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Patent Searching and Data


Matches 551 - 600 out of 4,337

Document Document Title
WO/1994/012451A1
A process is provided whereby S(+)-ibuprofen or R(-)-ibuprofen L-lysinate salt is produced by selective precipitation from a mixture containing enantiomers of ibuprofen and L-lysine. The quantity of L-lysine is not more than about a mola...  
WO/1994/012460A1
A process is disclosed for the production of a product which is enriched in a desired enantiomer of a phenylpropionic acid selected from ibuprofen and flurbiprofen, or their pharmaceutically acceptable salts, which comprises the followin...  
WO/1994/012275A1
Optically active adsorbents based on network polymerised derivatives of dicarboxylic acids, diamines or diols which are chemically bonded to a carrier. The derivatives can be polymerised by radical polymerisation or through hydrosilylati...  
WO/1994/011337A1
The invention relates to 3,3-diphenylpropylamines of formula (I), wherein R1 signifies hydrogen or methyl, R2 and R3 independently signify hydrogen, methyl, methoxy, hydroxy, carbamoyl, sulphamoyl or halogen, and X represents a tertiary ...  
WO/1994/011364A1
A process for preparing (+)-6-[(4-chlorophenyl)(1H_-1,2,4-triazol-1-yl)methyl]-1-met hyl-1H_-benzotriazole comprising the resolution of (U)-6-[(4-chlorophenyl-hydrazinomethyl)-1-methyl-1H_-benzotr iazole and converting the appropriate en...  
WO/1994/008937A1
A process for obtaining a substantially pure enantiomer of an aryl-substituted aliphatic carboxylic acid is described. The process utilizes first an enantiomerically enriched mixture of the aryl-substituted aliphatic carboxylic acid obta...  
WO/1994/008935A1
A process for obtaining a substantially pure enantiomer of an aryl-substituted aliphatic carboxylic acid is described. The process combines an aryl substituted aliphatic carboxylic acid, a base and water in an inert solvent to make a hyd...  
WO/1994/008934A1
A process for obtaining a substantially pure enantiomer of an aryl-substituted aliphatic carboxylic acid is described. The process utilizes first an enantiomerically enriched mixture of the aryl-substituted aliphatic carboxylic acid obta...  
WO/1994/008936A1
A process for obtaining a substantially pure enantiomer of an aryl-substituted aliphatic carboxylic acid is described. In this process, the aryl-substituted aliphatic carboxylic acid is reacted with an inorganic base in the presence of a...  
WO/1994/007814A1
Proposed is a process for separating enantiomers from a racemic mixture by countercurrent extraction using at least two liquids of mutually differing chiralities, said liquids being wholly miscible and separated from each other by a phas...  
WO/1994/006743A1
The invention concerns compounds which are effective anti-epileptica but have only a low sedative or teratogenic action and which have formulae (I), (II), (III) or (IV), the compounds of formulae (I) and (II) may also have multiple unsat...  
WO/1994/006747A1
A method for resolving (U)-/alpha/-(3-benzoylphenyl)propionic acid is disclosed. The method comprises: i) converting said propionic acid with (-)-cinchonidine in a solvent comprising a mixture of an aliphatic ester and an alkyl alcohol; ...  
WO/1994/003457A1
A process for the preparation of (-)-eserethole, of formula (I) starting from (U)-eserethole, or from mixtures of (+)-and (-)-eserethole in which the latter enantiomer prevails, by treating (U)-eserethole or mixtures of (+)- and (-)-eser...  
WO/1994/002226A1
Solid substrates with free hydroxyl groups as phosphorylated by thermolysing a solution of phosphoramidate of formula (I), in the presence of the substrate, whereby metaphosphate is generated which phosphorylates the substrate.  
WO/1994/000408A1
A high performance chiral selector having formula (I) whereinAr is a monocyclic or ortho-fused polycyclic aromatic moiety having up to 10 ring carbon atoms, either of which may be unsubstituted or substituted with one or more C1 to C6 al...  
