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JP3291345B2 |
PURPOSE: To obtain a highly pure 2-chloro-3-cyanopyridine in good yield, while suppressing the by-production of 2-chloro-5-cyanopyridine. CONSTITUTION: Phosphorus oxychloride is reacted with 3-cyanopyridine N-oxide in the presence of a t...
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JP3280977B2 |
PCT No. PCT/EP93/00586 Sec. 371 Date Sep. 20, 1994 Sec. 102(e) Date Sep. 20, 1994 PCT Filed Mar. 13, 1993 PCT Pub. No. WO93/19034 PCT Pub. Date Sep. 30, 1993Chlorine-substituted olefins I I (R1=organic radical; R2=-CN, -CO-R3, -CO-S-R3, ...
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JP2002104999A |
To provide a method for fluorinating an organic compound having an alcoholic hydroxyl group excellent in cost, safety and selectivity.This method for fluorinating is characterized by reacting an organic compound having a trialkylsiloxy g...
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JP2002105015A |
To provide a method for producing an α,α-difluoroether derivative, by which the α,α-difluoroether derivative useful as an intermediate for medicines and agrochemicals can profitably be obtained from easily available raw materials in ...
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JP2002097160A |
To provide a manufacturing method capable of obtaining an iodized aromatic compound in high yield.This method manufactures an iodized aromatic compound by treating an aromatic compound with iodine chloride in the presence of a compound e...
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JP2002080985A |
To provide a method of manufacturing a completely fluorine substituted organic compound which is continuously operative for a long period of time and prevents the degradation in an electrode area-time yield with lapse of time.The novel m...
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JP2002506839A |
In a process for chlorinating ketones which, apart from the carbonyl group, are inert in respect of triarylphosphine dichlorides, except for cyclopropyl methyl ketone, in which the ketones are reacted with a chlorinating agent in the pre...
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JP2002504921A |
The invention concerns a method for chlorinating an aromatic ring, characterised in that it consists in submitting the aromatic substrate to the action of a chlorinating agent in the presence of a Lewis acid containing a boron atom bound...
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JP2002504017A |
Systems and methods for synthesizing chemical compounds using a plurality reaction vessels. In particular, the present invention provides a synthesis apparatus capable of holding a plurality of reaction vessels for parallel synthesis of ...
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JP3252920B2 |
PURPOSE: To obtain 4-chlorophthalic acid anhydride with high yield by irradiating phthalic acid anhydride and chlorine with light. CONSTITUTION: Chlorine and phthalic acid anhydride in a vapor phase are sent to a reaction chamber and irr...
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JP2002502690A |
It has been found possible to separate catalytically-active aminophosphonium catalysts from mixtures composed predominately of aminophosphonium catalyst residue(s) and heavy ends from a halogen exchange reaction conducted in an aprotic s...
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JP2002503141A |
The present invention provides apparatus and methods for the synthesis of combinatorial chemical libraries. The apparatus comprises a plurality of reaction vessels having an inner surface, an outer surface, a first opening, and a second ...
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JP2002030012A |
To provide a practical and environmentally friendly method for producing fluorine compounds with reduced process steps in which bipyridinium salt industrially and inexpensively available is used as a fluorination agent for the substrates...
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JP2002030004A |
To provide a fluorinating agent consisting of a combination of N,N'- difluoro-2,2'-bipyridiniumbis(tetrafluoroborate), that is, an industrially applicable electrophilic fluorinating agent, with a reaction accelerator in which severe anhy...
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JP2002003410A |
To provide a method for producing an aromatic halogen compound in high yield by using an aromatic amine compound as a raw material, simpler in operability and capable of being produced at a low cost with requiring a small addition in a f...
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JP3242575B2 |
To provide a procedure for converting the amino group of a heterocyclic primary amine to a chloro group, a synthetic method of 2-chloro-5- methylthiazole and its derivatives utilizing this conversion. After a heterocyclic primary amine i...
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JP2001524459A |
A process for producing fluorinated organic compounds comprising reacting an organic compound fluorination agent in the presence of a fluorination catalyst, while maintaining a pressure less than sufficient for high-temperature distillat...
