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Matches 301 - 350 out of 45,984

Document Document Title
WO/2014/056779
The invention relates to a drug for the prophylaxis and/or treatment of a neurodegenerative disease.  
WO/2014/057180
The invention concerns a gaseous composition containing a mixture of gaseous xenon and argon for use by inhalation in order to prevent or treat at least one neurological consequence secondary to a septic shock in a patient.  
WO/2014/057484
An isolated peptide comprising a Huntingtin (Htt) amino acid sequence being no longer than 15 amino acids, wherein said Htt amino acid sequence comprises the sequence X1X2X3X4X5, wherein X1 is a hydrophobic amino acid or threonine, X2 is...  
WO/2014/059363
Oral solution formulations of aripiprazole, methods of manufacture of these formulations, methods of administration, and kits containing same.  
WO/2014/058000
The purpose of the present invention is to provide a 5-HT2B receptor antagonist which does not induce problematic adverse side effects or the like and can be used safely. Provided are a serotonin 2B receptor antagonist and a prophylactic...  
WO/2014/058875
Methods and compositions for enhancing one or more of: myelination, re- myelination, oligodendrocyte numbers, or neuroaxonal protection, while ameliorating an inflammatory condition in a human subject are disclosed. In certain embodiment...  
WO/2014/056710
The present invention relates to ethynyl derivatives of formula (I) wherein • R is phenyl, 3-fluorophenyl, 4-fluorophenyl or 2,5-di-fluorophenyl; • or to a pharmaceutically acceptable acid addition salt, in enantiomerically pure form...  
WO/2014/056816
The present invention relates to a combination of an Aβ antibody and a BACE1 inhibitor.  
WO/2014/057435
The present invention relates to [ortho bi-(hetero-)aryl]-[2-(meta bi-(hetero-)aryl)-pyrrolidin-1-yl]- methanone derivatives of formula (I) wherein R, and the rings A1 A2 and A3 are as described in the description, to pharmaceutically ac...  
WO/2014/059029
Disclosed herein are novel compositions and methods for the treatment of age- related diseases, mitochondrial diseases, the improvement of stress resistance, the improvement of resistance to hypoxia and the extension of life span. Also d...  
WO/2014/053418
The present invention relates to a method for obtaining mesenchymal stem cells (MSCs) from mammalian tissue or body fluid, comprising isolating said MSCs from tissue or body fluid and expanding said isolated MSCs in multiple cultivation ...  
WO/2014/055588
The present invention relates to methods of treatment using [3-(4-{2-butyl-1-[4-(4-chloro-phenoxy)-phenyl]-1H-imidazol-4 -yl}-phenoxy)-propyl]-diethyl amine ("COMPOUND I") or a pharmaceutically acceptable salt thereof. In various embodim...  
WO/2014/054635
Provided is a therapeutic agent for diseases associated with a cholinergic property of the central nervous system (CNS) and/or the peripheral nervous system (PNS), diseases associated with the contraction of smooth muscle, incretion dise...  
WO/2014/055541
The number of acne lesions in a human subject is reduced by administering to the subject a pharmaceutical composition that includes a pharmaceutically acceptable carrier and a therapeutically effective amount of an agent that selectively...  
WO/2014/055977
The plasma concentration of at least one branched chain amino acid in a mammal in need of such reduction is reduced by administering an agent that increases the plasma concentration of large neutral amino acids. The invention also includ...  
WO/2014/055932
The present invention is an ingestable blended formulation which will cause a series of distinct biochemical changes in-vivo; initiate desirable psychological consequences in that person; and induce an observable increase in cognitive fu...  
WO/2014/055055
A pharmaceutical composition for parenteral administration containing the active ingredient 1-adamantylethyloxy-3-morpholino-2-propanol, or pharmaceutically acceptable salts thereof, in a concentration range of from 3 to 100 mg/ml for th...  
WO/2014/055949
The invention generally features isolated platelets, compositions, methods, and kits useful for targeted delivery of one or more therapeutic agents to a site of injury, inflammation, disease, or disorder. Also featured are methods and ki...  
WO/2014/055047
The present invention is related to pharmaceutical compositions comprising idebenone and donepezil for use in symptomatic treatment of cerebral arteriosclerosis, symptoms following stroke and cerebral hemorrhage, age-associated cognitive...  
WO/2014/054965
The invention relates to the field of pharmacology and practical medicine, and specifically to the combined use of medicinal preparations, with neuro-tropic action, alleviating the manifestation of mental, behavioural and cognitive di...  
WO/2014/053418
The present invention relates to a method for obtaining mesenchymal stem cells (MSCs) from mammalian tissue or body fluid, comprising isolating said MSCs from tissue or body fluid and expanding said isolated MSCs in multiple cultivation ...  
WO/2014/054634
Provided is a therapeutic agent for diseases associated with a cholinergic property of the central nervous system (CNS) and/or the peripheral nervous system (PNS), diseases associated with the contraction of smooth muscle, incretion dise...  
WO/2014/053418
The present invention relates to a method for obtaining mesenchymal stem cells (MSCs) from mammalian tissue or body fluid, comprising isolating said MSCs from tissue or body fluid and expanding said isolated MSCs in multiple cultivation ...  
WO/2014/053857
Disclosed herein are mono or di-succinate compounds where one or both of the acid groups in the succinate core are protected in the form of biologically labile moieties, and the use of said compounds to enhance mitochondrial function. Th...  
WO/2014/054005
The invention involves the preparation of cholesterol lecithin nanosomes, without propylene glycol, from the complex formed by quercetin (or another flavonol or flavone or a derivative thereof) and 2-hydroxypropyl-β-cyclodextrin, by mea...  
