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Matches 101 - 150 out of 46,155

Document Document Title
WO/2014/095088
The present invention relates to compositions and methods for treatment of neurological disorders. In particular, the present invention relates to the epidermal growth factor receptor (EGFR) as a clinical target for treatment of neurolog...  
WO/2014/098098
A compound represented by formula (I) [wherein each symbol is as defined in the description] has a TRPA1 antagonistic activity, and the compound and a medicine containing the compound are useful for the prevention or treatment of disease...  
WO/2014/097474
Provided is a compound represented by formula (I), a pharmaceutically acceptable salt thereof or a solvate thereof. Formula (I) (In the formula: R1 and R2 are each independently selected from the group consisting of hydrogen, alkyl, alke...  
WO/2014/100728
Provided is a compound of formula (I), or a pharmaceutically acceptable salt thereof. Also provided is a method of treating, prophylaxis, or amelioration of a disease, comprising administering to a subject in need of treatment for the di...  
WO/2014/100022
A nutritional composition for use in enhancing learning and memory in an individual in need thereof which nutritional composition comprises at least one human milk oligosaccharide selected from lacto-N-neotetraose, lacto-N-tetraose, disi...  
WO/2014/096384
The present invention relates to the use of an antisecretory factor (AF) protein, peptide, derivative, homologue, and/or fragment thereof, having equivalent functional activity, and/or a pharmaceutically active salt thereof, for treating...  
WO/2014/094041
The present invention relates to compositions containing one or more of the compounds contained in bromelain, or salts, solvates or prodrugs thereof, and one or more mucolytic agents, or salts, solvates or prodrugs thereof, for treatment...  
WO/2014/098295
The present invention relates to a composition for preventing or treating oxidative brain damage and brain dysfunction, the composition comprising Astragalus membranaceus and Salvia miltiorrhiza as active ingredients. The composition acc...  
WO/2014/096321
The present invention relates to antibodies or fragments thereof that specifically bind to Tau phosphorylated at serine 422 (p S422), and to their use for treating and diagnosing Alzheimer's disease, Tauopathies and related Tau disorders.  
WO/2014/094623
Use of Tatarian Aster extract in preparing a medicament for treating pain and/or enhancing the analgesic effect of an opioid drug, the extract is extracted from fresh and/or dried roots and rhizomes of Tatarian Aster plant, in which the ...  
WO/2014/100353
8'-HydiOxy-Dihydroergotamine (8'-OH DHE) medicinal compounds, compositions, and dosage forms containing such compositions are provided. Also provided herein are methods of treatment, prevention, or amelioration of diseases, conditions or...  
WO/2014/100541
The present invention relates to compounds of Formula (I) wherein variables are as defined above. The compounds have apoptosis signal-regulating kinase ("ASKl") inhibitory activity, and are thus useful in the treatment of ASKl -mediated ...  
WO/2014/096093
The present invention relates to a compound of formula (I') or a pharmaceutically acceptable salt, solvate or hydrate thereof, in which: X3 is F, OH or SH, Y3 is F, OH or SH, X1, X2, X4, X5, Υ1, Y2, Y4 and Y5 are, independently of one a...  
WO/2014/096373
The present invention refers to solid forms of agomelatine, a process for their preparation and pharmaceutical compositions containing them. The present invention also relates to a process for the manufacture of N-[2-(7-methoxy- -naphtha...  
WO/2014/096958
The present invention relates to the identification of novel compounds that counteract the formation of the Membrane Attack Complex (MAC) which is the terminal process during complement activation of the immune system, and that is involv...  
WO/2014/095774
The invention concerns BET-protein-inhibiting, in particular BRD4-inhibiting, dihydropyridopyrazinones of general formula (I), in which A, X, R1, R2, R3, R4, R5, R6, R7 and n have the meanings given in the description, intermediates for ...  
WO/2014/096402
The present invention relates to an enzyme having a NMDA antagonist activity and/or an anticholinergic activity, wherein said enzyme is selected from the group comprising phosphotriesterases and phosphotriesterases derivatives. The prese...  
WO/2014/100501
Provided herein are small molecule neurotensin receptor agonists, compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.  
WO/2014/100228
The present disclosure is generally directed to neuroactive 19-alkoxy-17-substituted steroids as referenced herein, and pharmaceutically acceptable salts thereof, for use as, for example, an anesthetic, and/or in the treatment of disorde...  
WO/2014/100624
A stable, non-aqueous, liquid pharmaceutical composition contains remifentanil dissolved in a non-aqueous solvent. The formulation is provided with a pH ranging from about 2.0 to about 3.5 and can be used as an injectable. A method for p...  
WO/2014/098249
The purpose of the present invention is to provide a composition having a tissue repairing activity that is capable of promoting a reaction relating to tissue repairing. Disclosed is a composition having an activity of repairing a tissue...  
WO/2014/095775
The invention concerns BET-protein-inhibiting, in particular BRD4-inhibiting, dihydroquinoxalinones of general formula (I), in which A, X, R1, R2, R3, R4, R5, R6, R7 and n have the meanings given in the description, intermediates for pro...  
WO/2014/098512
The present invention relates to a novel use of fucosterol for the treatment of neurodegenerative diseases, and more particularly, to a pharmaceutical composition and functional health food comprising fucosterol, as an active ingredient,...  
WO/2014/099696
The present invention is directed to 2-pyridyloxy-4-ester compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the 2-pyridyloxy-4-ester compounds described herein in the potential treatme...  
