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Matches 501 - 550 out of 97,147

Document Document Title
WO/2014/085153A1
A TARP γ8 dependant AMPA receptor antagonist of the formula: (I) its pharmaceutically acceptable salts, uses, and methods for its preparation are described.  
WO/2014/083003A1
The invention relates generally to a compound according to formula I - more in particular la or lb, a stereochemically isomeric form thereof, an N-oxide form thereof, or a pharmaceutically acceptable acid or base addition salt thereof-, ...  
WO/2014/083071A1
A liquid formulation for intravenous infusion comprising tramadol and paracetamol in a non-deoxygenated aqueous solvent. The formulation has shown to be suitable for intravenous infusion, is stable upon autoclaving with a minimum loss of...  
WO/2014/085362A1
Methods for the treatment of Parkinson's disease psychosis which comprise the administration of pimavanserin.  
WO/2014/084085A1
The present invention addresses the problem of providing an efficacious means for preventing or treating declines in neurophysiological functions controlling hearing ability, motions, etc. Provided is a prophylactic/therapeutic agent for...  
WO/2014/085153A8
A TARP γ8 dependant AMPA receptor antagonist of the formula: (I) its pharmaceutically acceptable salts, uses, and methods for its preparation are described.  
WO/2014/085284A1
Provided herein are heteroaryl compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. In one embodiment, the compounds provided herein are useful for the treatment, preventi...  
WO/2014/082548A1
Disclosed are a 2-aryl selenazole compound and pharmaceutical composition thereof, being a compound as represented by formula (I) or pharmaceutically acceptable salt thereof. The 2-aryl selenazole compound has xanthine oxidase inhibition...  
WO/2014/084616A1
The present invention provides a pharmaceutical composition containing a Sceptridium japonicum extract, as an active ingredient, for preventing or treating stroke or degenerative brain diseases. The Sceptridium japonicum extract of the p...  
WO/2014/083327A1
The invention provides a compound of formula (I), wherein R1, R2, R3, R4, R5, Ra and Rb have the meanings given in the description, with the proviso that the compound is not a compound selected from the group given in the description. Th...  
WO/2014/085668A1
The present invention relates to methods of preventing, inhibiting, delaying, and/or mitigating seizures by administration of a steroid, e.g., a neurosteroid, e.g., allopregnanolone.  
WO/2014/083068A1
The invention relates to a compound of Formula (I), or a pharmaceutically acceptable salt thereof: wherein R1 is C1-8 alkyl, C1-8 alkoxy, CN, NO2, amino, COOH, COOCH3, OH, N3, or halogen and R2 is H, OH, Cl-8 alkyl, Cl-8 alkoxy, C2-C6 al...  
WO/2014/084460A1
The present invention relates to a composition comprising an Acanthopanax koreanum extract as an active ingredient. More particularly, the present invention relates a pharmaceutical composition comprising the Acanthopanax koreanum extrac...  
WO/2014/082738A1
The invention relates to substituted heteroquinoline-3-carboxamides, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or di...  
WO/2014/085413A1
Pharmaceutical compositions of the invention comprise disubstituted oxazolidin-2-ones derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of 5-hydroxytryptamine receptor 2b activity.  
WO/2014/082514A1
Provided in the present invention is a method for initiating the proliferation, migration and differentiation of stem cells in mammals, comprising the following steps: preparing a stem cell initiation agent containing chlorine dioxide an...  
WO/2014/080633A1
The present invention relates to novel crystal forms of 4-{[4-({[4-(2,2,2-trifluoroethoxy)-1,2-benzisoxazol-3-yl]oxy }methyl)piperidin-1-yl]methyl}-tetrahydro-2H-pyran-4-carboxy lic acid. More particularly, the invention relates to polym...  
WO/2014/080285A2
The present invention relates to a pharmaceutical composition that provides long-term stability of a hydrolytically labile antipsychotic agent  
WO/2014/081820A1
Novel CFTR corrector compounds that are effective in rescuing halide efflux, delF508-CFTR protein processing, and apical functional chloride ion transport in a cell are provided. Also provided are methods for treating protein folding dis...  
WO/2014/081029A1
The purpose of the present invention is to prevent, treat or alleviate peripheral nerve disorders caused by anti-cancer agents satisfactorily and sustainably. The present invention provides a prophylactic, therapeutic or alleviating agen...  
WO/2014/081025A1
This invention relates to an I-form crystal of the free form of 3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-N-(2-hydroxyetho xy)-5-(3-oxo-[1,2]-oxazinan-2-ylmethyl)benzamide, the crystal, in analysis by X-ray powder diffraction with CuK...  
WO/2014/080241A1
The invention provides compounds of formula (1), stereoisomers and tautomers thereof, or pharmaceutically acceptable salts, solvates and polymorphs thereof, and processes for their preparation. The invention further relates to pharmaceut...  
WO/2014/080973A1
Provided is an antidementia drug that has a high safety and is free of the problem of side effects. Also provided is a learning/memory function-improving drug that is useful in improving the learning/memory function and can be continuous...  
WO/2014/079504A1
The invention relates to a new class of compounds able to bind with high affinity and selectivity the 5-HT7 receptor. The invention also relates to the utilization of such compounds as medicaments useful in the treatment and prevention o...  
WO/2014/080063A1
The invention relates to a recombinant protein and to the uses thereof in the diagnosis and treatment of multiple sclerosis. The invention also relates to the recombinant protein IFNAR2.3, to antibodies, compositions comprising same, and...  
