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WO/2014/157653A1 |
The present invention addresses the problem of providing an efficient process for preparing important intermediate compounds (1) and (1a) for the production of FXa inhibitors (X) and (X-a). The present invention pertains to: a process wh...
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WO/2014/148591A1 |
The present invention provides a method for efficiently producing an optically active 1, 2-diol compound from an olefin. The production method for the optically active 1, 2-diol compound is characterized by including: a step in which an ...
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WO/2014/136868A1 |
The present invention pertains to a method of producing, in a few simple steps, a specified optically-active aldehyde represented by general formula (1) through the asymmetric isomerization of a specified allyl alcohol represented by gen...
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WO/2014/126244A1 |
Disclosed are a method for producing an amino acid and an amino acid synthesis kit that can efficiently and in an extremely short period of time synthesize a desired amino acid at a high stereoselectivity regardless of the presence/absen...
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WO/2014/126068A1 |
The present invention provides a catalyst precursor which contains ruthenium that has a first ligand, which is a chiral cyclic diene ligand, and a second ligand.
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WO/2014/119479A1 |
A method for producing a compound represented by general formula (I) or a salt thereof, which comprises a step of reacting lysine, a protected product of lysine or a salt of lysine or the protected product with allicin or a protected pro...
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WO/2014/113869A1 |
This invention provides processes for the preparation of Sitagliptin and pharmaceutically acceptable salts thereof, said processes comprising enantioselective hydrogenation of a prochiral enamine using chiral ruthenium catalyst.
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WO/2014/108487A1 |
The present invention concerns phosphinate universal P-stereogenic chiral precursors of formula (I) for chiral ligands, preparation processes thereof and their use for the preparation of optically pure or enriched chiral ligands. Claimed...
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WO/2014/101690A1 |
The present invention relates to the field of pharmaceutical synthesis, and specifically, to a method for preparing an Ezetimibe chiral intermediate. The method is as follows: a method for preparing a compound with a formula (b) structur...
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WO/2014/098063A1 |
The present invention addresses the problem of providing: a production method capable of high-yield/high-enantioselectively producing an optically active amino acid having few restrictions on the material that can be used as the substrat...
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WO/2014/096096A1 |
The present invention relates to a process of the asymmetric hydrogenation of a ketal of an unsaturated ketone or an acetal of an unsaturated aldehyde by molecular hydrogen in the presence of at least one chiral iridium complex. This pro...
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WO/2014/077323A1 |
The purpose of the present invention is to provide a method for producing optically active isopulegol and optically active menthol which makes it possible to reduce production expenses and minimize environment-polluting waste. The presen...
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WO/2014/077321A1 |
The present invention makes it possible to obtain 1-isopulegol with high yield and high selectivity by performing a citronellal selective-ring-closing reaction using an aluminum catalyst obtained by reacting: one or more types of aluminu...
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WO/2014/078491A1 |
Disclosed are methods for making chiral phosphorus ligands including chiral phosphines, chiral phosphine oxides, phosphonamides, and aminophosphines. The chiral phosphorus ligands prepared by the methods of the invention are useful as co...
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WO/2014/069351A1 |
The objective of the present invention is to provide a method for simply and efficiently producing an optically active bicyclic urea compound that is useful as an intermediate for a β-lactamase inhibitor. According to the present invent...
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WO/2014/046172A1 |
A method that enables isoxazolidine compounds to be produced at high yields is provided. A compound (1) is converted into a compound (2) in the presence of a tertiary amine catalyst having a hydrogen bond donor site within a molecule. (E...
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WO/2014/038666A1 |
A process for producing an optically active amine compound, characterized by asymmetrically hydrogenating a prochiral carbon-nitrogen double bond in the presence of a ruthenium complex represented by general formula (1) or (2) (wherein P...
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WO/2014/038665A1 |
A method for producing optically active 2,3-dihydrofarnesal represented by formula (1), characterized by aminating β-farnesene represented by formula (2) in the presence of a lithium salt of an amine to produce a (2E)-farnesylallylamine...
