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Matches 551 - 600 out of 46,052

Document Document Title
WO/2014/013338
The present invention relates to the use of compounds of formula (I): wherein R1 is H, substituted or unsubstituted aryl, heteroaryl or C1-24 aliphatic group, -(CH2)1-3-aryl or -(CH2 )1-3 - heteroaryl, R2 is selected from the group consi...  
WO/2014/013469
The invention relates to compound of the formula (I) or a salt thereof, wherein the substituents are as defined in the specification; to its preparation, to its use as medicament and to medicaments comprising it.  
WO/2014/015338
A method of inhibiting, reducing, and/or treating pathological apoptosis and/or protein aggregation in a subject includes administering to the subject an amount of a therapeutic polypeptide effective to inhibit, reduce, and/or treat the ...  
WO/2014/012593
The present invention relates to the use of compounds of formula (I) wherein R1 is selected from the group consisting of C1-8alkyl; R2 is selected from the group consisting of C1-8alkyl; R3 is selected from the group consisting of H and ...  
WO/2014/012593
The present invention relates to the use of compounds of formula (I) wherein R1 is selected from the group consisting of C1-8alkyl; R2 is selected from the group consisting of C1-8alkyl; R3 is selected from the group consisting of H and ...  
WO/2014/015125
New salts of a fused aminodihydrothiazine derivative, and pharmaceutical uses thereof.  
WO/2014/015125
New salts of a fused aminodihydrothiazine derivative, and pharmaceutical uses thereof.  
WO/2014/013090
The present invention relates to a solid composite of fingolimod base and a copolymer of methacrylic acid and divinylbenzene, a pharmaceutical formulation comprising said composite and the use of either the solid composite or pharmaceuti...  
WO/2014/013076
A compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 to R9 are as defined in the specification and which compound has an Αβ production inhibitory effect and may be useful as a prophylactic or therapeutic ...  
WO/2014/015047
The specification provides compositions and methods to treat neurodegenerative diseases.  
WO/2014/013311
Compounds and compositions for use as starting materials or intermediate materials in the preparation of opioids including, e.g., oxycodone base and/or an oxycodone salt; processes for preparing these compounds and compositions; uses of ...  
WO/2014/013497
The invention provides fatty acid derivatives for use in a method of treatment of at least one disease, disorder or condition selected from anxiety, depression, conditions associated menopause, stress, bipolar disorder, neuropathic pain ...  
WO/2014/013258
This invention relates to stem cell microparticles, their use and production, in particular neural stem cell microparticles and their use in therapy. The stem cell microparticle is typicallyan exosome or microvesicleand may be derived fr...  
WO/2014/015247
Disclosed herein are compounds of formula (I) and therapeutic methods of treatment with compounds of formula (I), wherein L1, L2, L4, R1, R4, R5, R6, and s are as defined in the specification. Compounds of formula (I) are EP4 agonists us...  
WO/2014/015261
Methods for producing new neurons in the brain in vivo are provided according to aspects of the present invention which include introducing NeuroDl into a glial cell, particularly into a reactive astrocyte or NG2 cell, thereby "convertin...  
WO/2014/008629
This invention relates to novel compounds and hydrochloric acid salts thereof. More specifically, this invention relates to novel compounds and hydrochloric acid salts thereof derived from donepezil. This invention also provides composit...  
WO/2014/008648
A composition comprising reduced glutathione and acetaminophen and preparation method thereof. The main drug of the composition is 0.1%-99.9% reduced glutathione, 99.9%-1% acetaminophen. The composition can be formulated as tablets, sust...  
WO/2014/011083
The invention relates to the field of pharmaceuticals, specifically to solid pharmaceutical compositions containing 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol or a pharmaceutically acceptable salt thereof, a stabiliser, a lubrica...  
WO/2014/010732
Provided is a compound having a PDE2A selective inhibitory effect which is useful as a prophylactic/therapeutic drug for integration disorder syndrome, Alzheimer's disease and the like. Provided is a compound represented by formula (1): ...  
WO/2014/011085
The invention relates to the field of medicine. Described is an effective, low-toxicity agent in the form of the methyl 2-cyano-3,12-dioxo-18βН-olean-1(2),11(9)-dien-30-oate of formula (1): which exhibits antioxidant, anti-inflammatory...  
WO/2014/011461
The present invention provides compounds of Formula (I) as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.  
WO/2014/009305
The present invention relates to novel imidazo[1,2-b]pyridazine and imidazo[1,2-a]-pyrazine derivatives which are inhibitors of the phosphodiesterase 10 enzyme (PDE10) and which may be useful for the treatment or prevention of neurologic...  
WO/2014/011768
The present invention relates to methods of using select small molecule and aptamer ligands that bind to a regulatory (binding site on nicotinic acetylcholine receptors to treat or to prevent anxiety behavior and symptoms, such as but no...  
WO/2014/011085
The invention relates to the field of medicine. Described is an effective, low-toxicity agent in the form of the methyl 2-cyano-3,12-dioxo-18βН-olean-1(2),11(9)-dien-30-oate of formula (1): which exhibits antioxidant, anti-inflammatory...  
WO/2014/011047
The invention relates to novel compounds that are useful for modulating mitochondrial morphology and/or expression of OXPHOS enzymes and/or cellular ROS. The compounds are derivatives of TroloxrM wherein the carboxylic acid moiety is rep...  