WO/2014/079995A3
The present invention relates to compounds of the formula I and their salts etc. which are inhibitors of phosphodiesterase type 10A and to their use for the manufacture of a medicament and which thus are suitable for treating or controll...  
WO/2014/079787A1
The present invention relates to the use of compounds of general formula (I) wherein R' is hydrogen or lower alkyl; R1 is halogen, lower alkyl, cycloalkyl or cyano; or is phenyl, optionally substituted by one to three substituents, selec...  
WO/2014/080342A1
Our invention relates to trans-(4-{4-[2-(4-amino-cyclohexyl)-ethyl]-piperazin-1-yl}-5 ,6- dichloro-pyrimidin-2-yl)-methylamine dihydrochloride monohydrate, the process for the synthesis of this compound, the new (4,5-dichloro-6-piperazin...  
WO/2014/079964A1
A frozen confection comprising from 0.002 wt% to 1 wt% of one or more compounds selected from the group consisting of benzyl cinnamate, piperonal, 4-methoxybenzaldehyde, and 4-hydroxybenzaldehyde is provided. A product for use in improvi...  
WO/2014/080784A1
An aqueous pharmaceutical preparation characterized in containing olanzapine and water, the pH during preparation being 7 to 10.  
WO/2014/081764A1
The present invention provides non-human animal models of neuronal injury and/or cognitive dysfunction and methods of making and using such animal models. The animal models of the invention are particularly suited to assessing neurodegen...  
WO/2014/081439A1
A method for inducing autophagy in a subject having an autophagy defect is provided. The method of the present invention includes the step of administering to the subject a therapeutically effective amount of a Ganoderma lucidum extract,...  
WO/2014/079850A1
The present invention relates to compounds of general formula (I-1) or (I-2) wherein R1 is hydrogen, lower alkyl, lower alkoxy, halogen, O(CH2)2-lower akoxy, O(CH2)2N(CH3)2, or O(CH2)-morpholinyl; R1' is hydrogen, lower alkyl, lower alko...  
WO/2014/080290A3
The present disclosure relates to compounds of formula I, which are useful for inhibition of BET protein function by binding to bromodomains, and their use in therapy.  
WO/2014/081675A1
The present invention provides methods and compositions for treating neurodegenerative diseases by cyclohexenone compounds.  
WO/2014/078378A1
Compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts, or solvates or prodrugs thereof, where R1, R2, Ra, Rb, Rc, Rd, X, Ring B, and Ring C are as defined herein, and wherein Ring B moiety and the NH...  
WO/2014/078328A1
Compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C and X are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment ...  
WO/2014/078408A1
Compounds of Formula I or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C and X are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of ...  
WO/2014/075309A1
Provided in the present invention are the use of compounds having the structure of general formula (I) and medicinal salts, hydrates or solvates thereof in the preparation of drugs for treating nervous system diseases associated with dop...  
WO/2014/077365A1
The present application provides: Lactobacillus gasseri strain CP2305 (FERM BP-11331), Lactobacillus gasseri strain CP2305s (NITE BP-1405), or a variant strain (e.g., a psychrotolerant variant strain) of Lactobacillus gasseri strain CP23...  
WO/2014/075203A8
The invention relates to a novel pharmaceutical formulation comprising polymer nanoparticles of the biodegradable and biocompatible polymer poly (lactic-glycolic) acid (PLGA), loaded with the drug pentoxifylline, the method for the synth...  
WO/2014/075203A1
The invention relates to a novel pharmaceutical formulation comprising polymer nanoparticles of the biodegradable and biocompatible polymer poly (lactic-glycolic) acid (PLGA), loaded with the drug pentoxifylline, the method for the synth...  
WO/2014/076702A1
A method of treating a disease selected from the group consisting of emphysema, sepsis, septic shock, ischemic injury, cerebral ischemia, a neurodegenerative disorder, meningitis, encephalitis, hemorrhage, cerebral ischemia, heart ischem...  
WO/2014/078314A1
The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In...  
WO/2014/075570A1
Disclosed are a beautyberry total glycosides extract, a preparation method thereof and the use in preparing drugs for treating neurodegenerative diseases or skin diseases. The extract is prepared from the leaves of Callicarpa cathayana o...  
WO/2014/075387A1
Provided are a compound as represented by formula I, or pharmaceutically acceptable salt, solvate, precursor drug, stereoisomer, tautomer, polymorph or metabolite thereof, pharmaceutical composition containing same, and uses thereof in t...  
WO/2014/078454A1
Compounds of Formula I: or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C and X are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of...  
WO/2014/077401A1
 Provided is a compound that has cholinergic muscarinic M1 receptor positive allosteric modulator activity and that is useful in the prevention and treatment of conditions such as Alzheimer's disease, schizophrenia, pain, and sleep dis...  
WO/2014/078645A1
Disclosed herein are heterocyclic compounds containing thiadiazole and/or pyridazine rings, as well as pharmaceutical preparations thereof. The compounds herein are further made known to be useful as glutaminase inhibitors with potential...  
WO/2014/076170A1
The present invention relates to new substituted pyrazolo[3,4- d]pyrimidine compounds of general formula (I) having a great affinity for sigma receptors, especially sigma-1 receptor, as well as to the process for the preparation thereof,...  

Matches 501 - 550 out of 97,147