WO/1994/000455A1
The present invention relates to a composition having general formula (I), wherein each of A, B, C, X, Y, and Z is independently O, NH, N(CH2)mCH3, N(C=O)(CH2)mCH3, CH2, S, or Se; each of R1, R2, and R3 is indepently phenyl, 4-hydroxyphe...  
WO/1993/023394A1
The object of the present invention is a process for producing optically pure S-timolol or its derivatives wherein racemic R,S-timolol, or its racemic derivative, at elevated pressure and dissolved in carbon dioxide is periodically fed t...  
WO/1993/022269A1
3(S)-methylheptanoic acid is prepared by fractional crystallization of the salt of racemic 3-methylheptanoic acid with (S)-alpha-methylbenzyl amine followed by acidification.  
WO/1993/021176A1
Novel cyclic amino acids which are useful in preparing biologically active peptides as well as a process for the preparation of D and L enantiomers of the cyclic amino acids are described where an N-protected derivative of the racemic cy...  
WO/1993/020052A1
(S)-$g(a)-phenyl-2-pyridineethanamine, and its pharmaceutically acceptable derivatives, are useful in the treatment of neurodegenerative disorders, and exhibit linear pharmacokinetics.  
WO/1993/017022A1
The (6S_) stereoisomer of folinic acid is obtained in high optical purity by salification of (R, S) folinic acid with di- or polyamines and subsequent selective crystallization of the desired diastereomeric salt.  
WO/1993/017055A1
Polymer particles having a hydrophobic core and various surface functional groups, particularly hydrophilic and chiral surface functional groups, are produced by adding a non-emulsified functional polymerizable monomer to the aqueous pha...  
WO/1993/016035A1
The method proposed for separating racemates of verapamil is characterized in that the free base of the compound is reacted with optically active dibenzoyltartaric acid or ditoluoyltartaric acid in the molar ratio 1:1 to 1:2 in a mixture...  
WO/1993/016074A1
A novel isoindolinone derivative of formula (I) in racemic form or in the form of its enantiomers; preparation thereof; and pharmaceutical compositions containing same. The novel product of formula (I) is useful in therapeutics as an anx...  
WO1993013053A3
Process for obtg. an isomer of a nitrile of formula RCH(CN)R1 (I), or a racemic- modification contg. isomer and enantiomer, comprising treatment of the epimer of the enantiomer, or a racemic- modification comprising epimer and enantiomer...  
WO/1993/015039A1
A process for the separation of a racemic mixture of certain aliphatic carboxylic acids or esters thereof is disclosed. In this process: i) a solid racemic mixture of an aliphatic carboxylic acid or ester thereof having formula (I), wher...  
WO/1993/015037A1
An improved process for the separation of enantiomers of a mixture of certain aliphatic carboxylic acids or esters thereof is disclosed. The process involves adding in inert liquid to the reaction solution formed by: (i) forming a salt s...  
WO/1993/015038A1
An improved process for the separation of enantiomers of a racemic mixture of certain aliphatic carboxylic acids or esters thereof is disclosed. The process involves adding a mixture of the aliphatic carboxylic acid to the material forme...  
WO/1993/015040A1
An improved process for the separation of enantiomers of a racemic mixture of certain aliphatic carboxylic acids or esters thereof is disclosed. The process involves: (i) forming a salt solution comprising said racemic mixture of a C1 to...  
WO/1993/014056A1
A process is disclosed that is useful for separating the enantiomers of a racemic mixture of an aliphatic carboxylic acid having formula (I), where R1 is hydrogen or alkyl, R2, R3 and R4 are independently different and are hydrogen, alky...  
WO/1993/013087A1
A process for the resolution of (+-)-alpha-[2-[acetyl(1-methylethyl)amino]ethyl]-alpha-(2-ch lorophenyl)-1-piperidinebutanamide having structure (I) into its (+) and (-) enantiomers using camphorsulfonic acid.  
WO/1993/013053A2
A process for obtaining an isomer of a compound of the general formula (I): R-CH(CN)-R', wherein each of R and R' may be any organic radical linked directly or through a heteroatom to the carbon atom bearing the cyano group provided that...  
WO/1993/013034A1
A process for separating a selected amino acid (enantiomer) from a mixture of different compounds including other amino acids is disclosed, in which process the mixture is contacted with a polymer material which is composed of cross-link...  
