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Matches 1 - 50 out of 15,301

Document Document Title
WO/2018/068114A1
The present invention relates to a combination of the drugs curcumin (Cur), which is a natural polyphenol, and sodium diethyldithiocarbamate (DETC), or its precursor disulfiram (DS), which exhibits synergistically increased antimalarial ...  
WO/2018/068090A1
The present invention relates generally to the field of glycanics and its application to the generation of glycoconjugates for therapeutic use. The present invention also relates to process for the preparation of glycoconjugates.  
WO/2018/069420A1
The present invention is related to new trioxolane derivatives in the manufacture of a medicament for preventing or treating malaria. Specifically, the present invention is related to trioxolane derivatives useful for the preparation of ...  
WO/2018/071741A1
The invention provides sulfoxyalkyl organonitro and related compounds, compositions containing such compounds, and methods for using such compounds and compositions to treat medical disorders, such as a neurodegenerative disorder, autoim...  
WO/2018/071836A1
Disclosed are compounds of formula (I) and formula (II): (I) (II) wherein R1, R2, A, and B are as defined herein. Also disclosed is a method of blocking transmission of a Plasmodium parasite and a method of treating or preventing malaria...  
WO/2018/070502A1
There has been a demand for the development of a novel pesticide for agricultural and horticultural use for reasons such that pests still cause extensive damage on the production of agricultural and horticultural crops and the like and p...  
WO/2018/070503A1
In crop production such as agriculture and horticulture, damage by pests and the like is still significant, and development of a novel agricultural and horticultural insecticide is desired due to factors such as the appearance of pests t...  
WO/2018/065809A1
The present invention relates to pharmaceutical compositions that can be used for the treatment of trichomoniasis, which comprise compounds with the chemical structure and which also exhibit a synergic effect and do not have the typical ...  
WO/2018/060423A1
The invention relates to novel compounds which are naphthalene diimide sugar conjugates of general formula (I) and its procedure of obtainment. The compounds of the invention are used in therapy; particularly they have shown antiprolifer...  
WO/2018/061006A1
The invention relates to cell preparations comprising dendritic cell (DC) sub- populations, methods of obtaining such cell preparations, and the use of such preparations for improved immune and cancer therapy. More specifically, embodime...  
WO/2018/062246A1
Provided is a method for controlling microsporidia or myxosporea in marine fishes (particularly cultured fishes) with an oral administration agent. A control agent for "Beko" disease or a myxosporean disease mediated by microsporidia par...  
WO/2018/062082A1
The purpose of the present invention is to provide a mesoionic compound, which exhibits an improved controlling effect on various harmful organisms, or a salt thereof. A mesoionic compound represented by formula (1) (wherein: R1 is selec...  
WO/2018/060483A1
The invention relates to compounds characterized by a general formula (1), wherein OM is an organometallic compound. OM is independently selected from the group of an unsubstituted or substituted metal sandwich compound, an unsubstituted...  
WO/2018/063472A1
This disclosure is directed to pharmaceutical, compositions for treating a parasitic disease, comprising Praziquantel or its analogues aid an extract isolated from Schisandra chinensis. The parasitic disease is susceptible to treatment w...  
WO/2018/050815A1
The present invention relates to a compound of formula (I), in which R' represents a -(CRaRb)n-X-(CRcRd)m-[Y-(CReRf)o]t-NR9R10 group, and X and Y independently represent a -NR11- group, an –O- group or a divalent heterocyclic group com...  
WO/2018/050814A1
The present invention relates to a compound of formula (I), in which R' represents a –(CRaRb)n-X-(CRcRd)m-[Y-(CReRf)o]t-NR9R10 group, and X and Y independently represent a -NR11- group, an –O- group or a divalent heterocyclic group c...  
WO/2018/049459A1
Apicomplexan parasites or red blood cells infected with apicomplexan parasites are administered to an animal in combination with a delayed death agent that initially allows parasite replication but subsequently kills the apicomplexan par...  
WO/2018/051291A1
The present technology relates to vaccine compositions comprising at least one of the nine peptides defined by SEQ ID NO 1-9, capable of stimulating the development of a T helper 1 (Th1)-type cell immune response with high production of ...  
WO/2018/049124A1
This disclosure is directed to immune treatment of a disease (e.g., an infectious disease) using a fusion protein in combination with an anti-chemorepellant agent. In particular, the fusion protein comprises an antigen-binding domain (e....  
WO/2018/046584A1
The invention is related to a cheap, efficient and low-environmental impact method for the preparation of highly pure 4-bromothymol, that can be obtained by the catalytic oxidative bromination of thymol. The oil obtained as product from ...  
WO/2018/049184A1
Suspensions of metronidazole or baclofen and/or salts or ester derivative thereof, such as metronidazole benzoate, are disclosed. The suspension may include metronidazole or baclofen, and/or a salt or ester derivative thereof a hydrocoll...  
WO/2018/041942A1
Embodiments of the invention are directed to new polymer linked multimeric guanosine-3', 5'-cyclic monophosphate (cGMP) analogues that modulate the cGMP-signaling system, preferably having activating properties, and more preferably being...  
WO/2018/043597A1
The development of novel agricultural/horticultural insecticides is desired due to damage by pests and the like continuing to be a major issue, the evolution of pests resistant to existing chemicals, and other such factors in crop produc...  
WO/2018/043400A1
A compound represented by formula (I) or a salt thereof. In formula (I), each of R1 and R4 independently represents a hydrogen atom, an unsubstituted or substituted C1-6 alkyl group or the like; R2 represents a hydrogen atom, an unsubsti...  
