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Matches 51 - 100 out of 46,375

Document Document Title
WO/2014/143201
A short treatment with noribogaine shows promise for treating drug dependency. Many opioid addicts are treated with methadone. We have found that giving noribogaine to mammal concurrently being administered methadone surprisingly exacerb...  
WO/2014/143646
The present invention is directed to an aqueous formulation of S-ketamine hydrochloride, preferably for nasal administration, wherein the formulation does not contain an antimicrobial preservative.  
WO/2014/145316
The present disclosure is directed to methods of identifying neuroprotective PKC activators comprising analyzing candidate PKC activators to determine if they are non-tumorigenic, non-toxic, accessible to the brain, have α and ε specif...  
WO/2014/143146
Methods of therapeutic treatment using monomethyl fumarate are disclosed.  
WO/2014/138812
The present invention provides amorphous arid crystalline forms of 1-ethyl-6-(indan-2- ylamino)-3-(morpholine-4-carbonyl)-1,8-naphthyridin-4-one (compound 1), and salts, co- crystals, and pharmaceutical compositions thereof. The inventio...  
WO/2014/139318
An application of a phthalide compound in preparing a medicament. The medicament is specially used for promoting a stem cell to secrete one of the following items: telomerase, a neurotrophic factor (brain-derived neurotrophic factor, BDN...  
WO/2014/143579
The present invention provides a compound of Formula (I): wherein R is H or F; and A is:(A), (B), (C) or (D); or a pharmaceutically acceptable salt thereof.  
WO/2014/146059
There are provided inter alia multisubstituted aromatic compounds useful for the inhibition of thrombin, which compounds include substituted pyrazolyl. There are additionally provided pharmaceutical compositions. There are additionally p...  
WO/2014/144115
The present invention relates to a fixed dosage unit, and methods for treating schizophrenia comprising administering the fixed dosage unit. More specifically, the present invention relates to a fixed dosage unit that reduces the inciden...  
WO/2014/143992
Provided herein are compositions, kits and methods related to the treatment of one or more lysosomal storage diseases (LSDs) in a subject and methods of identifying agents that are useful for the treatment of one or more LSDs. The compos...  
WO/2014/144508  
WO/2014/141091
Disclosed are compounds of the Formula (I), wherein R1, R2, R3, R4, R5, R6, R7 and m are as described herein, as modulators of the nicotinic acetylcholine receptors, particularly the α7 subtype, their tautomeric forms, stereoisomers, an...  
WO/2014/140184
The present invention relates to compounds of the formula (I), the N-oxides, tautomers, the prodrugs and the pharmaceutically acceptable salts thereof. In formula I the variables Het, A, X, Y, Z, R1, R2, R3, R4, R5 and Q are as defined i...  
WO/2014/142550
The present invention relates to a composition for preventing or treating a psychiatric disorder comprising a phenyl carbamate compound and a method for preventing or treating a psychiatric disorder therewith. The present invention provi...  
WO/2014/139681
The present invention relates to crystalline forms of cis-(E)-4-(3-Fluorophenyl)-2',3',4',9'- tetrahydro-N,N-dimethyl-2'-(1-oxo-3-phenyl-2-propenyl)-spiro [cyclohexane-1, 1 '[1 H]- pyrido[3,4-b]indol]-4-amine, pharmaceutical compositions...  
WO/2014/138003
The present disclosure relates generally to compositions and methods for treating a subject with a neurodegenerative disease and/or disorder) such as an injured spinal cord, stroke, or ALS. Such methods include administering to a subject...  
WO/2014/134772
Provided are indazole compounds which are potent inhibitors of LRRK2 kinase and useful in the treatment or prevention of diseases in which LRRK2 kinase is involved. Also provided are pharmaceutical compositions comprising these compounds...  
WO/2014/136305
The present invention relates to a morphinan derivative as represented by general formula (I); a tautomer or stereoisomer of said compound; a pharmaceutically acceptable salt thereof; a solvate of the morphinan derivative or of a tautome...  
WO/2014/138484
PERFLUORINATED CYCLOPROPYL FUSED 1,3-OXAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE ABSTRACT OF THE DISCLOSURE The present invention provides a new class of compounds useful for the modulation of beta-secretase ...  
WO/2014/134774
Disclosed are indazole compounds which are potent inhibitors of LRRK2 kinase and useful in the treatment or prevention of diseases in which LRRK2 kinase is involved. Also disclosed are pharmaceutical compositions in the prevention or tre...  
WO/2014/135529
This invention relates to a mixture of at !east three fatty acids selected from palmitic acid, oleic acid, stearic acid, linoleic acid, alpha-linolenic acid, gamma-linolenic acid, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), ...  
WO/2014/134776
The present invention is directed to indazole compounds which are potent inhibitors of LRRK2 kinase and useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease. The invention i...  
WO/2014/134692
The composition of extracts from the genus Hippeastrum and their components is intended for the production of pharmaceuticals and dietary supplements. The composition consists of galanthamine from 40% to 98%, haemanthamine from 0.01 % to...  
WO/2014/136717
Provided are: a novel transdermally absorbable pharmaceutical composition which has such characteristic properties that the skin permeability of duloxetine or a pharmaceutically acceptable salt thereof contained in the pharmaceutical com...  
WO/2014/137849
The present invention discloses pyridoinolobenz[b,e]azepine derivatives of Formula 1,wherein X is -O-, -S-, -SO-, or -SO2-. Y is a single bond or a double bond. A and B are independently -(CH2)n-; and 'n' varies from 0 to 3. R1 to R9 are...  
