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Matches 201 - 250 out of 103,546

Document Document Title
WO/2015/000412A1
The present invention relates to a benzocyclobutene derivative and a preparation method and pharmaceutical application thereof. Specifically, the present invention relates to a compound expressed by formula (I) or a stereoisomer, hydrate...  
WO/2015/002150A1
[Problem] The present invention addresses the problem of providing a novel compound. The present invention also addresses the problem of providing an OCT3 detection agent or an OCT3 activity inhibitor, which comprises the novel compound....  
WO/2015/002231A1
The present invention relates to compounds (I), which have RORγt inhibitory effects, and salts thereof. In formula (I), each notation is as described in the Specification. (I)  
WO/2015/000370A1
The present invention provides pyrroloquinoline quinone lithium salt crystal and a preparation method and application thereof. Characteristic absorption peaks appear when the diffraction angles are 6.222±0.2, 7.379±0.2, 7.941±0.2, 23....  
WO/2015/001488A1
The present invention relates to extended-release tablets of paliperidone. It further relates to processes for the preparation of the extended-release tablets and methods of treating neurological disorders by administering the extended-r...  
WO/2015/000032A1
The present invention relates to a method of preventing and/or treating chronic traumatic encephalopathy.  
WO/2014/210596A1
Disclosed in certain embodiments is a method of treating an arrhythmia comprising administering to a patient in need thereof an effective amount of an opioid antagonist to treat the arrhythmia.  
WO/2014/209239A1
The present invention relates to methods for treating ischemic stroke including extension of the therapeutic time window for reperfusion. More particularly, the invention relates to a method of treating stroke in a subject by inhibiting ...  
WO/2014/210456A1
This disclosure relates to pyrazoline dihydroquinolone derivatives, pharmaceutical compositions, and uses. In certain embodiments, the compounds are selective NMDA receptor inhibitors and are useful in therapeutic methods related thereto...  
WO/2014/209033A1
Provided is a pharmaceutical composition for preventing or treating a cognitive impairment-related disease, the pharmaceutical composition including N-(2-hydroxyethyl)piperazine-N'(3-propane sulfonic acid), a pharmaceutically acceptable ...  
WO/2014/206427A1
The present invention refers to the use of protein kinase inhibitors and more specifically to the use of inhibitors of the protein kinase c-Jun amino terminal kinase, JNK inhibitor sequences, chimeric peptides, or of nucleic acids encodi...  
WO/2014/207241A1
The present invention relates to a compound according to Formula (III) or a pharmaceutically acceptable salt, solvate, clathrate, hydrate or polymorph thereof and its use.  
WO/2014/207122A1
Antagonists of TMEFF2 (Transmembrane protein with EGF-like and two follistatin-like domains 2) for use in the treatment or prevention of a neurodegenerative disease, in particular plaque related diseases like Alzheimer's disease are desc...  
WO/2014/206349A1
The present invention relates to an oxa-thia-bicyclo[3.2.1]octane derivative, a preparation method, and use of same, and particularly to an oxa-thia-bicyclo[3.2.1]octane derivative represented by the general formula (I) or a hydrate, a s...  
WO/2014/209094A1
The invention relates to pyridazin-3(2H)-one derivatives of general formulae (I) and (II), having an anti-inflammatory, analgesic, sedative, myorelaxant and anxiolytic activity. In formulae (I) and (II), X is O, S or N; Y is O or S; and ...  
WO/2014/206563A3
The present invention refers to the use of protein kinase inhibitors and more specifically to the use of inhibitors of the protein kinase c-Jun amino terminal kinase, JNK inhibitor sequences, chimeric peptides, or of nucleic acids encodi...  
WO/2014/206899A1
The present invention relates to the boosting of Treg cells for the treatment of Alzheimer's disease and related disorders.  
WO/2014/207601A1
The present invention provides, in part, compounds of Formula (I) and pharmaceutically acceptable salts thereof; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds or sa...  
WO/2014/210389A1
The present invention provides new strategies for the treatment of Rett Syndrome and other MECP2-associated disorders, including for the identification and/or characterization of useful therapeutic modalities and/or for the stratificatio...  
WO/2014/205654A1
Disclosed are compound pharmaceutical compositions for treating pain, belonging to compound medicines, containing helicid and compounds of formula I, as well as optional pharmaceutically acceptable carriers. This composition can be used ...  
WO/2014/210538A1
Disclosed herein are methods and compositions for treating learning and memory deficits associated with Noonan Syndrome.  
WO/2014/207240A1
The present invention relates to a compound according to Formula (A) or a pharmaceutically acceptable salt, solvate, clathrate, hydrate or polymorph thereof, and its use.  
WO/2014/210596A9
Disclosed in certain embodiments is a method of treating an arrhythmia comprising administering to a patient in need thereof an effective amount of an opioid antagonist to treat the arrhythmia.  
WO/2014/209962A1
The invention relates to methods for treating pruritus with NK-1 receptor antagonists such as serlopitant. The invention further relates to pharmaceutical compositions comprising NK-1 receptor antagonists such as serlopitant. In addition...  
WO/2014/209991A1
The present invention provides compositions and uses thereof for reducing anxiety and/or impulsivity, including, for example, suicidality, in a subject undergoing treatment with a serotonin reuptake inhibitor (SRI) comprising administeri...  
WO/2014/204371A1
The compounds (R)-1-(5-chloro-6-methyl-1-(6-(trifluoromethyl)pyridin-2-yl) -1H- benzo[d]imidazol-2-yl)-N-(tetrahydrofuran-3-yl)piperidine-4- carboxamide and (R)-1-(6-chloro- -methyl-1-(6-(trifluoromethyl)pyridin-2-yl)-1H-benzo[d]imida zo...  
