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Matches 1 - 50 out of 92,024

Document Document Title
WO/2018/189683A1
The present invention refers to benzofuran derivatives, capable of efficaciously activating the enzymatic complex AMPK, useful for the prophylaxis and therapeutic treatment of diseases and disorders in particular metabolic disorders such...  
WO/2018/191357A1
The present invention relates to a pre-filled syringe containing Moxifloxacin and comprising a plunger, a barrel, a needle with gauge, kits comprising this syringe and the use of the syringe for the administration of Moxifloxacin for pos...  
WO/2018/188197A1
The present invention relates to the field of wound healing formulations, and provides an antibacterial and anti-inflammatory drug and a preparation method therefor. The antibacterial and anti-inflammatory drug is prepared from the follo...  
WO/2018/187838A1
Provided herein are methods for treating or preventing inflammation, or an inflammatory or autoimmune condition, methods for treating or preventing a skin or nail condition or infection, methods for treating or preventing symptoms of gas...  
WO/2018/191367A1
The present disclosure provides methods, pharmaceutical compositions, dosing regimens, and kits comprising 4,4'-trans-dihydroxystilbene (DHS), including methods of treating cancer in a subject and methods of decreasing or reversing resis...  
WO/2018/188643A1
Relating to an opioid receptor agonist (1S,4S)-4-ethoxy-N-(2-((R)-9-(pyridin-2-yl)-6-oxaspiro[4.5]d eca-9-yl)ethyl)-1,2,3,4-tetrahydronaphthalen-1-amine fumarate salt, a fumarate salt I crystal form thereof, and a preparation method and ...  
WO/2018/191732A1
Compounds, compositions, and methods for treatment of, or prophylaxis against, inflammation and/or oxidative stress are disclosed.  
WO/2018/190713A1
The invention relates to a specific inhibitor of FAM173B mitochondrial lysine methyltransferase for use as a medicament, more specifically for use in a method of treatment of chronic pain. The invention further relates to a pharmaceutica...  
WO/2018/189340A1
The present invention relates to novel benzohydroxamic compounds of formula (I) and (II) and pharmaceutically acceptable salts, isomers and prodrugs thereof, exhibiting a high selective inhibitory activity against histone deacetylase 6 (...  
WO/2018/186421A1
The present invention addresses the problem of providing a cell population which includes mesenchymal cells showing low cell aggregation and is useful for the intravenous administration of a cell preparation, a production method therefor...  
WO/2018/187228A1
Biomarkers to screen for, identify, and/or characterize lung cancer in a subject are disclosed. Also disclosed herein are methods for distinguishing lung cancer from another disease. Also disclosed herein are methods for detecting metast...  
WO/2018/187509A1
Disclosed herein, inter alia, compounds of formula (I) and methods of use thereof for the modulation of CCR4 activity.  
WO/2018/184059A1
There are described methods for the prophylaxis or treatment of pain in a mammal wherein the method comprising administering to the mammal an effective amount of a pain inhibitor comprising a pain inhibiting peptide having an amino acid ...  
WO/2018/187652A1
The present invention relates to 2,4-diaminopyrimidines of formula (I) and pharmaceutically acceptable salts thereof, purification methods for the same, pharmaceutical compositions containing them, methods of obtaining and using them for...  
WO/2018/186418A1
The present invention addresses the problem of providing a cell population which includes attached cells derived from fetal appendages and has a low differentiation potential, a production method therefor, and a pharmaceutical compositio...  
WO/2018/185347A1
The invention relates to a pharmaceutical composition based on an aqueous solution of chlorine dioxide adapted as a solution for rectal intestinal lavage, as a solution for ureteral and bladder lavage or as an isotonic injection or infus...  
WO/2018/185236A1
The invention relates to sulfonamide derivatives of formula (I), the pharmaceutically acceptable addition salts thereof, the hydrates and/or solvates thereof, and the use of same as inverse agonists of the RORγt retinoid-related orphan ...  
