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Matches 701 - 750 out of 120,109

Document Document Title
WO/2016/098119A1
The invention relates to the compounds of formula I and formula II or its pharmaceutical acceptable polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of ...  
WO/2016/100579A1
Disclosed herein are polymorphic and amorphous forms of anhydrate, hydrate, and solvates of (R)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa -1,4-dienyl)butanamide and methods of using such compositions for treating or suppre...  
WO/2016/100801A1
The invention provides therapeutic compositions containing ground seed of Aframomum meleguata or an extract thereof, and methods for using such compositions to reduce platelet aggregation and treat medical disorders in a patient, such as...  
WO/2016/098005A1
The present invention is related to amino thiazole derivatives of Formula (I), pharmaceutical composition thereof and to their use for the treatment and/or prophylaxis of disorders or conditions related to Nicotinamide adenine dinucleoti...  
WO/2016/097351A1
The present invention relates to compounds of Formula (I) wherein R1 and R2 are independently selected from 19F and 18F having selective binding for MAO-B as compared with MAO-A. The invention also provides radioactive versions of these ...  
WO/2016/099055A2
The present invention relates to a composition containing a mixed extract of mulberry and Poria cocos bark as an effective ingredient for preventing, improving, or treating neurodegenerative disorders, and to a use thereof. The mixed ext...  
WO/2016/096720A1
A compound of formula (I) or a pharmaceutically acceptable salt thereof, for use in the treatment of a condition or disorder associated with nicotinamide adenine dinucleotide phosphate oxidase.  
WO/2016/095702A1
The present invention belongs to the field of medicine and the chemical industry, and in particular relates to a variety of scutellarin aglycone crystal forms and a preparation method thereof. The present invention also relates to a use ...  
WO/2016/100184A1
The present invention relates to novel geminal substituted quinuclidine amide compounds, and pharmaceutical compositions of the same, that are suitable as agonists or partial agonists of α7- nAChR, and methods of preparing these compoun...  
WO/2016/099056A2
The present invention relates to a pharmaceutical composition containing a Poria cocos bark extract as an effective ingredient for preventing or treating neurodegenerative disorders, and to a food composition for preventing or improving ...  
WO/2016/099393A1
A compound of formula I, for use in pain therapy and a pharmaceutical composition comprising said compound.  
WO/2016/096979A1
The present invention relates to 2,3,4,5-tetrahydropyridin-6-amine and 3,4- dihydro-2H-pyrrol-5-amine compound inhibitors of beta-secretase having the structure shown in Formula (I), wherein the radicals are as defined in the specificati...  
WO/2016/097339A1
The present invention relates to compounds having selective binding for MAO-B as compared with MAO-A. The invention also provides radioactive versions of these compounds, and precursor compounds for the synthesis of these radioactive com...  
WO/2016/099394A1
A compound of formula I, For use in pain therapy and a pharmaceutical composition comprising said compound.  
WO/2016/096709A1
The present invention relates to novel heterocyclic derivatives having general formula (I) and their therapeutic use for diseases such as cancer, inflammation, pain, autoimmune diseases or neurodegenerative diseases like Alzheimer's or P...  
WO/2016/100576A9
The invention relates to methods of separating Trolox isomers (R)-Trolox and (S)-Trolox, comprising: (a) contacting a mixture of (R) and (S)-Trolox with a resolving agent selected from the group consisting of (1S,2S)-(+)-Pseudoephedrine,...  
WO/2016/097144A1
Compound of formula (I) wherein R1 is heteroaryl either unsubstituted or substituted by methyl, ethyl, halo or =O; and R2 is H, methyl or ethyl; and salts thereof are KMO inhibitors and may be useful in the treatment of various disorders...  
WO/2016/100708A1
A transdermal drug delivery device includes a backing and an adhesive composition disposed on the backing. The adhesive composition includes a copolymer having at least 50 percent by weight C4 to C10 alkyl acrylate units, based on the to...  
WO/2016/095204A1
The present invention is directed to pyrrolidine compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurologic...  
WO/2016/096127A1
The present invention relates to compounds having dual pharmacological activity towards both the sigma (σ) receptor, and the μ-opiod receptor and more particularly to methyl-1H-pyrazole alkylamine compounds having this pharmacological ...  
WO/2016/097345A1
The present invention relates to compounds having selective binding for MAO-B as compared with MAO-A. The invention also provides radioactive versions of these compounds, and precursor compounds for the synthesis of these radioactive com...  
WO/2016/100576A1
The invention relates to methods of separating Trolox isomers (R)-Trolox and (S)-Trolox, comprising: (a) contacting a mixture of (R) and (S)-Trolox with a resolving agent selected from the group consisting of (1S,2S)-(+)-Pseudoephedrine,...  
WO/2016/100515A1
The invention generally relates to substituted benzothiophenyl, substituted benzothiazolyl, substituted indolyl and substituted benzoimidazolyl compounds and, more particularly, to a compound represented by Structural Formula I: or a pha...  
WO/2016/095205A1
Disclosed are heteroaryl compounds and compositions which are antagonists of orexin receptors. Also disclosed are uses of the compounds and compositions in the potential treatment or prevention of neurological and psychiatric disorders a...  
WO/2016/100349A3
Disclosed are chemical entities of Formula (I): wherein R1 and Z are defined herein, as NR2B subtype selective receptor antagonists. Also disclosed are pharmaceutical compositions comprising a chemical entity of Formula (I), and methods ...  
WO/2016/097355A1
The present invention relates to compounds having selective binding for MAO-B as compared with MAO-A. The invention also provides radioactive versions of these compounds, and precursor compounds for the synthesis of these radioactive com...  
