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Patent Searching and Data


Matches 201 - 250 out of 103,646

Document Document Title
WO/2015/017715A1
The present invention relates to a new drug delivery strategy based on prodrug conversion, in which a water-soluble prodrug and its converting enzyme are co-delivered and at a point of administration such as the nasal or buccal mucosa. E...  
WO/2015/017407A1
The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I, wherein variables A4, A5, A6, A8, R1, R2, R3, R7and n of Formula I, indep...  
WO/2015/013903A1
The present invention relates to the p-toluenesulfonic acid co-crystals of agomelatine of formula (I), preparation and use thereof, and to pharmaceutical composition containing it. The p-toluenesulfonic acid co-crystals of agomelatine ob...  
WO/2015/014884A1
The invention relates to a fusion protein comprising an antibody directed to Aβ, a monovalent binding entity which binds to a blood brain barrier receptor and a neprilysin.  
WO/2015/016667A1
The present invention relates to an orally disintegrating film preparation containing donepezil, and a preparation method therefor and particularly, to an orally disintegrating film preparation for treating dementia, containing donepezil...  
WO/2015/017123A1
The present disclosure relates, in one aspect, to use of ghrelin splice variant or an analogue thereof, or a ghrelin splice variant-like compound for the preparation of a medicament for one or more of: treatment and/or prevention of neur...  
WO/2015/010210A1
Compounds of general formula (I) and their use to reduce circulating acylated ghrelin levels are provided. GSA-X-Y-B (I) in which "GSA-X" is a ghrelin moiety, "Y" is an optional peptide linker and "B" is a CPP moiety. The compounds of ge...  
WO/2015/011038A1
Compositions contain a therapeutically effective amount of tiglic aldehyde for at least one of provoking the swallowing reflex of dysphagic patients, decreasing appetite by delaying gastric emptying, reducing body weight gain, or reducin...  
WO/2015/010655A1
Triadic fused cyclic carboxylic acids derivatives, preparation method therefor and pharmaceutical use thereof, particularly relating to compounds represented by general formula (I), stereoisomers, hydrates, solvates, metabolites, eutecti...  
WO/2015/011037A1
Compositions contain a therapeutically effective amount of cuminaldehyde for at least one of provoking the swallowing reflex of dysphagic patients, decreasing appetite by delaying gastric emptying, reducing body weight gain, or reducing ...  
WO/2015/012708A1
A compound having a structure selected from the following: or a pharmaceutically acceptable salt thereof. The compound may be used as an inhibitor of fatty acid amide hydrolase.  
WO/2015/011036A1
Compositions contain a therapeutically effective amount of p-anisaldehyde for at least one of provoking the swallowing reflex of dysphagic patients, decreasing appetite by delaying gastric emptying, reducing body weight gain, or reducing...  
WO/2015/012704A1
This invention concerns pyrroloquinoline derivatives as antagonists of 5-HT6 receptors, to methods for the preparation of these compounds and to novel intermediates useful for their synthesis. The invention also relates to the uses of su...  
WO/2015/011189A1
The present invention is concerned with an oral pharmaceutical dosage form comprising oxycodone or a pharmaceutically acceptable salt thereof and naloxone or a pharmaceutically acceptable salt thereof for use in the treatment of pain in ...  
WO/2015/012328A1
A compound represented by formula (I) [In the formula, each symbol is as described in the specification.] or a salt thereof has a PDE2A inhibitory action and is effective as a preventive and therapeutic agent for schizophrenia, Alzheimer...  
WO/2015/012400A1
The present invention provides a novel compound represented by the following formula (I), or a pharmaceutically acceptable salt thereof, which, on the basis of glycine reuptake inhibiting action, is useful in prevention or treatment of d...  
WO/2015/011451A1
Compositions for use in a method of treatment, particularly for use in a method of treatment of epilepsy or an epilepsy-related disorder, are provided. Uses of the compositions are also described, along with methods for employing the com...  
WO/2015/010217A1
Dimiracetam or a solvate thereof is a suitable effective substance for being used in the treatment and/or prevention of depression.  
WO/2015/012780A1
The invention relates to medicine and the chemical and pharmaceutical industry, and more particularly to the creation, production and use of cerebroprotective agents for improving cerebral blood flood. The medicinal agent contains (in gr...  
WO/2015/013451A3
Provided are methods for enhancing hippocampal plasticity and hippocampal-mediated learning and memory, and/or enhancing the synaptic maturation of neurons, and/or optimizing or enhancing neuronal synaptic transmission, and/or enhancing ...  
WO/2015/011246A1
The present invention relates to the use of flecainide as an anti-connexin agent. This anti-connexin agent is advantageously used to potentiate the therapeutic effectof various psychotropic drugs. More specifically, the invention provide...  
WO/2015/011447A1
Provided are methods and materials for treating a neurological, behavioural, psychological, psychiatric, or personality disorder or syndrome in an individual, which disorder or syndrome is associated with a plurality of aberrant thoughts...  
WO/2015/012298A1
A compound represented by general formula (I) (I) has a strong Axl inhibiting activity by introducing a distinctive bicyclic structure in which a saturated carbocyclic ring is fused to a pyridone ring, and thus may be used as a therapeut...  
WO/2015/013318A1
This invention provides novel compounds of the following formula and pharmaceutical compositions containing such compounds.  
WO/2015/009195A1
The invention relates to novel substances, and more particularly to optical isomers of (+) and (-)-benzhydryl ureas of formula (I) and (+) and (-)-1-[(3-chlorophenyl)-phenyl-methyl] urea, a pharmaceutical composition based thereon, and a...  
WO/2015/010054A3