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JP3230099B2 |
PURPOSE: To provide a new process for easily and site-selectively fluorinating an aromatic ring by simple operation. CONSTITUTION: A fluorinated aromatic compound is synthesized by reacting an N-aryl-N-hydroxyamide with diethylaminosulfu...
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JP2001316300A |
To provide a method for industrially efficiently and simply producing a benzene iodide derivative useful as a synthetic intermediate of various kinds of foods, medicines, etc., from a benzene derivative having phenolic hydroxyl group, es...
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JP2001521816A |
According to the present invention there is provided a method of carrying out a chemical reaction between at least two fluids, the method comprising providing respective flow paths for the at least two fluids, said flow paths communicati...
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JP3226476B2 |
To provide a method for producing an organic halogen compound by a catalytic gaseous-phase reaction of the vapor of an aromatic compound which is solid at room temperature and needs vaporizing for the reaction, with a halogen gas in the ...
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JP2001520116A |
(57) [Summary] The system of the present invention is useful for the synthesis of chemical compounds and can be used for solid or liquid chemistry. In one embodiment, the system (10) comprises a reagent delivery / vent unit (20) and a ch...
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JP2001519405A |
Processes for the electrophilic substitution of aromatic compounds, such as alkylation, with a desired substituent are disclosed. The processes include contacting the aromatic compound, a precursor of the desired substituent and an aqueo...
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JP3220986B2 |
A process for preparing a fluorine-containing dicarbonyl compound of the formula: R<1>COCFR<2>COR<3> in which R<1> is a hydrogen atom, or a substituted or unsubstituted alkyl or aryl group; R<2> is a hydrogen atom, a halogen atom, or a s...
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JP2001261585A |
To provide a method for producing a vinyl halide in high selectivity in a high yield.This method for synthesizing the vinyl halide compound of general formula (3) is characterized by reacting an aromatic ketone of general formula (1) wit...
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JP2001516364A |
The process according to the invention can be illustrated by way of example by the following equation:The monosodium salt of the 3-cyano-2-hydroxy-5-fluoropyrid-6-one (cf. Formula (I)) and/or tautomers thereof are preferably employed in ...
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JP2001514238A |
PCT No. PCT/EP98/05296 Sec. 371 Date Feb. 20, 2000 Sec. 102(e) Date Feb. 28, 2000 PCT Filed Aug. 20, 1998 PCT Pub. No. WO99/11588 PCT Pub. Date Mar. 11, 1999The invention concerns a method for producing compound containing fluorine, part...
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JP3202960B2 |
To obtain a halogenating agent capable of halogenating a hydroxyl group in a stable yield in a high purity and in a short reaction time without producing by-products in which one or more sites except the target hydroxyl group are halogen...
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JP2001512090A |
PCT No. PCT/EP98/04485 Sec. 371 Date Jan. 11, 2000 Sec. 102(e) Date Jan. 11, 2000 PCT Filed Jul. 20, 1998 PCT Pub. No. WO99/06339 PCT Pub. Date Feb. 11, 1999Substituted benzyl bromides of the formula I where at least one substituent R1-5...
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JP2001512105A |
PCT No. PCT/EP98/04490 Sec. 371 Date Jan. 27, 2000 Sec. 102(e) Date Jan. 27, 2000 PCT Filed Jul. 20, 1998 PCT Pub. No. WO99/06373 PCT Pub. Date Feb. 11, 19992-(3-Pyrazolyloxymethylene)nitrobenzene [sic] derivatives of the formula I where...
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JP2001510173A5 |
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JP2001510173A |
The present invention provides a method of substituting a carbonyl compound with fluorine at the alpha-position, comprising reaching the carbonyl compound with a fluorinating present of a metal-containing catalyst. The reaction results i...
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JP3192515B2 |
PURPOSE: To obtain a halofluorinated product of various alkenes under relatively mild condition in high yield, stereoselectivity and site selectivity. CONSTITUTION: An alkene is made to react with a fluorination agent consisting of a tet...
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JP2001199911A |
To provide a production method capable of producing an α- bromoethylbenzene safely in a high yield. This production method for producing an α-bromoethylbenzene comprises continuously adding a radical initiator to a reaction system in b...
