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Matches 701 - 750 out of 46,195

Document Document Title
WO/2014/007447
The present invention relates to a composition containing a hydroxychalcone compound, as an active ingredient, for inhibiting angiogenesis. The compounds of the present invention have remarkable angiogenesis inhibition effects in the cho...  
WO/2014/007853
Disclosed herein are methods and compositions for treating a disease or disorder of the glutamatergic system, e.g., Alzheimer's disease, neuron damage and/or loss, and seizures, or a symptom thereof, e.g., decreased cognitive function, i...  
WO/2014/006402
The disclosures herein relate to novel compounds of formula wherein W, X and Y1, Y2, Y3 and Y4 are defined herein, and their use in treating, preventing, ameliorating, controlling or reducing the risk of neurological or psychiatric disor...  
WO/2014/006120
The present invention relates to compounds according to formula (I) wherein R1, R2, R3, R4 and R5 are H; R6 is selected from methyl and hydroxymethyl; A7 is C-R7, A8 is N and A9 is C-R9; R7, R10 and R11 are H; R9 is OR12, wherein R12 rep...  
WO/2014/005720
The present invention relates to the efficient treatment of an individual afflicted with fatigue, particularly mental fatigue, associated with certain diseases, particularly diseases of the central nervous system, including Parkinson's d...  
WO/2014/007554
This invention provides a method of preparing a benzofuran derivative, which has industrial safety and high yield and may thus be viably applied to industrial mass production.  
WO/2014/006528
The invention relates to the compounds of formula 1 or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof The pharmaceutical compositions comprising an effective amount o...  
WO/2014/005186
The present invention relates generally to methods for inhibiting neuron apoptosis and necrosis associated with excess glutamate release by administering a TRPC3 inhibitor to a subject.  
WO/2014/005421
Provided in the present invention are novel benzodioxole derivatives and the preparation method thereof. These compounds of formula (I) or pharmaceutically acceptable salts thereof have acetylcholine esterase inhibitory activity, so can ...  
WO/2014/005274
A formula I compound, a derivate thereof, a medicated salt thereof, and a hydrate or solvate thereof. A medicine composition of the formula I compound with pharmaceutically effective amount and a pharmaceutically acceptable carrier. Use ...  
WO/2014/004902
Disclosed are methods, compounds, and compositions useful for increasing autophagy and promoting longevity. The methods, compounds, and compositions relate to urolithins and urolithin precursors and use thereof. Certain urolithins are re...  
WO/2014/002039
The present invention relates to amphetamine prodrugs which provide colonic release of amphetamine.  
WO/2014/004902
Disclosed are methods, compounds, and compositions useful for increasing autophagy and promoting longevity. The methods, compounds, and compositions relate to urolithins and urolithin precursors and use thereof. Certain urolithins are re...  
WO/2014/001377
5-Azaindazole compounds of Formula (I), including stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof, are useful for inhibiting Pim kinase, and for treating disorders such as cancer mediated by Pim...  
WO/2014/001228
The present invention provides difluoro-cyclopentaoxazinyls and difluoroenzooxazinyls of formula (I) having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active...  
WO/2014/001280
This invention relates to a novel phenyl triazole derivative, pharmaceutical compositions containing this compound, and methods of treatment therewith. The compound of the invention is in particular considered useful for the treatment of...  
WO/2014/001427
The present invention relates to nalmefene for use in the reduction of alcohol consumption in a patient with alcohol dependence who has a high drinking risk level. The present invention also relates to nalmefene for use in the reduction ...  
WO/2014/004676
The present disclosure relates to methods of using a fatty acid amide hydrolase (FAAH) inhibitor of Formula I alone or in combination with one or more additional therapeutic agents for the treatment or prevention of neuronal injury or ne...  
WO/2014/001464
The invention relates to a compound of the general formula (I) or a physiologically functional derivative, solvate or salt thereof, (I) wherein A is a bond, alkyl or alkoxy optionally substituted with one or more R" as defined herein, *-...  
WO/2014/002599
Provided are a crude-drug-containing pharmaceutical composition exhibiting excellent storage stability, and a stabilization method and a storage stabilizing agent for the crude-drug-containing pharmaceutical composition. The pharmaceutic...  
WO/2014/004465
The present invention relates to compositions, methods and kits for delivery of active agents (X) to cells or tissues that express proteoglycans. More specifically, the present invention relates to conjugates comprising (HB-linker)n-Xm-(...  
WO/2014/000452
A traditional Chinese medicine compound gel for external treatment of cancer pain is formed of the following raw materials (in parts by weight): 40-60 parts of rhizoma dioscoreae nipponicae, 20-40 parts of caulis piperis kadsurae, and 20...  
WO/2014/002553
The purpose of the present invention is to provide an aripiprazole oral pharmaceutical preparation which has limited acidity and bitterness, poses little burden to the patient when administered, and is highly elutable, and for which the ...  
WO/2014/001282
This invention relates to a novel phenyl triazole derivative, pharmaceutical compositions containing this compound, and methods of treatment therewith. The compound of the invention is in particular considered useful for the treatment of...  
WO/2014/001742
Disclosed are processes for the production of composition comprising one or more fructose amino acids, said process comprising the steps of: (a) providing plant material derived from a botanical source selected from plants of the familie...  
WO/2014/001281
This invention relates to a novel phenyl triazole derivative, pharmaceutical compositions containing this compound, and methods of treatment therewith. The compound of the invention is in particular considered useful for the treatment of...  