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WO/2013/072830A9 |
The present invention discloses single step, highly enantioselective catalytic oxidative cyclization process for the synthesis of 3-substituted chiral phthalides. In particular, the invention discloses asymmetric synthesis of chiral phth...
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WO/2014/027658A1 |
A compound represented by general formula [1D] (in the formula, R1A, R1B, R2A, R2B, R3A and R3B each denote a hydrogen atom, an optionally substituted C1-6 alkyl group, and the like) is useful as an intermediate for producing a thionucle...
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WO/2014/024753A1 |
[Problem] To provide a β-substituted-β-trifluoromethyl-α,β-epoxyketone compound having an asymmetric quaternary carbon, and a method for producing same. [Solution] The target compound represented by general formula (1) can be obtaine...
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WO/2014/024898A1 |
The invention provides: a method for producing efficiently and inexpensively on an industrial scale a compound (VII) having a good diastereomer ratio and enantiomer excess; intermediates useful in this method, and methods for producing t...
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WO/2014/012371A1 |
Disclosed are aromatic spiroketal diphosphine ligands, preparation methods and uses thereof. The ligands have the structure of formula (I), in which R1, R2, R3, R4, R5, R6, R7, R8, X and n are defined as such described in the specificati...
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WO/2014/010250A1 |
To provide a chiral reagent or a salt thereof. The chiral reagent has following chemical formula (I). In the formula (I), G1 and G2 are independently a hydrogen atom, a nitro group (-NO2), a halogen atom, a cyano group (-CN), a group of ...
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WO/2014/000455A1 |
Disclosed are a chiral five-membered bicyclic guanidine compound, and a preparation method and an application thereof. The structure of the chiral five-membered bicyclic guanidine compound is shown in Formula (I). The preparation method ...
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WO/2013/183642A1 |
Provided is a pyridine derivative represented by general formula (1) or a salt thereof, by which an optically active form can be obtained with favorable enantioselectivity. (In the formula, R1 to R6 and R1' to R6' each independently are ...
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WO/2013/168780A1 |
Provided is a method for producing an optically active 1-amino-2-vinylcyclopropane-1-carboxylic acid ester and 2-vinylcyclopropane-1,1-dicarboxylic acid ester, which do not isomerize during a reaction, with an inexpensive and easily obta...
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WO/2013/146987A1 |
[Problem] To provide: an excellent rhodium catalyst; and a method for producing an amine compound. [Solution] A rhodium complex in which a compound represented by the formula is coordinated.
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WO/2013/137330A1 |
Provided is a method for producing optically active 1-amino-2-vinylcyclopropane-1-carboxylic acid ester and 2-vinylcyclopropane-1,1-dicarboxylic acid ester, which use an optically active material that can be cheaply and easily obtained a...
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WO/2013/133343A1 |
The purpose of the present invention is to provide a fluorine-containing α,β-unsaturated aldehyde, a method for producing same, an optically active fluorine-containing compound using the fluorine-containing α,β-unsaturated aldehyde, ...
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WO/2013/120257A1 |
Provided is a method for synthesizing a laevo-p-hydroxyphenylglycine compound, comprising: (1) subjecting an amine compound with a glyoxylic acid ester compound to a nucleophilic addition reaction; subjecting the product obtained in step...
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WO/2013/099623A1 |
As represented by formula (1), (1) when hydrolysis reaction of methyl laurate was performed by adding methyl laurate (2 mmol) and water (8 ml) to a pyrosulfuric acid ammonium salt catalyst (5 mol%) and heating the mixture to 60°C for 24...
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WO/2013/088972A1 |
Provided is a compound represented by general formula (1). (1) In general formula (1), R1 is either a protecting group for a hydroxyl group or a hydrogen atom. R2 is either a methyl group or an ethyl group.
