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Matches 451 - 500 out of 110,622

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WO/2015/191934A3
Engineered agents or multivalent and multispecific binding proteins capable of penetrating the cells or tissue of the blood-brain barrier (BBB) are provided, along with methods of making and uses in the prevention, diagnosis, and/or trea...  
WO/2015/191707A3
Disclosed are particles comprising a complex of nicotine and cerium oxide and a biodegradable coating comprising agglutinin. Also disclosed is a method of treating or preventing neurodegenerative or neurological disorders in a mammal in ...  
WO/2015/191403A1
The disclosure provides compounds of formula I including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic 7 receptor and may be useful for the treatment of various disor...  
WO/2015/190452A1
This invention addresses the problem of obtaining sake-yeast-containing tablets that exhibit sufficient tablet properties such as hardness and disintegrability even if each tablet contains a large amount of sake yeast. That is, this inve...  
WO/2015/191934A8
Engineered agents or multivalent and multispecific binding proteins capable of penetrating the cells or tissue of the blood-brain barrier (BBB) are provided, along with methods of making and uses in the prevention, diagnosis, and/or trea...  
WO/2015/190564A1
 The present invention provides a compound having cholinergic muscarinic M1 receptor positive allosteric modulator activity, the compound being useful as a drug for the prevention, treatment, or the like of Alzheimer's disease, schizop...  
WO/2015/190555A1
 The present invention provides a synthetic peptide whereby antibodies to an autoantigen can be derived, and specifically provides: a multiplex alloantigenic peptide including a dendritic core and a B-cell-recognition peptide, the mult...  
WO/2015/192014A1
The invention relates to methods of treating cancer, myeloproliferative diseases, or immunological or neurological diseases with a combination of a glutaminase inhibitor and an anticancer agent such as an enzyme inhibitor (such as a kina...  
WO/2015/191743A1
The present application provides fee compounds of formula (J), or pharmaceutically acceptable salts, isomers, tautomer, or a mixture thereof, wherein X, Y, Z, n, m', A', R1, R2, and R3 are described herein. The compounds are inhibitors t...  
WO/2015/189744A1
The present invention relates to imidazopyridazine derivatives. More particularly, it relates to 4-(biphenyl-3-yl)-7H-imidazo[4,5-c]pyridazine derivatives of formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, ...  
WO/2015/190797A1
The present invention relates to a pharmaceutical composition for treating neurogenic bladder, containing oral mucosa stem cells as an active ingredient, to a method for treating neurogenic bladder using the pharmaceutical composition, a...  
WO/2015/190455A1
The present invention provides a tablet that contains a sake yeast and silicon dioxide; that contains, per tablet, at least 15 mass% of sake yeast cells (A); and that has a mass ratio (B/A), of the silicon dioxide (B) content to the sake...  
WO/2015/190568A9
The present invention relates to a medicine for preventing and/or treating stress-induced diseases, said medicine being characterized in that (1S)-2-acetyl-1-(4-chloro-2-methoxyphenyl)-5-fluoro-1,2,3,9- tetrahydrospiro[β-carboline-4,1'-...  
WO/2015/186729A1
Provided are: an immediate-release tablet formulation that contains casein and/or casein hydrolysate at a high concentration as an active ingredient and yet has excellent mechanical strength; a composition for the immediate-release table...  
WO/2015/186128A1
The present invention disclosed methods of inducing maturation of oligodendrocyte cells. A method of inducing myelination in a patient suffering from demyelination is also disclosed  
WO/2015/188005A1
The invention relates to the preparation and characterization of novel salts of (R)-isometheptene and crystalline forms thereof; moreover, the invention describes the use of the novel salts alone or in combination with other therapeutic ...  
WO/2015/186056A1
The invention relates to compounds of formula (I) Formula (I) wherein X, Y, R1, R2, (R4)n, and (R5)m are as defined in the description, and to pharmaceutically acceptable salts of such compounds. These compounds are useful as calcium T-c...  
WO/2015/186134A1
Compounds, methods and uses of pseudo-trisaccharide aminoglycosides represented by the general formula I or a pharmaceutically acceptable salt thereof, wherein R1 is selected from the group consisting of alkyl, cycloalkyl and aryl; and a...  
WO/2015/184731A1
The invention provides fluoro-substituted chiral side chain-containing 2-arylbenzoheterocyclic compounds having affinity with Aβ plaque. The structural general formula of the compounds is shown as Formula (I), wherein X is N; Y is S or ...  
WO/2015/187845A1
Disclosed are chemical entities of formula (I) wherein X, Y, Z, R1, R3, R4, R5 and R6 are defined herein, as NR2B subtype selective receptor antagonists. Also disclosed are pharmaceutical compositions comprising a chemical entity of form...  
WO/2015/187905A1
The present invention relates to quinoline compounds, and pharmaceutically acceptable compositions thereof, useful as antagonists of P2X7, and for the treatment of P2X7-related disorders.  
WO/2015/187988A1
Current maintenance treatment for epilepsy (e.g., Dravet Syndrome and other intractable epilepsies) and/or epilepsy-related conditions remain under debate. Currently, the actions taken for epilepsy and/or epilepsy-related conditions invo...  
WO/2015/184542A1
The present application relates to novel compounds comprising a moiety that leads to the metabolic production of ketones bonded to a ketone- potentiated anti-epileptic drug, compositions comprising these compounds, and their use, for exa...  
WO/2015/187851A1
Methods of increasing tonic inhibition in a subject in need thereof, for example a subject with Fragile X syndrome or Angelman syndrome are disclosed. Methods of treating secondary insomnia in a subject with a neurodegenerative disease o...  