WO/2018/043675A1
The present invention addresses the problem of developing and providing a novel pesticide for agricultural and horticultural use for reasons such that there is still extensive damage on the production of agricultural and horticultural cr...  
WO/2018/037386A1
A method for treating or preventing protozoan parasite infection comprising administering to a mammal in need thereof naltrexone or a pharmaceutically acceptable salt thereof alone or in combination with one or more anti-protozoal agents...  
WO/2018/037343A1
The present technology relates to vaccine compositions for the treatment and/or prevention of visceral leishmaniasis in mammals, comprising six synthetic peptides that are free or expressed in the surface of non-infectious bacteriophages...  
WO/2018/034227A1
Provided is an anti-LAG-3 antibody that can be frequently administered to a non-rat animal. The anti-LAG-3 antibody comprises: (a) an L chain comprising an L-chain variable region that includes CDR1 having a QSLLDSDGNTY (SEQ ID NO. 16) a...  
WO/2018/027252A1
Disclosed are compounds for use in modulating immune responses. More particularly, the present invention discloses oligomeric forms of PD-L2 for use in modulating Th1 immune responses. The compounds of the present invention find utility ...  
WO/2018/023182A1
The present invention discloses red propolis extract-loaded nanospheres (RPNs), composed of standardized hydroalcoholic extract of red propolis originating from red propolis in its natural form, and of polymeric matrices having a functio...  
WO/2018/018121A1
The present invention relates to the composition comprising the peptide as defined in SEQ ID NO: 1, 3, 4 or 5 and a pharmaceutically acceptable carrier. The present invention further relates to the use of a peptide as defined in SEQ ID N...  
WO/2018/023111A1
Provided herein are γδ T cell suppressors and methods of using such in detecting and treating solid tumors, as well as detection of solid tumors such as PDA or CRC based on the level of γδ T cells.  
WO/2018/021400A1
The present invention relates to a medicine for treating cancer or an infectious disease, said medicine comprising a combination of an immune check point inhibitor with an adjuvant composition. More specifically, the present invention re...  
WO/2018/015940A1
The present application relates to the use of bacterial CNF (Cytotoxic Necrotizing Factor) and/or DNT (dermonecrotic toxin) as active ingredients or active ingredient for the prevention and/or the treatment of malaria caused by Plasmodiu...  
WO/2018/014473A1
Provided is a compound artesunate pharmaceutical composition for pet dogs and pet cats. The composition is prepared with the following raw materials (in parts by weight): artesunate (0.3-3), artemether (0.2-2), halofuginone extract (5-15...  
WO/2018/015595A3
The present invention relates to a family of compounds which are effective against parasites of the genus Leishmania, preferably caused by L. infantum, L. major or L. tropica, and which have low toxicity, even at high doses of the compou...  
WO/2018/010965A1
Embodiments of the invention are directed to new equatorially modified polymer linked multimers of guanosine-3', 5'-cyclic monophosphate (cGMP) analogues that inhibit the cGMP-signaling system. The invention is also directed to related m...  
WO/2018/008727A1
The present invention provides a heterocyclic compound that exhibits a superior control against harmful arthropods and that is represented by formula (I): (I) [in the formula, Q1 represents an oxygen atom or the like; Q2 represents an ox...  
WO/2018/003924A1
Provided is a novel pest control agent, especially a bactericide or a nematicide. An alkynylpyridine-substituted amide compound represented by formula (I) or a salt thereof; and a pest control agent which contains the compound or the sal...  
WO/2018/003976A1
In agricultural and horticultural crop production, etc., damage by pests and the like remains devastating even today, and due to factors such as the occurrence of pests resistant to existing chemicals, there is a demand for the developme...  
WO/2017/220517A1
The invention relates to a compound of formula (I) wherein R1 to R4 and n are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.  
WO/2017/221158A1
The present invention relates to a nanoparticle composition comprising one or more β-triketones selected from leptospermone, isoleptospermone, grandiflorone and flavesone, together with a carrier.  
WO/2017/222996A1
Provided herein are compounds, compositions and method of using thereof to treat or prevent malaria.  
WO/2017/214683A1
The present invention provides a method for the treatment or prophylaxis of an ectoparasitic infestation, the method comprising the step of: contacting an external surface of an animal in need thereof with an effective amount of a berber...  
WO/2017/211909A1
The invention concerns a lipid composition that is self-emulsifying in the presence of a hydrophilic phase, comprising between 0.001% and 20% by weight, relative to the total weight of the composition, of at least one active substance; b...  
WO/2017/212239A1
The present invention provides a sulphur-containing compound for use in the prophylaxis or treatment of an infection associated with at least one microbe or microbial strain displaying at least some degree of drug resistance. Also provid...  
WO/2017/214076A1
The present invention describes rhomboid protease inhibitors having high specificity and inhibition characteristics providing novel antibiotics, anti-malarial pharmaceutical agents, and provides a strategy for designing RiBns (rhomboid-i...  
WO/2017/210262A1
The present invention targets the Zika virus and other disease-causing microbes including viruses, bacteria, fungi, and parasites. It does this using agents and methods with little toxicity compared to existing therapies.  
WO/2017/205464A1
Disclosed are compounds of Formula (I), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders...  
WO/2017/198178A1
A thiazole derivative serving as a DHODH inhibitor, and applications thereof. The present invention specifically relates to a compound represented by formula I, a pharmaceutical composition containing the compound represented by formula ...  

Matches 1 - 50 out of 15,301