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Matches 501 - 550 out of 4,271

Document Document Title
WO/1996/027639A1
The invention relates to a process for the preparation of polysaccharide-N-arylcarbamates in suitable form as supports for chromatography, which process comprises adding to polysaccharide carbamates, which may be substituted in the aryl ...  
WO/1996/027615A1
The present invention relates to photochemically cross-linked polysaccharide derivatives of general formulae (IA) and (IB), wherein R is a polysaccharide radical in which the OH groups have been esterified as OR' groups or converted into...  
WO/1996/023764A1
A process is disclosed for separating racemates of phenyl acetonitriles having the formula (I), in which R1, R2, R3 and n have the meaning given in the description. The process consists in dissolving the racemates (I) in a polar solvent,...  
WO/1996/022959A1
A process for the separation of a racemic mixture of certain aliphatic carboxylic acids or esters thereof is disclosed. The process comprises: (i) forming a diastereomeric salt by reaction comprising said racemic mixture of a C1 to C6 li...  
WO/1996/022272A1
The present invention relates to a process for producing optically active 2-halogen propionic acids in which the corresponding optically active 2-halogen propionic acid alkyl ester is reacted at high temperature with a carboxylic acid in...  
WO/1996/020158A1
This invention relates to derivatives of 3,3-(disubstituted)cyclohexan-1-one monomers and related compounds which are useful for treating allergic and inflammatory diseases.  
WO/1996/012692A1
The proposal is for a process for producing derivatives of 4a,5,9,10,11,12,-hexahydro-6H-benzofuro[3,2-ef][2]benzazepin e facilitating in particular the production of galanthamine (6) via the novel bromine-N-demethyl galanthamine (4) and...  
WO/1996/012699A1
Levobupivacaine or an analogue thereof is prepared by reaction with a tartaric acid resolving agent in a solvent, in the presence of water and/or less than 0.5 equivalents of the resolving agent.  
WO/1996/011894A1
Proposed is a process for separating enantiomers from a racemic mixture by countercurrent extraction using at least two substances, one of them a liquid in which the racemic mixture to be separated is present, the other containing a chir...  
WO/1996/009290A1
A process for the racemisation of an optically-enriched piperidine-2-carboxanilide compound, comprises heating the compound in the presence of an alkanoic or arylalkanoic acid. A process for the asymmetric transformation of such a compou...  
WO/1996/002535A1
A novel process for enantioselective synthesis of single enantiomers of omeprazole or its alkaline salts, of other optically pure substituted 2-(2-pyridinylmethyl-sulphinyl)-1H-benzimidazoles as well as of other structurally related sulp...  
WO/1996/001995A1
A separating agent comprising a polysaccharide derivative having a molecular weight distribution of 1 to 3 in terms of Mw/Mn (wherein Mw and Mn represents, respectively, weight-average and number-average molecular weights thereof in term...  
WO/1995/033749A1
A process for the preparation, separation and purification of (6S) and (6R) diastereomers of folinic acid salts with at least dibasic amines is disclosed, which process comprises the hydrolysis of (6RS)-5,10-methenyl-5,6,7,8-tetrahydrofo...  
WO/1995/032178A1
The invention relates to a method for producing albuterol by the resolution of a mixture of enantiomers of 5-[2-[(1,1-dimethylethyl)amino]-1-hydroxyethyl]-2-hydroxyben zoate using di-toluoyltartaric acid. The invention further relates to...  
WO/1995/031420A1
A separating agent which, when used as the packing material for reversed-phase liquid chromatography, is excellent in the stability of the base line in the mobile phase and is increased in the number of the steps of the detected peak in ...  
WO/1995/031436A1
A process and diastereomeric salts useful for the optical resolution of racemic 'alpha'-[4-(1,1-dimethylethyl)phenyl]-4-(hydroxydiphenylmeth yl)-1-piperidinebutanol, 4-[4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-hydroxybuty l]-'alpha'...  
WO/1995/029142A1
A method of separating optical isomer, by which optical resolution of an optical isomer mixture can be efficiently conducted by using a packing material which is inexpensive per se and has an excellent ability to separate optically activ...  