WO/2018/185675A1
The present disclosure is directed to compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein ring A, R1, R2, R3, R4, L and m are as defined herein, which are active as modulators of retinoid-related orphan recept...  
WO/2018/183685A1
The disclosure provides methods of making a tetracycline inducible expression system in a cell. The methods include providing the cell with a first nucleic acid sequence comprising a first promoter operably linked to a tetracycline repre...  
WO/2018/183656A1
Disclosed is crystalline Form A of 6-(cyclopropanecarboxamido)-4-((2-methoxy-3-(1-methyl-1H-1,2 ,4-triazol-3-yl)phenyl) amino)-N-(methyl-d3)pyridazine-3-carboxamide. Form A is a neat crystalline form. Characterization data for Form A are...  
WO/2018/181638A1
Provided is a novel long-lasting adrenomedullin derivative that is capable of substantially inhibiting an undesired side reaction while maintaining the pharmacological effect of adrenomedullin. One embodiment of the present invention per...  
WO/2018/183122A1
Described herein are ASK1 inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders ass...  
WO/2018/180727A1
Provided is a method for producing a fucose-containing composition, the method being capable of producing fucose, from various raw materials containing polysaccharides having fucose as a portion of constituent sugars, at low cost regardl...  
WO/2018/183151A1
The present invention relates to topical compositions containing a therapeutically effective amount of tetrahydrocannabinol. The compositions are useful for treating a patient suffering from conditions such as pain and pruritus, particul...  
WO/2018/183649A1
The invention relates to an improved process for synthesizing 6-(cyclopropaneamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-tri azol-3-yl)phenyl)amino)-N-(methyl-d3)pyridazine-3-carboxamid e of the formula: [INSERT CHEMICAL STRUCTURE HERE] Co...  
WO/2018/176648A1
Disclosed is health-promoting wine, characterized in that the wine is prepared with the following ingredients: 400-600 g of grape wine, 30-60 g of a bamboo fruit, 8-24 g of Semen Hydnocarpi, 20-40 g of Radix Astragali, 1-10 g of Radix Ac...  
WO/2018/181456A1
Provided is a compound represented by the formula, or a salt thereof, the compound having RORγt-inhibiting activity and being useful as a prophylactic or therapeutic agent for autoimmune or allergic diseases.  
WO/2018/176645A1
A medicinal sausage, prepared with the following ingredients: 500-1000 g of meat, 30-60 g of a bamboo fruit, 8-24 g of Semen Hydnocarpi, 20-40 g of Radix Astragali, 1-10 g of Radix Achyranthis Bidentatae, 10-30 g of Rhizoma Gastrodiae, 1...  
WO/2018/183782A1
Provided herein are compounds, pharmaceutical compositions comprising the compounds, methods of preparing the compounds, and methods of using the compounds and compositions in treating conditions associated with voltage-gated sodium chan...  
WO/2018/177376A1
Provided are a viral vector for treating an autoimmune disease and diabetes and a construction method and an application thereof. The viral vector is a lentiviral expression plasmid or an adeno-associated viral expression plasmid cloned ...  
WO/2018/183411A1
Compounds of formula (I) as inhibitors of DCNl and compositions containing the same are disclosed. Methods of using the DCNl inhibitors in the treatment of diseases and conditions wherein inhibition of DCNl provides a benefit, like oxida...  
WO/2018/180728A1
The present invention addresses the problem of providing a composition for promoting the expression of an antiinflammatory gene and a composition for inhibiting the production of an inflammatory cytokine. A means for solving the problem ...  
WO/2018/176640A1
Disclosed is a medicinal porridge, prepared with the following ingredients: 200-300 g of cornmeal, 10-15 g of xylitol, 30-60 g of a bamboo fruit, 8-24 g of Semen Hydnocarpi, 20-40 g of Radix Astragali, 1-10 g of Radix Achyranthis Bidenta...  
