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Matches 251 - 300 out of 120,515

Document Document Title
WO/2016/205226A1
The methods of the present invention are useful for determining whether an individual has or is at risk of developing an affective disorder by detecting the expression level of connective tissue growth factor (CTGF) in a biological sampl...  
WO/2016/203405A1
The present invention relates to compounds of formula I. The compounds are inhibitors of the Src Homolgy-2 phosphatase (SHP2) and thus useful in the treatment of Noonan Syndrome, Leopard Syndrome and cancer.  
WO/2016/204153A1
The present invention provides a compound represented by general formula (Ia) or a pharmacologically acceptable salt thereof. In general formula (Ia), the two R each independently represent a C1-3 alkyl group or the like, and R1, R2, and...  
WO/2016/203221A1
The invention provides compositions comprising bacterial strains for treating and preventing inflammatory and autoimmune diseases.  
WO/2016/201524A1
The present invention provides a process for the preparation of metal ion complexes, the process comprising contacting a metal in the form of particles with a chelating agent in solid form and, while the metal is in contact with the chel...  
WO/2016/204988A1
Disclosed is a method of decreasing an amount of protein aggregate in a cell comprising contacting the cell with a compound of the formula (I): wherein R1, R2, and R3 are as defined herein, in an amount sufficient to induce autophagy in ...  
WO/2016/203217A1
The invention provides compositions comprising bacterial strains for treating and preventing inflammatory and autoimmune diseases.  
WO/2016/203223A1
The invention provides compositions comprising bacterial strains for treating and preventing inflammatory and autoimmune diseases.  
WO/2016/203401A1
The present invention relates to aryl analogs, pharmaceutical compositions containing them and their use as Nrf2 regulators.  
WO/2016/205739A1
This invention relates to benzodiazepine derivatives, compositions comprising therapeutically effective amounts of those benzodiazepine derivatives and methods of using those derivatives or compositions in treating cognitive impairment a...  
WO/2016/203239A1
The present invention relates to the use of cannabidiol (CBD) in the treatment of focal seizures. In one embodiment the patients suffering from focal seizures are children and young adults. CBD appears particularly effective in reducing ...  
WO/2016/202800A1
New pyrrolotriazinone derivatives having the chemical structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Phosphoinositid...  
WO/2016/202161A1
The present invention relates to a piperidine derivative and the preparation method and a pharmaceutical use thereof. In particular, the present invention relates to the piperidine derivative as shown by general formula (I) and the prepa...  
WO/2016/204268A1
[Problem] To provide a compound useful as a dopamine D1 receptor positive allosteric modulator (D1 PAM). [Solution] The present inventors have studied on compounds each of which has a positive allosteric modulating activity (a PAM activi...  
WO/2016/204230A1
A stem cell administration method includes an administration step for injecting a stem cell-containing solution containing stem cells collected from an animal (donor animal) or subcultured stem cells obtained by subculturing the stem cel...  
WO/2016/203218A1
The invention provides compositions comprising bacterial strains for treating and preventing inflammatory and autoimmune diseases.  
WO/2016/203406A1
The present invention relates to compounds of formula I. The compounds are inhibitors of the Src Homolgy-2 phosphatase (SHP2) and thus useful in the treatment of Noonan Syndrome, Leopard Syndrome and cancer.  
WO/2016/205270A1
The present invention provides dimethyl fumarate (DMF) particles and methods of preparing the DMF particles. Also provided is DMF coated particles comprising DMF particles coated with an enteric coating. The invention also provides vario...  
WO/2016/202453A1
A combination composition comprising as active components, in synergistically effective amounts a huperzine of natural or synthetic origin, a pharmaceutically acceptable salt thereof or a plant extract containing huperzine, and at least ...  
WO/2016/203402A1
The design and synthesis of a novel bis-furan scaffold tailored for high efficiency at inhibiting transthyretin amyloid formation is reported. In vitro results show that the discovered compounds are more efficient inhibitors of amyloid f...  
WO/2016/199878A1
Provided is a sigma-receptor binding agent that is characterized by containing an alkyl ether derivative represented by general formula [1] or a salt thereof. (In the formula, R1 and R2 are the same or different and indicate a hydrogen a...  
WO/2016/201096A1
The present invention relates to novel aminobenzisoxazole compounds, and pharmaceutical compositions of the same, that are suitable as agonists or partial agonists of ot7-nAChR, and methods of preparing these compounds and compositions, ...  
WO/2016/199906A1
The purpose of the present invention is to provide a novel low-molecular-weight compound which exhibits orexin receptor agonist activity and is expected to be useful as a prophylactic agent or therapeutic agent for narcolepsy and the lik...  
WO/2016/197877A1
Disclosed is a pharmaceutical composition for the treatment of depression, wherein the pharmaceutical composition is comprised of the following herbs in weight parts: 2-10 parts Ramulus Cinnamomi, 2-10 parts Rhizoma Zingiberis, 2-10 part...  
WO/2016/201373A1
The present invention relates to certain pyrazole derivatives of Formula (I) and pharmaceutical compositions thereof that modulate the activity of the 5-HT2A serotonin receptor and their uses for the treatment of REM sleep behavior disor...  
