydrogen atom or the like; and R4 an...  
WO/2011/078360A1
Disclosed is a compound represented by formula (I) or a salt thereof, which has GPR52 agonist activity and is useful as a prophylactic or therapeutic agent for schizophrenia and the like. (In the formula, ring Cy1 represents a five-membe...  
WO/2011/076811A1
The present invention relates to novel carboxamide compounds and their use for the manufacture of a medicament. The carboxamide compounds are inhibitors of calpain (calcium dependant cysteine proteases). The invention therefore also rela...  
WO/2011/077252A3
The invention relates to improvements of the physiochemical and/or the pharmaceutical properties of metaxalone. Disclosed herein are several new cocrystals of metaxalone, including: a 1:1 metaxalore adipic acid cocrystal, a 1:0.5 metaxal...  
WO/2011/078221A1
By making a search for many various compounds having inhibitory activity against IL-12/IL-23 production, provided are medicinal compositions that contain the compounds and therapeutic or prophylactic agents that contain the compounds and...  
WO/2011/077252A2
The invention relates to improvements of the physiochemical and/or the pharmaceutical properties of metaxalone. Disclosed herein are several new cocrystals of metaxalone, including: a 1:1 metaxalore adipic acid cocrystal, a 1:0.5 metaxal...  
WO/2011/070539A1
Compounds of Formula (II) wherein R1a is H; and R1b is C1-C6alkyl, Carbocyclyl or Het; or R1a and R1b together define a saturated cyclic amine with 3-6 ring atoms; R2a and R2b are independently H, halo, C1-C4alkyl, C1-C4haloalkyl or C1-C...  
WO/2011/071136A1
A therapeutic agent for fibromyalgia, comprising a 5-HT2C receptor agonist as an active ingredient.  
WO/2011/070541A1
Compounds of the formula (I) wherein R1a is H; and R1b is C1-C6alkyl, Carbocyclyl or Het; or R1a and R1b together define a saturated cyclic amine with 3-6 ring atoms; R2a and R2b are independently H, halo, C1-C4alkyl, C1-C4haloalkyl or C...  
WO/2011/068208A1
Disclosed is a novel treatment strategy for spinal and bulbar muscular atrophy (SBMA). Specifically disclosed is a therapeutic agent for spinal and bulbar muscular atrophy, which comprises triptan or a pharmacologically acceptable salt t...  
WO/2011/066656A1
Pharmaceutical compositions and methods for improving functional capacity of tissues and organs in both healthy and pathologic disease states for: reducing unwanted cosmetic effects of aging on the skin to reduce wrinkles, to increase co...  
WO/2011/068171A1
Provided are compounds having prophylactic and/or therapeutic effect on chronic rheumatoid arthritis, multiple sclerosis, inflammatory bowel diseases such as Crohn diseases and ulcerative colitis, autoimmune diseases typified by psoriasi...  
WO/2011/065791A3
The present invention provides a composition comprising Astragali Radix extract as an active ingredient. The composition can increase body energy consumption and muscle metabolism. The present invention also relates to pharmaceutical and...  
WO/2011/064552A1
A construct suitable for delivery of a biologically active compound into cells, comprising: (d) a positively charged peptide; (e) a targeting-delivery peptide; and (f) the biologically active compound; wherein the positively charged pept...  
WO/2011/065791A2
The present invention provides a composition comprising Astragali Radix extract as an active ingredient. The composition can increase body energy consumption and muscle metabolism. The present invention also relates to pharmaceutical and...  
WO/2011/062253A1
Disclosed is a prophylactic and/or therapeutic agent for diseases associated with autoimmunity, immune deficiency diseases or neurodegenerative diseases, said prophylactic and/or therapeutic agent containing a novel fused pyrimidine deri...  
WO/2011/060488A1
The invention relates to a recombinant microorganism comprising a transgene encoding angiogenin and optionally follistatin, a food product, beverage product or animal feed produced from or comprising said microorganism and uses thereof.  
WO/2011/059021A1
Disclosed is a compound represented by formula (1) or a pharmacologically acceptable salt thereof. (In the formula, A represents a group that is represented by formula (A-1); R1a and R1b may be the same or different and each independentl...  
WO/2011/057350A1
An antisense molecule capable of binding to a selected target site to induce exon skipping in the dystrophin gene, as set forth in SEQ ID NO: 1 to 59.  
WO/2011/058766A1
The present invention relates to aryl carboxamide derivatives of formula (I), wherein Ar1 is phenyl; Ar2 is aryl; n is 1-4; X is -O-, -S-, -SO- or –SO2-, a prodrug thereof or a pharmaceutically acceptable salt thereof, which have block...  
WO/2011/055944A2
The invention is directed to a method of treating fibromyalgia syndrome in a subject, comprising administering a therapeutically effective amount of a carbamoyl compound, or pharmaceutically acceptable salt thereof.  
