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Matches 1 - 50 out of 49,627

Document Document Title
WO/2018/013770A1
Disclosed are compounds of Formula (I) to (IV): [INSERT CHEMICAL STRUCTURE HERE] or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate or prodrug thereof. Also disclosed are methods of using such compounds as PAR4 inhibi...  
WO/2018/013774A1
Disclosed are compounds of Formula (I) to (VIII): (I) (II) (III) (IV) (V) (VI) (VII) (VIII); or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate or prodrug thereof, wherein R3 is a bicyclic heteroaryl group substituted...  
WO/2018/013915A1
Methods of preventing and/or treating reperfusion injury are provided. The methods involve administering alpha-2-macroglobulin (A2MG) to a subject with ischemia in one or more tissues or organs, in order to prevent or decrease reperfusio...  
WO/2018/013870A1
Provided herein are combinations of (a) ceftibuten or a pharmaceutically acceptable salt thereof, or a hydrate of the foregoing; and (b) clavulanic acid, or a pharmaceutically acceptable salt thereof for use in a method of treating or pr...  
WO/2018/013772A1
Disclosed are compounds of Formulas (I), (II), (III), (IV), (V), (VI), (VII), or (VIII): (I) (II) (III) (IV) (V) (VI) (VII) (VIII) or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate or prodrug thereof, wherein R3 is a...  
WO/2018/010332A1
The present invention belongs to the field of pharmaceutical chemical technologies, and in particular relates to the use of 7-hydroxy-butyphthalide in the preparation of drugs for preventing and/or treating cardiovascular and cerebrovasc...  
WO/2018/013936A1
In some aspects, the disclosure relates to GDF/BMP antagonists and methods of using GDF/BMP antagonists to treat, prevent, or reduce the progression rate and/or severity of pulmonary hypertension (PH), particularly treating, preventing o...  
WO/2018/006643A1
Provided is a traditional Chinese medicine for providing a man with kidney-tonifying, blood circulation-promoting and liver-soothing benefits. The traditional Chinese medicine consists of the following raw materials: 15-25 g of Salvia mi...  
WO/2018/006646A1
Provided is a decoction for tonifying the kidney, promoting the blood circulation and soothing the liver. The decoction is prepared with Radix bupleuri, white peony root, Cuscuta chinensis, Acorus gramineus, Eucommia ulmoides, Angelica s...  
WO/2018/007956A1
of the invention The present invention relates to a stable, immediate release solid oral pharmaceutical compositions comprising iron chelating agents like Deferasirox and at least one pharmaceutical acceptable excipient wherein the compo...  
WO/2018/009424A1
The present invention relates to PDE9 inhibitors, their synthesis, and their use for treatment of benign prostate hyperplasia, beta thalassemia, and sickle cell disease.  
WO/2018/007601A1
The present invention relates to clinically relevant dosing regimens of prophylactic subcutaneously administered long-acting factor IX (i.e., human FIX fused to human albumin) in human patients.  
WO/2018/009544A1
The present disclosure provides compounds of Formula (I), (II), and (III). The provided compounds are able to bind protein kinases (e.g., SIK) and may be useful in modulating (e.g., inhibiting) the activity of a protein kinase (e.g., SIK...  
WO/2018/007767A1
The invention relates to a composition comprising stable fibrinogen in liquid form.  
WO/2018/003899A1
The present invention pertains to a means and a method for ameliorating renal anemia. Specifically, the present invention pertains to a renal anemia-ameliorating composition that contains a lactic acid bacterium and/or a processed produc...  
WO/2018/000688A1
Disclosed are a traditional Chinese medicine oral liquid for treating insufficiency of qi and blood, and a preparation method therefor. The oral liquid is prepared from the following main raw materials in proportion by weight: 5-10 parts...  
WO/2018/003295A1
The present invention addresses the problem of providing: a 5-hydroxymethyl-2-furfural (5-HMF) production method which is suitable for the production of 5-hydroxymethyl-2-furfural (5-HMF) on an industrial scale; and a novel catalyst comp...  
WO/2018/001980A1
The present invention relates to a compound for use in a method for treating sepsis, severe sepsis or septic shock. The compound is selected from (2S)-2-amino-3-[4-(4- hydroxyphenoxy)-3,5-diiodo-phenyl]propanoic acid, and/or 3-[3,5-dibro...  
WO/2018/005417A1
A method of stimulating platelet formation using a drug that stimulates mitochondrial biogenesis is described. The drug can be used to treat a subject that has been diagnosed with thrombocytopenia or a relatively low platelet count, or i...  
WO/2018/002311A1
The present invention relates to an inhibitor of Syk kinase for use in the treatment and/or prevention of atherothrombosis. The present invention further relates to a method of treating and/or preventing atherothrombosis comprising admin...  
WO/2018/000690A1
A traditional Chinese medicine oral liquid for treating insufficiency of qi and blood is prepared from the following main raw materials in parts by weight: 5-10 parts of Panax ginseng, 4-9 parts of Saussurea involucrate, 10-20 parts of T...  
WO/2018/002377A1
The present invention relates to animal meat enriched with Omega-3 polyunsaturated fatty acids for use in increasing the Omega-3 polyunsaturated fatty acids levels in human plasma by dietary administration of the animal meat enriched wit...  
WO/2018/002316A1
The present invention relates to an inhibitor of Bruton's tyrosine kinase (Btk) for use in the treatment and/or prevention of atherothrombosis. The present invention further relates to a method of treating and/or preventing atherothrombo...  
