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Patent Searching and Data


Matches 351 - 400 out of 45,506

Document Document Title
WO/2013/184646
The invention features methods, compositions, dosing regimens, and infusion pumps for subcutaneously infusing acidic solutions of L-DOPA prodrugs, such as esters and amides of L-DOPA, for the treatment of Parkinson's disease. The methods...  
WO/2013/184703
The present invention is directed to a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a methanesulfonylalkylnitrile compound, or a pharmaceutically acceptable salt or solvate thereof. The present inventio...  
WO/2013/182851
The present invention relates to the prophylaxis or treatment of diseases and disorders wherein a modulator of Kv3.3 channels is required, including spinocerebellar ataxia, by administering a compound of formula (I):  
WO/2013/182411
The invention relates to a novel compound of formula (I) wherein F is 19F or 18F, in free base or acid addition salt form. In its radioactive form with 18F, the compound is useuful as a marker for radioimaging of brain and peripheral ner...  
WO/2013/182850
The invention provides compounds of the general type: (Formula (I)). Said compounds being modulators of Kv3 channels and of use in the prophylaxis or treatment of related disorders.  
WO/2013/182972
The present invention relates to compounds of the formula (I) wherein Ar1, R1, R2, R3, R4a, R4b and (R5)n are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharma...  
WO/2013/184794
A method of treating of a mammalian subject suffering from an inflammatory disease or condition by administering a peripherally-restricted kappa opioid receptor agonist for reducing the inflammation is provided. The peripherally-restrict...  
WO/2013/184824
The present invention provides methods for treating or alleviating one or more symptoms of depression and/or anxiety in a subject comprising administering an effective amount of an NCAM peptide mimetic to the subject. The symptoms of dep...  
WO/2013/182638
The present invention is directed to novel inhibitors of the BACE1 enzyme. Separate aspects of the invention are directed to pharmaceutical compositions comprising said compounds and uses of the compounds to treat disorders for which the...  
WO/2013/182862
The present invention relates to the combination of the phytocannabinoid cannabidiol with therapeutic hypothermia for use in the treatment of neuroprotection or astroprotection.  
WO/2013/184202
The present application discloses benzathine and related compounds and their use as FBXO-3 inhibitors.  
WO/2013/182274
The present invention provides compounds of Formula (I) used as Amyloid beta lowering agent for the treatment of neurodegenerative diseases.  
WO/2013/182946
The present invention provides vilazodone hydrobromide, its process of preparation, pharmaceutical composition, and method of use. The present invention further provides processes of preparation of vilazodone hydrochloride using vilazodo...  
WO/2013/183494
Provided are a therapeutic agent, a treatment method and a test method for diseases associated with the activation of neutrophils. More specifically, the present invention relates to a neutrophil activation regulator comprising a histidi...  
WO/2013/184591
Provided herein are small molecules that have a neuroprotective or modulatory effect in the nervous system. The small molecules provided herein modulate dopaminergic neuronal activity. Also provided herein are methods of for the prophyla...  
WO/2013/184708
The present invention is directed to a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a ω-(arylsulfonyl)alkylnitrile compound, or a pharmaceutically acceptable salt thereof. The present invention is also...  
WO/2013/183718
Provided is a screening method with which it is possible to determine the cause of a decrease or an increase in the amount of a target protein that is expressed by a cell. One or a plurality of embodiments include: cultivation of a cultu...  
WO/2013/183985
The present invention relates to the treatment, prevention or amelioration of a cognitive impairment in a subject comprising administering to said subject a therapeutically effective amount of a hyperpolarization-activated cyclic nucleot...  
WO/2013/184209
Described herein are materials and methods of prophylaxis and therapy for subjects with (or at risk for) a neurodegenerative disorder, such as amyotrophic lateral sclerosis, Alzheimer's Disease, Parkinson's Disease and Huntington's Disease.  
WO/2013/181786
Provided in the present invention are various labdane diterpenoid compounds and derivatives thereof for use in preparation of a pharmaceutical composition for preventing or treating neurodegenerative diseases. Also provided in the presen...  
WO/2013/182906
The subject of the invention is genistein for use in non-enzymatic method of treatment and/or prevention of the lysosomal storage diseases (LSDs) i.e. diseases with the underlying defect in degradation and resulting accumulation of organ...  
WO/2013/183912
The present invention provides a method for preparing a Chrysanthemum indicum extract which can exhibit anxiety alleviation activity when orally administrated at a dosage of no more than 15mg/weight kg (based on solids in the extract). O...  
WO/2013/184902
The present invention relates to methods for the synthesis of morphine, codeine, intermediates, salts and derivatives thereof. In preferred embodiments, the invention relates to methods for improving the efficiency, steroselectivity, and...  
WO/2013/180114
According to the present invention, a hot water extract of Mycobacterium tuberculosis, the hot water extract being established as being safe for humans from the results of long clinical testing, can be used as an agent for preventing and...  
WO/2013/177922
Disclosed are a polypeptide vaccine for treating Alzheimer's Disease and a DNA vaccine and a genetic vaccine thereof. The amino acid sequence of the polypeptide is: I1e-I1e-G1y-Leu-Met-Va1-G1y-G1y-Va1-Va1-I1e-A1a or G1y-G1y-Va1-Va1-I1e-A1a.  