WO/2014/053580
The present invention relates to the anticonvulsant activity of GSK-3βinhibitors and the use of GSK-3β inhibitors as agents for the treatment of neurological disorders characterized by seizures such as epilepsy.  
WO/2014/054651
A sleep-improving agent, a non-REM sleep time-increasing agent and a sedative agent, each of which comprises a fat-soluble anti-oxidative substance and a bivalent metal as active ingredients.  
WO/2014/055644
The present invention relates to pharmaceutical compositions comprising a compound and a pharmaceutically acceptable carrier. The present invention is also directed to a method of treating a genetic disease caused by premature terminatio...  
WO/2014/055629
The present disclosure provides compounds of formula (I): compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased ...  
WO/2014/053409
The present invention relates to compounds of general formula wherein R1 hydrogen, lower alkyl, halogen or lower alkyl substituted by halogen; R2 is hydrogen or halogen; X1 is N or CH; X2 is N or CH; with the proviso that only one of X1 ...  
WO/2014/055515
The invention relates to agents and to pharmaceutical compositions for reducing the formation of amyloid and/or for promoting the disaggregation of amyloid proteins. The compositions may also be used to detect amyloid.  
WO/2014/053420
The present invention relates to a method for the isolation of mesenchymal stem cells from the blood of mammals, comprising the isolation of mesenchymal stem cells from the blood-interphase of blood samples and preserving said cells in a...  
WO/2014/053210
The invention relates to compounds of formula I: wherein R, X and Y, have the meanings given in claim 1. The compounds useful e.g. in the treatment of autoimmune and/or inflammatory disorders, such as multiple sclerosis.  
WO/2014/055916
The present invention relates to substituted aryl 1,2,4-oxadiazoles derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.  
WO/2014/051056
The purpose of the present invention is to provide: crystals of (S,E)-2-(2,6-dichlorobenzamido)-5-[4-(isopropyl- pyrimidin-2-ylamino)phenyl]pent-4-enoic acid having excellent chemical and physical stability or a pharmacologically accepta...  
WO/2014/048865
The invention provides novel compounds having the general formula (I) wherein R1, Y, A, W, R2, m, n, p and q are as described herein, compositions including the compounds and methods of using the compounds.  
WO/2014/050779
To provide a combination therapy for cancer, which comprises a combination of a GSK3 inhibitor and an anti-DR5 antibody. Provided are a pharmaceutical product and a combination therapy, each of which comprises a combination of various an...  
WO/2014/052896
This disclosure relates to the use of uridine diphosphate (UDP) derivatives, salts and/or prodrugs thereof for the treatment of inflammatory conditions (e.g., psoriasis) and glaucoma, to prodrugs of UDP derivatives, compositions comprisi...  
WO/2014/050003
[Problem] To provide a substance capable of safely and effectively modulating expression of a period gene. [Solution] An expression modulator for a period gene containing Pelargonium plant extract as an effective component.  
WO/2014/052415
Provided herein are methods of diagnosing depressive disorders in a subject by comparing a CDP-diacylglycerol synthase 1 enzyme activity or expression level to enzyme activity or expression level of CDP-diacylglycerol synthase 1 in a con...  
WO/2014/052789
The invention relates to chimeric AAV capsids targeted to oligodendrocytes, virus vectors comprising the same, and methods of using the vectors to target oligodendrocytes.  
WO/2014/052849
The invention relates generally to novel compositions and methods comprising a scyllo-inositol compound and one or both of valproic acid compound and lamotrigine. The compositions and methods provide beneficial effects in the treatment o...  
WO/2014/052859
The present invention relates to intranasally administered pharmaceutical compositions for the treatment of headaches, such as migraines. Such pharmaceutical compositions comprise benzyl alcohol or a combination of benzyl alcohol and tet...  
WO/2014/052837
A drug delivery device comprising a non-erodible, non-porous housing member defining a reservoir is provided. The reservoir is loaded with a dry formulation of a selected salt of a neuroleptic agent. The housing member has one or more po...  
WO/2014/050084
The purpose of the invention is to create a compound that selectively activates liver glucokinase and in particular to provide a drug having low hypoglycemic risk for the treatment and prevention of diabetes and impaired glucose toleranc...  
WO/2014/052766
Small molecule, peptidic hepatocyte growth factors mimics, which act as both mimetics and antagonists, have been generated. These molecules have been shown or predicted to have therapeutic potential for numerous pathologies including dem...  
WO/2014/048380
A preparation method of an agomelatine solid preparation comprises: mixing agomelatine or pharmaceutically acceptable salts with cross-linked polyvinylpolypyrrolidone; hot-melting the mixture to prepare particles; and then mixing the par...  
WO/2014/052394
Pharmaceutical combinations and methods for using such combinations to treat depression are disclosed. In various embodiments (he pharmaceutical combinations include combinations of omega-3 fatty acids, pharmacological sleep agents, and ...  
WO/2014/048945
The present invention relates to BET protein-inhibiting 5-aryl triazole azepines, particularly BRD4-inhibiting 5-aryl triazole azepines of general formula (I) in which R1, R2, R3 and R4 have the meanings indicated in general formula (I)....  
WO/2014/049556
The invention relates to a method of regulating neurotrophin-tyrosine kinase receptor signalling in a cell comprising modulating the interaction between the juxtamembrane region of the intracellular domain of the neurotrophin receptor p7...  

Matches 301 - 350 out of 45,984