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Matches 1 - 50 out of 111,756

Document Document Title
WO/2018/070521A1
In one embodiment, the present invention addresses the problem of: providing an agent for inhibiting a lectin pathway and an alternative pathway; and others. In one embodiment, the present invention relates to: a fusion polypeptide conta...  
WO/2018/069086A1
Triterpenoid derivatives and compositions comprising said triterpenoids derivatives of Formula (I) are described, wherein R=-C(O)NHOH. Said triterpenoids and compositions show capacity to bind PHD2, stabilize HIF-1α and HIF-2α proteins...  
WO/2018/068296A1
Piperidine compounds of the Formular: (I) and pharmaceutically acceptable salts thereof, wherein X, Y, R 1, R 2, R 3, L, R 4, L 1, Q and R 5 are as defined herein. The compounds and pharmaceutically acceptable compositions comprising a c...  
WO/2018/069769A1
An object of the present invention is to provide a pharmaceutical composition for inhibiting neointima formation of a blood vessel. The object is attained by a pharmaceutical composition for inhibiting neointima formation of a blood vess...  
WO/2018/068295A1
Substituted aryl and heteroaryl ether compounds of the Formula (I) and pharmaceutically acceptable salts thereof, wherein X, R 1, R 2, R 3, L, R 4, L 1, Q, and R 5 are as defined herein. These compounds and pharmaceutically acceptable co...  
WO/2018/069408A1
The present invention relates to compositions of extracellular vesicles (EVs) which are characterized by a strong proangiogenic activity and are effective in the therapeutic treatment of ischemic diseases and ischemic injuries or in woun...  
WO/2018/071622A1
The present invention provides compounds of Formula (I) wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.  
WO/2018/068759A1
The present invention relates to a five-membered heteroaryl ring bridged ring derivative, a preparation method therefor and the medical use thereof. In particular, the present invention relates to a new five-membered heteroaryl ring brid...  
WO/2018/070545A1
The present invention addresses the problem of providing a composition that contains a choline ester such as acetylcholine as an active ingredient, can be orally ingested by humans by a simple method, and has a blood pressure-lowering ef...  
WO/2018/068347A1
Provided are recombinant plasmids containing the heterodimeric snake venom protein Agkisacutacin A chain gene and Agkisacutacin B chain gene, respectively, cell strains containing the recombinant plasmids, and a method for expressing the...  
WO/2018/064852A1
The present invention relates to the field of biomedicine, and discloses a naphthyridine compound, a pharmaceutical composition and use thereof. The naphthyridine compound has a structure as represented by formula (I) or in the form of a...  
WO/2018/065132A1
The present invention relates to the preventive or curative treatment of metabolic syndrome and the associated disorders with AhR agonist or microorganism producing AhR agonist.  
WO/2018/066676A1
The present invention addresses the problem of examining the physiological activity of selenoneine which is an organic selenium compound and thus finding novel uses thereof. To solve this problem, provided are a composition comprising an...  
WO/2018/066707A1
Provided are: a novel aging inhibitor, soft-tissue calcification inhibitor, and lung tissue destruction inhibitor; food and beverage products, pharmaceutical products, and cosmetic products which include said inhibitors; and a method for...  
WO/2018/064953A1
Use of isopropyl β-(3,4-dihydroxyphenyl)-α-hydroxypropionate (IDHP) in the preparation of a drug or a health product for prevention and treatment of coronary atherosclerosis diseases. The IDHP can also be used to inhibit platelet aggre...  
WO/2018/067709A1
Various embodiments of this invention are directed to pharmaceutical compositions and methods for treating disease. The compositions of such embodiments include reversible nitroxide derivatives of nitroalkenes. The methods of various emb...  
WO/2018/066427A1
The present invention addresses the problem of providing a composition for preventing and/or treating neurodegenerative diseases and cerebral infarction and a composition for improving learning disorders. Provided is a composition that c...  
WO/2018/064945A1
The present invention relates to a pharmaceutical composition comprising: (a) at least one neutral endopeptidase inhibitor or a pharmaceutically acceptable salt or ester thereof, (b) at least one compound represented by formula (I) or a ...  
WO/2018/064966A1
Nutritional supplement compositions for improving cardiovascular efficiency are disclosed. A nutritional supplement composition can include astaxanthin derived from Haematococcus pluvialis Extract blended with carrier oils and antioxidan...  
WO/2018/065546A1
The invention relates to the field of medicine, specifically to the field of treatment of rosacea. The invention relates to a novel composition and a novel kit of parts, both comprising a vasoconstrictive compound and a compound specific...  
WO/2018/062122A1
[Problem] To provide a novel composition that is capable of promoting the secretion of an atrial natriuretic peptide. [Solution] A composition for promoting the secretion of an atrial natriuretic peptide, said composition comprising a co...  
WO/2018/060373A1
The present invention relates to drugs derived from elafibranor. It relates more specifically to a composition comprising at least one active ingredient, characterised in that at least one active ingredient comprises an elafibranor metfo...  
WO/2018/058985A1
A health-promoting traditional Chinese medicine composition suitable for washing the feet of elderly persons. The composition consists of the following components provided in respective parts by weight: 15-20 parts of Ramulus Cinnamomi; ...  
WO/2018/062175A1
The purpose of the present invention is to provide molecularly altered adiponectin that can be produced as a uniform product, and has the same or greater activity compared to natural adiponectin. This molecularly altered adiponectin is p...  
WO/2018/059207A1
Disclosed is use of amlexanox or a salt thereof or a solvate thereof in preparation of a drug having an inhibitory action on the smooth muscle cells, in particular a drug for preventing and treating vascular restenosis. Further disclosed...  
