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Matches 551 - 600 out of 45,984

Document Document Title
WO/2014/009305
The present invention relates to novel imidazo[1,2-b]pyridazine and imidazo[1,2-a]-pyrazine derivatives which are inhibitors of the phosphodiesterase 10 enzyme (PDE10) and which may be useful for the treatment or prevention of neurologic...  
WO/2014/011768
The present invention relates to methods of using select small molecule and aptamer ligands that bind to a regulatory (binding site on nicotinic acetylcholine receptors to treat or to prevent anxiety behavior and symptoms, such as but no...  
WO/2014/011085
The invention relates to the field of medicine. Described is an effective, low-toxicity agent in the form of the methyl 2-cyano-3,12-dioxo-18βН-olean-1(2),11(9)-dien-30-oate of formula (1): which exhibits antioxidant, anti-inflammatory...  
WO/2014/011047
The invention relates to novel compounds that are useful for modulating mitochondrial morphology and/or expression of OXPHOS enzymes and/or cellular ROS. The compounds are derivatives of TroloxrM wherein the carboxylic acid moiety is rep...  
WO/2014/011754
The present invention provides novel benzoxazinone compounds, pharmaceutical compositions comprising such compounds, and methods of treating disease using such compositions. Pharmaceutical compositions of the invention are particularly u...  
WO/2014/010657
Provided are a processed plant product that has excellent TRPM8 activity, a method for producing the same, and an agent that produces a cold sensation and a TRPM8 activator using the processed plant product. A method for producing a proc...  
WO/2014/012034
The present invention encompasses methods of treating a subject who has been diagnosed as having a tic disorder or a movement disorder. The tic disorder can be Tourette's Syndrome, and the methods can include the steps of: (a) identifyin...  
WO/2014/012063
The present invention relates to novel pharmaceutical dosage forms comprising ecopipam or its pharmaceutically acceptable salt, a process for their preparation, and their use for the treatment of various central nervous system disorders ...  
WO/2014/011827
This invention provides a method of treating a subject afflicted with multiple sclerosis or presenting a clinically isolated syndrome comprising administering to the subject fampridine as an add-on therapy to or in combination with laqui...  
WO/2014/010748
The present invention relates to compounds of the Formula (I) and (II): wherein each variable is as defined in the specification, pharmaceutically acceptable salts and solvates thereof, as well as use of such compounds as a BACE1 inhibit...  
WO/2014/008692
Disclosed are ketogenic diet formula milk and a preparation method of the ketogenic diet formula milk. The ketogenic diet formula milk contains the following components per 100 g: 1.5-12.5 g of fat, 0-5 g of protein, 0-0.5 g of carbohydr...  
WO/2014/009936
The present invention relates to the field of compositions for the treatment of neuropathic pain. More specifically, the present invention relates to compositions comprising compounds obtained from plant extracts for the treatment of neu...  
WO/2014/011209
Methods and compositions containing a phorbol ester or a derivative of a phorbol ester are provided for the treatment and prevention of stroke and the sequelae of stroke. Additional compositions and methods are provided which employ a ph...  
WO/2014/006250
The invention relates to the use of a compound having formula I, in which R1 is an alkenyl group C5-C25 containing one ore more double carbon-carbon bonds, R2 is selected independently from the group consisting of methyl and fluorinated ...  
WO/2014/006307
The present invention relates to novel pyrrolidine derivatives of formula (I), where R1, R2, R3, R4, R5 and X are as defined in claim 1, optionally in zwitterionic form, in the form of a pure optical isomer, or in the form of a mixture o...  
WO/2014/005721
The present invention relates to the efficient treatment of an individual afflicted with Parkinson's disease (PD), the instant treatment comprising administering to the individual an effective amount of (R)-phenylpiracetam or a pharmaceu...  
WO/2014/007636
The invention relates to a nutritional composition comprising dietary fibre, a peptide having 7 or more amino acid units, the nutritional composition comprising a tryptophan source, which may be said peptide or different there from, for ...  
WO/2014/007606
The invention relates to a nutritional composition comprising dietary fibre, a peptide having 7 or more amino acid units, the nutritional composition comprising a tryptophan source, which may be said peptide or different there from, for ...  
WO/2014/006529
The invention relates to the compounds of formula 1 or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof The pharmaceutical compositions comprising art effective amount ...  
WO/2014/005363
Disclosed is a 2,2',6,6'-tetraisopropyl-4,4'-2-biphenol soft capsule preparation, which is formed by a capsule cover and capsule internal contents. The capsule internal contents contain 2,2',6,6'-tetraisopropyl-4,4'-2-biphenol, solvent, ...  
WO/2014/008118
Provided herein are methods for the concurrent treatment of pain and depression in a patient based, at least in part, on the discovery that the comorbid interaction between pain and depression can be treated by regulating two opposing pa...  
WO/2014/006023
The invention relates to a pharmaceutical preparation comprising extracts or components of sesame and/or saffron for use as a drug. The invention permits the successful treatment of persons with early stage impairment in order to improve...  
WO/2014/007447
The present invention relates to a composition containing a hydroxychalcone compound, as an active ingredient, for inhibiting angiogenesis. The compounds of the present invention have remarkable angiogenesis inhibition effects in the cho...  
WO/2014/007853
Disclosed herein are methods and compositions for treating a disease or disorder of the glutamatergic system, e.g., Alzheimer's disease, neuron damage and/or loss, and seizures, or a symptom thereof, e.g., decreased cognitive function, i...  
