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Matches 1 - 50 out of 91,197

Document Document Title
WO/2018/132372A1
Provided herein are small molecule activators of Nicotinamide Phosphoribosyltransferase (NAMPT), compositions comprising the compounds, and methods of using the compounds and compositions.  
WO/2018/130948A1
An intranasal composition as unit dosage, comprising tapentadol or a pharmaceutically acceptable salt thereof in an amount that is equivalent to about 19.3 mg tapentadol free base; and at least one nasal carrier. After intranasal adminis...  
WO/2018/130207A1
The present invention pertains to the field of pharmaceutical chemicals, and discloses a 4,4-diphenyl piperidine compound or a pharmaceutically acceptable salt thereof, a pharmaceutical composition using the same, and a use thereof. Spec...  
WO/2018/130679A1
The present invention relates to a method for reducing CD95-mediated cell motility. To identify chemicals disrupting CD95/PLCγ1 interaction, the inventors screened a chemical library of EMA/FDA-approved molecules against a protein-fragm...  
WO/2018/130213A1
Disclosed are an imidazopyrazine compound, a preparation method therefor and use thereof. Specifically, disclosed are a compound having a structure as represented by formula (I), a pharmaceutically acceptable salt, a stereoisomer or a pr...  
WO/2018/132676A1
Described are oxysterols, pharmaceutical compositions including the oxvsterols, and methods of using the oxysterols and compositions for treating diseases and/or disorders related to inflammation, such as necrotizing enterocolitis, mesen...  
WO/2018/129220A1
Disclosed herein are compositions comprising a drug such as a triptan (e.g. rizatriptan) and/or an NSAID (e.g. meloxicam) in combination with a cyclodextrin and/or a carbonate or a bicarbonate. These compositions may be orally administer...  
WO/2018/127582A2
The present invention relates to a new formulation of the oligonucleotide of SEQ ID NO:1.  
WO/2018/129261A1
Described herein are methods and compositions relating to anti-Chi3Ll antibodies, antibody reagents, and antigen-binding fragments thereof which display superior properties, e.g., high sensitivity, high specificity, high binding affinity...  
WO/2018/126304A1
The present invention discloses immediate-release red propolis microencapsulates, also called red propolis caseinates, composed of standardized red propolis hydroalcoholic tincture from the bioactive extract, a protein encapsulant, a dis...  
WO/2018/122409A1
Compositions including an fatty acid, such as an odd chain fatty acid or a very long even chain fatty acid, and salts and derivatives thereof, and methods for treatment and prophylaxis of conditions related to inflammation and conditions...  
WO/2018/121235A1
Provided is a BM23 peptide obtained by mutating and modifying BMP-2. The BM23 peptide has improved stability and duration of in vivo efficacy relative to BMP-2, can promote the differentiation of bone marrow mesenchymal stem cells into c...  
WO/2018/124216A1
The present invention pertains to a method for producing a lipid-containing extract substantially free of chlorophylls, the method including a step for obtaining a lipid-containing extract from one or more raw materials selected from the...  
WO/2018/123906A1
[Problem] To provide a composition for external use which contains a loxoprofen compound as an active ingredient, the composition being less apt to change to brown with the lapse of time. [Solution] A composition for external use which c...  
WO/2018/120035A1
A Chinese traditional medicine for connecting damaged sinews and bones comprises the following components in parts by mass: 80 to 90 parts of Chinese Polyphaga, 40 to 60parts of Chinese angelica, 20 to 30 parts of rhizome of Sichuan lova...  
WO/2018/124258A1
The present invention can provide: a prophylactic or ameliorating/therapeutic agent for chronic fatigue syndrome, idiopathic chronic fatigue and fibromyalgia, which contains a processed product of Japanese horseradish (wasabi) as an acti...  
WO/2018/119770A1
The present invention is applicable to the technical field of seleno-polysaccharide, in which use of seleno-polymannuronate (Se-PM) is provided, Se-PM being used for preparing an anti-inflammation drug or anti-inflammation health care fo...  
WO/2018/121689A1
The present invention provides a sulfonamide-aryl amide compound and a use thereof as a drug for treating hepatitis B. Particularly, the present invention provides a compound as an HBV replication inhibitor and having the structure shown...  
WO/2018/124089A1
The patch according to the present invention is provided with a support layer and a pressure-sensitive adhesive layer laminated on the support layer, wherein the support layer has a water vapor permeability of at least 400 g/m2·24hr, an...  
WO/2018/121427A1
An application of a combination of polyethylene glycol and a local anesthetic in non-narcotic analgesia. The local anesthetic is prepared into a prodrug or a sustained-release preparation; in the prodrug, a high molecular polymer, such a...  
WO/2018/120401A1
A cosmetic composition, comprising osteogenic growth peptide carbon-terminal pentapeptide, and at least one of a carrier, a diluent, and an adjuvant. The cosmetic composition can promote the proliferation of fibroblasts and the synthesis...  
WO/2018/126009A1
The present invention provides compositions and methods for reducing inflammation in the lungs of a mammal that is afflicted by a condition that leads to inflammation in the lungs. The compositions and methods described herein include ag...  
WO/2018/123968A1
In the present invention, mesenchymal stem cells cultured in a serum-free medium are used to provide a repair agent for repairing tissue damage in a living body and a method for producing said repair agent.  
WO/2018/120683A1
A multi-component injection liquid and a preparation process and a use thereof, the multi-component injection liquid being made of safflower, red peony root, Ligusticum striatum, Salvia miltiorrhiza and Angelica sinensis; the analysis of...  
