Login| Sign Up| Help| Contact|

Patent Searching and Data


Matches 651 - 700 out of 109,062

Document Document Title
WO/2015/091988A1
The present invention relates to compounds having dual pharmacological activity towards both the sigma (σ) receptor, and the μ-opiod receptor and more particularly to piperidene compounds having this pharmacological activity, to proces...  
WO/2015/091939A1
The present invention relates to compounds having dual pharmacological activity towards both the sigma receptor and the mu-opioid receptor, and more particularly to piperidine compounds having this pharmacological activity, to processes ...  
WO/2015/091505A1
The invention refers to a synergistic combination comprising a Sigma ligand of general formula (I), and a Gabapentinoid, a medicament comprising said active substance combination, and the use of said active substance combination for the ...  
WO/2015/090394A1
Compositions comprising omega 3 fatty acids for use in the treatment, amelioration or prevention of various conditions, disorders, and diseases which involve damage to the nervous system, as the peripheral nervous system neuropathy and g...  
WO/2015/091595A1
The present invention provides a compound of formula I' having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the pres...  
WO/2015/091411A1
The present invention provides spiro-oxazolones, which act as V1a receptor modulators, and in particular as V1a receptor antagonists, their manufacture, pharmaceutical compositions containing them and their use as medicaments. The presen...  
WO/2015/095728A1
The present invention provides compounds of formula (I): which are useful as modulators of GPR6, pharmaceutical compositions thereof, methods for treatment of conditions associated with GPR6, processes for making the compounds and interm...  
WO/2015/090209A1
Provided in the present invention are a general formula I compound, the isomers, pharmaceutically-acceptable salt or solvate thereof, and application thereof to manufacturing medicine for preventing and/or treating drug-resistant tumours...  
WO/2015/090224A1
The present invention provides a compound of a general formula I, a stereomeride, pharmaceutically acceptable salt or a solvate thereof, a preparation method thereof, and usages in preparing medicines for preventing and/or treating disea...  
WO/2015/092592A1
The present invention provides novel 3,4-disubstituted-1 H-pyrrolo[2,3- Jb]pyridine derivatives and 4,5-disubstituted-7H-pyrrolo[2,3-c]pyridazine derivatives of Formula (I), and the pharmaceutically acceptable salts thereof (I) wherein R...  
WO/2015/091833A1
The present invention relates to an opioid antagonist with κ- activity for use in treatment of depressive disorder with melancholic features. The invention further relates to the combination of an opioid antagonist with κ- activity and...  
WO/2015/095659A3
The invention described herein provides a solid dispersion of Indirubin, a pharmaceutical composition comprising the solid dispersion of Indirubin, a process for preparing the solid dispersion and pharmaceutical composition, and a method...  
WO/2015/093567A1
The present invention is a pain-related compound, a medicinal composition, and uses thereof. One or multiple embodiments are a compound represented by formula (I), a prodrug thereof, or a pharmaceutically permissible salt thereof.  
WO/2015/090223A1
Provided are extracellular matrix protein 1(ECM1) and fusion protein Fc-EcMI of the ECM1 and the Fc sequence, and also provided are cloning, construction and expression of the protein, and use of the protein in preparing a pharmaceutical...  
WO/2015/095059A1
The present application relates to compounds having the inhibitory activity to apoptosis signal-regulating kinase (ASK1), thus are thus useful in treating ASK1-mediated conditions, including autoimmune disorders, inflammatory diseases, c...  
WO/2015/091463A1
A compound of Formula (1) wherein R1 represents hydrogen, halo, a C1-C4 alkyl group, a C1-C4 alkylhalide group, a C1-C4 alkoxy-C2-C4 alkyl group, a C2-C4 alkenyl group, a C2-C4 alkynyl group or a C3- C7 cyclo alkyl group; R2 represents F...  
WO/2015/095644A1
Disclosed herein are compositions containing an opioid antagonist such as naloxone and one or more pharmaceutically acceptable excipients. The compositions may be used for intranasal delivery of Naloxone for the treatment of, for example...  
WO/2015/094670A1
The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the c...  
WO/2015/091931A1
The present invention relates to novel substituted oxindole derivatives of formula (I) wherein the variables are as defined in the claims and description; to pharmaceutical compositions comprising them, and to their use for treatment of ...  
WO/2015/087016A1
The invention relates to a novel use of a pharmaceutical composition comprising at least one methyl cyclodextrin having a molar substitution (MS) degree of between 0.05 and 1.5 in the treatment and/or prevention of diseases that can be t...  
WO/2015/086719A1
The present invention relates generally to supporting the optimal development of children through nutrition and cognitive exercise. In particular, the present invention relates to a growing-up milk composition comprising per daily dose a...  
WO/2015/087266A3
The present invention relates to the field of neurotrophic gene therapy and is based on genomics and nanotechnology in combination with a drug therapy, thereby promoting mitogenic, neurogenic, and neuritogenic events for the treatment of...  
WO/2015/088273A9
The present invention relates to sulfamate derivative compounds and a composition for treating and/or alleviating pain containing the sulfamate derivative compounds or a pharmaceutically acceptable salt thereof as an active ingredient. M...  
WO/2015/087865A1
Provided is a novel compound which has excellent Aβ aggregation inhibition effects and is useful as a drug. The present invention is an amide compound represented by general formula (1) or a salt thereof. (In the formula, Z is CH or N, ...  
WO/2015/088706A1
A composition and method for enhancing brain development in a pediatric subject, the method including administering to the pediatric subject a nutritional composition comprising at least about 0.08 g/100 kcal of stearidonic acid.  
