Login| Sign Up| Help| Contact|

Patent Searching and Data


Matches 1 - 50 out of 112,503

Document Document Title
WO/2018/129647A1
A purified oligosaccharide compound having antithrombotic activity or a mixture of a homologous compound thereof and a pharmaceutically acceptable salt thereof, a preparation method for the mixture, a pharmaceutical composition containin...  
WO/2018/130513A1
The present invention relates to CD47 antibodies or fragments thereof binding specifically to the CD47 immunogen for use in preventing or treating tissue injury in states of ischemia or reperfusion in an object whereby the CD47 antibodie...  
WO/2018/130537A1
The present invention is directed to cell-protective, in particular, cardio- and renal-protective organic compounds, preferably to organic compounds that inhibit substrate phosphorylation by the G-protein-coupled receptor kinase 2 (GRK2,...  
WO/2018/130207A1
The present invention pertains to the field of pharmaceutical chemicals, and discloses a 4,4-diphenyl piperidine compound or a pharmaceutically acceptable salt thereof, a pharmaceutical composition using the same, and a use thereof. Spec...  
WO/2018/130840A1
The invention relates to the treatment and/or prevention of cardiovascular disease, for example thromboembolic conditions, such as atherothrombotic disease. In particularly, the invention relates to an arginine methylation inhibitor ('Ar...  
WO/2018/130226A1
A crystal form CS4 and a crystal form CS9 of riociguat, and a preparation method and use thereof. The crystal form CS4 and the crystal form CS9 of riociguat have good solubility, high dissolution rate, good stability, and high purity, wh...  
WO/2018/132268A1
The present disclosure provides pharmaceutical agents, including those of the formula:(I) wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such pharmaceu...  
WO/2018/130131A1
Applications of miR-342-5p in preparing a medicament for preventing and treating cardiovascular disease. miR-342-5p has significant cardioprotective effects, reduces myocardial ischemia/reperfusion injury, and improves heart function. mi...  
WO/2018/130660A1
A drug delivery system and methods of using such for delivering a PEGylated therapeutic agent to heart. The drug delivery system may comprise an antibody embedded a hydrogel, comprising one or more biodegradable polymers, up to about 60%...  
WO/2018/127586A1
The invention relates to novel compounds which bind specifically to human CD160, comprising a light chain variable domain (VL), a chosen sequence defined by SEQ ID No: 14 or SEQ ID No: 13 and a heavy chain variable domain (VH), a sequenc...  
WO/2018/129258A1
The present application provides a novel phenyl derivative, 5-[(2,4- dinitrophenoxy)methyl]-l-methyl-2-nitro-lH-imidazole or a pharmaceutically acceptable salt thereof, which is useful for regulating mitochondria activity, reducing adipo...  
WO/2018/128999A1
The disclosed subject matter provides methods of using nitroxyl donating compounds and pharmaceutical compositions comprising such compounds in a dose escalation regimen.  
WO/2018/129557A1
The present disclosure is directed to compounds (Ι') and to their use in methods for the treatment of disorders associated with fluid retention or salt overload, such as heart failure (in particular, congestive heart failure), chronic k...  
WO/2018/126897A1
Disclosed is an application of sodium 5-bromo-2-(α-hydroxypentyl) benzoate (BZP) in drugs treating cardiovascular disease, belonging to the field of pharmaceutical chemistry. Experiments show that BZP has a protective effect with regard...  
WO/2018/129395A1
The present invention relates to antibodies, or antigen-binding fragments thereof, that specifically bind proMyostatin and/or latent Myostatin, and methods and uses thereof for treating metabolic diseases.  
WO/2018/129347A1
The present invention is directed to a method for treating cardiovascular diseases such as acute myocardial infarction, atherosclerosis, heart failure, stroke, thrombosis, carditis (including acute myocarditis, acute pericarditis and com...  
WO/2018/127748A1
The present invention relates to a pharmaceutical composition, characterized in that it comprises, as active ingredient, a combination of d-limonene, lupeol and a pharmaceutically active agent selected from cinnamaldehyde, epicatechin, m...  
WO/2018/122409A1
Compositions including an fatty acid, such as an odd chain fatty acid or a very long even chain fatty acid, and salts and derivatives thereof, and methods for treatment and prophylaxis of conditions related to inflammation and conditions...  
WO/2018/124210A1
The present disclosure provides a ring-shaped cardiac muscle cell mass in which an electric signal or a calcium signal can progress while circulating therethrough. Also provided is a method for producing the ring-shaped cardiac muscle ce...  
WO/2018/120437A1
Provided are an adult pluripotent olfactory stem cell and a separation method therefor and the use thereof. The isolated adult pluripotent olfactory stem cell expresses the B cell-specific Moloney murine leukemia virus insertion site 1.  
WO/2018/124216A1
The present invention pertains to a method for producing a lipid-containing extract substantially free of chlorophylls, the method including a step for obtaining a lipid-containing extract from one or more raw materials selected from the...  
WO/2018/121457A1
Provided is a pharmaceutical application of a polypeptide in preventing or treating myocardial ischemia reperfusion injury-related diseases. The polypeptide can significantly reduce the myocardial infarct size in myocardial ischemia repe...  
WO/2018/124236A1
Provided is a medicinal composition to be used for treating an intractable heart tissue fibrosis disease accompanying chronic heart failure. The medicinal composition, which is to be used for treating an intractable heart tissue fibrosis...  
WO/2018/123968A1
In the present invention, mesenchymal stem cells cultured in a serum-free medium are used to provide a repair agent for repairing tissue damage in a living body and a method for producing said repair agent.  
WO/2018/123908A1
[Problem] An objective of the present invention is to provide a novel composition that can inhibit the activity of PDE5. [Solution] A composition for inhibiting phosphodiesterase-5 activity, the composition comprising a processed product...  
