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Matches 251 - 300 out of 109,029

Document Document Title
WO/2015/165966A1
The invention discloses aluminium oxyhydroxide for use in the treatment and prevention of AD.  
WO/2015/165374A1
Methods and compositions comprising recombinant Arginase I proteins which are capable of depleting the plasma arginine levels in a subject are disclosed. The methods and compositions can be used to modulate the activity of the immune sys...  
WO/2015/165835A1
The present invention relates to compounds of formula (I) wherein X is CR or N; R is hydrogen, halogen or lower alkyl; L is a bond, -C(O)- or -C(O)NH-; Ar is phenyl or a five or six membered heteroaryl group, containing one or two N atom...  
WO/2015/168322A1
Various aspects provide a method for treatment of motor and cognitive functions, comprising administering a composition comprising sodium nitrite and a pharmaceutical excipient to a subject.  
WO/2015/162287A1
The present invention relates to isolated molecules, peptides, and polypeptides of specific consensus sequences or structures, and to compounds comprising or consisting of such molecules, peptides or polypeptides, that function as transp...  
WO/2015/162516A1
The present invention provides, in part, compounds of Formula I: and pharmaceutically acceptable salts thereof; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds or sal...  
WO/2015/164508A4
The invention provides a chemical entity of Formula (I) wherein R1, R2, X, Y and Z have any of the values described herein, and compositions comprising such chemical entities; methods of making them; and their use in a wide range of meth...  
WO/2015/163448A1
Granules of 9-ethyl-6,6-dimethyl-8-(4-morpholin-4-yl- piperidin-1-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-c arbonitrile or a salt thereof are produced, and the granules are allowed to coexist with a disintegrating agent to prepare...  
WO/2015/162076A3
This invention relates to a new medical use for certain chemical compounds and pharmaceutical compositions containing them. The invention relates to compounds which are mGlu2/3 negative allosteric modulators for use in the treatment of i...  
WO/2015/161766A1
The present invention relates to a choline salt of a selenium-containing compound, and preparation method and use thereof. The structure of the selenium-containing compound choline salt of the present invention is as represented by formu...  
WO/2015/163316A1
 The purpose of the present invention is to provide a novel composition having a preventative or ameliorative effect on peripheral neuropathy. A composition for preventing or improving peripheral neuropathy, the composition containing ...  
WO/2015/162518A1
The present invention provides, in part, compounds of Formula (I) and pharmaceutically acceptable salts thereof; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds or sa...  
WO/2015/161747A1
Provided are a use of 5α-androstane-3β,5,6β-triol and analogues thereof in the preparation of a drug for treating or preventing altitude sickness induced by hypobaric hypoxia.  
WO/2015/162870A1
The present invention addresses the problem of providing a pharmaceutical preparation with effects that effectively limit or inhibit amyloid fiber formation by the dissolution, elimination (discharge), etc. of amyloid fiber formation in ...  
WO/2015/163091A1
The present invention provides an unsaturated fatty acid absorption accelerator containing a wax as an active ingredient. The absorption of an unsaturated fatty acid can be accelerated using the absorption accelerator according to the pr...  
WO/2015/162452A1
The present invention relates to compounds of formula 1, or isotopic forms, stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, polymorphs, prodrugs, S-oxides or N-oxides thereof, and processes for their preparation. T...  
WO/2015/163435A1
Provided are compounds that exhibit an excellent autotaxin (ATX) inhibitory effect, etc. and are efficacious as a prophylactic or therapeutic agent for diseases in which ATX participates. Compounds represented by general formula (I) [whe...  
WO/2015/163486A1
A medicament comprising (I) brexpiprazole or a pharmaceutically acceptable salt thereof, and (II) nalmefene or a pharmaceutically acceptable salt thereof in combination, wherein brexpiprazole or a pharmaceutically acceptable salt thereof...  
WO/2015/163427A1
The present invention provides: a novel disubstituted 1, 2, 4-triazine compound that has an aldosterone synthase inhibitory activity and is useful in the prevention and/or treatment of various diseases or symptoms involving aldosterone, ...  
WO/2015/163339A1
Provided is a novel bicyclic or tricyclic heterocyclic compound indicated by formula (I) or a pharmaceutically acceptable salt thereof. [In the formula, the ring (A) is a substitutable aromatic group, either X1 or X2 is a carbon atom, th...  
WO/2015/164622A2  
WO/2015/163447A1
The present invention pertains to type II and type III crystals of 9-ethyl-6,6-dimethyl-8-(4-morpholin-4-yl-piperidin-1-yl)-11- oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile which are pharmacologically useful novel crystals.  
WO/2015/162930A1
 The present invention provides a method for improving protein expression, and a composition for protein expression. The composition, which is for use in causing target protein expression, comprises mRNA that codes the target protein...  
WO/2015/161730A1
The present invention relates to a new type of eutectic crystal of lorcaserin hydrochloride and benzoic acid. Compared with the prior art, the eutectic crystal has the improved properties of good stability, low solubility, and being suit...  
WO/2015/162246A1
The invention relates to the use of nutraceutical compositions comprising as active ingredients at least one poly-unsaturated fatty acid from microbial source for improving cognitive functions and/or for the treatment or prevention of ag...  
WO/2015/162515A1
The present invention provides, in part, compounds of Formula I: and pharmaceutically acceptable salts thereof; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds or sal...  
