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Matches 451 - 500 out of 97,147

Document Document Title
WO/2014/092104A1
The invention provides compounds represented by formula (1) (in the formula, Het represents the formula (Het-1) or the like; A represents the formula (A-1) or the like; B represents (B-1) or the like; R1A represents a hydrogen atom, alky...  
WO/2014/093114A8
The present invention relates to PPARy- sparing compounds and pharmaceutical compositions formulated with such compounds that are useful for treating, delaying the onset of, or reducing the symptoms of a neurodegenerative disorder includ...  
WO/2014/090929A1
Pharmaceutical compositions comprising vortioxetine and donepezil are provided and the use of such composition for the treatment of cognitive dysfunctions.  
WO/2014/093791A1
Provided herein are pharmaceutical compositions and formulations comprising mixed salts of gamma-hydroxybutyrate (GHB). Also provided herein are methods of making the pharmaceutical compositions and formulations, and methods of their use...  
WO/2014/092175A1
The present invention addresses the problem of providing a method for manufacturing a comparatively high-purity ≥4-mer polyphenol by precisely isolating said ≥4-mer polyphenol from a polyphenol mixture. This method for manufacturing ...  
WO/2014/091876A1
The fluorine-substituted piperidine compound represented in formula (I) or a pharmaceutically acceptable salt thereof is useful in the treatment or prevention of disorders that are on the basis of orexin (OX) receptor antagonism includin...  
WO/2014/091388A3
The invention provides methods for predicting therapeutic responsiveness of a subject suffering from cognitive impairments or dysfunctions, psychotic and/or neurodegenerative disorders to an alpha 7 nicotinic acetylcholine receptor activ...  
WO/2014/093114A1
The present invention relates to PPARy- sparing compounds and pharmaceutical compositions formulated with such compounds that are useful for treating, delaying the onset of, or reducing the symptoms of a neurodegenerative disorder includ...  
WO/2014/091415A1
The invention relates to indole carboxamide derivatives of formula (I), (I) wherein R1, R 2, R 3, R 4, R5 and R6 are as defined in the description, their preparation and their use as pharmaceutically active compounds.  
WO/2014/092227A1
The present invention relates to a composition for treatment of diseases related to the removal of extracellular alpha-synuclein and to a method for screening a therapeutic agent for said diseases.  
WO/2014/090921A1
The invention relates to a method of treating pain in a patient by applying a transdermal therapeutic system for the transdermal administration of buprenorphine for 7 days on the skin of a patient, said transdermal therapeutic system com...  
WO/2014/091352A1
The present invention provides compounds of Formula (I), and the tautomers thereof, and the pharmaceutically acceptable salts of the compounds and tautomers, wherein the compounds have the structure (I) wherein the variables R1, R2, R3, ...  
WO/2014/093901A1
Provided are methods for treating GLUT1 and related brain energy deficiencies comprising administering odd-carbon fatty acid sources, e.g., C5 or C7 fatty acid sources, and related compositions.  
WO/2014/093871A1
The present invention relates to methods for treating pruritus with anti-pruritic compositions.  
WO/2014/092100A1
The purpose of the invention is to provide a compound or salt thereof that is useful as an agent for the prevention or treatment of epilepsy, neurodegenerative disease, and the like. The invention pertains to compounds represented by for...  
WO/2014/093918A1
The disclosure provides compositions, methods and kits for treatment of neuronal injury. In one embodiment, the composition comprises polyethylene glycol (PEG), and magnesium in one composition. In another embodiment, the composition com...  
WO/2014/093475A1
Provided herein are methods and compositions for treatment of patients with Parkinson's disease and, in particular, motor impairments in patients with Parkinson's disease, using an aminopyridine.  
WO/2014/089620A1
The present invention provides compositions comprising a combination of: (i) one or more B vitamins or alternative form(s), derivative(s), or salt(s) thereof, or combinations thereof, and/or source(s) thereof; and (ii) phosphatidylserine...  
