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Matches 301 - 350 out of 45,506

Document Document Title
WO/2014/001281
This invention relates to a novel phenyl triazole derivative, pharmaceutical compositions containing this compound, and methods of treatment therewith. The compound of the invention is in particular considered useful for the treatment of...  
WO/2014/000694
Provided is a compound of general formula (I) as a potassium channel regulator and pharmaceutically acceptable equivalents thereof. The compound can be used in the preparation of medicines for increasing the ion flow in the potassium cha...  
WO/2014/000029
In one embodiment, the present invention relates to a method for reducing the frequency and/or severity of headache in a subject comprising administering to the subject a composition comprising the stromal vascular fraction or stromal ce...  
WO/2014/000629
The invention relates to hexahydropentaleno derivatives, the preparation method and use in medicine thereof, and in particular to hexahydropentaleno derivatives or stereo-isomers or pharmaceutically acceptable salts thereof as shown in g...  
WO/2014/003605
Disclosed is a method for treating relapsing-remitting multiple sclerosis in a patient by administering to the patient autologous, ex vivo-expanded CD4+CD25+Foxp3+CD127low T reg cells when the patient is in remission. Also disclosed i...  
WO/2014/001802
The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt, N-oxide, hydrate or solvate thereof: wherein:ring A, R1, R2, n, X, V, W, Z, ring B, [Linker] and R areas defined herein. The compounds are us...  
WO/2014/003154
An NO production-enhancing agent, which comprises citrulline or a salt thereof and serine or a salt thereof as active ingredients; an agent for preventing the deterioration in a vascular endothelial function or improving the vascular end...  
WO/2014/001278
This invention relates to a novel phenyl triazole derivative, pharmaceutical compositions containing this compound, and methods of treatment therewith. The compound of the invention is in particular considered useful for the treatment of...  
WO/2014/001279
This invention relates to a novel phenyl triazole derivative of formula (I), pharmaceutical compositions containing this compound, and methods of treatment therewith. The compound of the invention is in particular considered useful for t...  
WO/2014/001348
The present invention concerns a compound of the following formula (I): (I) or a pharmaceutically acceptable salt of same, and the method of preparing same, the pharmaceutical compositions comprising same and the use thereof as a drug, i...  
WO/2013/192225
Described herein are compounds and chemical entities of Formula (I), methods of their synthesis, compositions comprising them, and their use in treating numerous diseases and disorders, including cognitive deficits associated with CNS di...  
WO/2013/190299
Cyclohexane-1,2'-indene-1',2''-imidazole compounds, therapeutically acceptable salts thereof, processes for preparation thereof, therapeutic uses of such compounds for treating Aβ-related pathologies such as Down's syndrome, β-amyloid ...  
WO/2013/191509
The present invention relates to a pharmaceutical composition for preventing and treating Parkinson's disease, containing N-terminal truncated ubiquitin C-terminal hydrolase-L1 (NT-UCH-L1) as an active ingredient. Specifically, it is asc...  
WO/2013/188999
The present invention provides an application of Inula lineariifolia lactone A in the preparation of a medicine for treating rheumatoid arthritis. The Inula lineariifolia lactone A as an active component and a routine medicinal carrier a...  
WO/2013/192229
Described herein are compounds and chemical entities of Formula I, methods of their synthesis, compositions comprising them, and their use in treating numerous diseases and disorders, including cognitive deficits associated with CNS dise...  
WO/2013/190298
2H-imidazol-4-amine compounds, therapeutically acceptable salts thereof, processes for preparation thereof, therapeutic uses of such compounds for treating Αβ-related pathologies such as Down's syndrome, β-amyloid angiopathy, Alzheime...  
WO/2013/192273
Provided herein are heteroaryl compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. In one embodiment, the compounds provided herein are useful for the treatment, preventi...  
WO/2013/192163
The present invention features compositions and methods for treating gluten-related disorders. We describe compositions comprising one or more metabolites produced by Lactobacillus paracasei CBA L74, International Depository Accession Nu...  
WO/2013/190302
A camsylate salt of (1r,1 'R,4R)- 4-methoxy-5"-methyl-6'-[5-(prop-1-yn-1-yl)pyridin-3-yl]-3'H- dispiro[cyclohexane-1,2'-inden-1'2'-imidazole]-4"-amine, pharmaceutical compositions containing the salt and therapeutic uses of the salt for ...  
WO/2013/190301
Cycloalkyl ether compounds, therapeutically acceptable salts thereof, processes for preparation thereof, therapeutic uses of such compounds for treating Αβ-related pathologies such as Down's syndrome, β-amyloid angiopathy, Alzheimer's...  
WO/2013/192493
The disclosure provides nanoparticles of indirubin and methods of making and using these particles for the treatment of cancer, neurodegenerative disorders and inflammatory diseases. The effective average particle size of the nanoparticl...  
WO/2013/190068
The present invention relates to a composition comprising the probiotic strain Lactobacillus johnsonii CNCM I-1225 in combination with a polyphenol for use in the treatment or prevention of a cognitive and/or neurodegenerative disorder, ...  
WO/2013/191144
A novel indanesulfamide compound, such as N-[(1S)-2,2,5,7-tetrafluoro-2,3-dihydro-1H-inden-1-yl]- sulfamide, N-[(1S)-2,2,4,7-tetrafluoro-2,3-dihydro-1H- inden-1-yl]sulfamide and (+)-N-(2,2,4,6,7- pentafluoro-2,3-dihydro-1H-inden-1-yl)sul...  
WO/2013/192306
The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds modulate the mGluR2 receptor and may be useful for the treatment of various diso...  
WO/2013/191236
Provided is a composition for improving and/or treating central nervous system degenerative disease associated with learning and memory impairment. A composition for improving and/or treating central nervous system degenerative disease, ...  
