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Matches 1 - 50 out of 6,620

Document Document Title
WO/2018/207888A1
The present invention provides a method for simply and efficiently producing ramelteon, which is a sleep-inducing agent. According to the present invention, ramelteon can be produced through a few steps including a step in which (E)-2-[1...  
WO/2018/209243A1
The present disclosure provides methods for enantioselective synthesis of acyclic α- quaternary carboxylic acid derivatives via iridium-catalyzed allylic alkylation.  
WO/2018/189107A1
The present invention is related to a new chiral biphenyl diphosphine ligand of formula (I), wherein R1, R2, and R3 are independently H, alkyl or aryl; R6 and R7 is independently a substituent; and A is independently aryl or heteroaryl, ...  
WO/2018/189060A1
The invention comprises novel chiral metal complex compounds of the formula (I) wherein M, PR2, R3 and R4 are outlined in the description, its stereoisomers, in the form as a neutral complex or a complex cation with a suitable counter io...  
WO/2018/143165A1
The present invention provides a method for producing a compound represented by formula (VII), the method including reacting a compound represented by formula (VI) with a malonic acid derivative in the presence of a base and an asymmetri...  
WO/2018/106746A2
This invention relates to novel phosphorous ligands useful for organic transformations. Methods of making and using the ligands in organic synthesis are described. The invention also relates to processes for preparing the novel ligands  
WO/2018/106621A1
This invention relates to novel phosphorous ligands useful for organic transformations. Methods of making and using the ligands in organic synthesis are described. The invention also relates to processes for preparing the novel ligands.  
WO/2018/106746A3
This invention relates to novel phosphorous ligands useful for organic transformations. Methods of making and using the ligands in organic synthesis are described. The invention also relates to processes for preparing the novel ligands  
WO/2018/099146A1
Disclosed is a method for asymmetrically synthesizing aspidosperma alkaloid. In this method, a key intermediate of formula (4) is obtained by 6 steps of reactions, including [4+2] cycloaddition of the compound of formula (1a) and the com...  
WO/2018/086197A1
The present invention relates to the field of organic syntheses, and provides a catalytic asymmetric synthesis method for a chiral SPINOL derivate, comprising: using chiral phosphoric acid as a catalyst and reacting same with a compound ...  
WO/2018/021508A1
The present invention is a production method for a compound represented by formula [I] or a pharmaceutically acceptable salt thereof, or a hydrate of said compound or salt.  
WO/2017/197670A1
Disclosed in the present application is a method for synthesizing a 1,2-dimethylene cyclobutane chiral compound. The 1,2-dimethylene cyclobutane chiral compound is synthesized from an allenylamine compound in the presence of a rhodium co...  
WO/2017/177715A1
The present invention discloses a method for synthesizing a chiral ferrocene-like P, P ligand, and belongs to the technical field of organic synthesis. The method is implemented through the following steps: (1) using vinyl ferrocene as a...  
WO/2017/168313A1
The present invention provides an improved process for preparation of L-threo-(2S,3R)-3-(3.4- dihydroxyphenyl)serine (I) (Droxidopa) and its salts; comprising (a) reaction of the aldehyde compound (III) (as described herein) with Metal c...  
WO/2017/170952A1
The present invention relates to: a novel compound that is useful as a ligand in a variety of catalytic organic synthetic reactions; a method for easily and efficiently producing said novel compound; a synthetic intermediate of said nove...  
WO/2017/154738A1
The present invention addresses the problem of providing a novel method for producing an optically active amine compound that is useful as an intermediate for a medicine, an agrochemical, an electronic material and the like. A method for...  
WO/2017/122822A1
The present invention addresses the problem of providing an industrially advantageous method for producing an optically active amidocarboxylic acid derivative, which is an important intermediate of a depsipeptide compound expected to be ...  
WO/2017/114058A1
The present invention discloses a method for preparing an optically active carbonyl compound, comprising the following steps: subjecting an α,β-unsaturated aldehyde or an α,β-unsaturated ketone to an asymmetric hydrogenation catalyze...  
WO/2017/107789A1
Disclosed are a compound having a chiral spirobiindane skeleton and a preparation method therefor. The compound having a chiral condensed ring spirobiindane skeleton of the present invention is represented by formula I or I'. The prepara...  
WO/2017/111176A1
Synthesis of an organic compound with chirality is an important technique in the fields of medicines, pesticides, health foods, etc. However, catalysts to be used for such synthesis are produced from expensive starting materials and, fur...  
WO/2017/098975A1
A method for producing methyl (2Z)-3-(1,1'-biphenyl-4-yl)-2-[(tert-butoxycarbonyl)amino]- prop-2-enoate, comprising the steps of: reacting 4-phenylbenzaldehyde with glycine in the presence of sodium hydroxide or potassium hydroxide to pr...  
WO/2017/057642A1
Provided is a novel method for producing optically active 2-(2-fluorobiphenyl-4-yl) propanoic acid. This method is characterized by reacting an organometallic reagent prepared by the action of the compound represented by formula [1] and ...  
WO/2017/051856A1
A method for producing a specific enantiomer in a larger amount than the other enantiomer, said method comprising reacting a reaction substrate in the presence of cellulose nanofiber or a derivative thereof and a catalyst so as to improv...  
WO/2017/043626A1
Provided is a method for producing an optically active 4-carbamoyl-2,6-dimethylphenylalanine derivative, which is a compound useful as an intermediate for a medicine, in a simple manner and with high efficiency. 4-carbamoyl-2,6-dimethylb...  
WO/2017/037141A1
The present invention relates to chiral phosphoramidimidates, their salts and metal complexes as well as derivatives thereof and their use as catalysts, Formula (I).  
