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Patent Searching and Data


Matches 451 - 500 out of 131,777

Document Document Title
WO/2018/137627A1
Disclosed are a sustained release composition of aripiprazole and a derivative thereof and a preparation method therefor. The non-solvent preparation raw materials of the sustained release composition comprise aripiprazole and a sparingl...  
WO/2018/137629A1
Disclosed are a sustained release composition and a preparation method therefor. The non-solvent preparation raw materials comprise risperidone, a sparingly water-soluble polymer and a release regulator. The release regulator comprises a...  
WO/2018/137607A1
Provided are novel compounds that inhibit LRRK2 kinase activity, processes for their preparation, compositions containing them and their use in the treatment of or prevention of diseases associated with or characterized by LRRK2 kinase a...  
WO/2018/140799A3
Disclosed herein are compositions and methods for the treatment of non-otic diseases or conditions with Trk receptor agonist compositions and formulations.  
WO/2018/137593A1
Provided are novel compounds that inhibit LRRK2 kinase activity, processes for their preparation, compositions containing them and their use in the treatment of or prevention of diseases associated with or characterized by LRRK2 kinase a...  
WO/2018/140299A1
The present invention provides a compound of Formula (I): or a pharmaceutically acceptable salt thereof, and the use of compounds of Formula (I) for treatment of neurodegenerative diseases and disorders, such as Alzheimer's disease.  
WO/2018/137630A1
Disclosed are a risperidone sustained release composition and a preparation method therefor. The non-solvent preparation raw materials of the composition comprise risperidone, a sparingly water-soluble polymer and a release regulator. Th...  
WO/2018/138086A1
The present invention relates to bis-heteroaryl compounds of formula (I), pharmaceutical compositions containing them, and methods of using them, including methods for preventing, reversing, slowing, or inhibiting protein aggregation, an...  
WO/2018/138358A1
The present invention relates to UPR pathway inhibitors, in particular PERK and IRE-1 A inhibitors for use in the prevention or treatment of neurodevelopmental disorders, such as microcephaly caused by ZIKV.  
WO/2018/138400A3
The present invention relates to a high-yield method for the production of extracts enriched with organosulfur compounds of the S-alkenyl-L-cysteine and S-alkyl-L-cysteine type. Said compounds are obtained from plants of the genus Allium...  
WO/2018/140504A1
The disclosure provides methods for treating a subject suffering from a disease associated with sodium channel activity. The method comprises administering to the subject a therapeutically effective amount of a compound according to Form...  
WO/2018/138709A1
A brain-penetrating composition of amyloid-ß binding peptide is disclosed. This may be useful in the treatment of Alzheimer's disease, for example as a bifunctional molecule, comprising a blood-brain barrier crossing antibody and an amy...  
WO/2018/138389A1
The present invention relates to the use of methylphenidate or any of the salts or derivatives thereof, and to a composition, particularly a pharmaceutical composition containing same, for the production of a drug for the prevention and/...  
WO/2018/140965A1
Neuroinflammation mediated by microglia and infiltrating peripheral immune cells is a major component of stroke pathophysiology. The calcium activated potassium channel KCa3.1 is expressed selectively in the injured CNS by microglia, and...  
WO/2018/139471A1
The present invention relates to a dibenzodiazepine derivative represented by formula (1), which is useful as a therapeutic and/or prophylactic agent for central nervous system diseases, and a pharmaceutically acceptable salt thereof. (I...  
WO/2018/138085A1
The present invention relates to certain bis-heteroaryl compounds, pharmaceutical compositions containing them, and methods of using them, including methods for preventing, reversing, slowing, or inhibiting protein aggregation, and metho...  
WO/2018/137573A1
Provided are novel compounds that inhibit LRRK2 kinase activity, processes for their preparation, compositions containing them and their use in the treatment of or prevention of diseases associated with or characterized by LRRK2 kinase a...  
WO/2018/138929A1
Provided are a novel use of 1,2-di-O-galloyl-4,6-O-(S)-hexahydroxydiphenoyl-β-D-glucose (hereinafter abbreviated as "GHG") which is contained in a large amount in purple tea produced in Kenya (scientific name: Camellia sinensis, variet...  
WO/2018/140876A1
Provided are tetrahydroisoquinoline derivatives as Nrf2 activators.  
WO/2018/137618A1
Compounds of Formula (I) or pharmaceutically acceptable salt thereof, a pharmaceutical compositions comprising these compounds, the use of these compounds and compositions in the treatment of diseases in which LRRK-2 kinase is involved.  
WO/2018/137628A1
Disclosed are a sustained release composition of paliperidone and a derivative thereof and a preparation method therefor. The raw materials comprise paliperidone or a paliperidone derivative and a sparingly water-soluble polymer. The sus...  
WO/2018/136710A1
This application provides methods of treating Krabbe disease, for example in an infant. Such methods can include immunosuppressing the patient, for example by administration of a myeloablative regimen, administering an umbilical cord blo...  
WO/2018/135556A1
The present invention provides a pharmaceutical composition which can be used for the treatment of HTLV-1-associated myelopathy and contains an inhibitor selected from the group consisting of an EZH1 inhibitor, an EZH2 inhibitor and an E...  
WO/2018/136661A1
Provided herein are compounds of the Formula I: and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which A, B, D, E, X1, X2, X3 and X4 have the meanings given in the specification, which are inhibitors of RET...  
WO/2018/134243A1