WO/2018/119441A1
The present disclosure relates to bifunctional compounds, which find utility as modulators of receptor tyrosine kinase (RTK) proteins. In particular, the present disclosure is directed to bifunctional compounds, which contain on one end ...  
WO/2018/116285A1
The present disclosure is directed to compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein ring A, R1, R2, R3, X1, X2, m and n are as defined herein, which are active as modulators of retinoid-related orphan re...  
WO/2018/114786A1
The present invention relates to carboxylic acid aromatic amides compounds of general formula (I) as described and defined herein, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds...  
WO/2018/117249A1
An oral ibuprofen preparation which includes ibuprofen, magnesium oxide, and glycyrrhetinic acid and which is highly effective in mitigating the gastric-mucosa-disordering action of ibuprofen. Specifically, the oral ibuprofen preparation...  
WO/2018/119208A1
The present disclosure provides certain angular tricyclic compounds that are histone methyltransi erases G9a and/or GLP inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of G9a and/or GLP such as c...  
WO/2018/115341A1
The present invention relates to a composition consisting of or containing peptides selected from the group consisting of or containing RD2, D3, homologs having at least 50% identity and derivatives of RD2 or D3 and also polymers contain...  
WO/2018/119313A1
The presently disclosed subject matter provides compositions, kits, and methods comprising imaging agents that can detect Programmed Death Ligand 1 (PD-L1). The presently disclosed imaging agents can be used to detect diseases and disord...  
WO/2018/115069A1
The present invention relates to new compounds of formula (I): showing great affinity and activity towards the subunit α2δ of voltage-gated calcium channels (VGCC),especially the α2δ-1 subunit of voltage-gated calcium channels or dua...  
WO/2018/113201A1
A compound as represented by formula (I), or a stereoisomer, a tautomer thereof, a pharmaceutically acceptable salt thereof, a solvate thereof, or a prodrug thereof, a preparation method therefor, a pharmaceutical composition comprising ...  
WO/2018/114783A1
The present invention relates to tetrazole containing compounds of general formula (I) as described and defined herein, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufa...  
WO/2018/119115A1
Certain embodiments of the invention provide methods of ameliorating an infusion reaction in a mammal in need thereof.  
WO/2018/115965A1
In some embodiments, the invention relates to crystalline solid forms, including polymorphs and salt forms, of (S)-4-(8-amino-3-(1-(but-2-ynoyl)pyrrolidin-2-yl)imidazo[1,5 - a]pyrazin-1-yl)-2-methoxy-N-(pyridin-2-yl)benzamide. In some em...  
WO/2018/117244A1
Provided is a novel peptide that includes an amino acid sequence indicated by SEQ ID NO: 30, and inhibits protease activity.  
WO/2018/116190A1
The invention relates to topical sprayable compositions of ketorolac tromethamine, the composition comprising one or more solvents, penetration enhancer and a buffering agent. Methods of preparing such compositions are also provided. The...  
WO/2018/119284A1
The invention relates to novel heterocyclic compounds and pharmaceutical preparations thereof. The invention further relates to methods of treating or preventing cancer using the novel heterocyclic compounds of the invention.  
WO/2018/119076A1
This disclosure is directed to various compounds and methods of preparation of improved compounds that are capable of functioning as cannabinoid receptor 1 (CB1) antagonists with reduced central nervous system (CNS) side effects. The app...  
WO/2018/118947A1
The present invention provides compounds that modulate protein function, to restore protein homeostasis, including cytokine, CKla, GSPTl, aiolos, and/or ikaros activity, and cell-cell adhesion. The invention provides methods of modulatin...  
WO/2018/115381A1
The present invention relates to an extract obtained from or obtainable from Rubus idaeus, a composition comprising an extract obtained from or obtainable from Rubus idaeus, processes for providing such an extract, and methods and uses r...  
WO/2018/113888A1
A liquid cannabinoid composition (LCC) is disclosed, said liquid cannabinoid composition (LCC) comprising a vaporizer carrier liquid (VCL), and a tetrahydrocannabinolic compound and/or a cannabidiolic compound, wherein at least 95 percen...  
WO/2018/109461A1
Provided are compositions comprising a bacterial strain of the genus Blautia, for use in a method of increasing the microbiota diversity and/or inducing stability of the microbiota of a subject.  
WO/2018/109520A1
The present invention relates to a composition comprising a given Lactobacillus rhamnosus strain and a given Lactobacillus paracasei strain wherein the ratio of said given Lactobacillus rhamnosus strain to said given Lactobacillus paraca...  
WO/2018/110669A1
Disclosed is a compound of formula (I): wherein all symbols are defined in the description. Also disclosed are pharmaceutical compositions comprising the compounds, methods of making the compounds, kits comprising the compounds, and meth...  
WO/2018/109540A1
Provided herein are compositions including compounds and/or cells for treating a disease associated with Group 2 innate lymphoid cells (ILC2s), and methods of treatment.  
WO/2018/107984A1
The present invention discloses a polypeptide containing a T helper cell epitope (Th epitope), which can serve as an immunostimulant of a B cell epitope or a peptide hapten of a target antigen. The invention also discloses a polypeptide ...  
WO/2018/108971A2
The present invention relates to methods for treatment or prevention of asthma, mild intermittent asthma, mild persistent asthma, moderate persistent asthma, severe persistent asthma, eosinophilic asthma, neutrophilic asthma, steroid ref...  
WO/2018/109097A1
The invention provides novel compounds having RIP1 kinase inhibitory activity, pharmaceutical compositions including the compounds and methods of using the compounds.  

Matches 1 - 50 out of 91,197