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Matches 1 - 50 out of 90,476

Document Document Title
WO/2018/068131A1
The present invention provides substituted hydroxystilbenes compounds of the general formula I that inhibit the activities of numerous of protein kinases involving the signaling of inflammatory cytokines, therefore, the compounds can be ...  
WO/2018/071504A2
This invention generally relates to methods for the treatment of IL-23 related diseases, in particular inflammatory diseases, such as Crohn's Disease, utilizing anti-IL-23A antibodies.  
WO/2018/071741A1
The invention provides sulfoxyalkyl organonitro and related compounds, compositions containing such compounds, and methods for using such compounds and compositions to treat medical disorders, such as a neurodegenerative disorder, autoim...  
WO/2018/070406A1
The present invention provides a water-based adhesive patch which can stably contain only one of the optical isomers, S- and R-isomers, of a drug in a relatively high concentration over a long period and which has excellent tackiness and...  
WO/2018/070521A1
In one embodiment, the present invention addresses the problem of: providing an agent for inhibiting a lectin pathway and an alternative pathway; and others. In one embodiment, the present invention relates to: a fusion polypeptide conta...  
WO/2018/068296A1
Piperidine compounds of the Formular: (I) and pharmaceutically acceptable salts thereof, wherein X, Y, R 1, R 2, R 3, L, R 4, L 1, Q and R 5 are as defined herein. The compounds and pharmaceutically acceptable compositions comprising a c...  
WO/2018/068696A1
Disclosed are PEGylated sinomenine and derivative thereof and a preparation method and use of the same. The PEGylated sinomenine or derivative thereof can significantly reduce immunogenic reactions or allergic reactions, extend the half-...  
WO/2018/068282A1
Provided are compounds of formula (I),wherein R 1, Y, X 1, X 2, R 2, R 3, R 4, R 5, R 6 and m have any of the values defined in the specification and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment o...  
WO/2018/068670A1
Provided are the use of a peptide comprising an amino acid sequence YEKLLDTEI or a functional variant thereof, or a pharmaceutical composition comprising the peptide in the preparation of a drug for preventing, alleviating or treating pa...  
WO/2018/069525A1
The present invention provides a novel class of dithiocarbamate-metal complexes and their uses in medicine. Also provided by the invention are combinations and pharmaceutical compositions, comprising a dithiocarbamate (or thiuram disulph...  
WO/2018/071893A1
Methods of treating neuropathic pain in spinal cord injured individuals by administering levetiracetam or brivaracetam are described.  
WO/2018/071314A1
There are described RORγ modulators of the formula (I), and formula (II) or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein all substituents are defined herein. Also provided are pharm...  
WO/2018/067705A1
Various embodiments of this invention are directed to pharmaceutical compositions and methods for treating disease. The compositions of such embodiments include thiolated nitro fatty acids. The methods of various embodiments include admi...  
WO/2018/067432A1
Compounds of formula I or a stereoisomer or pharmaceutically-acceptable salt thereof, are useful in the modulation of IL-12, IL-23 and/or IFNa, by acting on Tyk-2 to cause signal transduction inhibition. The compounds of formula I are us...  
WO/2018/065697A1
The invention relates to an aqueous composition for stimulating the immune system with a view to preventing at least one of the diseases caused by the invasion of one or more pathogenic agents through the skin, the eye or a mucous membra...  
WO/2018/066676A1
The present invention addresses the problem of examining the physiological activity of selenoneine which is an organic selenium compound and thus finding novel uses thereof. To solve this problem, provided are a composition comprising an...  
WO/2018/067709A1
Various embodiments of this invention are directed to pharmaceutical compositions and methods for treating disease. The compositions of such embodiments include reversible nitroxide derivatives of nitroalkenes. The methods of various emb...  
WO/2018/067200A1
Compositions are described including a synergistic combination of hydroxytyrosol and 3-0-acetyl-11-keto-β-boswellic acid. The hydroxytyrosol may be sourced from an olive extract and the 3-0-acetyl-11-keto-β-boswellic acid may be source...  
WO/2018/064797A1
A crystal form of ACP-196, a preparation method of the crystal form, a pharmaceutical composition thereof and use of the crystal form in the preparation of drugs for treatment and/or prevention of Bruton's tyrosine kinase (BTK)-mediated ...  
WO/2018/059331A1
The present invention relates to a polyamide compound and a use thereof; specifically, the present invention relates to a type of polyamide compound (which preferably contains one or more amide bonds formed by the condensation of same or...  
WO/2018/060174A1
The invention relates to substituted benzimidazoles of formula (I), to the use thereof for treating and/or preventing diseases, and to the use thereof for producing drugs for treating and/or preventing diseases, in particular for treatin...  
WO/2018/062413A1
The present invention provides: nucleic-acid-containing lipid nanoparticles that include a lipid (lipid A) having a hydrophilic moiety that has one quaternary ammonium group and having three independently optionally substituted hydrocarb...  
WO/2018/064373A1
In one aspect, methods of treating non -alcoholic steatohepatitis (NASH) or preventing or delaying the progression of non-alcoholic fatty liver disease (NAFLD) to NASH are provided. In some embodiments, the method comprises administering...  
WO/2018/060528A2
A deflamin polypeptide composition for use in a method of treatment of the human or animal body by therapy wherein the therapy is preferably preventing or treating inflammation or cancer, or providing a nutraceutical.  
WO/2018/059429A1
The invention relates to non-solvated crystals A, B and C of N-(2-aminophenyl)-6-(7-methoxyquinoline-4-oxy)-1-naphthamide and preparation methods thereof. The invention also relates to pharmaceutical compositions containing the crystals...  
