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Matches 1 - 50 out of 163,717

Document Document Title
WO/2018/010441A1
Provided are a series of Chinese medicine healthcare preparations for slimming and weight loss prepared from basic active pharmaceutical ingredients consisting of rose flower, soybean protein isolate, konjac flour, soybean oligosaccharid...  
WO/2018/012578A1
The present invention addresses the problem of providing a novel, safe, and side-effect-free ghrelin secretion promotor capable of enhancing the ghrelin secretory function present in the human body, wherein the promotor is provided in th...  
WO/2018/010588A1
A therapeutic agent for restoring body function aging and delaying organ function decline, and particularly a therapeutic agent comprising mesenchymal stem cells, especially stromal cells having positive expression of GD2 and hematopoiet...  
WO/2018/013053A1
The invention relates to an ELABELA polypeptide or nucleic acid for use in the treatment, alleviation or prophylaxis of pre-eclampsia in an individual. In another aspect of the invention, there is provided a method of diagnosing or detec...  
WO/2018/013871A1
Compositions, e.g., pharmaceutical compositions, nutritional compositions, medical foods, and food ingredients, as well as their methods of use, are provided, for modulating exogenous substances, enzyme activities, and drug activities.  
WO/2018/010516A1
A method for modulating a methylation/demethylation state of a nucleic acid, more specifically, a method for site-removing one or more methylated bases from a genome guided by a sgRNA sequence in a cell.  
WO/2018/012004A1
[Problem] The purpose is to provide a "functional agent having a dynapenia-suppressing function" having as an active ingredient components isolated and obtained from leaves or flowers of a specific plant raw material by a specific method...  
WO/2018/012497A1
The present invention mainly addresses the problem of providing a novel and specific knockout model animal that presents a symptom of a disease accompanied by a synapse abnormality in the brain, a method for producing same, and a therape...  
WO/2018/012441A1
Provided are an anticancer agent, radiosensitizer, and food composition capable of heightening the effects of radiation therapy. The present inventors discovered that tumors shrink significantly in comparison to an untreated group and th...  
WO/2018/006646A1
Provided is a decoction for tonifying the kidney, promoting the blood circulation and soothing the liver. The decoction is prepared with Radix bupleuri, white peony root, Cuscuta chinensis, Acorus gramineus, Eucommia ulmoides, Angelica s...  
WO/2018/008750A1
Provided are a method for screening agents for the prevention or treatment of diseases caused by interleukin 6, interleukin 13, TNF, G-CSF, CXCL1, CXCL2, or CXCL5 and an agent for the prevention or treatment of diseases caused by interle...  
WO/2018/007871A1
Materials and methods for treating a patient with Transthyretin Amyloidosis, both ex vivo and in vivo, are provided, and materials and methods for modulating the expression, function, or activity of a Transthyretin (TTR) gene in a cell b...  
WO/2018/008569A1
Provided is an industrially advantageous method for producing a compound (1), specifically a compound (1) in an amorphous form. A method for producing a calcium salt of a 1, 5-benzodiazepine compound represented by formula (1), which is ...  
WO/2018/008219A1
The present invention provides: a method for producing an amidoxime compound, wherein a nitrile compound and hydroxylamine and/or an acid salt of hydroxylamine are reacted with each other in a reaction solvent that contains an alcohol ha...  
WO/2018/008470A1
Provided is an SIRPα-targeting antitumor agent which inhibits the binding of CD47 to SIRPα and exerts an improved antitumor effect. Also provided is an antitumor agent which is capable of more effectively exerting an antitumor effect w...  
WO/2018/008711A1
The present invention addresses the problem of discovering an effective cancer therapy method and providing a medicine. Provided is a medicine comprising a combination of a compound represented by general formula (I), a salt, solvate or ...  
WO/2018/003962A1
2- (Piperidin-1-yl) pyrimidin-4 (3H) -ones characterized by having a 1,8-diazaspiro [4.5] deca-3-ene, 1-oxa-8-azaspiro [4.5] deca-3-ene, 2,8-diazaspiro [4.5] deca-3-ene, 2-oxa-8-azaspiro [4.5] deca-3-ene, 2,9-diazaspiro [5.5] undeca-3-en...  
WO/2018/000047A1
The present invention relates to the use of substituted quinoline compounds for treating immunoglobulin light chain (LC) amyloidosis (AL), especially cardiotoxicity associated with immunoglobulin LC AL. In particular, the substituted qui...  
WO/2018/003531A1
The present invention provides a pyrroloquinone quinone monosodium having a structure represented by formula (1).  
WO/2018/001980A1
The present invention relates to a compound for use in a method for treating sepsis, severe sepsis or septic shock. The compound is selected from (2S)-2-amino-3-[4-(4- hydroxyphenoxy)-3,5-diiodo-phenyl]propanoic acid, and/or 3-[3,5-dibro...  
WO/2018/004498A1
The present invention provides a pharmaceutical composition comprising at least one NSAIA that selectively inhibits COX-2 in combination with at least one H2 receptor antagonist in a single unit pharmaceutical dosage form. Pharmaceutical...  
WO/2018/003829A1
Provided is a novel autophagy inhibitor. An autophagy inhibitor containing, as an active ingredient, a component selected from albendazole, carbazochrome sulfonic acid, carvedilol, cinacalcet, clemastine, clomifene, loratadine, pimobenda...  
WO/2018/002873A1
The present invention relates to the use of 0-(3-piperidino-2-hydroxy-l-propyl)- nicotinic amidoxime (BGP15), its tautomers, enantiomers and pharmaceutically acceptable salts thereof the treatment of diseases characterised at least in pa...  
WO/2018/003583A1
The purpose of the present disclosure is to provide a heat sensitive sheet having an excellent wearing feeling both in an initial state and in use. This heat sensitive sheet has the following configuration. This heat sensitive sheet (1) ...  
