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Matches 51 - 100 out of 112,611

Document Document Title
WO/2016/141499A1
The invention relates to blockers of hemichannels for the treatment of epilepsy. In particular, the invention relates to organic compounds that act as selective inhibitors of hemichannels formed by connexins and which are useful in the t...  
WO/2016/145193A1
The invention features methods and compositions for the treatment of Alzheimer's Disease using lysergic acid diethylamide and pharmaceutically acceptable salts thereof.  
WO/2016/143699A1
Provided are: a compound which is useful as an amyloid oxygenation catalyst that is applicable in vivo and is amyloid-selective, while being applicable not only to Aβ peptides but also to other amyloids; and a prophylactic and therapeut...  
WO/2016/144936A1
The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This inve...  
WO/2016/144749A1
Transdermal therapeutic system and method of using the same for safely treating hypocholinergic disorders of the central nervous system such as Alzheimer type dementia. The transdermal therapeutic system comprises oxybutynin in combinati...  
WO/2016/144901A1
Disclosed herein are new dosage regimens for deuterium-substituted benzoquinoline compounds, and methods for the treatment of abnormal muscular activity, movement disorders, and related conditions.  
WO/2016/141889A1
Provided are a novel triazolopyrimidine derivative represented by formula II, crystal form and preparation method thereof, and use thereof in the preparation of medicine for resisting coagulation and thrombus, treating or preventing cere...  
WO/2016/139586A1
The present invention is directed to N-desmethylclobazam or any suitable pharmaceutically acceptable thereof useful for the prevention and/or treatment of a chronic pain disorder and related methods and pharmaceutical formulations.  
WO/2016/141219A1
The disclosure herein relates to therapeutically-active compositions and formulations for treating pain, pruritus, irritation, inflammation, and tissue damage due to the irritation and inflammation. Specifically, the disclosure relates t...  
WO/2016/140118A1
A radioactive iodine labeled pyrido[1,2-a]benzoimidazole derivative compound represented by a definite general formula or a salt thereof, or a radioactive medicine comprising the same.  
WO/2016/139635A1
The present invention relates to pharmaceutical compositions for the parenteral administration of melatonin in the form of sterile aqueous solutions, provided with good stability even if devoid of any stabilising excipients and having a ...  
WO/2016/141003A1
The present disclosure relates to novel, safe and efficient processes for the synthesis of Pimavanserin and salts thereof, as well as novel intermediates that can be used in these processes.  
WO/2016/139530A2
The present invention relates to a method of treating drug addiction in an individual in need thereof, comprising administering to the individual an effective amount of one or more alkali metals selected from the group consisting of one ...  
WO/2016/140277A1
The present invention provides a peptide comprising any one of (i) an amino acid sequence LSSTQAQQSY (SEQ ID NO: 1), (ii) an amino acid sequence LSSTQAQQSW (SEQ ID NO: 6) and (iii) an amino acid sequence LSSTQAQQSF (SEQ ID NO: 7).  
WO/2016/139351A1
The invention relates to compounds of Formula (I) and their use as selective dipeptidyl peptidase I inhibitors, as well as pharmaceutical compositions comprising said compounds, and methods of treatment involving said compounds.  
WO/2016/139605A1
Carotenoid compositions are described for management, treatment, and/or prevention of stress by reducing cortisol levels and/or improving distribution and/or density of macular pigment and thus improving overall health status. More parti...  
WO/2016/139001A1
The present invention relates to acetylsalicylic acid and derivatives thereof for use in treating symptoms caused by endogenous virus, i.e. depression, schizophrenia, mania or psychosis.  
WO/2016/141188A1
Compounds and compositions that can modulate mitochondrial function in neuronal cells are provided herein, as are methods for using the compounds and compositions to treat or prevent conditions such as Alzheimer´s disease.  
WO/2016/139618A1
A composition comprises green coffee extract and yerba mate extract, and is suitable for mixing or infusing with a.base liquid to obtain an edible drink with an energizing and stimulating effect. A drink is made with such a composition.  
WO/2016/140879A1
Pharmaceutical compositions of the invention include substituted riluzole prodrugs useful for the treatment of cancers including melanoma, breast cancer, brain cancer, and prostate cancer through the release of riluzole. Prodrugs of rilu...  
WO/2016/141065A1
Methods for treating and preventing pyrexia and other diseases in equines such as horses involving administering an oral pharmaceutical formulation containing metamizole are disclosed.  
WO/2016/138569A1
Provided is a method treating or preventing central neuropathic pain in a subject, which includes administering a 1,2-dithiolane carboxylic acid compound, in particular R-(+)-a-lipoic acid, or a pharmaceutically effective salt or ester t...  
WO/2016/137040A1
The present invention relates to a composition for preventing or treating cerebrophathy or a neurological disorder, containing, as an active ingredient, a composite extract of Polygonum multiflorum, Rehmannia glutinosa, Polygala tenuifol...  
WO/2016/138099A1
The invention relates to methods of treating stress- sensitive psychiatric diseases from trauma in a subject by enhancing ghrelin signaling in the BLA of the subject. The invention also relates to methods of reversing ghrelin resistance.  
WO/2016/136944A1
The purpose of the present invention is to provide a compound that exerts a strong analgesic action against on pain, in particular, against neuropathic pain and/or fibromyalgia syndrome. Provided is a cyclic amine derivative represented ...  