WO/2013/191244
A compound represented by formula (I) (in the formula, X represents a nitrogen atom or the formula CH; R1 represents a C1-5 alkyl (this C1-5 alkyl may be substituted by 1-3 of the same or different substituents selected from hydroxy, hal...  
WO/2013/191128
A skin patch provided with a support layer and an adhesive layer, wherein the adhesive layer contains diclofenac sodium, dimethyl sulfoxide, and citric acid; the mass ratio of the diclofenac sodium and the citric acid (the mass of the di...  
WO/2013/190325
The present invention relates to the prevention of neural tube defects. In particular, the invention provides thymidine or dTMP for use in a method of preventing or prophylactically treating a neural tube defect. The method may comprise ...  
WO/2013/187451
Provided is a patch which is formed with an adhesive layer that retains a medicine on a support, wherein the adhesive layer contains a thermoplastic elastomer, a non-volatile hydrocarbon oil in an amount of over 50 parts by weight and 80...  
WO/2013/185353
The present invention relates to a compound having the structure of Formula I as inhibitor of WNT signal transduction pathways, as well as a composition comprising the compound. Further, the present invention relates to the use of the co...  
WO/2013/187467
A heteroaromatic methyl cyclic amine derivative represented by formula (IA) or a pharmaceutically acceptable salt thereof is useful for treatment or prophylaxis of diseases such as sleep disorder, depression, anxiety disorder, panic diso...  
WO/2013/188724
Azetidine and piperidine compounds of formula (I) as defined in the specification, compositions containing them, and processes for preparing such compounds and intermediates thereof. Provided herein also are methods of treating cognitive...  
WO/2013/185187
The present invention provides methods for treating symptoms including stereotypies, social behavior deficits, and obsessive behaviors in a subject afflicted with a neuropsychiatric or neurodevelopmental disorder. The methods comprise ad...  
WO/2013/185505
The present invention relates to an olanzapine oral instant membrane agent, a preparation method and pharmaceutical uses thereof. The membrane agent comprises the following components, by weight, 1-30% of olanzapine, 40-90% of a polymer ...  
WO/2013/187503
The present invention provides a novel compound represented by formula (I) or a pharmaceutically acceptable salt thereof, which is useful for prophylaxis or treatment of diseases such as schizophrenia, Alzheimer's disease, cognitive impa...  
WO/2013/186666
Compounds of Formula (I), wherein R1, R 2, X1, Y1, Z1, and Z2 are as defined herein, and pharmaceutically acceptable salts thereof, are described as useful for the treatment of cognitive deficits associated with schizophrenia and other p...  
WO/2013/187466
A branched chain alkyl heteroaromatic ring derivative represented by formula (Ia) or a pharmaceutically acceptable salt thereof is useful for treatment or prophylaxis of diseases such as sleep disorder, depression, anxiety disorder, pani...  
WO/2013/186766
The invention relates to compositions and formulations comprising isolated fractions derived from Cupressaceae plant material. More particularly, the invention relates to pharmaceutical compositions comprising an isolated fraction of Cup...  
WO/2013/187612
The present invention relates to uses for: restricting apoptosis of miRNA of Epstein-Barr virus, especially miR-BART3-5p, miR-BART3-3p, miR-BART21-5p, miR-BART21-3p, miR-BART18-5p, miR-BART18-3p, miR-BART7-5p, miR-BART7-3p, miR-BART8-5p,...  
WO/2013/185301
Disclosed is a use of flavones derivatives and flavanone derivatives in preparation of sedative and hypnotic drugs.  
WO/2013/185209
Vilazodone hydrochloride benzyl alcohol solvates are provided as well as processes for the preparation thereof.  
WO/2013/187795
The invention relates to the field of pharmacology and clinical medicine. A pharmaceutical composition in the form of tablets, said composition comprising an S1P receptor modulator, which constitutes 2-amino-2-[2-(4-octylphenyl)ethyl]...  
WO/2013/186220
The invention relates to a composition comprises hesperidin and apigenin. The invention also relates to a composition comprises hesperidin, wherein the composition is in a form suitable for sublingual and/or buccal administration. The co...  
WO/2013/187075
Provided is a prophylactic and/or therapeutic agent for mild cognitive impairment, which can improve interstitial flow in cerebral blood vessels and the like to achieve the sufficient clearance of harmful proteins accumulated in the brai...  
WO/2013/188214
The present invention is directed to a pharmaceutical composition comprising a pharmaceutically acceptable carrier and ω-(methylsulfonyl)alkylamine or ω-(methylsulfonyl)alkylamide. The present invention is also directed to a method for...  
WO/2013/188666
The present invention relates to the field or neurology. More specifically, the present invention provides methods and compositions useful for treating neurological diseases, disorders and conditions using Beta-Chimaerin modulators. In a...  
WO/2013/188509
A method and a composition are utilized to affect mitochondrial functions on a seizure-genic brain region.  
WO/2013/188881
The disclosure provides compounds, compositions, and methods for promoting motor neuron survival, and for treating or preventing neurodegenerative disorders, such as spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis (ALS).  
WO/2013/184023
The invention relates to the chemical-pharmaceutical industry, to the field of psychoneurology and specifically to means for treating multiple sclerosis. The composition (in a solid oral dosage form) is suitable for sublingual or buccal ...  
WO/2013/184732
Substantially pure, stable and crystalline (2S)-(4E)-N-methyl-5-[3-(5-isopropoxypyridin)yl]-4-penten-2- amine 1,5-naphthalenedisulfonate, and pharmaceutical compositions that include such as salt, methods for treating a wide variety of c...  

Matches 301 - 350 out of 45,506