WO/2015/162216A1
The present invention relates to high affinity compounds, able to bind the transient receptor potential cation channel, subfamily Vanilloid, type 1 or TRPV1. Being this receptor involved in pain processing and neurogenic inflammatory res...  
WO/2015/163431A1
 Provided is an agent for the prevention/treatment of migraines, the agent containing a compound (1) that exhibits a selective inhibitory action on PDE2A. A compound represented by formula (1): (the symbols in the formula are as descri...  
WO/2015/162615A1
The present invention relates to novel heterocyclic compounds based on a quinazoline scaffold of formula (I), which bind effectively to the mitochondrial translocator protein (TSPO), and counteract cell death processes. These compounds c...  
WO/2015/163318A1
Provided are: a clinically usable medicine to be used for fundamentally treating Alzheimer's disease (AD); and a therapeutic agent for neurological diseases, other than AD, associated with nerve axon dysfunction with the application of t...  
WO/2015/164480A1
The present invention relates to substituted pyrrolopyridinones and substituted pyrazolopyridinones which are inhibitors of BET proteins such as BRD2, BRD3, BRD4, and BRD-t and are useful in the treatment of diseases such as cancer.  
WO/2015/164508A1
The invention provides a chemical entity of Formula (I): wherein R1, R2, X, Y and Z have any of the values described herein, and compositions comprising such chemical entities; methods of making them; and their use in a wide range of met...  
WO/2015/161014A1
The present invention is directed to heterocyclic compounds which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which CGRP is involved, such as migraine. The invention is also directed to phar...  
WO/2015/158204A1
The present invention relates to amide derivatives and pharmaceutically acceptable salts thereof, preparation method therefor and medicinal application thereof. Specifically, the present invention relates to amide derivatives represented...  
WO/2015/161011A1
The present invention is directed to benzamide compounds which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which CGRP is involved, such as migraine. The invention is also directed to pharmac...  
WO/2015/158427A1
The invention relates to aryl substituted heterocyclyl sulfones as voltage gated calcium channel blockers, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis ...  
WO/2015/158817A1
The present invention relates to prodrugs of monomethyl fumarate (MMF) of formula (I) suitable as a medicament, preferably in the treatment and/or prevention of systemic diseases, autoimmune diseases, inflammatory diseases, for example m...  
WO/2015/157794A1
The present invention provides a method for the prevention or treatment of a neurodegenerative disorder in a subject, comprising administering to the subject a therapeutically effective amount of an agent that increases Nix -mediated mit...  
WO/2015/159103A1
Anti-angiogenic treatments, treatments of hyperpermeability disorders, treatments of neuropathic and neurodegenerative disorders, pain treatments, methods of reducing the risk of pre-eclampsia and compounds for use in such methods are de...  
WO/2015/160256A1
The invention relates to the use of glutamine, preferably in the form of free amino acids, dipeptides and/or tripeptides, in the manufacture of a nutritional composition for improving exploratory behavior, memory performance, particularl...  
WO/2015/160234A1
The invention relates to the use of glutamine, preferably in the form of free amino acids, dipeptides and/or tripeptides,in the manufacture of a nutritional composition for improving exploratory behavior, memory performance, particularly...  
WO/2015/160262A1
O. no. P61401155PCT00 The present invention relates to a composition comprising fertilized shell egg, shark cartilage, pea protein extract, coenzyme Q10, vitamin K2, fish oil and optionally borage oil; and use of said composition for del...  
WO/2015/160233A1
The invention pertains to the use of a preparation for the manufacture of a composition for preventing or treating impaired plasma levels of one or more phosphatidylcholines [PC] selected from the group consisting of phosphatidylcholine ...  
WO/2015/160281A1
The invention relates to the field of medicine, and specifically to medicinal agents exhibiting antidepressant activity. Proposed is the application of 8-(trifluoromethyl)benzo[f][1,2,3,4,5]pentathiepine-6-amine, of formula I, as an ...  
WO/2015/159922A1
Provided is a method for producing a carrot extract which contains Rg3 at a high concentration, undergoes discoloration to a reduced extent and has excellent color stability. A method for producing a carrot extract, said method comprisin...  
WO/2015/158214A1
The invention provides novel compounds and compositions comprising a 5-HT2B antagonist of formula I and related methods for treating a person having a disorder characterized by undesirable 5-HT2B receptor signaling, such as migraine, irr...  
WO/2015/160796A1
Described herein are dosing regimens and kits for the treatment and/or prevention of cerebral amyloidoses such as Alzheimer's disease (AD) and/or cerebral amyloid angiopathy (CAA).  
WO/2015/160766A1
Provided herein are methods, formulations and dosing regimens for treating hypersomnia in a subject. For instance, methods provided herein comprise administering a GABAA chloride channel blocker. In certain embodiments, the GABAA chlorid...  
WO/2015/161254A1
The present invention relates to methods of inhibiting neurodegeneration in a subject suffering from or genetically at risk and/or destined to develop Huntington's Disease comprising increasing, in neurons of the subject, the activity of...  
WO/2015/160247A1
The invention pertains to the use of a preparation for the manufacture of a composition for preventing or treating impaired plasma levels of one or more polar lipids such as phosphatidylcholines [PC] selected from the group consisting of...  

Matches 251 - 300 out of 109,029