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Matches 51 - 100 out of 6,655

Document Document Title
WO/2016/115688A1
Disclosed are processes for chiral induction ability improvement in carbene-ligated transition metal catalysis, and compounds prepared therewith.  
WO/2016/094677A3
The invention features a mononucleotide comprising a nucleobase bonded to a sugar having a 3'-carbon and a 5'-carbon, where the 5'-carbon is bonded to a phosphorus (V) atom of a phosphate group through an oxygen atom, the phosphorus (V) ...  
WO/2016/076160A1
[Problem] To provide a method for producing an industrially preferred optically active sulfoxide derivative. [Solution] A method for producing an optically active sulfoxide derivative represented by general formula (1), the method charac...  
WO/2016/056669A1
 Provided is a solid-supported ruthenium complex represented by general formula (1), (2) or (3). Further provided are: a method for manufacturing a reduction product by reducing an organic compound in the presence of the solid-supporte...  
WO/2016/047644A1
Provided is a production method for an optically active α-trifluormethyl-β-amino acid derivative whereby: a compound indicated by general formula (1) and a compound indicated by general formula (2) are reacted in the presence of a copp...  
WO/2016/047388A1
Provided is a process for producing an optically active hydroxyaldehyde or aminohydroxyaldehyde. The process for producing an optically active hydroxyaldehyde or aminohydroxyaldehyde is characterized by reacting an aldehyde or an imine w...  
WO/2016/043253A1
 A method for producing a compound (4), the method comprising reacting a compound (1) with hydrogen gas in an inert solvent in the presence of a specific chiral ligand and a ruthenium catalyst, or in the presence of the chiral ligand a...  
WO/2016/013033A4
The present invention discloses a novel vinylic 3-amino-1,2 diol compounds of formula (I) and a one pot cost-effective process for the synthesis of vinylic-3-amino-1,2-diols of formula (I) which comprises tandem α-amination-benzoyloxyal...  
WO/2016/039691A1
Compounds of formula (I): wherein R and A- are defined herein as a catalyst for making chiral heterocyclic sulfoxides and a method of producing enantioenriched sulfoxide in the presence of the said compounds.  
WO/2016/031736A1
As a result of this pyridine derivative represented by general formula (1), or a salt thereof, a catalyst is provided which is capable of shortening reaction time and achieving high product selectivity in asymmetric Steglich reactions of...  
WO/2016/023787A1
The present invention relates to a process for the preparation of a compound of formula (I) wherein A1 and A2 are C-H, or one of A1 and A2 is C-H and the other is N; R1 is C1-C4alkyl, C1-C4haloalkyl or C3-C6cycloalkyl; each R2 is indepen...  
WO/2016/021711A1
 The present invention addresses the problem of providing a method for inexpensively, stably and industrially producing, at high yields, lacosamide having high optical purity. The abovementioned problem is solved by providing a method ...  
WO/2016/019630A1
Disclosed is a method for synthesizing 1,3-disubstituted allene with high optical activity, namely a method for preparing 1,3-disubstituted allene with high optical activity in one step of functionalizing terminal alkyne, aldehyde and ch...  
WO/2015/189862A4
Described herein is the general synthesis of chiral amine from vinyl nitro compounds using Josiphos catalyst. The process is applied to develop a novel route to Sitagliptin (a DPP-IV inhibitor).  
WO/2016/013033A1
The present invention discloses a novel vinylic 3-amino-1,2 diol compounds of formula (I) and a one pot cost-effective process for the synthesis of vinylic-3-amino-1,2-diols of formula (I) which comprises tandem α-amination-benzoyloxyal...  
WO/2015/189862A1
Described herein is the general synthesis of chiral amine from vinyl nitro compounds using Josiphos catalyst. The process is applied to develop a novel route to Sitagliptin (a DPP-IV inhibitor).  
WO/2015/188005A1
The invention relates to the preparation and characterization of novel salts of (R)-isometheptene and crystalline forms thereof; moreover, the invention describes the use of the novel salts alone or in combination with other therapeutic ...  
WO/2015/186614A1
 The present invention addresses the problem of providing a novel compound capable of imparting a highly appealing floral and verdant aroma, and a fragrance composition containing the same. This compound is a racemic or optically activ...  
WO/2015/181491A1
The invention relates especially to a method for grafting oligopeptides into porous hybrid materials, especially metal-organic frameworks (MOFs). The invention also relates to porous hybrid materials functionalised on the outer surface a...  
WO/2015/178847A1
There is provided a method for the preparation of an enantiomerically enriched amine by asymmetric hydrogenation of a prochiral oxime.  
WO/2015/178846A1
There is provided a method for the preparation of an enantiomerically enriched amine from a prochiral ketone.  
WO/2015/107553A3
The present invention is relates to a process for the preparation of crizotinib or an acid addition salts thereof. More specifically the invention pertains to crizotinib free base in amorphous form and crizotinib dihydrochloride in cryst...  
WO/2015/174377A1
The objective of the present invention is to provide a method for producing a compound represented by formula (1) or the like, said compound being a 2-pyridone compound that is useful as a pharmaceutical product or a pharmaceutical inter...  
WO/2015/166827A1
A method for producing an optically active anti-1,2-nitroalkanol compound, the method including a supplying step for continuously supplying an aldehyde compound and a C2 or higher nitroalkane compound to a reaction container, a reaction ...  
WO/2015/066612A3
Provided are methods for site- and stereo-retentive cross-couplings with unactivated secondary boronic acids, particularly useful in building block-based approach for small molecule synthesis. Also provided is a method of forming an air-...  