The invention relates to a liquid pharmaceutical composition for use in medical treatment, said liquid pharmaceutical composition being a monophasic aqueous solution of non- complexed 3-methyl-1-phenyl-2-pyrazolin-5-one (edaravone) and c...  
WO/2018/136918A1
Provided herein is the use of one or more small-conductance calcium-activated potassium channel positive modulators (SK positive modulators) for the treatment of tremors.  
WO/2018/134698A1
The present invention provides, in part, heterocyclic spiro compounds of Formula I: and pharmaceutically acceptable salts thereof; processes for the preparation of; intermediates used in the preparation of; and compositions containing su...  
WO/2018/134230A1
The present invention relates to a specialized pro-resolving lipid mediator comprising maresins, D-series resolvins, E-series resolvins, protectins or lipoxins, or a combination thereof, for use in the treatment of neurodegenerative dise...  
WO/2018/136910A1
Methods and systems directed to monitoring for the presence or progression of amyloid diseases via detection of amyloid fibrils in a sample from an individual are disclosed. An individual, or sample from an individual, is treated with a ...  
WO/2018/132880A1
The invention relates to an effervescent pharmaceutical composition, containing metamizole sodium monohydrate, and to a method of preparing same. The effervescent dosage form has a low sodium contents, is stable during storage, has high ...  
WO/2018/133835A1
A circadian rhythm phase-shifting nucleoside analogue is used to modulate circadian rhythm.  
WO/2018/136890A1
The present disclosure relates to novel sulfonylurea and sulfonyl thiourea compounds and related compounds and their use in treating a disease or condition responsive to modulation of cytokines such as IL-1β and IL-18, modulation of NLR...  
WO/2018/136600A1
The invention provides a method of treating a subject afflicted with fragile X syndrome (FXS) or a FXS related disorder, comprising periodically administering to the subject a pharmaceutical composition comprising an amount of pridopidin...  
WO/2018/136575A1
Small molecule agonists of the pregnane X receptor (PXR), compositions and methods are disclosed for treating or preventing gut barrier dysfunction, an illness associated with gut barrier dysfunction, toxic or inflammatory injury to inte...  
WO/2018/133854A1
Provided are a kind of nucleoside analogue compounds, and compositions comprising these compounds and pentostatin, their use for modulating circadian rhythm, preferably, for shifting circadian phase, and methods for modulating circadian ...  
WO/2018/136917A1
Provided are compounds and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with potassium channels.  
WO/2018/133670A1
The invention discloses a butylphthalide-telmisartan heterocomplex, a preparation method and an application thereof. The invention specifically relates to an optically active ring-opening butylphthalide-telmisartan heterocomplex shown in...  
WO/2018/133563A1
Disclosed are a Panax plant extract and a pharmaceutical composition and the use thereof. The mass ratio of Rk1 and Rg5 in the Panax plant extract is 1 : 1.0-1.5, and the content of Rg3, Rg5 and Rk1 in the extract is relatively high. The...  
WO/2018/134761A1
The invention relates to a solid form, namely crystalline Form A, of Compound 1, (1) and discloses the process for making said solid form of Compound 1. Also disclosed are further solid forms of Compound 1, including its hydrate and amor...  
WO/2018/135943A1
The present invention relates to the use of one or more cannabinoids and/or terpenes in combination with psilocybin and/or psilocin for use in the prevention or treatment of psychological or brain disorders. Preferably the one or more ca...  
WO/2018/132886A1
The present invention relates to the combination of one or more calming or sleep-inducing substances with one or more stimulating substances in the same composition, for individuals who have difficulty falling asleep and then lack willin...  
WO/2018/134760A1
The present invention relates to a pharmaceutical composition comprising an oxazine derivative BACE-1 inhibitor, a process for the preparation thereof, and its use in the treatment or prevention of Alzheimer's disease.  
WO/2018/135977A1
The invention relates to the field of pharmaceutical chemistry, namely to new biologically active substances and their use and to a method of production. In particular, the invention relates to a derivative of creatine - phenylcreatine, ...  
WO/2018/133457A1
The present invention falls within the field of medical technology, and in particular relates to the use of a compound as shown in formula (I). In particular, the present invention relates to the use of the compound as shown in formula (...  
WO/2018/133756A1
The present invention relates to a targeted autophagy agonist and an application thereof in the treatment of neurodegenerative diseases, pertaining to the technical field of pharmaceuticals for the treatment of neurodegenerative diseases...  
WO/2018/134962A1
The present invention relates to an improving agent for female frequent urination including cranberry juice, a female sleep-improving agent including cranberry juice, or a female skin condition improving agent including cranberry juice.  
WO/2018/136762A1
Provided herein are methods comprising autologous cytotoxic T cells expressing a T cell receptor that specifically binds to an Epstein Barr virus (EBV) or expressing CD107a, TNF, IFN-gamma or IL-2 for the treatment of multiple sclerosis ...  
WO/2018/136635A1
Methods of treatment of Huntington's disease or its symptoms, with PPARϒ agonists, and in particular, the compound of formula (I) known as INT131:  
WO/2018/135659A1
According to the present invention, a compound represented by general formula (I), a tautomer or stereoisomer of the compound, a pharmaceutically acceptable salt thereof, or a solvate of the compound, the tautomer, the stereoisomer or th...  
WO/2018/132372A1
Provided herein are small molecule activators of Nicotinamide Phosphoribosyltransferase (NAMPT), compositions comprising the compounds, and methods of using the compounds and compositions.  

Matches 451 - 500 out of 131,777