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Matches 251 - 300 out of 106,038

Document Document Title
WO/2015/066344A1
Provided are 5-HT2C receptor agonists. Also provided are methods for weight management, inducing satiety, and decreasing food intake, and for preventing and treating obesity, antipsychotic-induced weight gain, type 2 diabetes, Prader-Wil...  
WO/2015/066696A1
The present invention relates to Fused Morpholinopyrimidines, pharmaceutical compositions comprising an effective amount of a Fused Morpholinopyrimidine and methods for using a Fused Morpholinopyrimidine in the treatment of a neurodegene...  
WO/2015/063775A1
The present invention relates to compositions and methods for modulating autophagic cell death, particularly by regulating alpha-1- antitrypsin activity, thereby useful for treating autophagy-associated diseases. In particular, the prese...  
WO/2015/062555A1
Disclosed are a compound of formula I having higher inhibition of protein kinase G (PKG) activity and pharmaceutically acceptable salts thereof. In formula I, R1 and R2 are the same or different, each being independently chosen from the ...  
WO/2015/064447A1
 [Problem] The purpose of the invention is to provide a drug effective in the treatment and prevention of diseases and the like caused by a decrease in frataxin production. [Solution] The invention provides a frataxin enhancer containi...  
WO/2015/059697A1
The invention provides compositions comprising choline and water soluble derivatives thereof, processes for their preparation from natural sources and uses thereof.  
WO/2015/058536A1
Disclosed in the present invention is the use of a recombinant ganoderma immunomodulatory protein (rLZ-8) in preparing drugs for treating Parkinson's disease. Animal model experiments show that the recombinant ganoderma immunomodulatory ...  
WO/2015/060430A1
The purpose of the present invention is to provide a method for screening substances that participate in metabolic conversion and a kit for screening substances that participate in metabolic conversion. Said problem can be solved with mu...  
WO/2015/060333A1
Provided is a peptide characterized by having a structure, wherein a peptide that comprises an amino acid sequence represented by formula (I) is attached to the C-terminal side of a peptide that forms an α-helix, or a salt thereof: (I) ...  
WO/2015/061779A1
Methods for treating a subject in need thereof are provided which include administering a pharmaceutical composition comprising a protein transduction reagent-modified reprogramming protein to the subject, wherein the protein transductio...  
WO/2015/061328A3
The present invention provides methods, compositions, and kits for treating intestinal hyperpermeability in a subject in need thereof, including conditions such as hyperglycemia and underlying diseases such as diabetes, autism, fibromyal...  
WO/2015/060368A1
The present invention addresses the problem of providing a compound which has a PDE2A inhibitory action and is useful as an agent for preventing or treating schizophrenia, Alzheimer's disease, etc. The present invention relates to a comp...  
WO/2015/061792A1
Compounds having the following formula (E): Formula E or a pharmaceutically acceptable salt thereof, wherein R, R', R'', X and n are as defined herein are provided. Methods comprising use of such compounds for the treatment of neurologic...  
WO/2015/059632A1
Provided herein are methods for treating a neurodegenerative disease or disor- der, or stroke using a combination of one or more RXR agonist and/or one or more Nurr1 agonist and one or more trophic factor, or pharmaceutically acceptable ...  
WO/2015/060365A1
Provided is a compound represented by formula (1), with which it is possible to perform tau imaging with a high specificity to tau, and with excellent sensitivity, while having high brain uptake, low or non-existent bone-seeking properti...  
WO/2015/060348A1
The present invention relates to a cyclic aminomethyl pyrimidine derivative and a pharmacologically acceptable salt thereof which have a highly selective action on a dopamine D4 receptor and are useful as a therapeutic agent for attentio...  
WO/2015/059432A1
The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain di-isopropyl-phosphinoyl- alkanes as described herein (DIPA-1-6, DIPA-1-7, DIPA-1-8, and DIPA-1-9...  
WO/2015/061317A1
The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing at least one plasma sample from the subject to determine a value of the subjec...  
WO/2015/061421A1
This disclosure relates to deuterated bile acid compositions. A deuterated compound is selected from the disclosed groups of bile acids and their derivatives, analogs and salts. At least one of the hydrogen atoms in the compound is repla...  
WO/2015/060313A1
 The invention provides a preparation having controlled release ability with excellent production uniformity, handling properties, and productivity; and a method for producing the same. The invention pertains to a preparation having co...  
WO/2015/060746A1
The invention relates to the field of pharmacology and applied medicine, and specifically to the combined application of medicinal preparations which have a neurotrophic effect and which reduce manifestations of psychiatric, behaviora...  
WO/2015/058258A1
48 Abstract The present invention relates to an Aβ modulating peptide comprising a peptide selected from the list of peptides comprising: (i) Arg-Lys-Leu-Met-Gln-Pro-Thr-Arg-Asn (SEQ ID NO:1); (ii) Arg-Lys-Leu-Met-Gln-Pro-Thr-Arg-Asn-Ar...  
WO/2015/058868A1
The invention relates to anti-tumor compounds which have been designed to functionally disrupt the cross-talk between AEG-1 and the p65 subunit of NF-κB. Therefore, the invention relates to methods and compositions for the treatment of ...  
WO/2015/056675A1
 Exceptional antidepressant action, improving action on cognitive function associated with depression, improving action on suppression of stress-induced Akt activation, and suppressive action on stress-induced GSK-3β activation are ob...  