WO/1995/026950A1
Substituted phenyl compounds endowed with chain extension activity for formulations such as polyurethanes are disclosed, and which have general formula (I) wherein n is 1-1000 and m is 1-100; and R1 and R2 are each independently selected...  
WO/1995/023805A1
The title compounds are obtained by racemic resolution of D, L-homoalanin-4-yl-(methyl)phosphinic acid by precipitating out one of the diastereomeric salts with chiral bases such as quinine or cinchonine. The yield of desired enantiomers...  
WO/1995/022521A1
An optically active compound represented by general formula (1), a racemate thereof, and a pharmaceutically acceptable acid-addition salt thereof, wherein R represents either a C1-C5 (un)saturated linear or branched aliphatic group, or a...  
WO/1995/022390A1
Macrocyclic antibiotics having ring structures with at least 10 members act as separation agents in crystallization, precipitation, filtration, electrophoresis and chromatography. The macrocyclic antibiotics include ansamacrolides, macro...  
WO/1995/020590A1
The subject invention provides chiral receptor molecules useful for the purification of enantiomers of amino acid derivatives and other compounds. The subject invention also provides methods of preparing said receptor molecules.  
WO/1995/018833A1
Polysaccharide derivatives containing unsaturated substituents and aromatic substituents, and their use for preparing stationary chiral phases suitable for separating isomers of chemical compounds, are disclosed.  
WO/1995/017433A1
The use of mono-3,6-anhydro-cyclodextrins for solubilising a hydrophobic compound and monitoring the purity of an enantiomer is disclosed. Said mono-3,6-anhydro-cyclodextrin has formula (I), wherein n is 5, 6 or 7, preferably 6. The hydr...  
WO/1995/015953A1
The invention relates to novel substituted oxazolidines of formula (I) wherein R1 and R2 are simultaneously hydrogen or both together are the identical lower alkyl radical, and to the salts thereof in racemic and chiral form, to a proces...  
WO/1995/014934A1
A chiral shift reagent comprising a sugar derivative for 1H-NMR and 13C-NMR spectrometry, of which the starting material is readily available and the synthesis is easy and which has good performance. An analytical method which comprises ...  
WO/1995/009907A1
Disclosed is a method of separating a compound from a solution comprising passing the solution through at least one crystal of a biological macromolecule capable of selectively binding the compound.  
WO/1995/008529A1
Chiral surfactants, methods for their synthesis and use, and apparatus designed to facilitate chiral separations using micellar capillary electrophoresis is disclosed. A chiral surfactant having general formula (I) is described. R1 is th...  
WO/1995/008522A1
A method of optical enantiomer resolution by preferential crystallization involves entering, each time crystallization starts, the two-phase domain containing excess enantiomer and the saturated solution, and cooling according to a well-...  
WO/1995/005879A1
A process for separating enantiomeric mixtures by liquid chromatography using a stationary phase that includes cellulose or amylose derivative and a mobile phase that includes methanol and pentane, the concentration of methanol in the mo...  
WO/1995/000492A1
Optical isomers of 4-(5-fluoro-2,3-dihydro-1H-inden-2-yl)-1H-imidazole and pharmaceutically acceptable salts thereof, their use and preparation are described. Both isomers are potent in the treatment of cognitive disorders.  
WO/1995/000463A1
A polysaccharide derivative is immobilized on a carrier such as silicagel by cross-linking only the derivatives with each other by using a polyfunctional cross-linking agent. The optical isomer separating agent thus obtained is excellent...  
WO/1994/028040A1
Optically-active, amphiphilic, free-radical addition copolymers having an optically-active hydrophobic portion and an ionic hydrophilic portion are effective resolving agents. This utility is based on a unique combination of properties, ...  
WO/1994/027963A1
This invention relates to a process for the preparation of optically pure alkylated oxindoles which are useful in the preparation of enantiomers of physostigmine and physostigmine-like compounds having pharmaceutical activity.  
WO/1994/020493A1
A method for preparing N-methyl-2-(3-pyridyl) (1R,2R)-2-tetrahydrothiopyrancarbothioamide-1-oxide of formula (I) from a sel of a mixture of trans isomers (1S,2S) and (1R,2R) with an optically active acid.  