WO/2018/003584A1
The purpose of the disclosure is to provide a warming sheet that does not tend to cause low-temperature burns and the fixing part of which does not tend to remain on clothing. The warming sheet of the disclosure has the following configu...  
WO/2018/002219A1
Fused aromatic bicyclic substituted 5-(2-amino-4-pyrimidinyl)- cyanoindoline derivatives (I) useful for therapy and/or prophylaxis in a mammal, and in particular to inhibitors of NF-KB-inducing kinase (NIK - also known as MAP3K14) useful...  
WO/2018/003035A1
Provided is a novel Sirtuin 1 activator. The present invention provides a Sirtuin 1 activator characterized by comprising enmeisou (Isodon japonicus Hara) plant matter or a solvent extract thereof.  
WO/2017/222016A1
The present invention provides a cationic lipid which is able to be used for nucleic acid delivery to the cytoplasm. A cationic lipid according to the present invention is, for example, a compound represented by formula (1a) or a pharmac...  
WO/2017/222035A1
It becomes possible to induce cell death of cancer cells and inhibit cell proliferation of cancer cells. A medicinal agent capable of inhibiting both of GST-π and MRPL17 is contained as an active ingredient, or a medicinal agent capable...  
WO/2017/223254A1
Provided herein are methods and devices for measuring and monitoring proliferation and toxicity in vitro.  
WO/2017/221142A1
The present disclosure relates to a Wingless-type (wnt) inhibitor of formula (I) for use in the treatment of fibrosis and some fibrosis mediated disorders such as stiff skin syndrome and systemic sclerosis. The present disclosure also pr...  
WO/2017/219081A1
This invention relates to peptides and their use for modulating sodium channels. More particularly, the present invention relates to peptides from the venom of the tarantula Pamphobeteus nigricolor and their use in methods of inhibiting ...  
WO/2017/221799A1
The problem is solved by an upper gastrointestinal flora-improving agent, the agent containing lactobacilli as an active ingredient, to be used in persons positive and negative for Helicobacter pylori. Lactobacilli of the genus Lactobaci...  
WO/2017/223254A8
Provided herein are methods and devices for measuring and monitoring proliferation and toxicity in vitro.  
WO/2017/222029A1
The present invention provides fermented milk having a high angiotensin converting enzyme inhibition activity, a high hypotensive activity and/or a high stroke-preventing activity. The present invention also provides a method for produci...  
WO/2017/217478A1
Provided is a combination agent which is composed of a halogenated isoquinoline derivative and another active ingredient and has an excellent ocular hypotensive effect. An ophthalmic composition comprising the components (A) and (B) ment...  
WO/2017/217326A1
The purpose of the present invention is to provide a diarrhea-preventing nutritional composition that enables the ingestion or administration of nutritional components while effectively preventing diarrhea and that can maintain a stable ...  
WO/2017/217545A1
The present invention provides a plexin binding regulator comprising a cyclic peptide having an Arg-Trp-Thr structure or a Leu-Ser-Trp structure or a pharmaceutically acceptable salt thereof.  
WO/2017/217517A1
Provided are: a vein formation promoter containing phosphatidylcholine as an active ingredient and has an activity to promote the change of a tumor blood vessel to a vein; a blood vessel diameter dilator having an activity to dilate the ...  
WO/2017/217556A1
The purpose of the present invention is to provide a medicine for preventing or treating TGFβ-related diseases by inhibiting signal transduction of TGFβ. Provided are: a TGFβ inhibitor that contains, as an active ingredient, the REIC/...  
WO/2017/217477A1
Provided is a technology whereby a decrease in the contained amount of a halogenated isoquinoline derivative is inhibited in an aqueous composition containing the halogenated isoquinoline derivative and timolol. The aqueous composition c...  
WO/2017/213076A1
The present invention relates to an absorption promoter for S-allyl cysteine (SAC) and alliin, including garlic egg yolk.  
WO/2017/212006A1
The invention relates to carrier compositions for nucleic acid delivery which comprise a cationic peptide or polymer in combination with a cationic lipid. In a further aspect, the invention relates to nanoparticles comprising a complex o...  
WO/2017/212007A1
Compositions for nucleic acid delivery are provided which comprise a relatively low amount a permanently cationic lipid or lipidoid, such as a lipid comprising a quaternary ammonium group. The compositions are suitable for the delivery o...  
WO/2017/212008A1
The invention relates to carrier compositions for nucleic acid delivery which comprise a cationic peptide or polymer in combination with a cationic lipid. The peptide or polymer comprises a disulfide linkage or an -SH moiety capable of f...  
WO/2017/214282A1
The invention relates to anti-Epidermal Growth Factor Receptor (EGFR) antibody drug conjugates (ADCs) which inhibit Bcl-xL, including compositions and methods of using said ADCs. Formula (IIa), (IIb), (IIc)  
WO/2017/213176A1
[Problem] To provide a food or beverage composition, a food or beverage and the like which include astaxanthin and/or an astaxanthin-containing extract as an active ingredient. [Solution] A food or beverage composition which includes ast...  
WO/2017/213210A1
The present invention relates to a compound potentially useful as a prophylactic or therapeutic drug for cancer.  
WO/2017/212009A1
A composition for the delivery of a nucleic acid compound is provided which comprises a cationic peptide or polymer and a lipidoid compound. The nucleic acid compound may be any chemically modified or unmodified DNA or RNA. The amount of...  
WO/2017/208868A1
The purpose of the present invention is to provide a pharmaceutical composition and a food which have the effect of preventing central nervous system diseases and inhibiting the advancement thereof. This pharmaceutical composition, which...  

Matches 1 - 50 out of 163,717