WO/2018/121559A1
A mannuronic dicarboxylic acid oligosaccharide composition, which comprises mannuronic dicarboxylic acid of formula (III) or a pharmaceutically acceptable salt thereof, where n is an integer selected from 1-9, M is selected from 0, 1, or...  
WO/2018/120777A1
Provided are a rivaroxaban self-emulsifying preparation and a preparation method therefor, wherein the preparation comprises by mass percentage, 1 to 13% of rivaroxaban, 5 to 50% of oil phase, 20 to 70% of emulsifier, 0 - 50% of the coem...  
WO/2018/113094A1
Disclosed is the use of a fullerene structure in the preparation of a drug for treating diabetes and complications thereof. The fullerene structure comprises at least one effective ingredient selected from the group consisting of an oil-...  
WO/2018/115181A1
The present invention relates to novel salts and physical forms of ivabradine, methods for their formation, and uses thereof, such as in the treatment of myocardial ischemia and the like.  
WO/2018/113080A1
An application of berberine in preparation of drugs for prevention and treatment of pulmonary hypertension, cardiac failure caused by pulmonary hypertension and in-stent restenosis and antithrombotic drugs. Berberine can inhibit stimulat...  
WO/2018/112814A1
The present disclosure provides a method of reducing the contractile response of smooth muscle cells that is induced by one or more inflammatory constrictors by TMEM16A inhibitors. Embodiments herein include contacting target cells with ...  
WO/2018/113145A1
Provided is a method for preparing human pluripotent stem cells for resisting both cellular senescence and malignant transformation. Genetically enhanced stem cells having increased resistance to adverse situations are obtained by mutati...  
WO/2018/112541A1
The present invention relates to methods of increasing vascular density and/or blood flow in tissue of a subject, and to increasing exercise capacity of a subject, the methods include administering to a subject an effective amount of an ...  
WO/2018/117244A1
Provided is a novel peptide that includes an amino acid sequence indicated by SEQ ID NO: 30, and inhibits protease activity.  
WO/2018/119284A1
The invention relates to novel heterocyclic compounds and pharmaceutical preparations thereof. The invention further relates to methods of treating or preventing cancer using the novel heterocyclic compounds of the invention.  
WO/2018/119190A1
Disclosed are methods and pharmaceutical compositions for treating cardiomyopathies. The disclosed methods and pharmaceutical compositions may be used for treating lamin A/C (LMNA)-related dilated cardiomyopathies (DCM) in a subject in n...  
WO/2018/107690A1
A method for preventing and/or treating lipid metabolism disorders and related diseases thereof, comprising administering an effective amount of plasminogen to a subject prone to suffer or suffering lipid metabolism disorders and related...  
WO/2018/111888A1
A method of regulating blood pressure in a subject is provided. The method comprises administering a preparation comprising ammonia oxidizing microorganisms to the subject, thereby regulating blood pressure in the subject. Related prepar...  
WO/2018/107289A1
Compounds described herein are inhibitors of retinoic acid inducible P450 (CYP26) enzymes, and are useful for treating diseases that are responsive to retinoids. Certain compounds have retinoid activity, are resistant to CYP26-mediated c...  
WO/2018/108161A1
Disclosed in the present invention is a method for preventing and/or treating overweight, obesity and related diseases. The method comprises: administrating an effective dosage of plasminogen to a test participant having or easy to have ...  
WO/2018/110669A1
Disclosed is a compound of formula (I): wherein all symbols are defined in the description. Also disclosed are pharmaceutical compositions comprising the compounds, methods of making the compounds, kits comprising the compounds, and meth...  
WO/2018/108156A1
A ROCK inhibitor represented by formula (I) and a preparation method and application thereof. An experiment has demonstrated that the compound has good ROCK-inhibiting activity, and can be effectively used in treating a disease related t...  
WO/2018/107707A1
A method for preventing and/or treating myocardial injury and its related diseases of a subject, comprising administering an effective amount of plasminogen for preventing and/or treating to a subject who is in risk of suffering from myo...  
WO/2018/107686A1
A method for treating atherosclerosis and related diseases thereof of a subject, comprising administering a preventively and/or therapeutically effective amount of plasminogen to a subject suffering or suspected to suffer atherosclerosis...  
WO/2018/107984A1
The present invention discloses a polypeptide containing a T helper cell epitope (Th epitope), which can serve as an immunostimulant of a B cell epitope or a peptide hapten of a target antigen. The invention also discloses a polypeptide ...  
WO/2018/109649A1
The present invention relates to ether-linked triazole compounds, methods of making them, pharmaceutical compositions containing them and their use as NRF2 activators. In particular, the invention relates to compounds of Formula (I), and...  
WO/2018/107684A1
A method for treating and preventing atherosclerosis, comprising administering a preventively effective amount of plasminogen to a subject prone to suffer atherosclerosis. Also provided are a medicine, pharmaceutical composition, product...  
WO/2018/109648A1
The present invention relates to bisaryl lactam compounds, methods of making them, pharmaceutical compositions containing them and their use as NRF2 activators. In particular, the compounds of this invention include a compound of Formula...  
WO/2018/107685A1
A method for preventing and/or treating coronary atherosclerosis and related diseases thereof of a subject, comprising administering a preventively and/or therapeutically effective amount of plasminogen to a subject suffering, suspected ...  
WO/2018/109641A1
The present invention relates to 3-carboxylic acid pyrrole compounds, methods of making them, pharmaceutical compositions containing them and their use as NRF2 regulators. In particular, the compounds of this invention include a compound...  

Matches 1 - 50 out of 112,503