WO/2014/093190A1
In its many embodiments, the present invention provides certain C2-ring-substituted iminothiadiazine compounds, or a tautomers thereof, and pharmaceutically acceptable salts of said compounds and said tautomers. The novel compounds of th...  
WO/2014/093277A1
The present invention relates generally to the fields of treating psychiatric disorders, in particular, anxiety disorders including post-traumatic stress disorder (PTSD) in subjects, e.g., human subjects, by administering a xenon and/or ...  
WO/2014/091020A1
The present invention refers to phenanthrene derivatives for use as medicaments, in the prevention and/or treatment of Myotonic Dystrophy Type 1, Huntington's Disease Like 2, Spinocerebellar Ataxia Type 8, Myotonic Dystrophy Type 2, Spin...  
WO/2014/093251A1
Engineered chloride channel receptors, nucleic acids encoding these receptors, expression vectors including these nucleic acids are disclosed herein. Nanoparticles and pharmaceutical compositions including these engineered chloride chann...  
WO/2014/086098A1
Disclosed are a cyclohexane amine compound and an application thereof for anti-schizophrenia drugs. The cyclohexane amine compound of the present invention has high affinity for a dopamine D3 receptor and 5-ΗΤ1Α, and a lead compound h...  
WO/2014/089480A1
The present specification provides immunosuppressive Tat derivative polypeptides, compositions, and methods of using such polypeptides and compositions to treat an autoimmune disease, an inflammation-associated disease and/or a neurodege...  
WO/2014/089209A2
Engineered multivalent and multispecific binding proteins capable of penetrating the blood-brain barrier (BBB) are provided, along with methods of making and uses in the prevention, diagnosis, and/or treatment of disease.  
WO/2014/088932A1
Provided herein are methods of treatment of individuals having schizophrenia, or schizophreniform disorder, using angiogenic cells from amnion, referred to as amnion derived adherent cells, and populations of, and compositions comprising...  
WO/2014/086104A1
The present invention relates to the field of drugs, and more particularly to an AMPK activator and an application thereof in preparing drugs for treating and/or preventing diabetes and/or diabetes complications. The present invention pr...  
WO/2014/087165A1
The present invention relates to a compound of formula I wherein X is C(R6) or N, Y is C or N, and ring A, ring B, R1 and R2 have the meanings defined herein, provided that when ring B is carbocyclic, X is C(R6); or a pharmaceutically ac...  
WO/2014/087367A3
The invention relates to the compounds of formula I or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount ...  
WO/2014/087110A1
A method for the industrial synthesis of an addition salt with a pharmaceutically acceptable acid of 4-{3-[cis-hexahydrocyclopenta[c]pyrrol-2(1H)-yl]propoxy}benz amide of formula (I), in which ΗΧ represents a pharmaceutically acceptabl...  
WO/2014/088326A1
The present invention relates to a composition and health functional food for inhibiting apoptosis of cranial nerve cells, and to a method for inhibiting apoptosis, wherein the composition and health functional food comprising a phosphod...  
WO/2014/089449A1
Provided herein are methods for treatment of a neurodegenerative disease, such as neuronal ceroid lipofuscinosis including administering to a subject in need of such treatment a composition comprising a therapeutically effective amount o...  
WO/2014/088106A1
A substance capable of binding to mSin3B, said substance exhibiting an analgesic effect on an ICS (intermittent cold stress) mouse, which is an experimental animal model of fibromyalgia, and, therefore, being useful as a prophylactic or ...  
WO/2014/088519A1
The present invention relates to certain piperazine-based compounds that act as inhibitors of the MAP kinase interacting kinases MNK2a, MNK2b, MNK1a, and MNK1b and/or as ABL or ABL (T315I) inhibitors. The invention further relates to pha...  