WO/1993/012054A1
This invention relates to certain salts of leukotriene antagonists and the use of a particular amine to form these salts as a means for selectively crystallizing optical isomers of the leukotriene antagonists disclosed herein.  
WO/1993/012062A1
A novel multi-step process for preparing the (4S_-enantiomer of 4-(3,4-dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenone in a highly-optically pure form is disclosed. The process involves (1) first esterifying 4-(3,4-dichlorophenyl)-4-keto...  
WO/1993/010118A1
Described is a method of preparing (6S)-5-methyl-tetrahydrofolic acid by separation of the racemic mixture, (6R,S)-5-methyl-tetrahydrofolic acid, using a base, characterized in that N-ethyl-2-aminomethylpyrrolidine or one of its optical ...  
WO/1993/008903A1
A process is disclosed for separating enantiomers by an electrokinetic process in capillary columns, using surface-immobilized chiral components. The chiral component used may be a polysiloxane to which alkylated cyclodextrine (alpha, be...  
WO/1993/009075A1
A method for separating enantiomers of derivatives of aryloxipropanolamines is disclosed. In the method, the derivative is contacted with a chiral solid-phase chromatography material containing molecular imprints of an optically pure ena...  
WO/1993/008162A1
The present invention is directed to a compound of formula (I), wherein R represents a hydrogen atom or an acyl, aroyl or cycloalkylcarbonyl radical or a residue of formula (Ia); R1 represents an alkyl radical; R2 represents an aryl or h...  
WO/1993/007135A1
3-(N-isopropyl-N-n-propylamino)-5-(N-isopropyl)carbamoylchro man having formula (I), as racemate, (R)-enantiomer in the form of free base or pharmaceutically acceptable salts thereof. The object of the present invention is to provide com...  
WO/1993/007104A1
A carrier and a column for high-performance liquid chromatography having an ability to separate optical isomers. A separating agent for optical isomers is prepared by chemically bonding conalbumin to a carrier such as silica gel or synth...  
WO/1993/006080A1
The invention relates to a chiral selector useful in separating underivatized enantiomers of non-steroidal anti-inflammatory agents, particularly naproxen and other arylacetic acid compounds, and relates to a process for achieving such s...  
WO/1993/005004A1
A compound represented by general formula (I) and a separating agent comprising the same. In formula (I), Ar and Ar' represent each an aromatic group and two substituents on the central benzene ring may be positioned ortho, meta or para ...  
WO/1993/004022A1
A method of recovering and reusing a solvent and an optical isomer, characterized by providing a packed bed, which is disposed in the passage for circulating a solvent and packed with a packing material for optical resolution, with a por...  
WO1993000330A3
PCT No. PCT/US92/04697 Sec. 371 Date Dec. 14, 1993 Sec. 102(e) Date Dec. 14, 1993 PCT Filed Jun. 11, 1992 PCT Pub. No. WO93/00330 PCT Pub. Date Jan. 7, 1993The present invention relates to novel azanorbornane derivatives having the formu...  
WO/1993/002079A1
Optically pure thiazolidinedione alcohols and ethers, and synthetic intermediates for preparing said alcohols and ethers. These compounds have utility as hypoglycemic and hypocholesterolemic agents.  
WO/1993/001190A1
A novel 2-amino naphthyridine derivative having formula (I), optical isomers and salts thereof, and its preparation. The product of formula (I) is particularly useful for preparing the eutomer of the product of formula (II), which has re...  
WO/1993/001156A1
A process for obtaining a substantially pure enantiomer of ibuprofen is described. The process utilizes first an enantiomerically enriched mixture of ibuprofen obtained from kinetic resolution, diastereomeric crystallization or asymmetri...  
WO/1993/001167A1
Compounds of formule (I), salts thereof, the preparation thereof, and drugs containing same.  
WO/1993/000330A2
The present invention relates to novel azanorbornane derivatives having formula (I), wherein R1 through R12 are as defined in the description, and to novel intermediates used in their synthesis. The compounds having formula (I) are usefu...  

Matches 551 - 600 out of 4,337