WO/1994/014746A1
The invention relates to a method for separating the ortho- and para-isomers of hydroxymandelic acid or a salt thereof. For that purpose the starting material is a solid mixture of these ortho- and para-isomers in the alkali metal salt f...  
WO/1994/014742A1
Compounds of general formula (1) are described wherein Y is a halogen atom or a group -OR1, where R1 is an optionally substituted alkyl group; X is -O-, -S- or -N(R8)-, where R8 is a hydrogen atom or an alkyl group; R2 is an optionally s...  
WO/1994/012451A1
A process is provided whereby S(+)-ibuprofen or R(-)-ibuprofen L-lysinate salt is produced by selective precipitation from a mixture containing enantiomers of ibuprofen and L-lysine. The quantity of L-lysine is not more than about a mola...  
WO/1994/012460A1
A process is disclosed for the production of a product which is enriched in a desired enantiomer of a phenylpropionic acid selected from ibuprofen and flurbiprofen, or their pharmaceutically acceptable salts, which comprises the followin...  
WO/1994/012275A1
Optically active adsorbents based on network polymerised derivatives of dicarboxylic acids, diamines or diols which are chemically bonded to a carrier. The derivatives can be polymerised by radical polymerisation or through hydrosilylati...  
WO/1994/011337A1
The invention relates to 3,3-diphenylpropylamines of formula (I), wherein R1 signifies hydrogen or methyl, R2 and R3 independently signify hydrogen, methyl, methoxy, hydroxy, carbamoyl, sulphamoyl or halogen, and X represents a tertiary ...  
WO/1994/011364A1
A process for preparing (+)-6-[(4-chlorophenyl)(1H_-1,2,4-triazol-1-yl)methyl]-1-met hyl-1H_-benzotriazole comprising the resolution of (U)-6-[(4-chlorophenyl-hydrazinomethyl)-1-methyl-1H_-benzotr iazole and converting the appropriate en...  
WO/1994/008937A1
A process for obtaining a substantially pure enantiomer of an aryl-substituted aliphatic carboxylic acid is described. The process utilizes first an enantiomerically enriched mixture of the aryl-substituted aliphatic carboxylic acid obta...  
WO/1994/008935A1
A process for obtaining a substantially pure enantiomer of an aryl-substituted aliphatic carboxylic acid is described. The process combines an aryl substituted aliphatic carboxylic acid, a base and water in an inert solvent to make a hyd...  
WO/1994/008934A1
A process for obtaining a substantially pure enantiomer of an aryl-substituted aliphatic carboxylic acid is described. The process utilizes first an enantiomerically enriched mixture of the aryl-substituted aliphatic carboxylic acid obta...  
WO/1994/008936A1
A process for obtaining a substantially pure enantiomer of an aryl-substituted aliphatic carboxylic acid is described. In this process, the aryl-substituted aliphatic carboxylic acid is reacted with an inorganic base in the presence of a...  
WO/1994/007814A1
Proposed is a process for separating enantiomers from a racemic mixture by countercurrent extraction using at least two liquids of mutually differing chiralities, said liquids being wholly miscible and separated from each other by a phas...  
WO/1994/006743A1
The invention concerns compounds which are effective anti-epileptica but have only a low sedative or teratogenic action and which have formulae (I), (II), (III) or (IV), the compounds of formulae (I) and (II) may also have multiple unsat...  
WO/1994/006747A1
A method for resolving (U)-/alpha/-(3-benzoylphenyl)propionic acid is disclosed. The method comprises: i) converting said propionic acid with (-)-cinchonidine in a solvent comprising a mixture of an aliphatic ester and an alkyl alcohol; ...  
WO/1994/003457A1
A process for the preparation of (-)-eserethole, of formula (I) starting from (U)-eserethole, or from mixtures of (+)-and (-)-eserethole in which the latter enantiomer prevails, by treating (U)-eserethole or mixtures of (+)- and (-)-eser...  

Matches 501 - 550 out of 4,271