WO/2016/138286A1
The present invention relates to the discovery that IRGM, encoded by a uniquely human gene which confers risk for inflammatory diseases, affects autoophagy through a hitherto unknown mechanism. The present invention shows that IRGM contr...  
WO/2016/136907A1
Provided is a highly safe apoptosis inhibitor having an excellent effect in inhibiting apoptosis. An apoptosis inhibitor containing as an active ingredient a compound shown by formula (1). (In the formula, R1 and R2 each independently ar...  
WO/2016/138135A1
This invention provides a method of treating a subject suffering from a neurodegenerative disease or neurodegenerative disorder comprising administering to the subject a therapeutically effective amount of a modulator of the Sigma-1 rece...  
WO/2016/135048A1
The present invention relates to novel pyridine derivatives of formula (I) as A2B adenosine receptor antagonists and ligands of MT3 melatonin receptor, to processes for their preparation, to pharmaceutical compositions comprising said co...  
WO/2016/136933A1
A pharmaceutical composition for treating IL-6-related diseases having as an active ingredient an IL-6 inhibitor, wherein the pharmaceutical composition is administered as usual after a short-interval dosing period where the same dose as...  
WO/2016/135644A1
The present invention relates to methods of treating autoimmune diseases with siponimod in patients receiving additionally a beta-blocker.  
WO/2016/135199A1
The invention relates to a xanthine derivative defined by chemical formula I or a salt thereof, its use as a medicament, especially for use in the treatment of serotonin-related diseases or disorders, and a pharmaceutical preparation com...  
WO/2016/137788A1
The present invention provides a compound of Formula II: or a pharmaceutically acceptable salt thereof.  
WO/2016/137811A1
Monoclonal antibodies to human tau aggregate, compositions comprising such tau antibodies, and methods of using such tau antibodies for the treatment of neurodegenerative diseases including Alzheimer-s disease, Progressive Supranuclear P...  
WO/2016/138270A2
Composition and methods for treating brain "plaques" and "tangles" in a patient or an animal wherein the method comprises administration of a therapeutically effective amount of a composition comprising Uncaria tomentosa extract and an o...  
WO/2016/136727A1
A drug for preventing and/or treating dementia comprising as an active ingredient a compound represented by formula (I) that has a xanthine oxidase inhibitory effect.  
WO/2016/134563A1
Disclosed is a use of albiflorin or a pharmaceutically acceptable salt for the prevention and/or treatment of irritable bowel syndrome. The experimental results demonstrate that the prevention, remission and/or treatment of irritable bow...  
WO/2016/138130A1
This invention provides a method of improving cognitive function in a subject comprising periodically administering to the subject an amount of pridopidine or a pharmaceutically acceptable salt thereof effective to improve a cognitive fu...  
WO/2016/134091A1
The invention is directed to a method for improving learning and/or memory (e.g., auditory, visual, somatosensory or motor) in adults and children of an age which is beyond the early critical period for learning, said method comprising i...  
WO/2016/134246A2
The present invention relates to the field of protein conformational diseases. More specifically, the present invention provides compositions and methods for treating protein conformational diseases including amyotrophic lateral sclerosi...  
WO/2016/131776A1
The invention provides compounds for use in the treatment of a disease or condition selected from brain disorders and triple-negative breast cancer, the compounds being of the formula (1) or a salt or tautomer thereof; wherein: X1 is N o...  
WO/2016/131098A1
ABSTRACT The present invention provides for certain sulfonyl ureas and related compounds which have advantageous properties and show useful activity in the inhibition of activation of the NLRP3 inflammasome. Such compounds are useful in ...  
WO/2016/132217A1
The present invention provides a method of improving GABAB receptor agonist therapy. The invention also provides methods of administering the dosage form and of treating conditions that are therapeutically responsive to GABAB receptor ag...  
WO/2016/132220A1
The present invention provides a simple and improved dose form that is capable of providing a controlled release of GABAB receptor agonist contained in the core thereof. The invention also provides methods of administering the dosage for...  
WO/2016/132218A1
The present invention provides a simple and improved method of administering a controlled release dose form that is capable of providing a controlled release of GABAB receptor agonist contained in the core thereof. The invention also pro...  
WO/2016/133160A1
The purpose of the present invention is to provide a novel low molecular weight compound that exhibits orexin receptor agonist activity and is expected to be useful as an excellent preventative or therapeutic agent for narcolepsy or the ...  
WO/2016/132233A1
The present invention provides a simple and improved dosage form that is capable of providing a controlled release of GABAB receptor agonist contained in the core thereof. The invention also provides methods of administering the dosage f...  
WO/2016/131947A1
The present invention relates and the combination of lacosamide and brivaracetam for the preparation of a fixed dose combination that is useful in the treatment of epilepsy, epileptogenesis, seizure disorders and convulsions.  
WO/2016/131640A1
The present invention provides a medium chain fatty acid (MCFA) for use in treating and/or preventing anxiety.  
WO/2016/132343A1
The present invention describes a process for the synthesis of 3-(2-cyanophenyl)-5-(2- pyridyl)-1-phenyl-1,2-dihydro-pyridin-2-one (Perampanel) represented by the structure of formula (1), and salts thereof, especially salts with pharmac...  

Matches 51 - 100 out of 112,611