WO/2015/146881A1
The present invention is a process for producing a 1-arylimino-2-vinylcyclopropanecarboxylic acid derivative represented by formula (2) in a yield close to that attained with lithium t-butoxide, preferably in a yield higher than that att...  
WO/2015/141564A1
Provided is a method for manufacturing an optically active compound represented by formula (2), the method comprising bringing hydrogen and a compound represented by formula (1) into contact in the presence of a transition metal catalyst...  
WO/2015/135984A1
The present invention relates to a catalytic method for producing 3-triazolyl-sulfoxide derivatives in enantiomerically pure or in enantiomerically enriched form.  
WO/2015/137496A1
The present invention provides a process for efficiently producing an optically active 6-(3-aminopiperidin-1-yl)-2,4-dioxo-1,2,3,4-tetrahydropyrimi dine derivative. 1,4,5,6-tetrahydropyridine-3-carboxamide or a derivative thereof is asym...  
WO/2015/131299A1
The present invention relates to a method of preparation and chiral inversion of chiral-1-t-butoxycarbonyl-3-hydroxy piperidine, the method mainly comprising the steps of: using N-benzyl-3-hydroxy piperidine as raw material, and splittin...  
WO/2015/133405A1
[Problem] To provide a novel stereoselective method for manufacturing an optically active azetidinone compound. [Solution] Provided is an industrially useful manufacturing method capable of manufacturing an optically active azetidinone c...  
WO/2015/129630A1
[Problem] To provide a novel method for producing (S)-2-(5-chloro-2-nitrophenyl)-4-cyclopropyl-1,1,1-trifluoro but-3-yne-2-ol. [Solution] An alkynyl ketone represented by belowmentioned formula (1) is reacted with (trifluoromethyl) trime...  
WO/2015/125781A1
 A method for producing a compound represented by general formula (II) via a step for reacting a compound represented by general formula (I) with a sulfur compound, and a compound. In general formulas (I) and (II), R1 represents a hydr...  
WO/2015/125782A1
 A method for producing a compound represented by general formula (II) via a step for reacting a compound represented by general formula (I) with a sulfur compound, and a compound. In general formulas (I) and (II), R1 represents a hydr...  
WO/2015/122502A1
The present invention pertains to a method for producing an optically active compound which includes a step for reducing an imino group of an imine compound or a step for reducing an unsaturated bond of a heterocyclic compound, while in ...  
WO/2015/115650A1
 Provided is a method for producing an optically active carboxylic acid ester at a high yield and with high enantioselectivity using dynamic kinetic resolution, said optically active carboxylic acid ester having an α-nitrogen substitu...  
WO/2015/072290A1
Provided is a method for producing a mono active ester in a simple and selective manner using a 1,2,3-triol as a raw material. In a method for producing a 1,2,3-triol optically active monoester compound according to the present invention...  
WO/2015/037460A1
Optically active 3-(biphenyl-4-yl)-2-[(t-butoxycarbonyl)amino]propan-1-ol can be produced through: a step of reacting an optically active biphenylalanine compound represented by formula [I] with a reducing agent to produce an optically a...  
WO/2015/037243A1
 The present invention provides a method for producing an optically active hydantoin compound having an LXRβ-activating effect and a production intermediate thereof. In the present invention, an optically active carbinol compound repr...  
WO/2015/033753A1
Provided is a method that makes it possible to obtain an endo-9-azabicyclo[3.3.1]nonane-3-ol derivative that is useful as an intermediate of agricultural and horticultural chemicals or pharmaceuticals at a low cost by reacting a 9-azabic...  
WO/2015/033974A1
 Provided is a method with which it is possible to efficiently manufacture a compound having a spirooxindole structure, for example a compound having a spirooxindole structure and having antitumor activity which inhibits the interactio...  
WO/2015/030002A1
[Problem] The present invention addresses the problem of providing a method for producing an optically active 5-hydroxy-3-ketoester compound which has a high reaction yield and high stereoselectivity, and is useful as an intermediate for...  
WO/2015/030001A1
[Problem] The purpose of the present invention is to provide a method for manufacturing optically active 5-hydroxy-3-ketoesters with high yield and high stereoselectivity that can be used as a pharmaceutical intermediate. The purpose of ...  
WO/2015/019928A1
The present invention relates to a novel synthesis method that is capable of producing an optically active binaphthyldiamine derivative, under conditions whereby the binaphthyldiamine derivative can be produced more safely and efficientl...  
WO/2015/008097A1
The present invention provides processes for the production of chiral compounds in a stereoisomeric excess, the processes comprising: (i) contacting a first compound comprising an alkene or alkyne bond with a hydrometallating agent, wher...  
WO/2015/002769A1
Disclosed are novel ruthenium compounds of formula (Ia) and (Ib): wherein R1 and the moiety L ∩ L are defined herein. Also disclosed is a process for using these novel ruthenium compounds as catalysts for asymmetric hydrogenation and t...  
WO/2014/203944A1
The present invention addresses the problem of providing an aldol reaction catalyst and a method for producing a stereoselective cyclic β-hydroxy aldehyde compound using this catalyst. As a means for solving the above-mentioned problem,...  
WO/2014/202816A1
The invention relates to a method for the production of various chiral esters with a high enantiomeric purity, by means of catalytic hydrogenation reactions of enol esters. The invention also relates to the chiral esters obtained and to ...  
WO/2014/200094A1
[Problem] To provide a novel production method for a stereoselective, optically active alcohol compound. [Solution] From the compound represented by formula (3), the optically active alcohol compound represented by formula (8) can be pro...  
WO/2014/196542A1
In the present invention, in an optically active compound production method that uses a column reactor, the column reactor is produced by filling asymmetric catalyst particles in a column for the column reactor, and a compound to be reac...  

Matches 51 - 100 out of 6,655