WO/2014/201972A1
Disclosed are a benzimidazole-2-piperazine heterocyclic derivative, preparation method and medical use thereof. Particularly disclosed are a new benzimidazole-2-piperazine heterocyclic derivative as represented by general formula (I), pr...  
WO/2014/202994A1
The invention provides a new bioorthogonal deprotection method for preparing heterocyclic compounds by bond cleavage using palladium. The methods have general application in the field of biological synthetic chemistry. Compounds, such as...  
WO/2014/203696A1
Provided is a novel anti-epileptic drug for the prevention and/or treatment of epileptic seizures that has a mode of action different from that of conventional anti-epileptic drugs. The anti-epileptic drug comprises as the active ingredi...  
WO/2014/204175A1
The present invention relates to a crystalline form of (2-(3,4-dimethoxyphenyl)-5-(3-methoxypropyl)benzofuran) and a method for preparing the same. The crystalline form of (2-(3,4-dimethoxyphenyl)-5-(3-methoxypropyl)benzofuran) according...  
WO/2014/202834A1
The present invention relates to treatment of neuronal injury. The present invention discloses a novel use of an agent and a novel method for promoting neurite out growth and/or neural regeneration in CNS injuries. A novel mechanism of p...  
WO/2014/201986A1
Provided is a mesenchymal stem cell separation method, comprising: A) utilizing collagenase to digest an animal sample, and dispersing cells contained in the animal sample to obtain a cell mixture comprising stem cells; B) introducing th...  
WO/2014/202763A1
The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof. Wherein n, R1, R2, R3, R4, R5, A, Q and X are as defined in the description. These compounds selectively modulate, regulate, and/or i...  
WO/2014/205338A3
Described herein are methods and compositions relating to modulating the permeability of the blood-brain barrier, e.g. increasing or decreasing the permeability of the blood-brain barrier for therapeutic purposes.  
WO/2014/202493A1
The present invention is concerned with 2-oxo-2,3-dihydro-indoles of general formula (I) wherein Ar is a heteroaryl group, containing one, two or three heteroatoms, selected from N, S or O; R1 is hydrogen, lower alkyl, halogen, amino, di...  
WO/2014/202597A1
Disclosed is a compound having the formula a) or b); a: R = CH3; b: R = CH2CH3, and its use in the prevention and/or treatment of Alzheimer's disease.  
WO/2014/202578A1
The invention relates to BET-protein-inhibiting, in particular BRD4-inhibiting, substituted phenyl-2,3-benzodiazepines of general formula (I), in which X, R1a, R1b, R1c, R2, R3, R4, and R5 have the meanings specified in the description, ...  
WO/2014/202999A1
The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof in which m, n, W, X, Y, Z, R1 , R2, R3, R4 and R5 are as defined in the specification, compositions containing them and their use in th...  
WO/2014/202646A1
The present invention relates to the use of (RS)-[2-(3,4-dimethoxyphenyl)ethyl][2-hydroxy-3-(3-methylphe noxy)propyl]amine having the formula (IA), or a pharmaceutically acceptable salt thereof for the formulation of a pharmaceutical com...  
WO/2014/202833A1
The present invention relates to treatment of neuronal injuries. Specifically, the present invention relates to novel mechanisms and means for promoting neurite outgrowth, neural regeneration and/or maintenance of neurites (axons and den...  
WO/2014/203150A1
Disclosed are compounds of the formula (I), wherein R1, R2, R3, R4, R5, R6, R7 and m are as described herein, as modulators of the nicotinic acetylcholine receptors, particularly the α7 subtype, their tautomeric forms, stereoisomers, an...  
WO/2014/198808A1
The present invention provides compounds of Formula (I) as M1 receptor positive allosteric modulators for the treatment of diseases mediated by the muscarinic M1 mediator.  
WO/2014/198592A1
The invention relates to a compound of formula (I), wherein R1 and R2 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.  
WO/2014/200078A1
The present invention provides a novel compound having P2X3 and/or P2X2/3 receptor antagonism. A compound indicated by formula (I) or a pharmaceutically acceptable salt thereof. In formula (I), Ra and Rb together, and Rd and Re together ...  
WO/2014/198854A1
The present invention relates to novel 6,7-dihydro[1,2,3]triazolo[1,5-a]pyrazin- 6-yl derivatives as inhibitors of beta-secretase, also known as beta-site amyloid cleaving enzyme, BACE, in particular BACE1 and/or BACE2 (wherein BACE1, is...  
WO/2014/200018A1
A therapeutic effect of the administration of interferon-β (IFN-β) on a relapsing-remitting multiple sclerosis (RRMS) patient can be predicted and an RRMS case, wherein the administration can be hardly continued because of the occurren...  
WO/2014/200075A1
Provided are 4-alkynyl imidazole derivatives represented by general formula (I) and pharmacologically permissible salts thereof. The derivatives have excellent EP4 receptor antagonist effects and are useful as medicines for treating dise...  
WO/2014/198880A1
The invention provides a compound of formula (I) wherein R2-R10 represent different meanings, and pharmaceutically acceptable salts thereof. The invention also provides synthetic procedures for preparing the compounds of formula (I), pha...  
WO/2014/200882A1
Disclosed are compounds, compositions and methods for treating Type II diabetes. Such compounds are represented by Formula (I) as follows: wherein R1, R2, L, and Q are defined herein.  
WO/2014/198842A1
The present invention is related to a product comprising a pentacyclic triterpene and hydroxytyrosol or derivatives thereof, uses, and pharmaceutical composition thereof.  

Matches 201 - 250 out of 103,546