WO/2014/136730
A method of producing, at a high conversion rate and with good reproducibility, a 3‒[(S)‒7‒bromo‒2‒(2‒oxo‒propylamino)‒5‒pyr idine‒2‒yl‒3H‒1,4‒benzodiazepine‒3‒yl]methyl propionate through the oxidization ...  
WO/2014/136075
The present invention relates to new histamine H 3(H 3) receptor subtype selective ligands of the general formula (I) and/or geometric isomers and/or stereoisomers and/or diastereomers and/or salts and/ or hydrates and/or solvates thereo...  
WO/2014/136118
An aspect of embodiments of the invention relates to a method for preventing and/or treating post-traumatic stress disorder (PTSD) by administration to a subject an effective amount of melanocortin receptor antagonist. Additional embodim...  
WO/2014/134380
One embodiment of the present invention is to improve the safety and efficacy of the administration of GHB or a salt thereof to a patient. It has been discovered that the concomitant administration of an MCT inhibitor, such as diclofenac...  
WO/2014/133022
A compound represented by general formula (I) [wherein R represents a hydrogen atom, a C1-6 alkyl group or the like; R1 represents a C1-6 alkyl group, a C1-6 alkoxy group or the like; R2 represents a halogen atom, a C1-6 alkyl group, a C...  
WO/2014/132430
The purpose of the present invention is to provide a ginsenoside composition which is capable of exerting a specifically high efficacy against various symptoms and diseases including unidentified clinical syndrome. The ginsenoside compos...  
WO/2014/132982
Ingestion of a composition which contains either Lactobacillus gasseri or both Lactobacillus gasseri and αLA as an active ingredient brings about enhancement of immune responses and a reduction of physical fatigue.  
WO/2014/131855
It relates to certain compounds having a polycyclic structure and a hydroxamic acid moiety, wherein the polycyclic structure comprises at least three ring systems, wherein one ring system is a polycyclic ring system comprising from 2 to ...  
WO/2014/132210
The invention describes antibodies having a high affinity for aggregated forms of a-synuclein and a low affinity for monomeric forms of α-synuclein. The antibodies are useful in the diagnosis of neurodegenerative diseases.  
WO/2014/131825
The present invention relates to a multilayer tablet formulation comprising a combination of quetiapine or a pharmaceutically acceptable salt thereof and escitalopram or a pharmaceutically acceptable salt thereof.  
WO/2014/134306
The invention relates to compounds useful in treating conditions associated with voltage-gated ion channel function, particularly conditions associated with sodium channel activity. More specifically, the invention concerns heterocyclic ...  
WO/2014/133046
There has been a demand for a pharmaceutical composition which is used for a prophylactic and/or therapeutic agent for various diseases associated with PDE10 (for example, mental disorder, neurodegenerative disorder and the like). The pr...  
WO/2014/134349
The invention provides for methods of decreasing dual leucine zipper kinase (DLK) stability in a neuron, or decreasing or inhibiting the phosphorylation of certain amino acid residues of DLK, comprising administering to a neuron, or port...  
WO/2014/132215
A timed release pharmaceutical composition comprising donepezil is provided, wherein the composition exhibits the in vitro dissolution profile when tested in a Paddle dissolution apparatus at 50 rpm in 900 ml 6.8 buffer at 37°C, less th...  
WO/2014/134341
The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula (I): wherein variables A4, A5, A6, A8, each of R1 and R2, R3 and R7 of Formu...  
WO/2014/131374
The invention relates to chemistry and biochemistry applied to the field of medicine, and particularly to a novel method for the prevention and therapeutic treatment of conformational diseases (CD), especially diseases of an amyloid orig...  
WO/2014/132218
A timed release pharmaceutical composition comprising donepezil is provided wherein the single dose AUC(14-22) of the said composition administered in the morning is about % to about 30% less than the single dose AUC(2-10) of an immediat...  
WO/2014/134221
The invention provides dosage forms and methods for treating Parkinson's Disease, symptoms resulting from Parkinson's Disease, side effects resulting from treatment of Parkinson's Disease with other pharmaceutical agents, and reducing th...  
WO/2014/128067
The invention relates to BET protein-inhibiting, in particular BRD4-inhibiting, bicyclo 2,3-benzodiazepines and spirocyclically substituted 2,3-benzodiazepines of the general formula (I), to the pharmaceutical agents containing the compo...  
WO/2014/129598
A novel use of 8-[2-(2-pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid, which has a protein tyrosine phosphatase 1B (PTP1B) inhibitory effect, Akt activating effect, GSK-3βphosphorylating effect and Aβ1-42-induced τ protein phosp...  
WO/2014/128259
The present invention is directed to a pharmaceutical composition or a kit-of-parts and its use in the treatment of burnout syndrome and longevity therapy.  
WO/2014/128223
Compounds of formula (I), wherein X, Y, Z, R1-R7, m and n are as defined herein, exhibit 5-HT6 antagonistic activity and are thus useful for the treatment of certain CNS disorders. Methods of use of said compounds are also provided.  
WO/2014/129792
The present invention relates to a composition for treating inflammatory brain diseases which includes a stem cell as an active ingredient. When the stem cell according to the present invention is directly administered to animal models w...  
WO/2014/128254
The present invention relates to the fields of life sciences and medicine. Specifically, the invention relates to therapies of neurodegenerative diseases. More specifically, the present invention relates to interleukin-33 (IL-33), a frag...  
WO/2014/130581
Provided herein are methods of treatment of migraine headaches comprising administration of adrenocorticotropic hormone (ACTH), or fragment, analog, complex or aggregate thereof, or any combination thereof, to an individual in need thereof.  

Matches 51 - 100 out of 46,375