WO/2016/201086A1
The present invention generally relates to compositions and methods for stimulating ADAMI O-mediated nonamyloidogenic proteolysis of amyloid precursor protein. One aspect of the invention provides a method of preventing or treating Alzhe...  
WO/2016/199796A1
[Problem] To provide a novel non-peptidic compound that can be used as a GAPDH aggregation inhibitor. [Solution] Provided is a GAPDH aggregation inhibitor which contains, as an active ingredient, a compound represented by chemical formul...  
WO/2016/201246A1
The disclosure provides, among other things, compositions and methods useful for maintaining splicing fidelity in a cell. The compositions can include a compound that modulates the expression level or activity of one or more components o...  
WO/2016/201434A3
Provided herein are stable compositions containing anti-tau antibodies. In particular, compositions containing C2N-8E12 anti-tau antibody and a buffering system are provided herein.  
WO/2016/200827A1
A compound, or a pharmaceutically acceptable salt thereof, having a formula I of: (I) wherein Ar is an arylene or heteroarylene; R1 has a structure of: (II) wherein W is an alkanediyl, alkenediyl, a carbonyl, or a combination thereof; X ...  
WO/2016/197944A1
Disclosed are uses of an antidepressant compound in the preparation of antidepressant drugs and antidepressant health foods, wherein the antidepressant compound has the structure of formula I. The antidepressant compound is used as a uni...  
WO/2016/199430A1
Provided is a theranostic bubble preparation which makes it possible to diagnose and treat a tissue of interest by the irradiation with ultrasound such as diagnostic ultrasound and low-intensity therapeutic ultrasound. The theranostic bu...  
WO/2016/197945A1
The present invention relates to the use of a composition for preparing a medicament for the treatment of amyotrophic lateral sclerosis and associated disorders. The composition comprises 3-methyl-1-phenyl-2-pyrazoline-5-one or pharmaceu...  
WO/2016/198627A1
The present invention relates to methods and pharmaceutical compositions for the treatment of Alzheimer's disease. In particular the present invention relates to a method of treating Alzheimer's disease in a subject in need thereof compr...  
WO/2016/198374A1
Substituted aromatic sulfonamides of formula (I) pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a di...  
WO/2016/198878A1
The present invention relates to interferon-gamma (IFN-γ) inhibitors, and their utility in treating or controlling diseases that can be treated or controlled through inhibition of IFN-γ production, such as Alzheimer's disease, prion di...  
WO/2016/199892A1
The purpose of the present invention is to provide a therapeutic agent that is more effective in refractory amyloidosis. More specifically, it is to provide a novel substance that is highly safe and has a TTR protein amyloid fibril forma...  
WO/2016/198645A1
The invention relates to the use of HNRNPC-expressing vectors for preventing and/or treating a tauopathy, such as Alzheimer's disease. The invention relates to methods for detecting a risk of developing a tauopathy such Alzheimer's disea...  
WO/2016/197987A1
The present invention provides a heterocyclic compound serving as a Syk inhibitor and/or a Syk-HDAC dual inhibitor. Specifically, the present invention provides a compound represented by formula (I), wherein each group is defined by a de...  
WO/2016/198401A1
A series of substituted indazole derivatives, being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neuro...  
WO/2016/201168A1
The present disclosure relates to oxadiazine compounds, pharmaceutical compositions comprising an effective amount of an oxadiazine compound and methods for using an oxadiazine compound in the treatment of a neurodegenerative disease, co...  
WO/2016/198663A1
New 2-(pyrazolopyridin-3-yl)pyrimidine derivatives are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).  
WO/2016/198398A1
A series of substituted fused tricyclic imidazo pyrazine derivatives and analogues thereof, represented by formula (I), being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of vari...  
WO/2016/193551A1
Compounds of formula I (formula I), wherein A is an optionally substituted five-membered unsaturated heterocyclic ring containing 1, 2 or 3 N, O or S ring heteroatom(s) exhibit alpha2C antagonistic activity and are thus useful for the tr...  
WO/2016/196328A1
The present invention relates to compositions and methods for promoting the degradation of misfolded proteins and protein aggregates. The compositions and methods may be used to treat a disorder associated with misfolded proteins or prot...  
WO/2016/191935A1
The present invention is directed to 6-alkyl dihydropyrazolopyrimidinone compounds of formula (I) which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). Th...  
WO/2016/191895A1
The invention relates to self-assembled nanofibres of chitosan and bioactive compounds, which can be used as nutraceuticals or drugs. The bioactive compounds suitable for the nanofibres of the invention are molecules of a low molecular s...  
WO/2016/195164A1
The present invention relates to a composition for preventing, ameliorating, or treating neurodegenerative disorders, containing, as active ingredients, turmeric, gastrodia, milkwort, Salvia miltiorrhiza, Chinese quince, white woodland p...  
WO/2016/192657A1
The invention relates to substituted piperazine compounds and methods of use and uses thereof, and further to the pharmaceutical compositions comprising the compounds and uses thereof, wherein the compound has Formula (I) or a stereoisom...  
WO/2016/194638A1
The present invention provides a honey fraction which is obtained by a method comprising (a) a step for obtaining an adsorption component by bringing a honey into contact with an adsorbent, (b) a step for obtaining an organic solvent fra...  

Matches 251 - 300 out of 120,515