WO/2014/000694
Provided is a compound of general formula (I) as a potassium channel regulator and pharmaceutically acceptable equivalents thereof. The compound can be used in the preparation of medicines for increasing the ion flow in the potassium cha...  
WO/2014/000029
In one embodiment, the present invention relates to a method for reducing the frequency and/or severity of headache in a subject comprising administering to the subject a composition comprising the stromal vascular fraction or stromal ce...  
WO/2014/000629
The invention relates to hexahydropentaleno derivatives, the preparation method and use in medicine thereof, and in particular to hexahydropentaleno derivatives or stereo-isomers or pharmaceutically acceptable salts thereof as shown in g...  
WO/2014/003605
Disclosed is a method for treating relapsing-remitting multiple sclerosis in a patient by administering to the patient autologous, ex vivo-expanded CD4+CD25+Foxp3+CD127low T reg cells when the patient is in remission. Also disclosed i...  
WO/2014/000629
The invention relates to hexahydropentaleno derivatives, the preparation method and use in medicine thereof, and in particular to hexahydropentaleno derivatives or stereo-isomers or pharmaceutically acceptable salts thereof as shown in g...  
WO/2014/001802
The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt, N-oxide, hydrate or solvate thereof: wherein:ring A, R1, R2, n, X, V, W, Z, ring B, [Linker] and R areas defined herein. The compounds are us...  
WO/2014/003154
An NO production-enhancing agent, which comprises citrulline or a salt thereof and serine or a salt thereof as active ingredients; an agent for preventing the deterioration in a vascular endothelial function or improving the vascular end...  
WO/2014/001278
This invention relates to a novel phenyl triazole derivative, pharmaceutical compositions containing this compound, and methods of treatment therewith. The compound of the invention is in particular considered useful for the treatment of...  
WO/2014/001279
This invention relates to a novel phenyl triazole derivative of formula (I), pharmaceutical compositions containing this compound, and methods of treatment therewith. The compound of the invention is in particular considered useful for t...  
WO/2014/001348
The present invention concerns a compound of the following formula (I): (I) or a pharmaceutically acceptable salt of same, and the method of preparing same, the pharmaceutical compositions comprising same and the use thereof as a drug, i...  
WO/2013/192225
Described herein are compounds and chemical entities of Formula (I), methods of their synthesis, compositions comprising them, and their use in treating numerous diseases and disorders, including cognitive deficits associated with CNS di...  
WO/2013/190299
Cyclohexane-1,2'-indene-1',2''-imidazole compounds, therapeutically acceptable salts thereof, processes for preparation thereof, therapeutic uses of such compounds for treating Aβ-related pathologies such as Down's syndrome, β-amyloid ...  
WO/2013/191509
The present invention relates to a pharmaceutical composition for preventing and treating Parkinson's disease, containing N-terminal truncated ubiquitin C-terminal hydrolase-L1 (NT-UCH-L1) as an active ingredient. Specifically, it is asc...  
WO/2013/188999
The present invention provides an application of Inula lineariifolia lactone A in the preparation of a medicine for treating rheumatoid arthritis. The Inula lineariifolia lactone A as an active component and a routine medicinal carrier a...  
WO/2013/192229
Described herein are compounds and chemical entities of Formula I, methods of their synthesis, compositions comprising them, and their use in treating numerous diseases and disorders, including cognitive deficits associated with CNS dise...  
WO/2013/190298
2H-imidazol-4-amine compounds, therapeutically acceptable salts thereof, processes for preparation thereof, therapeutic uses of such compounds for treating Αβ-related pathologies such as Down's syndrome, β-amyloid angiopathy, Alzheime...  
WO/2013/192273
Provided herein are heteroaryl compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. In one embodiment, the compounds provided herein are useful for the treatment, preventi...  
WO/2013/192163
The present invention features compositions and methods for treating gluten-related disorders. We describe compositions comprising one or more metabolites produced by Lactobacillus paracasei CBA L74, International Depository Accession Nu...  
WO/2013/190302
A camsylate salt of (1r,1 'R,4R)- 4-methoxy-5"-methyl-6'-[5-(prop-1-yn-1-yl)pyridin-3-yl]-3'H- dispiro[cyclohexane-1,2'-inden-1'2'-imidazole]-4"-amine, pharmaceutical compositions containing the salt and therapeutic uses of the salt for ...  
WO/2013/190301
Cycloalkyl ether compounds, therapeutically acceptable salts thereof, processes for preparation thereof, therapeutic uses of such compounds for treating Αβ-related pathologies such as Down's syndrome, β-amyloid angiopathy, Alzheimer's...  
WO/2013/192493
The disclosure provides nanoparticles of indirubin and methods of making and using these particles for the treatment of cancer, neurodegenerative disorders and inflammatory diseases. The effective average particle size of the nanoparticl...  
WO/2013/190068
The present invention relates to a composition comprising the probiotic strain Lactobacillus johnsonii CNCM I-1225 in combination with a polyphenol for use in the treatment or prevention of a cognitive and/or neurodegenerative disorder, ...  
WO/2013/191144
A novel indanesulfamide compound, such as N-[(1S)-2,2,5,7-tetrafluoro-2,3-dihydro-1H-inden-1-yl]- sulfamide, N-[(1S)-2,2,4,7-tetrafluoro-2,3-dihydro-1H- inden-1-yl]sulfamide and (+)-N-(2,2,4,6,7- pentafluoro-2,3-dihydro-1H-inden-1-yl)sul...  
WO/2013/192306
The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds modulate the mGluR2 receptor and may be useful for the treatment of various diso...  

Matches 701 - 750 out of 46,195