WO/2014/011754
The present invention provides novel benzoxazinone compounds, pharmaceutical compositions comprising such compounds, and methods of treating disease using such compositions. Pharmaceutical compositions of the invention are particularly u...  
WO/2014/010657
Provided are a processed plant product that has excellent TRPM8 activity, a method for producing the same, and an agent that produces a cold sensation and a TRPM8 activator using the processed plant product. A method for producing a proc...  
WO/2014/012034
The present invention encompasses methods of treating a subject who has been diagnosed as having a tic disorder or a movement disorder. The tic disorder can be Tourette's Syndrome, and the methods can include the steps of: (a) identifyin...  
WO/2014/012063
The present invention relates to novel pharmaceutical dosage forms comprising ecopipam or its pharmaceutically acceptable salt, a process for their preparation, and their use for the treatment of various central nervous system disorders ...  
WO/2014/011827
This invention provides a method of treating a subject afflicted with multiple sclerosis or presenting a clinically isolated syndrome comprising administering to the subject fampridine as an add-on therapy to or in combination with laqui...  
WO/2014/010748
The present invention relates to compounds of the Formula (I) and (II): wherein each variable is as defined in the specification, pharmaceutically acceptable salts and solvates thereof, as well as use of such compounds as a BACE1 inhibit...  
WO/2014/008692
Disclosed are ketogenic diet formula milk and a preparation method of the ketogenic diet formula milk. The ketogenic diet formula milk contains the following components per 100 g: 1.5-12.5 g of fat, 0-5 g of protein, 0-0.5 g of carbohydr...  
WO/2014/009936
The present invention relates to the field of compositions for the treatment of neuropathic pain. More specifically, the present invention relates to compositions comprising compounds obtained from plant extracts for the treatment of neu...  
WO/2014/011209
Methods and compositions containing a phorbol ester or a derivative of a phorbol ester are provided for the treatment and prevention of stroke and the sequelae of stroke. Additional compositions and methods are provided which employ a ph...  
WO/2014/006250
The invention relates to the use of a compound having formula I, in which R1 is an alkenyl group C5-C25 containing one ore more double carbon-carbon bonds, R2 is selected independently from the group consisting of methyl and fluorinated ...  
WO/2014/006307
The present invention relates to novel pyrrolidine derivatives of formula (I), where R1, R2, R3, R4, R5 and X are as defined in claim 1, optionally in zwitterionic form, in the form of a pure optical isomer, or in the form of a mixture o...  
WO/2014/005721
The present invention relates to the efficient treatment of an individual afflicted with Parkinson's disease (PD), the instant treatment comprising administering to the individual an effective amount of (R)-phenylpiracetam or a pharmaceu...  
WO/2014/007636
The invention relates to a nutritional composition comprising dietary fibre, a peptide having 7 or more amino acid units, the nutritional composition comprising a tryptophan source, which may be said peptide or different there from, for ...  
WO/2014/007606
The invention relates to a nutritional composition comprising dietary fibre, a peptide having 7 or more amino acid units, the nutritional composition comprising a tryptophan source, which may be said peptide or different there from, for ...  
WO/2014/006529
The invention relates to the compounds of formula 1 or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof The pharmaceutical compositions comprising art effective amount ...  
WO/2014/005363
Disclosed is a 2,2',6,6'-tetraisopropyl-4,4'-2-biphenol soft capsule preparation, which is formed by a capsule cover and capsule internal contents. The capsule internal contents contain 2,2',6,6'-tetraisopropyl-4,4'-2-biphenol, solvent, ...  
WO/2014/008118
Provided herein are methods for the concurrent treatment of pain and depression in a patient based, at least in part, on the discovery that the comorbid interaction between pain and depression can be treated by regulating two opposing pa...  
WO/2014/006023
The invention relates to a pharmaceutical preparation comprising extracts or components of sesame and/or saffron for use as a drug. The invention permits the successful treatment of persons with early stage impairment in order to improve...  
WO/2014/007447
The present invention relates to a composition containing a hydroxychalcone compound, as an active ingredient, for inhibiting angiogenesis. The compounds of the present invention have remarkable angiogenesis inhibition effects in the cho...  
WO/2014/007853
Disclosed herein are methods and compositions for treating a disease or disorder of the glutamatergic system, e.g., Alzheimer's disease, neuron damage and/or loss, and seizures, or a symptom thereof, e.g., decreased cognitive function, i...  
WO/2014/006402
The disclosures herein relate to novel compounds of formula wherein W, X and Y1, Y2, Y3 and Y4 are defined herein, and their use in treating, preventing, ameliorating, controlling or reducing the risk of neurological or psychiatric disor...  
WO/2014/006120
The present invention relates to compounds according to formula (I) wherein R1, R2, R3, R4 and R5 are H; R6 is selected from methyl and hydroxymethyl; A7 is C-R7, A8 is N and A9 is C-R9; R7, R10 and R11 are H; R9 is OR12, wherein R12 rep...  
WO/2014/005720
The present invention relates to the efficient treatment of an individual afflicted with fatigue, particularly mental fatigue, associated with certain diseases, particularly diseases of the central nervous system, including Parkinson's d...  
WO/2014/007554
This invention provides a method of preparing a benzofuran derivative, which has industrial safety and high yield and may thus be viably applied to industrial mass production.  
WO/2014/006528
The invention relates to the compounds of formula 1 or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof The pharmaceutical compositions comprising an effective amount o...  

Matches 551 - 600 out of 46,052