WO/2018/176149A1
Disclosed is a method of administration and device for the improved bioavailability of leukotriene receptor antagonists. This method and device involve an alkaline surface pH oral film dosage form designed to deliver leukotriene receptor...  
WO/2018/171405A1
Provided is a hydrophis cyanocinctus venom-derived selective TNFR1 antagonist peptide Hydrostatin-SN10 which has an amino acid sequence as shown in SEQ ID NO: 2. Selective modification is realized by means of covalent linkage of carboxyl...  
WO/2018/171411A1
Disclosed in the present invention are a fusion protein, a preparation method therefor and an application thereof in preparing a ophthalmic disease treatment, anti-inflammation and anti-tumor medicament, which relate to the technical fie...  
WO/2018/171816A1
Disclosed in the present invention are a deuterated dipeptide boronic acid or an ester compound thereof, or a crystalline form, pharmaceutically acceptable hydrate or solvate thereof, the structure thereof being shown in formula (a), whe...  
WO/2018/170762A1
Provided are an RNAi expression vector of TNLG5A gene, a construction method therefor, and an application thereof. Provided are: an isolated polynucleotide having a sequence as shown in SEQ ID NO:1; a vector containing the polynucleotide...  
WO/2018/174141A1
The purpose of the present invention is to provide a regulatory T cell-increasing agent that is capable of sufficiently increasing regulatory T cells at a lower dose while reducing restrictions on storage conditions and dosing form. A re...  
WO/2018/171410A1
Provided are a fusion protein, a preparation method therefor and a use thereof. A flexible linker is used to fuse RGD-endostatin active fragment with immunoglobulin Fc fragment, which improves the drug efficacy, prolongs the half-life an...  
WO/2018/172206A1
Compounds of formula (I) wherein Base1 and Base2 are defined as in claim 1 are modulators of STING.  
WO/2018/172950A1
The present relates to the sodium salt of (S)-2-(diphenylacetyl)-1,2,3,4-tetrahydro-6- methoxy-5-(phenylmethoxy)-3-isoquinolinecarboxylic acid (EMA401) in anhydrous crystalline forms. The present invention also discloses methods of using...  
WO/2018/170764A1
Provided are: a GP34-RNAi sequence and a recombinant vector containing the sequence, the GP34-RNAi sequence being as shown in SEQ ID NO:1; a recombinant vector containing a sequence as shown in SEQ ID NO:2; and an RNA interference vector...  
WO/2018/172129A1
The invention relates to sialic acid derivatives of formula (I) which contain a C-C triple bond, methods for the preparation thereof, conjugates produced therefrom and drugs containing same, wherein the symbols have the meanings defined ...  
WO/2018/175707A1
The invention provides 4-piperidin-chroman-7-sulfonamide derivatives and salts thereof that are sodium channel modulators, as well as compositions containing such a compound or salt and therapeutic methods for using such a compound, salt...  
WO/2018/170386A1
This disclosure relates to extended-release fluticasone propionate (FP) formulations that include small microparticles and/or nanoparticles and methods of using these extended-release FP formulations for treating pain and/or inflammation...  
WO/2018/169853A1
Compounds, compositions, and methods for treatment and/or prevention of at least one disease, disorder, and/or condition by inhibiting binding of an E-selectin to an E-selectin ligand are disclosed. For example, E-selectin antagonists ar...  
WO/2018/168818A1
The present invention relates to tetrahydroquinoline derivatives of the present invention or a pharmaceutically acceptable salt thereof or a prodrug thereof, processes for their preparation, pharmaceutical compositions containing them an...  
WO/2018/168920A1
The present invention pertains to a composition for treating joint diseases and a kit including the same, and the purpose of the present invention is to provide a composition for treating joint diseases which can be used in patients with...  
WO/2018/169811A1
Provided herein are methods and compositions, such as kits, related to compositions comprising synthetic nanocarriers comprising an immunosuppressant and compositions comprising an uricase and a composition comprising an anti-inflammator...  

Matches 1 - 50 out of 92,024