WO/2018/059429A1
The invention relates to non-solvated crystals A, B and C of N-(2-aminophenyl)-6-(7-methoxyquinoline-4-oxy)-1-naphthamide and preparation methods thereof. The invention also relates to pharmaceutical compositions containing the crystals...  
WO/2018/060704A1
Compounds of Formula (I), which are activators of long form cyclic nucleotide phosphodiesterase-4 (PDE4) enzymes (isoforms) are provided. Methods and uses of these compounds for the treatment or prevention of disorders requiring a reduct...  
WO/2018/053588A1
The present invention relates to novel compounds and their use in the prophylactic and/or therapeutic treatment of hypertension and/or fibrosis.  
WO/2018/057933A1
The invention provides compounds, compositions, and methods for reducing oxidative stress in cardiomyocytes. In certain embodiments, the compound or composition comprises a selective class IIa histone deacetylase (HDAC) inhibitor, or a s...  
WO/2018/054959A1
The present disclosure relates to use of heparin analogues as inhibitors of proprotein convertase subtilisin-like/kexin type 9 (PCSK9) for the treatment of lipoprotein metabolism disorders.  
WO/2018/055235A1
The present invention concerns compounds of Formula 1a and its uses as a drug, particularly in treatment of cardiac diseases, and in methods and products relating to cell differentiation.  
WO/2018/056123A1
Disclosed is a composition containing enzyme-decomposed royal jelly granules and zein, the composition serving as a food item, a pharmaceutical item, or a quasi-drug.  
WO/2018/055526A1
The present invention relates to pyrrolidine sulfonamide analogs (I), pharmaceutical compositions containing them and their use as TRPV4 antagonists.  
WO/2018/055527A1
The present invention relates to pyrrolidine sulfonamide analogs (I), pharmaceutical compositions containing them and their use as TRPV4 antagonists.  
WO/2018/053587A1
The present invention relates to novel compounds and their use in the prophylactic and/or therapeutic treatment of hypertension and/or fibrosis.  
WO/2018/057884A1
The present invention relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of SHP2 phosphatase with the compounds and compositions of the invention. The present invention further rel...  
WO/2018/058124A1
Provided are novel prodrugs of treprostinil, as well as methods of making and methods of using these prodrugs.  
WO/2018/056453A1
The present invention provides a compound represented by formula (I) in which an indole ring or a pyrrolo[2,3-b]pyridine ring and a pyrazolopyridine skeleton are bonded using a substituent, or a salt of the compound; solvates thereof; an...  
WO/2018/054300A1
Provided is a crystalline form cholic acid derivative free alkali, a preparation method therefor and an application. The chemical name of the cholic acid derivative free alkali is (5R)-5-((2R)-2-((3R,5S,6R,7R,10S,13R)-6-ethyl-3,7-dihydro...  
WO/2018/055016A1
The invention relates to crystalline forms of 4-((R)-2-{[6-((S)-3-methoxy-pyrrolidin-1-yl)-2-phenyl-pyrimi dine-4-carbonyl]-amino}-3-phosphono-propionyl)-piperazine-1- carboxylic acid butyl ester hydrochloride, processes for the preparat...  
WO/2018/055524A1
The present invention relates to pyrrolidine sulfonamide analogs (I), pharmaceutical compositions containing them and their use as TRPV4 antagonists.  
WO/2018/054846A1
The invention relates to novel, in position 3, cyclically substituted thieno[2,3-d]pyrimidine-2,4-dione ("thienouracil")-derivatives, to methods for the production thereof, to the use thereof alone or in combinations for treating and/or ...  
WO/2018/053595A1
Provided herein are methods for improving cerebrovascular function and cognitive performance, and for preventing or reducing cognitive impairment or decline, in peri-menopausal and post-menopausal human subjects, comprising the administr...  
WO/2018/055097A1
The present invention relates to LIM Kinase inhibitors of Formula (I) and pharmaceutically acceptable salts or solvates thereof, wherein R1, R2, R3, R4, X1, X2, X3, Y1, Y2 and Z are as defined in the claims, and their use for the treatme...  
WO/2018/053010A1
The present disclosure provides compositions and methods for targeted delivery of therapeutic agents. The present disclosure further provides methods for treating or preventing the metastasis or recurrence of a cancer using platelets loa...  
WO/2018/052374A1
The invention is a method for treating a heart disease, in particular acute myocardial infarction (AMI) in a subject comprising the step of administering to the subject a Tjp1 inhibitor, wherein administration of said Tjp1 inhibitor prom...  
WO/2018/052356A1
A glycerol ester composition comprising glyceryl monobutyrate, for use in use in treating systemic low-grade inflammation, thereby alleviating long term sequelae metabolic diseases comprising coronary heart diseases and atheroscleorosis ...  
WO/2018/050286A1
The invention relates to compounds which are suitable for the treatment of cancer, an immune disease, Parkinson's disease, Cardiac Hypertrophy or Type-2 diabetes and to pharmaceutical compositions containing such compounds. The invention...  
WO/2018/051180A1
The present invention is directed to cardiac therapy. Specifically, the invention is directed to pharmaceutical compositions for use in treating dysfunction, and methods and kite thereof. More specifically, the compositions of the invent...  
WO/2018/052082A1
This Lin28a activator includes, as an active ingredient, a polysaccharide which contains at least one substance selected from the group consisting of ribose, xylose, and derivatives of each. A monocyte dedifferentiation inducer includes,...  

Matches 1 - 50 out of 111,756