WO/2015/185602A1
The invention discloses monocytes and/or a monocyte inducing agent and/or a monocyte activating agent and/or a monocyte recruiting agent for use in the treatment and prevention of PD.  
WO/2015/187289A1
This invention relates to an ingestible drug delivery device configured for wireless communication with other ingestible drug delivery devices.  
WO/2015/188142A1
Described herein are methods for diagnosing and monitoring traumatic brain injury by imaging a subject retinal to determine the presence and/or extent of deviations from a normal retina.  
WO/2015/184528A1
The present invention relates to botulinum toxins for use in the treatment of paratonia. In particular, the present invention relates to the treatment of paratonia by local administration of a botulinum toxin to a muscle of a patient.  
WO/2015/184509A1
H:\svm\Interwoven\NRPortbl\DCC\SVM\7886476_1.docx-5/06/2015 ABSTRACT The present invention relates generally to methods for the treatment and/or prophylaxis of neurological diseases and disorders involving administration of trans 10-HDA....  
WO/2015/184260A2  
WO/2015/180679A1
Provided herein are 19-nor C3, 3-disubstituted steroids of Formula (I) : and pharmaceutically acceptable salts thereof; wherein R1, R2, R3, and R4are as defined herein, and A is a heteroaryl ring system comprising 3 or 4 nitrogens as def...  
WO/2015/183530A1
This invention provides a compound selected from the group consisting of L- nicotine(X1)(X2) and D-nicotine(X1)(X2), or a pharmaceutically acceptable salt thereof, wherein (i) each of Χ1 and X2 is independently a pharmaceutically accept...  
WO/2015/181449A1
The present invention relates to the field of medicine and in particular to Parkinson's disease (PD). Specifically the present invention relates to methods and means for early detection of PD. The invention relates also to methods and me...  
WO/2015/180060A1
Disclosed are a salt of diazacycloheptane compound and a crystal form and an amorphous substance thereof, which have improved features in the aspects of solubility, stability, dissolution of solid preparations and the like. Also disclose...  
WO/2015/182724A1
 Provided are compounds that are useful as prophylactic or therapeutic agents for various diseases involving T-type calcium channels, such as hypertension, arrhythmia, pain and cancer, said compounds having antagonistic activity agains...  
WO/2015/181640A1
A preparation comprising krill oil and phospholipids. Methods of treatment comprising administering the same.  
WO/2015/181094A1
The present invention relates to the therapeutic use of derivatives of 1-(2-fluorobiphenyl-4-yl)-cyclopropanecarboxylic acid for improving the cognitive capacity of patients with intellectual disabilities, an IQ of less than 85, diagnose...  
WO/2015/184105A1
The present invention features methods for stimulating clearance of misfolded or aggregated proteins or peptides in microglia or neurons, and treating neurodegenerative diseases associated with such pathology in brain by selectively inhi...  
WO/2015/180342A1
The present invention provides a deuterium substituted 1-[2-(2,4-dimethyl-thiophenyl)-phenyl] piperazine compound with a structure represented by formula (I) or a derivative thereof, a pharmaceutical composition containing the compound o...  
WO/2015/184003A1
Methods for the safe administration of imidazole or imidazolium compounds, and conditions that may be treated by these methods, are described herein.  
WO/2015/180485A1
The present invention relates to an amantadine nitrate compound having a neuroprotective effect and a preparation and a medical use thereof. The compound has the structure of the general formula (I). The compound has multiple mechanisms ...  
WO/2015/184279A1
A method is provided for treating a Mendelian disorder of the epigenetic machinery (e.g., Kabuki syndrome) in a subject in need thereof. In particular, the method comprises administering to the subject a ketogenic composition in an amoun...  
WO/2015/183673A1
A TARP ϒ8 dependant AMPA receptor antagonist of the formula: wherein X is CH or N; A is; and R1 is as defined herein; its pharmaceutically acceptable salts, uses, and methods for its preparation are described.  
WO/2015/181567A1
According to the invention there is provided N,N-bis-2-mercaptoethyl isophthalamide, or a pharmaceutically acceptable salt or derivative thereof, for use in the therapeutic treatment of a neurodegenerative disorder, such as Alzheimer's d...  
WO/2015/180582A1
Provided are a β crystalline form of aripiprazole hemiethanolate, a preparation method thereof and the use for preparing a I crystal form of aripiprazole with a low hygroscopicity. The preparation method for the β and I crystal forms o...  
WO/2015/182232A1
The purpose of the present invention is to provide a novel anti hallucination drug whereby hallucination symptoms can be suppressed, treated or prevented. The anti hallucination drug comprises a crude drug derived from a plant belonging ...  
WO/2015/181061A1
The invention relates to compounds of formula (I) wherein.....C.....is -CH2- or -CH2-CH2-; X is -NH-, -C(0)NH- or -NHC(0)NH-; Ar is phenyl or a 5 or 6-membered heteroaryl group containing one or two N atoms; R1 is halogen, lower alkyl, l...  
WO/2015/181336A1
The invention relates to a compound comprising the following general formula (1) for use in the treatment of psychiatric or neurological disorders and inflammation, in particular neuroinflammation: (1) wherein each of R1, R 2 and R 3 are...  
WO/2015/182723A1
 Provided are a novel pyrrolidine compound having melanocorin receptor agonist activity, a pharmacologically acceptable salt thereof, and pharmaceutical applications thereof. The present invention pertains to a pyrrolidine derivative r...  
WO/2015/181337A1
The invention relates to a compound comprising the following general formula (1) and said compound for use as a medicament, in particular for use in the treatment psychiatric or neurological disorders and inflammation, in particular neur...  

Matches 451 - 500 out of 110,622