WO/2014/094664
The present invention belongs to the technical field of medicines, and relates to a crystal form of a compound used as a mineralocorticoid receptor antagonist and a preparation method therefor, and in particular, to a method for preparin...  
WO/2014/100438
The present invention provides compounds of formula (I) or a pharmaceutically acceptable salt, solvate, or prodrug thereof, wherein W, X, n, s, t, and Ra are as described herein. The present invention relates generally to selective inhib...  
WO/2014/100540
The invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The compounds of Formula (I) inhibit protein kinase activity thereby making them useful as anticancer agents.  
WO/2014/100833
Benzamide compounds and derivatives thereof, as can be used for selective inhibition of the SIRT2 enzyme and/or therapeutic use in the treatment of Huntington's disease.  
WO/2014/100359
Provided herein are 8'-Hydroxy-2-CF3-dihydroergotamine (8 ' OH-2-CF3 -DHE) compounds, compositions, and dosage forms containing such compositions. Also provided herein are methods of treatment, prevention, or amelioration of a variety of...  
WO/2014/094632
A pharmaceutical composition for treating headache, prepared from eleven Chinese herbal medicines: Chinese angelica root, ligusticum chuanxiong, radix paeoniae lactiflorae, prepared rhizome of rehmannia, uncaria tomentosa, leatherleaf mi...  
WO/2014/096212
The present invention is concerned with novel tricyclic 3,4-dihydro-2H-pyrido[l,2-a]pyrazine-l,6-dione derivatives of Formula (I) wherein R1, R2, R3, R4, L, Y, Z and X have the meaning defined in the claims. The compounds according to th...  
WO/2014/096377
New hydroxy aliphatic substituted phenyl aminoalkyi ether compounds of formula (I), compositions thereof and their use as a medicament in the treatment of nervous system diseases and/or the treatment of developmental, behavioral and/or m...  
WO/2014/096941
The present disclosure provides cyclic sulfonamides of Formula (I), and the pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3a, R3b, and n are defined as set forth in the specification. The present disclosure is ...  
WO/2014/090515
The present invention relates to an algal extract comprising sulphated and non-sulphated polyanionic polysaccharides, to a method for preparing an algal extract, and also to the therapeutic and prophylactic uses thereof.  
WO/2014/089913
The present invention relates to a compound shown in a formula (I), a method for preparing the compound, a pharmaceutical composition containing the compound, and applications of the compound in preparing drugs for preventing and/or trea...  
WO/2014/090990
The invention relates to a pharmaceutical composition comprising a leukotriene antagonist or a leukotriene receptor antagonist for the treatment of a subject suffering from dementia in Parkinson's disease. Further, the invention provides...  
WO/2014/092006
[Problem] To provide a novel compound that exhibits an agonistic effect on dopamine D2 receptors. [Solution] A compound that can be represented by general formula (I) (in which R1 represents a C1-6 alkyl or the like; R2 represents hydrog...  
WO/2014/092104
The invention provides compounds represented by formula (1) (in the formula, Het represents the formula (Het-1) or the like; A represents the formula (A-1) or the like; B represents (B-1) or the like; R1A represents a hydrogen atom, alky...  
WO/2014/090929
Pharmaceutical compositions comprising vortioxetine and donepezil are provided and the use of such composition for the treatment of cognitive dysfunctions.  
WO/2014/093791
Provided herein are pharmaceutical compositions and formulations comprising mixed salts of gamma-hydroxybutyrate (GHB). Also provided herein are methods of making the pharmaceutical compositions and formulations, and methods of their use...  
WO/2014/092175
The present invention addresses the problem of providing a method for manufacturing a comparatively high-purity ≥4-mer polyphenol by precisely isolating said ≥4-mer polyphenol from a polyphenol mixture. This method for manufacturing ...  
WO/2014/091876
The fluorine-substituted piperidine compound represented in formula (I) or a pharmaceutically acceptable salt thereof is useful in the treatment or prevention of disorders that are on the basis of orexin (OX) receptor antagonism includin...  
WO/2014/093114
The present invention relates to PPARy- sparing compounds and pharmaceutical compositions formulated with such compounds that are useful for treating, delaying the onset of, or reducing the symptoms of a neurodegenerative disorder includ...  
WO/2014/091415
The invention relates to indole carboxamide derivatives of formula (I), (I) wherein R1, R 2, R 3, R 4, R5 and R6 are as defined in the description, their preparation and their use as pharmaceutically active compounds.  
WO/2014/092227
The present invention relates to a composition for treatment of diseases related to the removal of extracellular alpha-synuclein and to a method for screening a therapeutic agent for said diseases.  
WO/2014/090921
The invention relates to a method of treating pain in a patient by applying a transdermal therapeutic system for the transdermal administration of buprenorphine for 7 days on the skin of a patient, said transdermal therapeutic system com...  
WO/2014/091352
The present invention provides compounds of Formula (I), and the tautomers thereof, and the pharmaceutically acceptable salts of the compounds and tautomers, wherein the compounds have the structure (I) wherein the variables R1, R2, R3, ...  
WO/2014/093901
Provided are methods for treating GLUT1 and related brain energy deficiencies comprising administering odd-carbon fatty acid sources, e.g., C5 or C7 fatty acid sources, and related compositions.  
WO/2014/093871
The present invention relates to methods for treating pruritus with anti-pruritic compositions.  
WO/2014/092100
The purpose of the invention is to provide a compound or salt thereof that is useful as an agent for the prevention or treatment of epilepsy, neurodegenerative disease, and the like. The invention pertains to compounds represented by for...  

Matches 101 - 150 out of 46,155