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Matches 1 - 50 out of 113,282

Document Document Title
WO/2018/188551A1
Uses of an HCBP6 gene or HCBP6 protein as a medicament target in screening and/or preparing a medicament for preventing and/or treating fatty liver, steatohepatitis, diabetes, multiple sclerosis, hypertriglyceridemia, hypercholesterolemi...  
WO/2018/188590A1
Fluorine-substituted indazole compounds, pharmaceutical compositions containing these compounds and uses thereof. The compounds and pharmaceutical compositions can be used as soluble guanylate cyclase simulators.  
WO/2018/188546A1
Disclosed is the use of Isaria cicadae Miquel in the preparation of a drug or health care product with a hypolipidemic/hypoglycemic effect, wherein the Isaria cicadae Miquel alone or in combination with an edible and medicinal traditiona...  
WO/2018/188635A1
A cerasome delivery system for use in the targeted activation of a CD44 molecule, a preparation method and use thereof: a surface of a cerasome is partially modified by a targeting ligand, the targeting ligand being a ligand which may sp...  
WO/2018/191747A1
It has been established that inhibition of the expression and function of nicotinamide phosphoribosyltransferase (NAMPT) can treat Pulmonary Arterial Hypertension (PAH) in a patient in need thereof. Compositions and methods of an effecti...  
WO/2018/189672A1
Disclosed is a combination of extracts of Cynara cardunculus and Citrus bergamia which are useful for the prevention and treatment of hepatic steatosis and other disorders correlated with dyslipidaemic conditions.  
WO/2018/189246A1
The present invention relates to the use of a serotoninergic receptor antagonist for the treatment and/or prevention of heart damages in mammals.  
WO/2018/189671A1
The invention concerns the use of LIK066 in heart failure patients and those patients with heart failure in conjunction with Type II diabetes.  
WO/2018/186421A1
The present invention addresses the problem of providing a cell population which includes mesenchymal cells showing low cell aggregation and is useful for the intravenous administration of a cell preparation, a production method therefor...  
WO/2018/184274A1
Provided in the present application are a compound for enhancing the spatial coupling of endothelial ion channel complex TRPV4-KCa2.3 and antihypertensive applications of the compound.  
WO/2018/185516A1
The invention relates to methods for treating cardiovascular toxicity induced by anti-cancer and anti-angiogenic compound. The inventors explored the cardiotoxicity induced by the antiangiogenic therapy, sunitinib, in the mouse heart. Th...  
WO/2018/186419A1
The present invention addresses the problem of providing a cell population which includes mesenchymal stem cells having a high angiogenic potential, a production method therefor, mesenchymal stem cells having a high angiogenic potential,...  
WO/2018/186418A1
The present invention addresses the problem of providing a cell population which includes attached cells derived from fetal appendages and has a low differentiation potential, a production method therefor, and a pharmaceutical compositio...  
WO/2018/184976A1
The invention relates to new substituted imidazo[1,2-a]pyridinecarboxamides, to methods for the production of same, the use of same alone or in combination for the treatment and/or prophylaxis of diseases, and the use of same for produci...  
WO/2018/184526A1
Use of a plant extract in the preparation of a composition for regulating PDGFC, FGF2, IGF1R, PTGIS, NOS3, EDN1, PLAT, PROC, VWF, F3, SERPINE1, IL-8, ICAM1, VCAM1, and CASP8 genes. Said plant extract is selected from a group consisting o...  
WO/2018/185210A1
The present invention relates to a compound comprising a modified saccharide moiety conjugated to a nucleic acid. The compound is useful in medicine for RNA interference therapy or for research and diagnostic purposes. In particular, the...  
WO/2018/186480A1
The inventors of the present invention found that an HMGB1 peptide fragment having a specific amino acid sequence is effective at suppressing finger fusion and scarring of the digestive tract, and at prolonging survival in malnutrition- ...  
WO/2018/185684A1
The present technology is directed to compounds (e.g., Avermectin derivatives), compositions, and methods related to modulation of FXR. In particular the present compounds and compositions may be used to treat FXR-mediated disorders and ...  
WO/2018/182051A1
The present invention aims to provide a heterocyclic compound having an IP6K inhibitory action and expected to be useful as a prophylactic or therapeutic agent for- diseases such as cardiac failure, diabetes and the like. A compound repr...  
WO/2018/177244A1
An shRNA expression cassette, a polynucleotide sequence carrying the expression cassette, and an application thereof. The shRNA expression cassette contains, in order from 5' to 3', a DNA sequence expressing the shRNA and a filler sequen...  
WO/2018/179441A1
[Problem] To provide: a substance and a method both for effectively preventing the worsening of insulin resistance or for ameliorating insulin resistance; a method for treating diabetes, impaired glucose tolerance, obesity, hyperlipemia,...  
WO/2018/181380A1
To provide an edible composition for intestinal bacteria which ameliorates intestinal flora (intestinal bacterial flora) and promotes the diversity thereof so as to contribute to human health. A composition comprising: a natural dietary ...  
WO/2018/181638A1
Provided is a novel long-lasting adrenomedullin derivative that is capable of substantially inhibiting an undesired side reaction while maintaining the pharmacological effect of adrenomedullin. One embodiment of the present invention per...  
WO/2018/183122A1
Described herein are ASK1 inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders ass...  
WO/2018/181345A1
Provided is a compound which has an Nrf2-activating activity and is expected to be useful as a prophylactic or therapeutic agent for diseases associated with oxidative stress, particularly hepatitis (e.g., non-alcoholic steatohepatitis (...  
WO/2018/176330A1
Provided are microRNA from a rhodiola root and uses thereof in the prevention and/or the treatment of a fibroplasia medical sign and/or syndrome.  