WO/2011/056549A1
Dietary supplement compositions include an adaptogenic agent, an anti- inflammation agent, and an anti-oxidant. Methods for using dietary supplement compositions include (i) inhibiting, decreasing, and/or preventing delayed onset of musc...  
WO/2011/054659A1
The present invention relates to methods for restoring the function of a mutated dysferlin comprising the step of preventing splicing of one or more exons which encode amino acid sequences that cause said dysferlin dysfunction. Particula...  
WO/2011/055944A3
The invention is directed to a method of treating fibromyalgia syndrome in a subject, comprising administering a therapeutically effective amount of a carbamoyl compound, or pharmaceutically acceptable salt thereof.  
WO/2011/050808A1
The invention relates to carbamylated erythropoietin for use in the treatment of Friedrich's ataxia.  
WO/2011/049053A1
It was discovered that myeloid cells, which occurs in the lamina propria of healthy animals and are highly positive to Gr-1, positive to CD11b and positive to CD11c, can induce T cell apoptosis and, in its turn, inhibit T cell activation...  
WO/2011/048350A1
A method of treating various diseases, disorders, or conditions in patient using reprogrammed cells such as retrodifferentiated, transdifferentiated, or redifferentiated cells. The method comprises obtaining committed cells from the pati...  
WO/2011/050262A2
The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.  
WO/2011/047093A3
The stem cells that can be propagated and maintained for extended periods of time in culture in the absence of a feeder layer, and can be used to repair tissue damage. These cells are derived from fetal tissues and are able to repair dif...  
WO/2011/047093A2
The stem cells that can be propagated and maintained for extended periods of time in culture in the absence of a feeder layer, and can be used to repair tissue damage. These cells are derived from fetal tissues and are able to repair dif...  
WO/2011/041937A1
The use of hydroxytyrosol or an olive juice extract containing hydroxytyrosol for improving muscle differentiation and thus improving or maintaining the body's adaptation to exercise is disclosed. The pharmaceutical and nutraceutical com...  
WO/2011/038471A1
The technical subject matter of the present invention relates to a pharmaceutical composition that contains, as the active principle, substances obtained by extraction and purification of essential oils from a plant of the Alpinia genus....  
WO/2011/040823A1
The present invention relates to novel synthetic myostatin antagonists, comprising a synthetic mature myostatin peptide, wherein the peptide comprises at least two cysteine residues at positions 281 and 282 which are forced to bond and f...  
WO/2011/034912A1
Disclosed are methods of treating spasticity by administering to a patient in need of such treatment a compound having formula (I).  
WO/2011/034078A1
Disclosed is a compound which is useful as the active ingredient of a medicinal composition, in particular, a medicinal composition for preventing and/or treating a VAP-1 associated disease. As the results of intensive studies on compoun...  
WO/2011/034532A1
Disclosed are compositions, formulations and methods relating to one or more stilbene-based compounds for use in humans. In particular, compositions and formulations comprising an effective amount of the stilbene-based insulinogenic comp...  
WO/2011/033884A1
A pharmaceutical material or a food material which contains a caroteine oxidation derivative derived from a land animal, a land plant or a microorganism as an active ingredient, is suitable for use in a food, a beverage or a drug, and ca...  
WO/2011/034920A1
Disclosed are methods of treating a seizure disorder by administering to a patient in need of such treatment a compound having the following formula (I).  
WO/2011/030981A1
A method for preparing [18F]fallypride is disclosed, which comprises a first step for trapping a fluorine-18 to a polymer ion exchange cartridge; a second step for extraction of fluorine-18 by inputting low base concentrations: 5.0~25μL...  
WO/2011/031901A1
In certain aspects, the present invention provides compositions and methods for promoting bone growth and increasing bone density, as well as for the treatment of multiple myeloma. Methods for dosing a patient with an ActRIIb antagonist ...  
WO/2011/030116A1
This invention pertains to the use of steroid compounds including spirosteroid analogues in treating, preventing or ameliorating the symptoms of inflammatory conditions. The steroid compounds are useful for treating a range of inflammato...  
WO/2011/024077A3
Methods for stabilizing unstable proteins or for restoring functionality to non-functional or poorly functioning (semi-functional) proteins using exon skipping technology are provided. The methods involve the administration of antisense ...  
WO/2011/024822A1
Provided are a diagnosis marker, a diagnosis method, and a therapeutic agent suitable for diagnosing and treating amyotrophic lateral sclerosis (ALS). Also provided are an animal model and a cell model suitable for developing a therapeut...  
WO/2011/025368A1
Disclosed is a method of treatment or prevention of frailty in an elderly patient, particularly having an age of 60 or older. The method provides the concomitant parenteral administration of a combination of an anabolic steroid and a vit...  

Matches 401 - 450 out of 15,685