WO/2014/086243A1
Disclosed are a miRNA molecule for negatively regulating a type I interferon pathway and uses thereof, discovering that Has-miR-127-3p is closely related to systemic lupus erythematosus, and also verifying the target pathway of the miRNA...  
WO/2014/085851A1
The present invention broadly relates to methods for acutely improving/enhancing cognitive performance in a human subject comprising administration of an extract of Bacopa monnieri.  
WO/2014/089149A1
This invention is a method and kit for treating a disease associated with, or resulting from, the accumulation of soluble oligomer amyloid beta 1-42 using an antibody, or antibody fragment thereof, that has a higher affinity for amyloid ...  
WO/2014/087298A1
The present invention relates to a compound of Formula 1, 2 or 3: wherein A is N or –CR0 --, where R0 is hydrogen, C1 -C6 linear or branched chain alkyl, etc., Z is –CRe --, or, –N--, where Re is hydrogen, C1 -C6 linear or branched...  
WO/2014/087298A4
The present invention relates to a compound of Formula 1, 2 or 3: wherein A is N or –CR0 --, where R0 is hydrogen, C1 -C6 linear or branched chain alkyl, etc., Z is –CRe --, or, –N--, where Re is hydrogen, C1 -C6 linear or branched...  
WO/2014/086258A1
The present invention discloses that Yam glycoprotein can improve the activity of the key enzyme of brain cell mitochondria for oxidative metabolism, i.e., pyruvate dehydrogenase and α-ketoglutarate dehydrogenase, and thus can be used f...  
WO/2014/089209A3
Engineered multivalent and multispecific binding proteins capable of penetrating the blood-brain barrier (BBB) are provided, along with methods of making and uses in the prevention, diagnosis, and/or treatment of disease.  
WO/2014/085367A1
A method for treating a condition selected from Alzheimer's disease, mild cognitive impairment, age-associated dementia, and frontotemporal dementia, comprises administering to a patient in need of such treatment a safe and effective amo...  
WO/2014/084744A1
The invention relates to dendritic compounds, the use of these compounds as pharmaceuticals, pharmaceutical compositions containing the compounds, processes for preparing the compounds, and methods of treating diseases or conditions in w...  
WO/2014/083107A1
The present invention relates to a process of preparation of Crystal Forms of 4- (cyclopropylmethoxy)-N-(3,5-dichloro-1-oxidopyridin-4-yl)-5- methoxypyridine-2- carboxamide of formula (I), said Crystal Forms which are designated as Cryst...  
WO/2014/084311A1
The purpose of the present invention is to provide an adhesive patch that is obtained by blending ropinirole, which is in a free form, in an adhesive base, said adhesive patch having good and lasting percutaneous absorption, excellent me...  
WO/2014/085600A1
A compound having formula I is useful for treating a neurodegenerative disease: I, R1 is an C1-12 organyl group; is a C1-12 heterocyclic ring system containing 5 to 12 ring atoms and up to three heteroatoms individually selected from the...  
WO/2014/082739A1
The invention relates to amino-arylcarboxamides of formula (I), to pharmaceutical compositions containing these compounds and also to these compounds for use In the treatment and/or prophylaxis of pain and further diseases and/or disorders.  
WO/2014/082737A1
The invention relates to specific carboxamides of formula (I) as KCNQ2/3 modulators, to processes for their preparation, to medicaments comprising these compounds and to the use of these compounds in the preparation of medicaments.  
WO/2014/083522A1
The present invention relates to trans-4-{2-[4-(2,3-dichlorophenyl)-piperazin-1-yl]- ethyl}-N,N-dimethylcarbamoyl-cyclohexylamine (cariprazine) and pharmaceutically acceptable salts and hydrates and solvates and polymorphs thereof for us...  
WO/2014/084401A1
[Problem] To provide a medical patch with an adhesive layer formed thereon, said medical patch containing a large amount of a drug and a dissolution auxiliary, being flexible without losing shape and leaving behind adhesive residue, and ...  

Matches 451 - 500 out of 97,147