WO/2018/178304A1
Inhibitors of ALCAT1 are described having the general formula: (I). These compounds offer a treatment for aging and age-related diseases.  
WO/2018/177899A1
The present invention relates to novel modified macrocyclic compounds with improved tolerability of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of...  
WO/2018/178141A1
The present invention is directed to a crystalline sodium salt of 5-methyl-(6S)- tetrahydrofolic acid wherein the molar ratio of 5-methyl-(6S)-tetrahydrofolic acid to sodium is from 1:0.5 to 1:1.5 (in mol/mol) and/or hydrates and/or solv...  
WO/2018/176643A1
Disclosed in the present invention is a medicinal venison snack, characterized in that the snack is prepared with the following ingredients: 500-1000 g of venison, 30-60 g of a bamboo fruit, 8-24 g of Semen Hydnocarpi, 20-40 g of Radix A...  
WO/2018/178280A1
The present invent ion relates to substituted quinoxaline and pyridopyrazine derivatives of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present inv ention are useful as pI3Κβ...  
WO/2018/176648A1
Disclosed is health-promoting wine, characterized in that the wine is prepared with the following ingredients: 400-600 g of grape wine, 30-60 g of a bamboo fruit, 8-24 g of Semen Hydnocarpi, 20-40 g of Radix Astragali, 1-10 g of Radix Ac...  
WO/2018/181820A1
The present invention relates to a compound that can be effective for prevention and/or treatment of pulmonary hypertension, pulmonary fibrosis, fibrosis in the liver, kidney, skin, or heart, non-alcoholic steatohepatitis, diabetic nephr...  
WO/2018/176645A1
A medicinal sausage, prepared with the following ingredients: 500-1000 g of meat, 30-60 g of a bamboo fruit, 8-24 g of Semen Hydnocarpi, 20-40 g of Radix Astragali, 1-10 g of Radix Achyranthis Bidentatae, 10-30 g of Rhizoma Gastrodiae, 1...  
WO/2018/183825A1
The invention relates to an ex vivo generated population of tissue-specific anti-inflammatory macrophages and methods of making and using such macrophages.  
WO/2018/183411A1
Compounds of formula (I) as inhibitors of DCNl and compositions containing the same are disclosed. Methods of using the DCNl inhibitors in the treatment of diseases and conditions wherein inhibition of DCNl provides a benefit, like oxida...  
WO/2018/176640A1
Disclosed is a medicinal porridge, prepared with the following ingredients: 200-300 g of cornmeal, 10-15 g of xylitol, 30-60 g of a bamboo fruit, 8-24 g of Semen Hydnocarpi, 20-40 g of Radix Astragali, 1-10 g of Radix Achyranthis Bidenta...  
WO/2018/178659A1
The present invention provides heat and heat based treatments that may be used to modulate, inhibit and/or prevent one or more of the processes that contribute to certain vascular and/or arterial complications.  
WO/2018/178253A1
The inventors demonstrate that the phosphatase and hydrolase domains of soluble expoxide hydrolase (sEH) regulate the cardiovascular calcification process and revealed that inhibition of the phosphatase domain of sEH could represent a ne...  
WO/2018/177889A1
The present invention relates to novel modified macrocyclic compounds with improved tolerability of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of...  
WO/2018/178275A1
The present disclosure relates, in general, to the prevention and/or reduction of ischemia-related damage. More specifically, the present disclosure relates to compounds for use in the prevention and/or reduction of ischemia-related dama...  
WO/2018/178144A1
The present invention is directed to a crystalline sodium salt of 5-methyl-(6S)- tetrahydrofolic acid wherein the molar ratio of 5-methyl-(6S)-tetrahydrofolic acid to sodium is from 1:1.51 to 1:2.5 and/or hydrates and/or solvates thereof...  
WO/2018/181071A1
The present invention addresses the problem of providing an agent for degrading a non-collagenous glycoprotein, a composition for degrading a non-collagenous glycoprotein, a medicinal composition for degrading a non-collagenous glycoprot...  
WO/2018/171684A1
Provided in the present invention are a class of 7H-azulene[1,2,3-i,j]isoquinolin-7-one compounds, a single crystal and a use thereof: a 7H-azulene[1,2,3-i,j]isoquinolin-7-one compound has a structure represented by formula (I), and the ...  
WO/2018/171816A1
Disclosed in the present invention are a deuterated dipeptide boronic acid or an ester compound thereof, or a crystalline form, pharmaceutically acceptable hydrate or solvate thereof, the structure thereof being shown in formula (a), whe...  
WO/2018/172998A1
The invention provides a composition rich in flavonoids based on natural extracts, comprising a flavonoid extract dispersed by melt mixing or extrusion and encapsulated in a polymer matrix. The invention is also a novel dietary supplemen...  
WO/2018/175449A1
The present invention relates to proline amide compounds and their azetidine derivatives of formula I wherein the variables are as defined in the claims and the description. The invention further relates to a pharmaceutical composition c...  
WO/2018/171279A1
Disclosed is the use of compound Szeto-Schiller-31 (SS-31) in the preparation of a drug for treating atherosclerosis and related diseases, such as carotid stenosis, lower extremity arteriosclerosis obliterans and coronary heart disease. ...  
WO/2018/175460A1
The disclosure relates to novel uses and methods for preventing and/or treating heart disease, which employ a therapeutically effective amount of an ActRII receptor antagonist, e.g., an ActRII receptor binding molecule, e.g., an ActRII r...  
WO/2018/171004A1
Provided are a class of compounds, which have an anti-platelet aggregation activity, of general formula I and a pharmaceutically acceptable salt thereof, a preparation method therefor, and a pharmaceutical composition and use thereof. Th...  

Matches 1 - 50 out of 113,282