WO/2017/036577A1
The present invention provides methods of preparing Praziquantel, in particular (R)-Praziquantel and analogues thereof in a stereoselective manner. One method involves asymmetric hydrogenation of the following intermediate compound (I) a...  
WO/2017/036577A8
The present invention provides methods of preparing Praziquantel, in particular (R)-Praziquantel and analogues thereof in a stereoselective manner. One method involves asymmetric hydrogenation of the following intermediate compound (I) a...  
WO/2017/037662A1
The present invention provides an improved process for the preparation of N-protected ((3S,4R)- 4-(4-fluorophenyl)piperidin-3-yl)methanol (compound (A)) and further its transformation to Paroxetine and its pharmaceutically acceptable sal...  
WO/2017/029362A1
The present invention relates to processes, process steps and intermediates useful in the asymmetric bisamidation of malonic ester derivatives wherein the new processes, process steps and intermediates are, for example, useful in the pre...  
WO/2017/006929A1
The present invention makes it easy to obtain, with good yield and stereoselectivity, an optically active α-tetrasubstituted α-amino nitrile derivative, or an intermediate for the synthesis of said derivative, by reacting a cyanometala...  
WO/2016/208699A1
[Problem] To provide a method for the industrial production of an optically active fluoroalkyl ethylene oxide. [Solution] An optically active fluoroalkyl chloromethyl alcohol having a high optical purity can be produced at a high yield b...  
WO/2016/203005A1
The present invention relates to a complex of the Formula 2, and a compound of Formula 1, and the use of said compound of Formula 1 for the synthesis of said complex of Formula 2, processes for synthesis of said compound of Formula 1, an...  
WO/2016/198836A1
Processes of forming Csp2-Csp3 bonds at the allylic carbon of a cyclic allylic compound starting material are disclosed, in which a racemic mixture of a cyclic allylic compound having a leaving group attached to the allylic carbon is rea...  
WO/2016/195016A8
The present invention provides: a novel HYA derivative that has excellent physiological functions inherent to HYA and allows easy intake and handling; and a use thereof. The present invention relates to: a triglyceride or optical isomer ...  
WO/2016/195016A1
The present invention provides: a novel HYA derivative that has excellent physiological functions inherent to HYA and allows easy intake and handling; and a use for said HYA derivative. The present invention relates to: a triglyceride or...  
WO/2016/160579A1
This invention provides efficient and scalable enantioselective methods that yield 2-alkyl-2-allylcycloalkyanone compounds with quaternary stereogenic centers. Methods include the method for the preparation of a compound of formula (I), ...  
WO/2016/146689A1
Provided is an organozinc composition comprising (a) an organozinc complex carrying an allylic ligand, (b) a magnesium component and (c) a lithium component. The organozinc composition is useful as a synthetic intermediate with excellent...  
WO/2016/140189A1
The purpose of the present invention is to provide a novel method for producing an optically active α-fluoro amino acid compound or a salt thereof. More specifically, the purpose is to produce an α-fluoro amino acid compound or a salt ...  
WO/2016/133020A1
[Problem] To provide a novel stereoselective method for producing an optically active allyl alcohol compound. [Solution] A method for producing an optically active allyl alcohol compound represented by formula (7) characterized by includ...  
WO/2016/133217A1
The present invention is able to provide a method for stereoselectively introducing an amino group having various substituents into the α-position of an oxindole compound by a single step by having a specific compound (a carbonyl compou...  
WO/2016/115688A1
Disclosed are processes for chiral induction ability improvement in carbene-ligated transition metal catalysis, and compounds prepared therewith.  
WO/2016/094677A3
The invention features a mononucleotide comprising a nucleobase bonded to a sugar having a 3'-carbon and a 5'-carbon, where the 5'-carbon is bonded to a phosphorus (V) atom of a phosphate group through an oxygen atom, the phosphorus (V) ...  
WO/2016/076160A1
[Problem] To provide a method for producing an industrially preferred optically active sulfoxide derivative. [Solution] A method for producing an optically active sulfoxide derivative represented by general formula (1), the method charac...  
WO/2016/056669A1
 Provided is a solid-supported ruthenium complex represented by general formula (1), (2) or (3). Further provided are: a method for manufacturing a reduction product by reducing an organic compound in the presence of the solid-supporte...  
WO/2016/047644A1
Provided is a production method for an optically active α-trifluormethyl-β-amino acid derivative whereby: a compound indicated by general formula (1) and a compound indicated by general formula (2) are reacted in the presence of a copp...  
WO/2016/047388A1
Provided is a process for producing an optically active hydroxyaldehyde or aminohydroxyaldehyde. The process for producing an optically active hydroxyaldehyde or aminohydroxyaldehyde is characterized by reacting an aldehyde or an imine w...  
WO/2016/043253A1
 A method for producing a compound (4), the method comprising reacting a compound (1) with hydrogen gas in an inert solvent in the presence of a specific chiral ligand and a ruthenium catalyst, or in the presence of the chiral ligand a...  
WO/2016/039691A1
Compounds of formula (I): wherein R and A- are defined herein as a catalyst for making chiral heterocyclic sulfoxides and a method of producing enantioenriched sulfoxide in the presence of the said compounds.  
WO/2016/031736A1
As a result of this pyridine derivative represented by general formula (1), or a salt thereof, a catalyst is provided which is capable of shortening reaction time and achieving high product selectivity in asymmetric Steglich reactions of...  
WO/2016/023787A1
The present invention relates to a process for the preparation of a compound of formula (I) wherein A1 and A2 are C-H, or one of A1 and A2 is C-H and the other is N; R1 is C1-C4alkyl, C1-C4haloalkyl or C3-C6cycloalkyl; each R2 is indepen...  

Matches 1 - 50 out of 6,620