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JP2012158599A |
To provide a method for the production of pyrrole-2-carbonitriles such as 1-methylpyrrole-2-carbonifirile.The method preferably includes the steps of: reacting a pyrrole with chlorosulfonyl isocyanate in the presence of a solvent; and co...
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JP4990620B2 |
Methods of forming camptothecin compounds which are effective anti-tumor compounds are disclosed. These compounds inhibit the enzyme topoisomerase I and may alkylate DNA of the associated topoisomerase I-DNA cleavable complex.
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JP4971170B2 |
The present invention relates to a process for the preparation of compounds of formula I wherein R1 is C1-C4haloalkyl; R2 is C1-C6alkyl and R3 is methyl or ethyl, by reaction of compounds of formula II wherein the substituents are as def...
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JP2012121843A |
To provide a method capable of producing a corresponding amine compound with high yield and high selectivity by deoxidizing an amide compound in a mild condition.The method for producing amine comprises deoxidizing amide in the presence ...
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JP4959092B2 |
Starting material streams are mixed in a mixer (13) for the phosgenation of amines by a process in which the reaction product (3) is removed in a closed loop and the starting material streams (1.2) contain organic solvents. The main stre...
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JP4944604B2 |
The invention relates to a process for the preparation of secondary nitroxide radicals from their corresponding secondary amines by oxidation with an organic peracid, comprising the steps a) adding to a reaction vessel a secondary amine,...
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JP4934586B2 |
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JP2012087138A |
To provide a hydrogenation method useful for the hydrogenation of substrates having a carbon-hetero atom double bond.The catalysts of formula (II): [Ru(L)m(L')wXY] are used to reduce a compound having the carbon-hetero atom double bond b...
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JP2012072151A |
To provide a compound useful for preparing caspase inhibitors and/or prodrugs thereof.The invention relates to processes and compounds useful for producing modified aspartic acid derivatives, such as aspartic acid aldehyde moieties. Aspa...
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JP4898658B2 |
The invention relates to a process of producing a compound of comprising purifying a mixture of wherein R 8 is a protecting group, and purifying includes chromatographing, selectively crystallizing, or dynamically crystallizing the mixture.
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JP4890267B2 |
The invention concerns a method for producing: a) nitriles of formula (II) and b) isonitriles of formula (III) by reacting: a) carboxylic acid amides (RCO-NH2), ammonium salts of carboxylic acids (RCOO-NH4+) or carboxylic acids in the pr...
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JP4884639B2 |
In a process for mixing reactant streams ( 1, 2; 5 ) to produce a product stream ( 10 ) using a mixing configuration ( 15, 16 ) having a number of reactant feed points, an excess component stream of one reactant is divided into two react...
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JP4842816B2 |
The present invention relates to a method of making a compound of the formula wherein X1, X2 and R3-R4 are as defined herein. The method includes reacting a compound of the formula with an amine of formula 3 (HNR3R4) in the presence of a...
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JP4820020B2 |
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JP2011201895A |
To provide a method for industrially producing an intermediate of useful compounds expressing the inhibitory action of activated blood coagulation factor X by using an inexpensive raw material in a short process with good efficiency.A me...
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JP4778405B2 |
The following are claimed: (A) anthracycline compounds of formula Q-O-R-P (I) Q = a group of formula (i):R = H (sic) or C(O)-(CH2)n-C(O);n = 0-7;R' = NH2; or an aromatic or hydrogenated 5 or 6 membered heterocycle having at least one rin...
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JP4759388B2 |
A process for producing a compound of formula (5) or a salt thereof: [F10] wherein the process is characterized by comprising reacting a compound of formula (2) or a salt thereof: [F8] with an alkali metal nitrite in the presence of a re...
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JP4734587B2 |
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JP4705307B2 |
A process for the nitration of conjugated alkenes of formula (I) wherein R, R1, R2, R3 and R4 have the meanings reported in the description, which allows to obtain the corresponding beta-nitro-alkenes, characterised in that the nitrating...
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JP4688292B2 |
Production of N-methyl-N-[(1S)-1-phenyl-2-((3S)-3-hydroxypyrrolidino)ethyl
]-2,2-diphenylacetamide (Ia) or N-methyl-N-[(1R)-1-phenyl-2-((3R)-3-hydroxypyrrolidino)ethyl
]-2,2-diphenylacetamide (Ib) comprises (a) reacting the corresponding...
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JP4685996B2 |
In the invented process for producing a nitro compound, an organic substrate and nitrogen dioxide are reacted in the presence of oxygen or are reacted in a molar ratio of nitrogen dioxide to the organic substrate of less than 1 to yield ...
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JP4653108B2 |
A process for the preparation of urea comprising adding methanol to a carbon monoxide containing gas, contacting the carbon monoxide-containing gas, methanol and water in at least one shift step in the presence of a catalyst comprising c...
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JP2011506530A |
Processes for preparing an amine, which processes comprise: reacting a reactant selected from the group consisting of primary alcohols, secondary alcohols, aldehydes, ketones, and mixtures thereof, with hydrogen and a nitrogen compound s...