WO/2017/223377A1
Method for transfusion medicine to reduce adverse events in transfusion patient populations based on underlying patient physiology.  
WO/2017/219078A1
The present invention relates to the discovery of the importance of the vicinal cysteine residues located in von Willebrand factor (VWF) domain A2. Thus the invention discloses modified VWF wherein: (a) the vicinal cysteine residues of V...  
WO/2017/219510A1
A quinoid chalcone c-glycoside dimer compound having an anti-tumor activity and an anti-inflammatory activity and a method for preparing same. The compound is a quinoid chalcone c-glycoside dimer compound separated from Carthamus tinctor...  
WO/2017/221209A1
Compositions comprising crystalline apixaban particles having a D90 more than 89 I m, and a pharmaceutically acceptable carrier that can be used to for the treatment and/or prophylaxis of thromboembolic disorders.  
WO/2017/219690A1
The present invention relates to an application of a pyrimidine compound or salt thereof for manufacturing a pharmaceutical product for preventing and/or treating an FLT3-related disease or disorder. The structure of the pyrimidine compo...  
WO/2017/216724A1
The present invention relates methods of treatment using BMP6 antagonists.  
WO/2017/217524A1
The invention provides anti-C5 antibodies and methods of using the same. In some embodiments, an isolated anti-C5 antibody of the present invention binds to an epitope within the beta chain of C5 with a higher affinity at neutral pH than...  
WO/2017/217895A1
The invention relates to area of medicine, in particular to pharmacology, namely to novel pharmaceutical compositions for oral use for treatment of diseases associated with increased thrombus formation. The compositions comprise the anti...  
WO/2017/213256A1
A biocompatible peritoneal dialysate according to the present invention is a sterilized biocompatible peritoneal dialysate composed of an acidic first solution containing icodextrin and a second solution containing a pH modifier, wherein...  
WO/2017/212460A1
The present invention refers to nucleotide sequences used for driving the expression of a therapeutic gene, preferably FVIII and/or its variants specifically in endothelial cells and/or hematopoietic, preferably myeloid cells. The sequen...  
WO/2017/211779A1
The present invention relates to a solid dispersion comprising amorphous betrixaban maleate and a pharmaceutically acceptable carrier selected from the group consisting of organic polymers and silicon-based inorganic compounds, and to a ...  
WO/2017/210989A1
Disclosed are a phloroglucinol-oxytocin injection and a preparation method therefor. Each 10,000 ml injection contains 100 ml of an oxytocin solution and 0.2 g of phloroglucinol, and a 1 ml injection contains 10 units of the oxytocin sol...  
WO/2017/214005A1
The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicament.  
WO/2017/208169A1
The present application relates to solid state forms of Betrixaban and its Maleate salt, and processes for preparation thereof.  
WO/2017/210683A1
The present invention relates to aptamer-based assays to capture and/or detect analytes comprising primary and secondary aptamers, as well as compositions comprising such primary and secondary aptamers, wherein analytes comprise small mo...  
WO/2017/204298A1
This invention relates to a method for treatment of persistent edema in patients with exudative age-related macular degeneration. In particular, the present invention relates to treatment of wet age-related macular degeneration with intr...  
WO/2017/203304A1
The present invention provides pyrazine derivatives according to formula (I), their enantiomers, stereoisomers, salts and hydrites thereof, for use in the treatment of diseases associated with cell cycle dysregulation, wherein R1, R2, k,...  
WO/2017/205074A1
In some embodiments, the invention provides a method for identifying a patient suffering from or suspected of suffering from a disease associated with the cardiovascular system that is having a subnormal response to the treatment for the...  
WO/2017/205795A1
The invention relates to compounds that promote hematopoietic regeneration. The invention further relates to methods of promoting hematopoietic regeneration using the novel compounds of the invention.  
WO/2017/198049A1
Disclosed is a novel pyrazolopyrimidine compound as shown in formula (I), and a stereoisomer, or a pharmaceutically acceptable salt, or a solvate, or a prodrug thereof. In addition, also disclosed are a preparation method for the compoun...  
WO/2017/200415A1
The invention relates to the field of medicine and veterinary science and may be used for preventing and treating iron deficiency anemia and for stimulating hematopoiesis. The invention describes an injection composition for preventing a...  
WO/2017/195762A1
The present invention relates to: a novel prostaglandin derivative having an alkynyl group in a ω-chain, particularly a novel prostaglandin derivative having a double bond at position-2 and also having an alkynyl group in a ω-chain; an...  
WO/2017/190526A1
The present invention belongs to the technical field of drugs, and relates in particular to an application of a tetramethylpyrazine derivative tetramethylpyrazine nitrone in the preparation of a drug and the prevention and treatment of b...  
WO/2017/192931A1
The invention provides substituted imidazo[1,2-α]pyridine compounds, substituted imidazo[1,2-α]pyrazine compounds, related compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compos...  
WO/2017/192940A1
A method of treating and/or preventing blood-associated disorders is provided. Also provided is a method of treating and/or preventing hemophilic arthropathy and/or hemochromatosis arthropathy in a subject.  
WO/2017/187336A4
The present invention relates to pharmaceutically acceptable complex formulations comprising complexes of Ivacaftor, or a salt, or derivatives thereof and complexation agents and pharmaceutically acceptable excipients, process for the pr...  
WO/2017/188356A1
The present invention relates to a stable antibody-containing liquid preparation which rarely undergoes the formation of aggregates of Emicizumab (ACE910) that is a bispecific antibody having a function alternative to the function of FVI...  

Matches 1 - 50 out of 49,627