WO/2018/064633A1
This disclosure provides methods and compositions for treating diseases and disorders by targeting ILC2s that express the α7-nicotinic acetylcholine receptor (α7nAChR).  
WO/2018/062382A1
Provided are novel crystals of [2-(1-methyl-1H-pyrazol-4-yl)-6-(morphlin-4-yl)-9H-purin-8-y l][4-(morpholin-4-yl)piperidin-1-yl]methanone and a pharmaceutically acceptable salt thereof having advantageous characteristics. [2-(1-Methyl-1H...  
WO/2018/059533A1
Disclosed is a class of pyrazole compounds of formula (I) having a p38α inhibitory effect, and included are uses of the compounds in the field of p38α-related diseases, such as various inflammatory diseases and immunological abnormalit...  
WO/2018/055058A1
A pharmaceutical composition comprising polyunsaturated long-chain ketones and a silicone vehicle or a blend of silicone vehicles. The composition has utility in the treatment and prevention of inflammatory conditions including skin diso...  
WO/2018/057808A1
The present application provides the compounds of formula I or IA or pharmaceutically acceptable salts, isomers, tautomer, or a mixture thereof, wherein s, t, m, n, R1, R2, R3, R4, R5, R6 and R7are as described herein. The compounds of f...  
WO/2018/057810A1
The present application provides the compounds of formula I or pharmaceutically acceptable salts, isomers, tautomer, or a mixture thereof, wherein s, t, n, R1, R2, R3, R4, R5, and R6 are as described herein. The compounds of formula I se...  
WO/2018/056269A1
These eye drops contain (3S, 4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazine-8-yl) -N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxylic acid amide or a salt thereof, and have a pH of 4.0 to 9.0.  
WO/2018/056123A1
Disclosed is a composition containing enzyme-decomposed royal jelly granules and zein, the composition serving as a food item, a pharmaceutical item, or a quasi-drug.  
WO/2018/056268A1
Provided is an agent for the treatment and/or prevention of inflammatory eye disorder, containing (3S, 4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazine-8-yl) -N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxylic acid amide or a salt th...  
WO/2018/057858A1
Molecular determinants of cancer response to immunotherapy are described, as are systems and tools for identifying and/or characterizing cancers likely to respond to immunotherapy.  
WO/2018/057669A1
Provided herein, inter alia, are isolated antibodies that bind an extracellular domain of a human SIRP-α v1 polypeptide (e.g., the D1 domain), an extracellular domain of a human SIRP-α v2 polypeptide, or both. In some embodiments, the ...  
WO/2018/054932A1
The present invention provides a pharmaceutical composition comprising 1-perfluorohexyl-octane (F6H8) for use in the therapy, treatment, prevention or amelioration of anterior or posterior blepharitis, preferable posterior blepharitis or...  
WO/2018/053618A1
There is described herein a method for culturing mesenchymal stromal cells (MSCs) comprising: a) providing a population comprising mesenchymal stromal cells; and b) enhancing the population under conditions that allow the MSCs to loosely...  
WO/2018/057199A1
Negatively charged nanoparticulate compositions are used to deliver therapeutic, prophylactic or diagnostic agents to macrophages or other phagocytic cells in the brain and central nervous system. The negative charge of the nanoparticles...  
WO/2018/055388A1
The invention relates to compositions and uses thereof in methods for treating an inflammatory disease, disorder or condition in a subject, in particular an inflammatory disease, disorder or condition of the digestive tract such as infla...  
WO/2018/057805A1
The present application provides the compounds of formula I or pharmaceutically acceptable salts, isomers, tautomer, or a mixture thereof, wherein t, R1, R2, R3, R4, and R6 are as described herein. The compounds of formula I selectively ...  
WO/2018/058144A1
This invention is directed to the use of a SHIP1 activator, preferably AQX-1125, to treat prostatitis.  
WO/2018/055578A1
What is described is a method of preventing, ameliorating and/or treating disorders or diseases associated with integrated stress response (ISR) involving the p-eIF2α pathway arising from various cellular stresses such as oxidative stre...  
WO/2018/057588A1
Disclosed are chemical entities which are compounds of Formula (I): (I) and pharmaceutically acceptable salts thereof, wherein A, R1, R2, E, n and Z are as defined herein. These chemical entities are useful as inhibitors of the PAR-2 sig...  
WO/2018/053645A1
The present document describes methods and uses of compositions which comprise at least one photoactivator or chromophore in association with a pharmacologically acceptable carrier for use in reducing pain that is associated with a medic...  
WO/2018/055082A1
The present invention relates to an inhibitor of GPR132 for use in preventing and/or treating chemotherapy-induced neuropathic pain in a subject. Also encompassed by the invention are a pharmaceutical composition comprising an inhibitor ...  
WO/2018/057737A1
The invention relates to methods for treating symptoms of PMS and PMDD including muscle ache, bloating, cramping, acne, tender breasts, bloating, fatigue, difficulty concentrating, diminished impulse control, irritability, anxiety, tensi...  
WO/2018/053190A1
The application provides methods of treating or reducing thrombocytopenia, leukopenia, anemia, or neutropenia in a patient in need thereof, comprising the step of administering an effective amount of a compound selected from Compounds 1-...  
WO/2018/052058A1
The present invention provides: a heterocyclic compound which has an IRAK-4-inhibiting activity and is expected to be useful for the prevention/treatment of inflammatory diseases, autoimmune diseases, osteoarticular degenerative diseases...  
WO/2018/052936A1
Provided herein are therapeutic acrylate compounds useful as medical adhesives, comprising a therapeutic agent covalently linked to a methacrylate or cyanoacrylate moiety. Adhesive compositions and kits, such as liquid sutures and bone c...  

Matches 1 - 50 out of 90,476