Described herein are neuroactive steroids of the Formula (I): (Formula (I)) or a pharmaceutically acceptable salt thereof; wherein R1a and R1b are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GAB...  
WO/2015/008073A1
The disclosures herein relate to novel compounds of formula wherein R1, R2, R3 and R4 and n are defined herein, and their use in treating, preventing, ameliorating, controlling or reducing the risk of inflammation, neurological or psychi...  
WO/2015/009710A1
The present invention generally relates to compositions, reagents and methods for detecting and treating a neural tube defect in a fetus. One aspect of the invention provides a method including administrating a composition containing nog...  
WO/2015/008848A1
A self-emulsifying composition which comprises, when taking the total amount of the self-emulsifying composition as 100mass%, 70 to 90mass% of at least one compound selected from the group consisting of ω-3 polyunsaturated fatty acids, ...  
WO/2015/007249A1
An N-alkyl tryptanthrin derivative, a preparation method for same, and an application thereof. The structure of the derivative is as represented by formula I. The N-alkyl tryptanthrin derivative can serve as a highly active IDO inhibitor...  
WO/2015/009500A1
Anatabine is delivered in a volatilized form for treating substance addictions such as nicotine addiction, alcohol addiction, marijuana addiction, heroin addiction, or cocaine addiction. Devices such as electronic inhalers may be used fo...  
WO/2015/009008A1
The present invention relates to a novel adenine derivative and a pharmaceutical use thereof and, more specifically, to a novel adenine derivative having a structure of chemical formula 1 or a pharmaceutically acceptable salt thereof and...  
WO/2015/007191A1
The present invention belongs to pharmaceutical chemistry field. Paliperidone amino acids derivates and use thereof are disclosed After experiment, it is found that the compounds can be used for preparing medicant for treating mental dis...  
WO/2015/006829A1
The invention relates to a composition or method for treating at least one of infection, sepsis and injury or inducing a hypotensive state or a low pain or analgesic state in a subject susceptible to or suffering from at least one of inf...  
WO/2015/008206A1
The present invention provides compounds acting as Insulin/IGF signaling modulators useful in the treatment of neurodegenerative diseases and disorders. The invention provides pharmaceutical compositions including such compounds, and met...  
WO/2015/008849A1
A self-emulsifying composition which comprises, when taking the total amount of the composition as 100mass%, 70 to 90mass% of at least one compound selected from the group consisting of ω-3 polyunsaturated fatty acids, pharmaceutically ...  
WO/2015/007222A1
Provided is the discovery of the role of EphA4 signaling in neurodegenerative disorders involving β-amyloid induced neurotoxicity such as Alzheimer's Disease. New therapeutic methods, therapeutic agents, and kits for treating diseases c...  
WO/2015/009909A1
Generally provided herein are methods, compounds, and compositions described useful for the treatment of light chain amyloidosis and other amyloid protein diseases.  
WO/2015/007730A1
The present invention relates to compounds which are inhibitors of non-apoptotic regulated cell death, and to pharmaceutical compositions containing such compounds. Furthermore, the present invention relates to the use of such compounds ...  
WO/2015/009952A1
The invention provides a herpes simplex virus (HSV) vector that does not express toxic HSV genes in non-complementing cells and which comprises a genome comprising one or more transgenes, wherein the vector is capable of expression of a ...  
WO/2015/006827A1
The invention relates to a composition and method for inducing whole-body arrest, a coma-like state or a sleep state, a hypotensive state or a low pain or analgesic state. The composition comprises (i) a compound selected from at feast o...  
WO/2015/008861A1
Provided are: a compound represented by formula (1) or a pharmaceutically acceptable salt thereof; and a therapeutic agent for all of pathologic conditions in which Nav1.7 or Nav1.8 is concerned, specifically, for diseases such as neurop...  
WO/2015/008317A1
The present invention addresses the problem of providing a hydrogen sulfide production-inducing agent that has a higher efficiency and a lower toxicity than L-cysteine. The present invention is characterized in that, by administering D-c...  
WO/2015/007613A1
The present invention provides compounds of formula I and pharmaceutical compositions for inhibiting fatty acid amide hydrolase (FAAH). Inhibition of FAAH is contemplated as a method to sustain the levels of the fatty acid ethanolamides ...  
WO/2015/008827A1
A benzopyran derivative represented by general formula [1], or a salt thereof, is useful in therapeutic or preventive treatment of disease, wherein said therapeutic or preventive treatment is effective because said benzopyran derivative,...  
WO/2015/007615A1
The invention provides compounds of Formula (I) or pharmaceutically acceptable salts thereof wherein Ar', R1, R2, R3, R4, X, Y are as defined in the description of invention, as multi-target directed ligands (MTDLs) that are at the same ...  
WO/2015/007129A1
The present invention relates to a method for preparing (-)-huperzine A. The method involves: allowing (±)- huperzine A mixture obtained from chemical synthesis and a chiral acid to form (±)-huperzine A chiral acid salt under suitable ...  
WO/2015/004007A1
The present invention relates to ethynyl derivatives of formula (I) wherein Y is N or CH; R1 is hydrogen, fluoro or chloro; and R2 is hydrogen or lower alkyl; or to a pharmaceutically acceptable acid addition salt thereof. It has now sur...  
WO/2015/006315A1
The present invention relates to new dihydoxyphenyl modulators of neurotransmitter levels, pharmaceutical compositions thereof, and methods of use thereof.  
WO/2015/004464A1
The invention provides a polypeptide, for use in suppressing or treating itch, wherein the polypeptide comprises: a non-cytotoxic protease, which protease is capable of cleaving a SNARE protein in an itch-specific DRG neuron or a prurice...  

Matches 201 - 250 out of 103,646