WO/2015/088272A1
The present invention relates to sulfamate derivative compounds and a composition for treating and/or alleviating pain containing the sulfamate derivative compounds or a pharmaceutically acceptable salt thereof as an active ingredient. M...  
WO/2015/088273A1
The present invention relates to sulfamate derivative compounds and a composition for treating and/or alleviating pain containing the sulfamate derivative compounds or a pharmaceutically acceptable salt thereof as an active ingredient. M...  
WO/2015/089327A1
The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.  
WO/2015/088000A1
The objective of the present invention is to provide a novel low molecular weight compound which exhibits an orexin agonist activity and is expected to be useful as an excellent therapeutic or preventive agent for narcolepsy. The present...  
WO/2015/088271A1
The present invention relates to a pharmaceutical composition for treating or preventing epilepsy containing a sulfamate derivative compound and/or pharmaceutically acceptable salt thereof as an active ingredient. Furthermore, the presen...  
WO/2015/088625A3
A method for promoting myelination and treating a demyelinating disease in a subject is disclosed herein. The method comprises administering to the subject a 1,3-diazole compound of formula I or a sterane of formula II. Both series of co...  
WO/2015/088272A9
The present invention relates to sulfamate derivative compounds and a composition for treating and/or alleviating pain containing the sulfamate derivative compounds or a pharmaceutically acceptable salt thereof as an active ingredient. M...  
WO/2015/087017A1
The invention relates to a novel use of a pharmaceutical composition comprising at least one methyl cyclodextrin having a degree of molar substitution (MS) of between 0.05 and 1.5 in the treatment and/or prevention of diseases that can b...  
WO/2015/089337A1
The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.  
WO/2015/087927A1
A patch which is provided with a patch member and a cover member, wherein: the patch member is provided with a support layer and a drug reservoir layer which is laminated on one surface of the support layer and which contains both a drug...  
WO/2015/086866A1
The invention relates to the use of compounds of the 12-deoxyphorbol family or a pharmacologically active salt of said compounds, for stimulating the proliferation of neural precursors or neural stem cells in a culture. The invention als...  
WO/2015/089182A1
The present patent application discloses at least the compounds according to Formula 1 shown below, or pharmaceutically acceptable salts thereof, wherein ringj B,n, JD, J,0, X, X1, J, RC, and W are as defined herein. These compounds are ...  
WO/2015/087094A1
The invention relates to novel arylalkenylpropargylamine derivatives of general formula (I) or enantiomers or diastereomers thereof or salts, optionally pharmaceutically acceptable salts, or solvates of any of these. The compounds can be...  
WO/2015/088915A1
Methods and compositions are provided for treating a subject for aging-associated conditions, e.g., cognitive impairment conditions. Aspects of the methods include administering a young plasma-comprising blood product to an individual in...  
WO/2015/089368A3
The invention relates to iRNA, e.g., double- stranded ribonucleic acid (dsRNA), compositions targeting the complement factor B (CFB) gene, the complement component C3 gene, and the complement component C9 gene and methods of using such i...  
WO/2015/085909A1
Provided in the present invention is a aminopyrimidine heterocyclic compound with adenosine receptor antagonist activity, comprising the compound and pharmaceutically acceptable salts, various isotopes, isomers and crystal structures the...  
WO/2015/085909A8
Provided in the present invention is a aminopyrimidine heterocyclic compound with adenosine receptor antagonist activity, comprising the compound and pharmaceutically acceptable salts, various isotopes, isomers and crystal structures the...  
WO/2015/089416A1
Methods for treating a patient suffering from neural cell injury, the method comprising administering to the patient an effective amount of a HIF prolyl-4-hydroxylase inhibiting compound having the following general formula (1) wherein R...  
WO/2015/086836A1
The present invention claims a chromone derivative and pharmaceutical compositions and combinations comprising a least the said derivative, which is a dopamine D3 receptor antagonist, for their use for the treatment of autism spectrum di...  
WO/2015/088286A1
The present invention relates to a pharmaceutical composition for treating cerebrovascular diseases, containing a stem cell-derived exosome as an active ingredient. The stem cell-derived exosome according to the present invention has rem...  
WO/2015/088288A1
The present invention relates to a method for promoting the generation of a stem cell-derived exosome by using thrombin. The method according to the present invention has a remarkable effect of promoting the generation of a stem cell-der...  
WO/2015/085739A1
A multilayer solid pharmaceutical dosage form, comprising a core having active ingredients, a first layer of sustained release coating covering the core, a drug layer having active ingredients and covering the first layer of sustained re...  
WO/2015/085860A1
Disclosed are a heterocyclic hydroxamic acid compound having a general formula I, and pharmaceutically acceptable acid or alkali salts or stereoisomers thereof. The present compound and pharmaceutically acceptable salts thereof effective...  
WO/2015/087926A1
A laminate-type patch which is provided with a support layer, a drug reservoir layer and a pressure-sensitive adhesive layer, wherein: the drug reservoir layer contains at least one drug selected from the group consisting of rivastigmine...  
WO/2015/089349A1
This invention provides methods and pharmaceutical compositions that can treat neuroinflammatory disease by reducing the production of pyrophosphate intermediates produced during the biosynthesis of isoprenoids. The pyrophosphate compoun...  

Matches 651 - 700 out of 109,062