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Matches 351 - 400 out of 97,147

Document Document Title
WO/2014/110090A1
In one embodiment, the invention provides a method of regenerating organs and tissues in a subject suffering from one or more organ or tissue manifestations of glucose supply side associated metabolic syndrome, the method comprising: (a)...  
WO/2014/110065A1
A dual H1 inverse agonist/5-HT2A receptor antagonist of the formula: [Formula I], its uses, and methods for its preparation are described.  
WO/2014/109725A3
The present invention provides a prophylactic or therapeutic agent for depression (including each subtype according to DSM-IV of depression) or anxiety by increasing the levels of serotonin in the brain comprising administration of glycy...  
WO/2014/110185A1
Some embodiments comprise methods, systems, and compositions to promote, improve and/or increase white matter remodeling, neurite outgrowth, or neurological function in a patient in need thereof. Some embodiments also comprise the admini...  
WO/2014/109524A1
The present invention relates to a composition for protecting nerve cells, a composition for preventing or treating nerve disorders, and a health functional food for preventing or improving nerve disorders, which comprise thymoquinone an...  
WO/2014/108475A1
The present invention relates to an isolated peptide for use in the treatment of cancer consisting of 12 to 50 amino acid residues comprising - at least two beta-strands, or - at least two alpha-helices or - at least one beta-strand and ...  
WO/2014/110259A1
The present invention relates to solid state forms of JAK inhibitor (R)-2-(2-(lH-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-ylamino) -2-methyl-N-(2,2,2-trifluoroethyl)butanamide (Compound 1) including solvates, salts, co-crystals, and an amo...  
WO/2014/108168A1
The present invention provides compounds of Formula (I) for the treatment of parasitic diseases including malaria, as well as neurodegenerative diseases. Formula (I) wherein R3, R4, X and Y have the meaning given in claim 1.  
WO/2014/108899A1
The present invention relates to fluorine substituted CBD compounds, compositions thereof and uses thereof for the preparation of medicaments.  
WO/2014/110234A1
The invention relates to the use of scyllo-inositol in treating personality disorders, in particular social withdrawal, as well as pharmaceutical compositions comprising effective amounts of scyllo-inositol for treating such disorders.  
WO/2014/108514A1
Disclosed herein is a novel and stable salt of tapentadol, tapentadol maleate, its polymorphic Forms as well as processes for its preparation, pharmaceutical compositions, and preparation thereof.  
WO/2014/107794A1
The presently disclosed invention and particular invention embodiments relate to formulations, methods, procedures, and combinations thereof for treating numerous types of trauma-induced and other neurological disorders and injuries, suc...  
WO/2014/109414A1
A compound represented by general formula [1] or a salt thereof. (In general formula [1], Z1 represents a group such as N or CH; X1 represents a group such as NH; R1 represents a group such as a heteroaryl group; R2, R3, and R4 represent...  
WO/2014/109296A1
Disclosed is a compound represented by formula (1) or a salt thereof. In formula (1): X represents a residue of a compound having an activity to bind to at least one member selected from the group consisting of amyloid β protein, a tau ...  
WO/2014/110103A1
The present invention relates to compounds of Formula (Ia) and pharmaceutically acceptable salts, solvates, and hydrates thereof, that modulate the activity of the histamine H3 receptor (Ia). Compounds of the present invention and pharma...  
WO/2014/106861A1
The present, invention relates to novel the (4E)-4-(4-substituted benzylideneamino)- 2,3-dihydro-3-substituted -2-thioxothiazole-5-carbonitriles of general formula A and a process for the preparation thereof. The compounds of present inv...  
WO/2014/106660A1
The present invention relates to benzodioxane-piperidine derivatives corresponding to general formula I: in which in particular: -R1 is one or more identical or different substituent(s) on the benzene ring, each being independently a hyd...  
WO/2014/107686A1
This invention relates to the use of geranylgeranyl acetone (GGA), its isomers, and GGA derivatives in a method for for treating a disease in a subject mediated in part by miRNA-378 or miRNA-711 increased activity comprising administerin...  
WO/2014/106612A1
The present invention is directed to aminopyridine derived compounds of formula (A). The compounds are considered useful for the treatment of diseases associated with LRRK2 such a Lewy body dementia, Parkinson's disease or cancer.  
WO/2014/106622A1
The present invention relates to new 1,2,3-triazole-amine derivatives of formula (I), having affinity for sigma receptors, especially sigma-1 receptor, as well as to the process for the preparation thereof, to compositions comprising the...  
WO/2014/106988A1
The present invention relates to a method for protecting nerve cells from nerve cell death induced by kainic acid by pretreating nerve cells with anthocyanin, and to a composition comprising anthocyanin, as an active ingredient, for prot...  
WO/2014/103801A1
[Problem] To provide an OCT3 activity inhibitor having a different basic skeleton than that of conventional OCT3 activity inhibitors. [Solution] This inhibitor of organic cation transporter 3 (OCT3) contains, as an active component, an i...  
WO/2014/103475A1
The purpose of the present invention is to provide a skin-exterior anti-ageing composition for preventing or improving trouble areas upon the exterior of the skin caused by ageing and degradation such as wrinkles, fine lines, blotches, a...  
WO/2014/102417A1
The invention relates to a use of a compound of formula (I), or one of the salts thereof, wherein: R represents a linear or branched aliphatic chain selected from the group consisting of a C1-C16 saturated hydrocarbonated chain and a C2-...  
WO/2014/104171A1
The purpose of the present invention is to provide a skin-exterior anti-ageing composition for preventing or improving trouble areas upon the exterior of the skin caused by ageing and degradation such as wrinkles, fine lines, blotches, a...  