WO/2016/099055A3
The present invention relates to a composition containing a mixed extract of mulberry and Poria cocos bark as an effective ingredient for preventing, improving, or treating neurodegenerative disorders, and to a use thereof. The mixed ext...  
WO/2016/094850A1
The invention includes a composition comprising an astrocyte comprising aligned and elongated astrocyte processes resulting from ex vivo machine-driven, physical stretching of the astrocyte maintained in culture, as well as a method of m...  
WO/2016/091079A1
The present invention relates to donepezil derivatives of general formula (I) or pharmaceutically acceptable salts thereof, wherein R is described in the specification; preparation methods therefor and compositions comprising an effectiv...  
WO/2016/090495A1
The present invention is related to a compound that includes (a) α-L-iduronidase (IDUA), a fragment, or analog thereof and (b) a dendrimeric targeting moiety, for example, a dendrimeric targeting moiety including Angiopep-2. In certain ...  
WO/2016/092042A1
The present invention relates to a pharmaceutical combination comprising a first active ingredient which is (R)-5-[3-chloro-4-(2,3-dihydroxy-propoxy)-benz[Z]ylidene]-2- ([Z]- propylimino)-3-o-tolyl-thiazolidin-4-one or a pharmaceutically...  
WO/2016/093515A1
Disclosed in the present specification is a composition for activating any one or more genes of an XPD gene, a Klotho gene, a Sirt-1 gene, an ERCC8 gene and a FoxO3 gene, the composition containing catechin comprising a methyl group, a s...  
WO/2016/092878A1
[Problem] To enable the easy mass production of an ether phospholipid having superior therapeutic and ameliorating effects on cranial nerve diseases such as Alzheimer's disease, Parkinson's disease, depression and schizophrenia, metaboli...  
WO/2016/094659A1
A compound of Formula II, or a salt, ester, solvate, hydrate or prodrug thereof: where: X1 is a branched or unbranched C1-10 alkyl, (CH2)s-NH-(CH2)t, (CH2)s-0-(CH2)t, or (CH2)S-C(NH2)- (CH2)v-NH-(CH2)t,where s, t and v are each, independ...  
WO/2016/092539A1
The present invention discloses a composition comprising a therapeutically effective amount of Tetrahydrocannabinol (THC) or a derivative thereof, or Cannabidiol (CBD) or a derivative thereof, or a combination thereof for use in relievin...  
WO/2016/094566A3
The present invention relates to antibodies that bind to receptors expressed on the blood brain barrier and methods of using the same.  
WO/2016/092479A1
The invention relates to a stable oral liquid formulation developed for treating negative effects of Advanced Glycation end Products (AGEs) in a clear oral liquid formulation containing Resveratrol, Benfotiamine, Pyridoxamine and one or ...  
WO/2016/094881A2
The disclosure provides binding proteins that specifically bind to LRP-8 and optionally cross the blood brain barrier (BBB), localize to the brain and/or localize to the spinal cord.  
WO/2016/092459A1
The invention provides compositions and methods for treatment of epilepsy in an animal. In one embodiment, a dietary regime suitable for enhancing the effect of an anti-epileptic drug (AED) in an animal can comprise a food composition co...  
WO/2016/094881A3
The disclosure provides binding proteins that specifically bind to LRP-8 and optionally cross the blood brain barrier (BBB), localize to the brain and/or localize to the spinal cord.  
WO/2016/094566A2
The present invention relates to antibodies that bind to receptors expressed on the blood brain barrier and methods of using the same.  
WO/2016/092865A1
Provided is an antibody or an immunologically reactive fragment thereof which targets exclusively an Aβ having a specific turn structure of Aβ (a toxic conformer of Aβ). Also provided are a medicinal composition comprising, as an acti...  
WO/2016/093342A1
Compounds represented by formula (I) or pharmaceutically-acceptable salts thereof. (The symbols in formula [I] are as defined in the description.)  
WO/2016/092002A1
The present invention relates to novel 1,2,4-triazolo[4,3-a]pyridine compounds of formula (I) as positive allosteric modulators (PAMs) of the metabotropic glutamate receptor subtype 2 ("mGluR2"). The invention is also directed to pharmac...  
WO/2016/091776A1
The present invention relates to 1,3-thiazol-2-yl substituted benzamide compounds of general formula (I) as described and defined herein, to pharmaceutical compositions and combinations comprising said compounds and to the use of said co...  
WO/2016/091996A1
The present invention relates to a dosing regimen for (R)-5-[3-chloro-4-(2,3-dihydroxy-propoxy)-benz[Z]ylidene]-2- ([Z]-propylimino)-3-o-tolyl-thiazolidin-4-one.  
WO/2016/092453A1
The invention relates to prevention, treatment and slowing the progression of brain pathology in a disease or condition associated with ApoE4 genotype such as Alzheimer's Disease (AD) in a subject having the ApoE4 genotype through activa...  
WO/2016/090299A1
The present disclosure relates to certain amine derivatives of fused bicyclic heterocycles that inhibit the amine reuptake function of the biogenic amine transporters, dopamine transporter (DAT), serotonin transporter (SERT) and norepine...  
WO/2016/086320A1
Provided herein are antigen-binding constructs such as antibodies that bind to the RRM-1 domain of TDP-43. The antigen-binding constructs are capable of blocking the interaction of TDP-43 with NF-κB in cells. Also provided herein are me...  
WO/2016/088125A1
This disclosure relates to compositions for use in treatment of Alzheimer's Disease, and/or a ocular and retinal degenerative disease, such as age related macular degeneration. The described compositions include effective amounts of LLMe...  

Matches 701 - 750 out of 120,109