WO/2013/178880
The present invention concerns a non-toxic solid pharmaceutical composition for oral administration, containing one or more cysteine compounds from the group of L-cysteine, D-cysteine and N-acetyl cysteine, combined with one or more addi...  
WO/2013/178846
The invention relates to a pharmaceutical composition comprising diacetylmorphine and naloxone for oral administration, comprising diacetylmorphine or one of the pharmaceutically acceptable salts thereof, naloxone or one of the pharmaceu...  
WO/2013/180238
The present invention provides a novel therapeutic agent or prophylactic agent for dementia. The present invention provides a therapeutic agent, prophylactic agent, or the like for dementia that contains a substance such as the following...  
WO/2013/178569
The invention relates to compounds of formula I wherein A1, A2, A3, B, R1, R2, R3 and R4 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit PDE10A and can be ...  
WO/2013/181472
Provided herein are methods and compositions for the treatment of stress related, particularly post-traumatic stress disorder (PTSD) and co-morbid disorders using neuropeptide.  
WO/2013/181454
The current invention involves the use of protein lectins produced by plants including the non-toxic carbohydrate binding subunits (B subunits) of plant "AB toxins" (PTB lectins) as delivery vehicles for mobilizing associated drug substa...  
WO/2013/181618
Non-familial late-onset Alzheimer's disease (LOAD), a condition associated with the accumulation of the amyloid precursor protein- derived (APP) Abeta fragment in the brain, can be the consequence of combined genetic and environmental ri...  
WO/2013/179144
The current application relates to the use of a compound selected from the group consisting of camptothecin and its analog, 10-hydroxy camptothecin, topotecan, irinotecan, 18-beta-glycyrrhetinic acid and its analog, carbinoxolone, etopos...  
WO/2013/179910
A medicine effective in preventing and/or treating peripheral neuropathic pain, such as allodynia, caused by an anti-cancer drug treatment; wherein the medicine contains thrombomodulin as an active ingredient.  
WO/2013/181296
The present disclosure provides Diels-Alder adducts of chalcone and prenylphenyl moieties capable of modulating the activity of cannabinoid receptors, and to oligomers of flavan-3-ol capable of modulating fat absorption and storage. Such...  
WO/2013/181451
Improved methods of treating multiple sclerosis and/or psoriasis using prodrugs of methyl hydrogen fumarate are disclosed. The methods comprise administering certain prodrugs of methyl hydrogen fumarate. The methods are able to achieve h...  
WO/2013/181296
The present disclosure provides Diels-Alder adducts of chalcone and prenylphenyl moieties capable of modulating the activity of cannabinoid receptors, and to oligomers of flavan-3-ol capable of modulating fat absorption and storage. Such...  
WO/2013/179049
The invention relates to spiro derivatives, to the use of said derivatives in treating diseases and conditions mediated by modulation of voltage-gated sodium channels, to compositions containing said derivatives and processes for their p...  
WO/2013/180271
Provided are a fluorine-containing amino acid prodrug represented by general formula (I) that makes a fluorine-containing amino acid which is a group 2 metabotropic glutamate receptor agonist into a prodrug, or a pharmacologically accept...  
WO/2013/180265
Provided is a compound having an excellent JAK inhibitory activity and therefore useful as a prophylactic or therapeutic agent for autoimmune diseases (e.g., rheumatoid arthritis, psoriasis, inflammatory bowel disease, Sjogren's syndrome...  
WO/2013/180240
The purpose of the present invention is to provide a general anesthetic medicine which can prevent and/or alleviate an anesthetic-induced neuropathy in the brain (preferably the developing brain). The present invention relates to a medic...  
WO/2013/179024
The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof : (I) in which m, n, W, X, Y, Z, R1, R2, R3 and R4 are as defined in the specification, for use in the treatment or prevention of a dis...  
WO/2013/180066
The purpose of the invention is to provide a compound represented by general formula (1) having an excellent prophylactic and therapeutic effect on autoimmune disease, inflammation, allergies, and the like; the compound inhibiting at lea...  
WO/2013/178322
The present invention provide compounds of Formula (I) used as BACE inhibitors for the treatment of neurodegenerative diseases  
WO/2013/179309
The present invention relates to a new series of chemical compounds with a novel norneolignan skeleton (chemical formula I) possessing a biological activity on the central nervous system (CNS), especially memory-enhancing and acetylcholi...  
WO/2013/179153
Disclosed are compounds of formula (I) or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. Provided are also pharmaceutical compositions comprising an effective amount...  
WO/2013/181228
Fusion proteins comprising a DNA binding domain, e.g., a TAL effector repeat array or zinc finger array, and a catalytic domain comprising a sequence that catalyzes hydroxylation of methylated cytosines in DNA, and methods of use thereof.  
WO/2013/181135
The disclosure relates to quinazoline derivatives, compositions, and methods related thereto. In certain embodiments, the disclosure relates to inhibitors of NADPH-oxidases (Nox enzymes) and/or myeloperoxidase.  
WO/2013/174245
Disclosed in the present invention are a hederagenin derivative and the preparation method and uses thereof, and the general formula of the derivative is (I). The preparation method is as follows: the derivative can be obtained via acyla...  
WO/2013/177062
The present invention relates to compositions and methods for improving the safety of blood-brain barrier receptor-mediated blood-brain barrier transport.  

Matches 351 - 400 out of 45,506