WO/2014/103481A1
Provided is a novel compound which has excellent Aβ aggregation inhibitory activity and is useful as a pharmaceutical product. A cyclic peptide comprising the amino acid sequence represented by formula (1), wherein an α-amino group at ...  
WO/2014/104757A1
The present invention relates to a compound selected from the group consisting of a compound represented by chemical formula 1, a pharmaceutically acceptable salt thereof, an ester, a prodrug, a hydrate, a solvate, and an isomer thereof,...  
WO/2014/100934A1
The compounds with enhanced permeability for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds are provided. The methods of treating disea...  
WO/2014/105666A1
Disclosed are compounds of Formula Gl (structurally represented): where "RG3" "Rd1" to "Rd4", "n", "m", "p", "W", "X", "Y", and "Z" are defined herein which compounds are antagonists of A2A receptor. Disclosed herein also are uses of the...  
WO/2014/104220A1
The objective of the present invention is to provide a method for preventing denaturation by oxygen of drugs inside a patch that is enclosed in a packaging container. The present invention is a packaging comprising a packaging container ...  
WO/2014/104414A1
This invention relates to salts and crystal forms of (S)-6-chloro-7-(1,1-dimethylethyl)-2-trifluoromethyl-2H-1-be nzopyran-3-carboxylic acid, Compound A, which is cyclooxygenase-2 inhibiter. The present invention provides a salt of compo...  
WO/2014/106050A1
This invention relates to compositions comprising lithium and methods of their use.  
WO/2014/101295A3
Disclosed is an isoxazole derivative that inhibits the activity of the Janus kinases (JAKs), the structure thereof as presented in formula I, formula II, formula IX, and formula XI. The substituent groups in the formulas are described in...  
WO/2014/102594A3
The disclosure relates to Substituted Benzimidazole-Type Piperidine Compounds of Formula (I) and pharmaceutically acceptable salts or solvates thereof, e.g., a pharmaceutically acceptable salt or solvate, wherein R1, R2, R3, Qa, W, U, A,...  
WO/2014/102090A1
The present invention concerns a pharmaceutical compound having the Formula (1), or a pharmaceutically acceptable salt thereof, for use in the prevention or treatment of a cognitive, neurodegenerative or neuronal disorder disease such as...  
WO/2014/102780A1
This invention relates to the use Pulicaria incisa (Pi) infusion for granting cells and tissues with anti-oxidative effect. The invention further relates to the use Pulicaria incisa (Pi) infusion for treating neuroinflammatory conditions...  
WO/2014/102589A1
The present disclosure relates to Quinazolin-4(3H)-one-Type Piperidine Compounds, such as those of Formule (I) and the pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, Q, Y1, Z, A, B, E, and a are as defined he...  
WO/2014/105870A1
Methods of treating an age-related disorder in a subject are provided. Aspects of the methods include administering to the subject a nucleic acid vector including a coding sequence for telomerase reverse transcriptase (TERT) and/or telom...  
WO/2014/101120A1
Disclosed are compounds of Formulae A defined herein, which have specific binding on an A2A-receptor and are useful for quantifying in vivo receptor-site occupancy of various compounds which have an affinity for binding to an A2A receptor.  
WO/2014/105620A1
Pregn-4-en-20-yn-3β-one is useful in the treatment of depressive disorders by nasal administration.  
WO/2014/102377A1
The present invention relates to compounds of the following formula (I) and/or the pharmaceutically acceptable addition salts, solvates, enantiomers, diastereoisomers thereof, as well as mixtures thereof. The subject matter of the presen...  
WO/2014/102588A3
The disclosure relates to indole-type piperidine compounds, indoline-type piperidine compounds and related piperidine-type bicyclic compounds containing a five-membered nitrogen- containing ring (e.g., pyrrole or dihydropyrrole) fused to...  
WO/2014/101373A1
Disclosed are compounds of heterobicyclo-substituted [1,2,4]triazolo[1,5-c]quinazolin-5-amine herein, which have specific binding on an A2A-receptor and are useful for quantifying in vivo receptor-site occupancy of various compounds whic...  
WO/2014/104272A1
The present invention provides a cinnamic acid amide derivative having an excellent analgesic activity. The cinnamic acid amide derivative according to the present invention is a compound that exhibits an excellent analgesic activity on ...  
WO/2014/104372A1
Provided is a novel α-halogen substituted thiophene compound which has strong LPA receptor antagonist activity and is useful as a pharmaceutical product, or a pharmacologically acceptable salt thereof. A compound represented by general ...  
WO/2014/101113A1
Disclosed are compounds of Formula (A), as defined herein, which have binding activity for an A2A-receptor and are believed to be useful for treatment or management of CNS diseases or conditions which can be treated or managed using comp...  
WO/2014/105576A1
Provided herein are compositions comprising eicosapentaenoic acid (EPA) and polar lipids (e.g., glycolipids and phospholipids), and which do not contain any docosahexaenoic acid (DHA) or esterified fatty acids.  
WO/2014/102592A3
The present disclosure relates to Oxime-Substituted Quinoxaline-Type Piperidine Compounds, such as of those of Formula (I): and the pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, R4, R20, R21, Q, Y1, Z, A, B,...  
WO/2014/102778A3
Disclosed is treatment of genetic neurodegenerative or neurodevelopmental diseases that are caused by or associated with nonsense mutations or premature termination codons using macrolides. Further disclosed are methods for identifying a...  
WO/2014/106238A1
Provided herein are heterocyclyl compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or manage...  

Matches 351 - 400 out of 97,147