WO/2015/055770A1
The present invention relates to aminochromane, aminothiochromane and amino-1,2,3,4- tetrahydroquinoline derivatives of the formula (I) or a physiologically tolerated salt thereof. The invention relates to pharmaceutical compositions com...  
WO/2015/054730A1
A composition comprising two or more active agents in a micro-dose amount, such as a micro- dose of naltrexone in combination with a micro-dose of flumazenil, in the treatment of craving or anxiety resulting in rapid settling of the crav...  
WO/2015/057939A1
Antibodies and antibody fragments thereof that specifically bind to sphingosine-1-phosphate receptor 4 (S1P4) are disclosed. Also disclosed are methods of using these anti-S1P4 antibodies and antibody fragments to treat or prevent neurol...  
WO/2015/056922A1
The present invention relates to a composition for improving, preventing or treating cranial nerve diseases, including an extract of brassica oleracea as an effective component. According to the present invention, the composition has a s...  
WO/2015/057662A1
Compositions including a combination of a source of choline, a source of magnesium, and a source of L-tryptophan are provided for improving cognitive performance in a subject. The compositions may improve a cognitive impairment and/or br...  
WO/2015/055771A1
The present invention relates toaminotetralineand aminoindane derivatives of the formula (I) (I) or a physiologically tolerated salt thereof. The invention relates to pharmaceutical compositions comprising such aminotetralineand ami- noi...  
WO/2015/058053A1
The present invention encompasses methods of treating a subject who stutters. The methods can include the steps of: (a) identifying a subject in need of treatment; and (b) administering to the subject a therapeutically effective amount o...  
WO/2015/055698A1
The present inventions relate to substituted piperazine derivatives of general formula (I) and to the manufacture of said compounds, pharmaceutical compositions comprising a compound according to general formula (I), and the use of said ...  
WO/2015/056771A1
[Problem] To provide a compound useful as a pharmaceutical composition for prevention and/or treatment of diseases such as schizophrenia. [Solution] The inventors developed the present invention upon investigating a pharmaceutical compos...  
WO/2015/053614A1
Present invention discloses an oil palm composition for use in prevention or treatment of Alzheimer's disease. The composition is useful in impeding formation of neurotoxic peptide. Present invention can be used in preparation of a medic...  
WO/2015/054358A1
The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.  
WO/2015/052105A1
The present invention relates to a compound of general formula (I) wherein R is hydrogen or tritium; F is fluoro or 18fluoro; or to a pharmaceutically acceptable acid addition salt. Compounds of formula I include 2-(6-fluoro-pyridin-3-yl...  
WO/2015/051448A1
Provided herein are compositions and methods for reducing neurogeneration in a patient suffering from Parkinson's Disease, comprising administration of a composition comprising CoQ10 and polyoxyethanyl-a-tocopherylsebacate (PTS). The com...  
WO/2015/051738A1
Crystalline particle of tofacitinib citrate, process for the preparation of a crystalline particle of tofacitinib citrate, pharmaceutical composition, substantially pure amorphous form of tofacitinib citrate, process for preparing the su...  
WO/2015/054005A1
The present invention provides, among other things, methods and compositions for treating brain-derived neurotrophic factor (BDNF)-related conditions. In some embodiments, the methods include administering to a subject suffering form or ...  
WO/2015/053402A1
In order to provide a compound capable of treating or preventing spinocerebellar degeneration, analysis was undertaken using screening, etc., using a spinocerebellar degeneration type 1 (SCA1) fly model. As a result, RPA1, PNKP, XRCC3, X...  
WO/2015/052226A1
The present invention relates to certain thiazolopyrimidinone compounds for use in modulating NMDA receptor activity, pharmaceutical compositions comprising such compounds and methods of treating neurological and psychiatric conditions.  
WO/2015/051747A1
Disclosed in the present invention are a pramipexole extended release tablet and a preparation method and use thereof, wherein the extended release tablet consists of pramipexole or a pharmaceutically acceptable salt thereof, two or more...  
WO/2015/054059A2  
WO/2015/053561A1
A composition, a dietary supplement or a treatment method of the present invention has a remarkable cranial nerve protection effect and simultaneously has a sensorimotor function recovery promotion effect and a body weight increasing eff...  
WO/2015/054103A1
The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands, agonists and partial agonists for the mGluR5 receptor and may be us...  
WO/2015/054063A1
Aspects of the invention include methods of treating withdrawal syndrome by applying a transdermal delivery device containing a dexmedetomidine composition formulated to deliver a non-sedative amount of dexmedetomidine to a subject diagn...  
WO/2015/051766A1
The present invention relates to amide substituted indazoles and benzotriazoles which are inhibitors of the enzyme poly (ADP-ribose) polymerase (PARP), previously known as poly (ADP-ribose) synthase and poly (ADP-ribosyl) transferase. Th...  
WO/2015/054062A2  
WO/2015/052610A1
Provided herein are antagonists (I) of prostaglandin EP3 receptor, processes to make said antagonists, and methods comprising administering said antagonists to a mammal in need thereof. (Formula I)  
WO/2015/053337A1
The purpose of the present invention is to provide: a foodstuff, etc., containing a histidine having a novel composition and/or form; a foodstuff, etc., having a novel function on the basis of the histidine; and, more specifically, a foo...  

Matches 251 - 300 out of 106,038