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WO/2013/074326A1 |
Embodiments of the present disclosure relate to asymmetric epoxidation of olefinic alcohols, using a chiral alcohol chelated titanium catalyst and an organic peroxide performed in a microreactor flow reactor system that can comprise mult...
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WO/2013/073525A1 |
The present invention is a method for producing an optically active 3-cyclopropylaminomethyl-4-fluoropyrrolidine Cbz protected form, comprising an amino group protection step for protecting amino groups of an optically active 3-cycloprop...
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WO/2013/073596A1 |
An optically active bisoxazoline compound represented by formula (1) (wherein R1, R2 and R3 independently represent an alkyl group having 1 to 8 carbon atoms, a phenyl group or a benzyl group; n represents an integer of 0 to 3; and * rep...
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WO/2013/065867A1 |
The present invention relates to a novel method for producing an optically active β-hydroxy-α-aminocarboxylic acid ester, the method comprising performing an asymmetric reduction reaction of a β-keto-α-aminocarboxylic acid ester by u...
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WO/2013/065189A1 |
The present invention provides a method for producing a reduction reaction product, wherein recovery of the reaction solvent and/or distillation is carried out after adding a nitrogen-containing compound into a reaction liquid of a reduc...
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WO/2013/061999A1 |
Provided is a method for producing an optically active alcohol with high yield by an industrially advantageous process with use of a low-cost asymmetric catalyst, while using a ketone, which may have various structures, as a starting mat...
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WO/2013/061515A1 |
[Problem] The present invention provides: a composition for imparting a cooling sensation, which contains 3-menthoxy propanol; and a method for producing 3-menthoxy propanol with high selectivity and high yield using 3-menthoxy-1,2-epoxy...
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WO/2013/058241A1 |
The present invention makes it possible to produce (R)-2-amino-2-ethylhexanol, which is useful as a pharmaceutical intermediate, easily and efficiently without complicated procedures. (R)-2-amino-2-ethylhexanol is produced by asymmetrica...
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WO/2013/054131A1 |
The present invention provides processes for the production of chiral compounds in a stereoisomeric excess. The present processes involve reacting a hydrometallated alkene compound with a compound comprising a conjugated -bond system und...
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WO/2012/150825A9 |
The present invention relates to a method for preparing an optically pure (S)-cyclohexylamino acid derivative by continuously hydrogenating an optically pure (S)-phenylamino acid derivative in the presence of a metal supported catalyst. ...
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WO/2013/011930A1 |
Provided are: a novel iridium (III) complex that is chiral; and a production method wherein a 2-substituted-quinoline is converted into an optically active 2-substituted-1,2,3,4-tetrahydroquinoline with use of a chiral iridium (III) comp...
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WO/2012/175837A1 |
The subject of the invention is the use of an organometallic compound for the implementation of a process for preparing chiral derivatives consisting of phospho α- or β-amino acids and also derivatives thereof with enantiomeric excesse...
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WO/2012/176830A1 |
Provided are a novel 1,2-bis(dialkylphosphino)-4,5-(methylenedioxy)benzene derivative that forms a metal complex having particularly high asymmetry induction capacity and catalytic activity on β-dehydroamino acids, a method for manufact...
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WO/2012/176715A1 |
The present invention relates to a 1-amino-2-vinyl cyclopropane carboxylic acid amide or a salt thereof. By obtaining an optically active 1-amino-2-vinyl cyclopropane carboxylic acid amide or a salt thereof by hydrolyzing an optically ac...
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WO/2012/158513A1 |
A process for preparing enantioselectively a compound of formula la or lb: over a compound of formulas 1-2 - Ih:
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WO/2012/158515A1 |
A process for preparing enantioselectively a compound of formula (la) or (Ib) over a compound of formulas I-2—1h.
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WO/2012/153684A1 |
Provided is a ruthenium complex that is represented by general formula (1*) and is useful as an asymmetric reduction catalyst. (In the formula, * is an asymmetric carbon atom; R1 is an arenesulfonyl group, and the like; R2 and R3 are a p...
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