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WO/2024/081284A1 |
A microfluidic apparatus includes a microfluidic chip for MicroOrganoSpheres (MOS) generation. A first channel is defined in a surface of the microfluidic chip and includes: a droplet generation portion including an inlet portion, a junc...
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WO/2024/081876A1 |
Extracellular vesicles (EVs) are natural liposome-like vesicles secreted by cells into the extracellular space. Provided herein are techniques to enrich cargo-loaded EVs over non-loaded EVs and contaminants. To achieve EVs were engineere...
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WO/2024/081551A1 |
Provided herein are methods for purifying recombinant adeno-associated virus (rAAV) particles using chromatography in a large scale. Further provided include the rAAV particles and the pharmaceutical composition prepared by the method.
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WO/2024/050168A3 |
Systems and methods for generating radionuclides, such as radium-224. Systems herein may include a first cartridge having a first opening, a second opening, and a chamber therebetween having a first resin having affinity for thorium-228 ...
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WO/2024/079539A1 |
The invention relates to a method and a system for the processing of rare earth concentrate, which allow efficiency to be improved in terms of recovering the mineral and the resources involved in the process. The method comprises the ste...
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WO/2024/078898A1 |
The invention relates to a simulated moving bed, SMB, separation column/method comprising/using a shell (1) which comprises a plurality of adsorbent beds separated by a plurality of trays, each tray comprising a plurality of panels (6), ...
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WO/2024/081766A1 |
A chromatography column stand includes a floor portion, a wall portion, an internal volume, and a base portion. The floor portion supports a chromatography column. The wall portion extends from a first side of the floor portion around a ...
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WO/2024/075083A1 |
Provided herein is a method and system for PFAS analysis using a liquid chromatography technique that employ a first column (e.g., an isolator column) and a second column (e.g., an analytical column), wherein at least one of the first co...
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WO/2024/075406A1 |
Provided is a method for producing a cation exchange resin, in which the metal impurity content of a cation exchange resin is reduced, and metal elution is minimal even when the cation exchange resin is used in refining an organic acid s...
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WO/2024/073856A1 |
A method of separating one or more metal compounds from a feed material stream that includes one or more metals, includes: subjecting the feed material stream to a metal compound precipitation process to yield a metal compound slurry; an...
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WO/2024/076723A1 |
Provided herein are methods to harvest EVs (such as increased yields of EVs) from bacterial cultures.
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WO/2024/068683A1 |
A stationary phase for use in affinity chromatography for recovering adeno-associated virus (AAV) vectors (3) from a solution. The stationary phase comprises a porous polymer matrix (1) having a mean flow pore size of 0.1-2.0 µm, wherei...
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WO/2024/069196A1 |
Present invention relates to a novel separation process for the preparation of comfrey root extract with reduced pyrrolizidine alkaloid content by means of liquid-liquid chromatography (LLC) using a biphasic binary solvent system obtaine...
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WO/2024/069493A2 |
A method of processing a liquid sample includes providing the sample. A first set of beads is introduced to the sample. The first set of beads includes a bead characteristic and a first bead performance value. A second set of beads is in...
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WO/2024/072337A1 |
The invention relates to a solid phase extraction column to be used in the enrichment of biological samples such as blood, urine, saliva, and low concentrations of analytes in food and environmental samples by solid phase extraction prio...
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WO/2024/068682A1 |
The present disclosure provides a chromatography ligand defined by Formula I: wherein: X1 is selected from CO and SO2; each of R1-R5 is independently selected from H, F, Cl, O, N, S, C1-3 alkyl, and C1- 3 alkyl-X2; any two adjacent moiet...
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WO/2024/065035A1 |
Compositions and processes for fabricating sorption units or filter units containing sorbent materials, for example activated carbon or charcoal powders, are disclosed. The sorbents are embedded within a porous matrix. In some examples, ...
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WO/2024/064309A1 |
A method for selectively isolating lower immunogenic biomolecule-polymer conjugates from an initial source of biomolecule-polymer conjugate, the method comprising eluting the initial source of biomolecule-polymer conjugate through a hydr...
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WO/2024/057744A1 |
The present invention provides an impurity acquisition method characterized by comprising: an adsorption/capturing step in which an organic solvent is passed through an adsorbent and metal impurities in the organic solvent are adsorbed o...
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WO/2024/056561A1 |
Herein is reported a method for separating full and empty recombinant adeno- associated virus particles using an anion exchange chromatography step, wherein the method comprises a sequence of a applying a solution comprising empty and/or...
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WO/2024/056626A1 |
The present invention relates to a method for separating a product of interest from impurities and an apparatus for performing the method. The method comprises the steps in the indicated order: (1) loading on a chromatography matrix a fi...
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WO/2024/055988A1 |
Provided are an isolated polypeptide consisting of a mutant B domain of Protein A, an unnatural immunoglobulin binding protein containing the mutant B domain, a conjugate containing the mutant B domain or the unnatural immunoglobulin bin...
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WO/2024/053515A1 |
The present invention belongs to the technical field of gas-liquid separators for separating fluid in a supercritical fluid device into liquid and gas and quickly discharging the separated liquid, and provides a gas-liquid separator (10)...
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WO/2024/054992A1 |
The present disclosure is directed to methods of separating a chelator from a mixture and measuring the concentration of the chelator in the mixture using a chromatography column. Such methods can be useful in adjusting the concentration...
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WO/2024/048091A1 |
The present invention addresses the problem of providing a novel adsorbent that has a high adsorption capacity and that is capable of adsorbing a substance to be adsorbed with a small amount of use. The present disclosure provides an a...