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JP4638006B2 |
Trifluoromethylnitro compound is prepared in a high yield from an alkali salt and a cationic trialkyl or triaryl salt. Compound of formula (I): (((R<1)R<3>)k)lAxKt)<+>N(CF3)2 (I) Kt = N, P, As, Sb, S or Se; A = N, P, P(O), O, S, S(...
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JP2010536912A |
The present invention relates to a process for preparing isocyanates.
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JP4562370B2 |
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JP4554595B2 |
Production of polyisocyanates comprises mixing an amine with phosgene, reacting the amine with the phosgene in a tubular reactor, and passing the reactor effluent to a distillation column. Independent claims are also included for: (1) tu...
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JP4554266B2 |
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JP4525951B2 |
To obtain a solid-phase particle, capable of producing a carboxylic acid, ketone or oxazole derivative with increased carbon content, and useful for solid-phase synthesis or the like. This solid-phase particle has a group shown by the fo...
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JP2010159237A |
To provide a method for producing an aromatic amine by directly aminating an aromatic compound at a normal temperature under normal pressure. An aromatic compound and ammonia water are fed to a reaction vessel and irradiated with a light...
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JP4489976B2 |
Peptide substances, their preparation and their use as complement inhibitors are described. These are in particular substances having a guanidine or amidine radical as a terminal group. In particular, inhibitors of the complement proteas...
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JP4480080B2 |
A method for the production of aromatic di-isocyanates (I) by gas-phase reaction of phosgene with diamines involves carrying out the reaction in a reaction zone under a pressure of more than 3 bar and less than 20 bar. An Independent cla...
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JP4473450B2 |
The invention is directed to a nickel catalyst comprising 0.1 to 12.5 wt.% of at least one structural promoter, selected from the group of oxides of metals and metalloids and combinations thereof, and 87.5 to 99.9 wt.% of nickel, calcula...
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JP4464505B2 |
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JP4464388B2 |
Palladum-phosphine complexes obtained by reacting a 5 compound of formula (1) below with a palladium compound: F(I) (wherein R1 is a hydrogen atom, an alkyl group, a cycloalkyl group or a phenyl group which may be substituted; R2 and R3 ...
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JP4440606B2 |
Production of perfluoroalkyl aniline derivatives (I) comprises reacting an aniline (II) with a dihalo perfluoroalkane (III) and reacting the intermediate product (IV) with an ionic fluoride. Production of perfluoroalkyl aniline derivativ...
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JP4426465B2 |
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JP4420416B2 |
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JP4410411B2 |
The present invention relates to compounds of the general formula I wherein A is a group of the formula and Z is an O or S atom, to the further processing thereof to form novel sec-amidoalkylcarbonic acid derivatives and to those sec-ami...
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JP2009541385A |
The present invention provides a new method for preparation and crystallization of hydrochlorides, hydrobromides or hydroiodides of pharmaceutical compounds or their intermediates in which the base or its acid addition salt is reacted in...
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JP2009541379A |
Process for the preparation of a nitrogen-containing compound, comprising the steps of: a) bringing N2, optionally NH3 and optionally a recycle stream together with a carbon- and hydrogen-containing compound or a carbon-containing compou...
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JP4349749B2 |
A process for producing a carboxylic acid derivative characterized by mixing a quaternary ammonium salt having a specific triazine ring in the molecule, a carboxylic acid compound, and a compound having a nucleophilic functional group to...
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JP4346141B2 |
Single vessel preparation of pyridine dicarboxylate comprises sequential condensation of alkyl vinyl ether and Vilsmeier reagent, oxalacetate and ammonia. Preparation of substituted pyridine derivatives of formula (I) comprises: (a) reac...
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JP4348078B2 |
A process for the nitration of an aromatic compound, wherein the aromatic compound is admixed with a nitrating agent in the presence of an ionic liquid is described. The method for the nitration of aromatic compounds in (e.g. neutral) io...
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JP4347488B2 |
A process for the addition of an azide function to an organic compound in which process a mixture is prepared by adding an epoxide-derivative of the organic compound and an alkali metal azide salt to a solvent is described. The mixture i...
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JP4320059B2 |
PCT No. PCT/EP98/01163 Sec. 371 Date Sep. 10, 1999 Sec. 102(e) Date Sep. 10, 1999 PCT Filed Mar. 2, 1998 PCT Pub. No. WO98/41504 PCT Pub. Date Sep. 24, 1998The present invention relates to the preparation of 5-aminomethyl-2-chloropyridin...
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JP4320062B2 |
A shaped, activated metal, fixed-bed catalyst with a pore volume of 0.05 to 1 ml/g and an outer activated layer consisting of a sintered, finely-divided, catalyst alloy and optionally promoters. The catalyst alloy has metallurgical phase...
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JP4318753B2 |
The present invention relates to a hydrogenation process for the preparation of aromatic amino compounds containing directly on the aryl ring or in a side chain one or more entities that may also undergo hydrogenation, such as carbon mul...
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JP4300450B2 |
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JP4285980B2 |
Preparation of an oxime comprises ammoxidation of a ketone or an aldehyde in a system of one aqueous phase and one inert hydrocarbon phase in the presence of a catalyst system comprising (i) a heterogeneous catalyst based on titanium, si...
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