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JP2001181218A |
To provide a simple method for preparing a reaction mixture containing a compound of formula (1), at reasonable cost. AzxArFwCl(y-w)Rz (1) [wherein Az is a group of F, Cl, Br, NO2, CN, CF3, CCl3, CHO, CO(CnH2n+1) (n is an integer of 1-10...
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JP2001508359A |
PCT No. PCT/EP90/00332 Sec. 371 Date Jul. 21, 1999 Sec. 102(e) Date Jul. 21, 1999 PCT Filed Jan. 22, 1998 PCT Pub. No. WO98/32532 PCT Pub. Date Jul. 30, 1998Catalyst for halogen-fluorine exchange reactions on aromatics, consisting essent...
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JP2001506593A |
The invention concerns a reagent and a family of compounds. The reagent contains by successive or simultaneous addition: a material of formula RfH, a silicophilic base, a trivalent nitrogenous derivative containing no hydrogen and at lea...
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JP2001505926A |
A method of fluorinating an organic compound comprising reacting an organic compound with a fluorinating agent characterized in that a perfluorocarbon compound is present in the reaction medium. The perfluorocarbon compound may replace a...
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JP2001097898A |
To provide a method for producing a fluorinated bisphenyl compound (formula (b)) on an industrial scale safely under a mild condition. This method for producing the fluorinated bisphenyl compound comprises reacting a diazonium compound s...
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JP2001504495A |
Chloropentafluorobenzene or bromopentafluorobenzene is formed by heating perhalobenzene, C6FnX6-n where n is 0 to 4, and each X is, independently, a chlorine or bromine atom, with alkali metal fluoride, and an aminophosphonium catalyst (...
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JP2001064290A |
To obtain the subject novel compound that is useful as a catalyst or a component in a catalyst system used in a phase transition reaction, particularly in a halogen-fluorine exchanging reaction with low toxicity to skin, can attain the r...
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JP3142025B2 |
A fluorinating reagent represented by general formula (I), and a method of fluorinating an alcoholic hydroxyl group with the same, wherein R represents C1-C5 alkyl or dialkylamino having C1-C3 alkyl groups. The starting material of the r...
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JP2001058965A |
To obtain a fluorinated aromatic compound of high purity in high yield with easy recovery of the solvent, that is useful as a starting chemical or the like by allowing a specific halogenated aromatic compound to react with an alkali meta...
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JP2001046865A |
To well circulate a fluid body in a reactor regardless of the amt. thereof while reducing cost and facilitating handling. In a circulation reactor 1 for fluid bodies 5, 6 having different densities, the first fluid body 5 is introduced i...
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JP3132923B2 |
Methyl-substituted aromatics of the formula (I) in which R<1>, R<2> and R<3> have the meaning given in the description, can be advantageously reacted under free radical conditions to give the respective trichloromethyl- or tribromomethyl...
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JP3131021B2 |
PURPOSE: To industrially advantageously obtain an alkyl, alkenyl or alkynyl chloride useful as an org. synthesis intermediate, etc., by allowing an alcohol to react with phosgene or thionyl chloride in the presence of an aliphatic, cyclo...
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JP2000516941A |
The invention concerns a process for the bromination of aromatic compounds with ozone, wherein the aromatic compound is reacted with a bromide source in the presence of ozone at a pH of less than or equal to 7. The process according to t...
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JP3094677B2 |
PURPOSE: To obtain a new compound as a fluorinating agent having improved fluorinating efficiency and reaction selectivity, excellent in terms of yield of synthesis, reaction condition, handling and regeneration efficiency of fluorinatin...
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JP2000256298A |
To provide a method by which an aromatic α-bromoalkyl compound can efficiently be produced from an aromatic alkyl compound without using an expensive brominating agent. This method is to brominate an aromatic alkyl compound in an organi...
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JP2000510139A |
PCT No. PCT/FR97/00803 Sec. 371 Date Jan. 19, 1999 Sec. 102(e) Date Jan. 19, 1999 PCT Filed May 6, 1997 PCT Pub. No. WO97/43231 PCT Pub. Date Nov. 20, 1997The invention features a useful method for the synthesis of fluorinated derivative...
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