WO/2014/006402
The disclosures herein relate to novel compounds of formula wherein W, X and Y1, Y2, Y3 and Y4 are defined herein, and their use in treating, preventing, ameliorating, controlling or reducing the risk of neurological or psychiatric disor...  
WO/2014/006120
The present invention relates to compounds according to formula (I) wherein R1, R2, R3, R4 and R5 are H; R6 is selected from methyl and hydroxymethyl; A7 is C-R7, A8 is N and A9 is C-R9; R7, R10 and R11 are H; R9 is OR12, wherein R12 rep...  
WO/2014/005720
The present invention relates to the efficient treatment of an individual afflicted with fatigue, particularly mental fatigue, associated with certain diseases, particularly diseases of the central nervous system, including Parkinson's d...  
WO/2014/007554
This invention provides a method of preparing a benzofuran derivative, which has industrial safety and high yield and may thus be viably applied to industrial mass production.  
WO/2014/006528
The invention relates to the compounds of formula 1 or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof The pharmaceutical compositions comprising an effective amount o...  
WO/2014/005186
The present invention relates generally to methods for inhibiting neuron apoptosis and necrosis associated with excess glutamate release by administering a TRPC3 inhibitor to a subject.  
WO/2014/005421
Provided in the present invention are novel benzodioxole derivatives and the preparation method thereof. These compounds of formula (I) or pharmaceutically acceptable salts thereof have acetylcholine esterase inhibitory activity, so can ...  
WO/2014/005274
A formula I compound, a derivate thereof, a medicated salt thereof, and a hydrate or solvate thereof. A medicine composition of the formula I compound with pharmaceutically effective amount and a pharmaceutically acceptable carrier. Use ...  
WO/2014/004902
Disclosed are methods, compounds, and compositions useful for increasing autophagy and promoting longevity. The methods, compounds, and compositions relate to urolithins and urolithin precursors and use thereof. Certain urolithins are re...  
WO/2014/002039
The present invention relates to amphetamine prodrugs which provide colonic release of amphetamine.  
WO/2014/004902
Disclosed are methods, compounds, and compositions useful for increasing autophagy and promoting longevity. The methods, compounds, and compositions relate to urolithins and urolithin precursors and use thereof. Certain urolithins are re...  
WO/2014/001377
5-Azaindazole compounds of Formula (I), including stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof, are useful for inhibiting Pim kinase, and for treating disorders such as cancer mediated by Pim...  
WO/2014/001228
The present invention provides difluoro-cyclopentaoxazinyls and difluoroenzooxazinyls of formula (I) having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active...  
WO/2014/001280
This invention relates to a novel phenyl triazole derivative, pharmaceutical compositions containing this compound, and methods of treatment therewith. The compound of the invention is in particular considered useful for the treatment of...  
WO/2014/001427
The present invention relates to nalmefene for use in the reduction of alcohol consumption in a patient with alcohol dependence who has a high drinking risk level. The present invention also relates to nalmefene for use in the reduction ...  
WO/2014/004676
The present disclosure relates to methods of using a fatty acid amide hydrolase (FAAH) inhibitor of Formula I alone or in combination with one or more additional therapeutic agents for the treatment or prevention of neuronal injury or ne...  
WO/2014/001464
The invention relates to a compound of the general formula (I) or a physiologically functional derivative, solvate or salt thereof, (I) wherein A is a bond, alkyl or alkoxy optionally substituted with one or more R" as defined herein, *-...  
WO/2014/002599
Provided are a crude-drug-containing pharmaceutical composition exhibiting excellent storage stability, and a stabilization method and a storage stabilizing agent for the crude-drug-containing pharmaceutical composition. The pharmaceutic...  
WO/2014/004465
The present invention relates to compositions, methods and kits for delivery of active agents (X) to cells or tissues that express proteoglycans. More specifically, the present invention relates to conjugates comprising (HB-linker)n-Xm-(...  
WO/2014/000452
A traditional Chinese medicine compound gel for external treatment of cancer pain is formed of the following raw materials (in parts by weight): 40-60 parts of rhizoma dioscoreae nipponicae, 20-40 parts of caulis piperis kadsurae, and 20...  
WO/2014/002553
The purpose of the present invention is to provide an aripiprazole oral pharmaceutical preparation which has limited acidity and bitterness, poses little burden to the patient when administered, and is highly elutable, and for which the ...  
WO/2014/001282
This invention relates to a novel phenyl triazole derivative, pharmaceutical compositions containing this compound, and methods of treatment therewith. The compound of the invention is in particular considered useful for the treatment of...  
WO/2014/001742
Disclosed are processes for the production of composition comprising one or more fructose amino acids, said process comprising the steps of: (a) providing plant material derived from a botanical source selected from plants of the familie...  
WO/2014/001281
This invention relates to a novel phenyl triazole derivative, pharmaceutical compositions containing this compound, and methods of treatment therewith. The compound of the invention is in particular considered useful for the treatment of...  
WO/2014/000694
Provided is a compound of general formula (I) as a potassium channel regulator and pharmaceutically acceptable equivalents thereof. The compound can be used in the preparation of medicines for increasing the ion flow in the potassium cha...  
WO/2014/000029
In one embodiment, the present invention relates to a method for reducing the frequency and/or severity of headache in a subject comprising administering to the subject a composition comprising the stromal vascular fraction or stromal ce...  

Matches 551 - 600 out of 45,984