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WO/2024/050398A1 |
The present disclosure provides chromatography compositions and methods for separation of biomolecules, in particular, stationary phases and chromatography columns for improved separation and resolution of DAR species in antibody drug co...
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WO/2024/047096A1 |
The present invention relates to processes for the purification of an oligosaccharide from a solution, a product of such processes, and the use of a product of such processes.
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WO/2024/049540A1 |
A hydrophobic interaction chromatography (HIC) composition includes a solid phase substrate and a hydrophobic-modified hydrophilic ligand covalently coupled to the solid phase substrate. The hydrophobic-modified ligand includes a hydroph...
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WO/2024/047349A1 |
The invention relates to a non-woven mat or shaped article comprising a mixture of both fibrillated feather barb material and fibrillated feather quills. The invention provides a method for absorbing oil, the method comprising the steps ...
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WO/2024/045430A1 |
The present invention relates to the technical field of biological functions of proteins, and specifically relates to a polypeptide, a fused polymer protein and the use thereof. The polypeptide is selected from: (1) a polypeptide that ha...
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WO/2024/048438A1 |
The present invention addresses the problem of providing: a diastereomer preparation method whereby it becomes possible to produce a desired diastereomer from a diastereomer mixture with high efficiency; and a solid-phase photosensitizer...
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WO/2024/042738A1 |
A liquid immersion cooling device that cools a heating element provided on a substrate, the liquid immersion cooling device comprising: a casing that houses the substrate inside and stores a refrigerant in the lower part of the inside; a...
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WO/2024/044090A1 |
The invention is directed to a valve switching system for selectively interconnecting components of a bioprocess installation (2), comprising a valve switching cassette (15) and an actuator block (16). It is proposed, that the valve swit...
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WO/2024/042249A1 |
What is described is a process for producing decaffeinated raw coffee beans. One process step comprises the extraction of caffeine from raw coffee beans by means of an aqueous extraction liquid, a further process step the binding of caff...
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WO/2024/043296A1 |
An amine separation method comprises a separation step for separating an amine through chromatography using: a stationary phase obtained by supporting, on a carrier, a ligand having a crown ether-like cyclic structure; and a mobile phase...
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WO/2024/042739A1 |
A liquid immersion cooling system for cooling a heat generator provided to a substrate, the cooling system comprising: a cooler main body including a casing which accommodates the substrate and the heat generator inside and in which a re...
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WO/2024/042372A1 |
The present disclosure pertains to non-porous composite particles that are non-porous, polymer-based particles. In various embodiments, a non-porous polymer core is surface modified. In various embodiments, a non-porous hybrid organic-in...
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WO/2024/042371A1 |
The present disclosure pertains to non-porous composite particles that are non-porous, polymer-based, organic-inorganic materials. In various embodiments, a non-porous polymer core is surface modified. In various embodiments, a non-porou...
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WO/2024/038432A1 |
The present invention in some embodiments thereof relates to an apheresis device for collecting and/or removing substances from the blood, such as, circulating tumor cells (CTCs), selected proteins, lipids, pathogens, various harmful sub...
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WO/2024/036251A1 |
Provided are methods of separating full capsid particles and empty capsid particles in a viral capsid preparation by overloading viral capsid preparations onto an anion exchange medium integrated with weak partitioning chromatography and...
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WO/2024/028498A1 |
The present invention pertains to a chromatography method for the purification and/or separation of target nanoparticles. Said method relies on a hydrophilic stationary phase that comprises rigid beads with throughpores, making these bea...
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WO/2024/027080A1 |
An adsorption resin column device, comprising: a vessel body (1), a partition plate (2), a first resin structure (3) and a second resin structure (4). The vessel body (1) is provided with a first circulation port (11) and a second circul...
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WO/2024/028225A1 |
The invention relates to an ion exchange material for use as a stationary phase in an analytical or preparative separation process, in particular for the separation of anions, preferably halo acetic acids. The material comprises - a poly...
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WO/2024/030509A1 |
Disclosed herein are embodiments of matrixes made of a porous size exclusion support and a cationic moiety for separating one or more small molecules from one or more large molecules in a sample using differences in one or more propertie...
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WO/2024/029394A1 |
The present invention provides a carrier which is for chromatography, which has a large dynamic binding capacity with respect to an antibody or a fragment thereof, and through which a protein ligand is unlikely to leak even when the carr...
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WO/2024/023265A2 |
It is provided a purification processe for removing impurities, such as GroEL, from samples of outer membrane vesicles (OMVs). For example, the process is applied to OMVs derived from Bordetella or from Neisseria, for example Neisseria g...
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WO/2024/026446A1 |
The present application relates to systems and methods for purifying polypeptides, such as His-tagged polypeptides, using immobilized metal chelate affinity chromatography (IMAC). The method includes loading a composition comprising the ...
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WO/2024/022894A1 |
The present disclosure relates to a process for recovery of a nucleic acid product from a composition. The process (100) comprising: (i) contacting (110) the composition with a chromatography material functionalised with a ligand. The ch...
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WO/2024/025404A1 |
The invention consists in recycling and then purifying, by means of a closed-loop cascade of nanofiltrations, sulphuric acid for regenerating ion-exchange resin, and thus concentrating the uranium initially contained therein with a view ...
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WO/2024/020596A1 |
Fusion proteins, comprising at least one single chain antibody fragment (scFV), and a cancer antigen or marker, or a fragment thereof are provided. The scFV is capable of selectively binding to a cytokine released by chimeric antigen rec...
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