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WO/1992/003404A1 |
Process for transforming (benzoyl-3 phenyl)-2 propionic-R(-) acid into an S(+) isomer through the action of a base either in situ during the splitting of racemic ketoprofen or on the crystallization mother liquor of a (benzoyl-3 phenyl)-...
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WO/1992/002283A1 |
The media is an ether derivative of cyclodextrin such as a permethylated hydroxy ether of cyclodextrin or a dialkyl trifluoroacetyl ether derivative of cyclodextrin and is used in capillary gas chromatographic columns. Particular benefit...
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WO/1992/000965A1 |
1R-cis,1'R-cis isomer of a 2',2'-(3,11-dioxo-4,10-dioxatridecylene)-bis-(1,2,3,4-tetrah
ydro-6,7-dimethoxy-2-methyl-1-veratrylisoquinolinium) salt, substantially free from other geometrical and optical isomers thereof. The 1R-cis,1'R-cis...
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WO/1992/000275A1 |
The description relates to a process for producing enantiomer-pure $g(a)-hydroxypropionoaldehyde derivatives of the general formula (I) in which: R¿1? is the substituent Q which may be a hydrocarbon radical interrupted by oxygen atoms, ...
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WO/1991/018878A1 |
Novel processes are disclosed for the preparation and resolution of substituted piperidines of formula (I), wherein R1 and R2 are defined as below, and related compounds, as well as novel intermediates used in such processes.
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WO/1991/018910A1 |
A compound of general formula (I), in which each of R1, R2, R3 and R4 independently represent a hydrogen atom or a group -(CO)nR5 in which n is 0 or 1 and R5 represents an alkyl, aryl, cycloalkyl, alkaryl or aralkyl group, or R1 or R2 to...
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WO/1991/017816A1 |
The invention relates to a process for the high yield, cost efficient means of separating enantiomers. The process utilizes a supported liquid membrane and a chiral carrier which selectively complexes with one of the two enantiomeric opt...
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WO/1991/017977A1 |
Process for the stereoselective preparation of phenylisoserin derivatives of general formula (I) from benzylamine. In the general formula (I), R is a phenyl radical or tert.butoxy and R1 is a hydroxy function protective group.
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WO/1991/017159A1 |
(-)-4-Amino-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(1H)-pyr
imidin-2-one, its pharmaceutically acceptable derivatives, pharmaceutical formulations thereof, methods for its preparation and its use as an antiviral agent are described.
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WO/1991/015471A1 |
A process is disclosed for the isolation of an enantiomerically enriched alcohol from a first mixture of an enantiomerically enriched alcohol and an enantiomerically enriched ester. The process includes the steps of: (a) contacting the m...
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WO1991013066A3 |
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WO/1991/015472A1 |
A process is disclosed for the separation of an enantiomerically enriched 1-tosyloxy-2-acyloxy-3-butene and an enantiomerically enriched 1-tosyloxy-2-hydroxy-3-butene from a first mixture containing both compounds. The process includes t...
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WO/1991/014671A1 |
The new (S)-4-(2-bromobenzoyl)-5-hydroxy-benzocyclobutene-1-carboxyl
ic acid, i.e., the compound of formula (I), in free or salt form, can be used as the active substance in pharmaceutical preparations and can be made by a new process wh...
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WO/1991/013066A2 |
Method for the preparation of beta-phenylglycidic-(2R,3R) acid optionally in the form of salt or ester by precipitation of the salt of the beta-phenylglycidic-(2R,3R) acid with (+)-alpha-methylbenzylamine-(R) in a solution of a mixture o...
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WO/1991/013046A1 |
A process for separating optical isomers in a pseudo-moving bed system, which comprises introducing a solution containing an optical isomer mixture and a desorbing liquid into a packed bed containing an optical resolution packing therein...
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WO/1991/012072A1 |
Disclosed are processes and apparatus for separating a desired solute (A), such as an optically active isomer, from a complex mixture (A, X, Y) using carrier (C) facilitated transport in an immobilized liquid membrane (50) or carrier (C)...
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WO/1991/007366A1 |
A novel process for preparing the R(+)-enantiomer of terodiline (N-tert.butyl-1-methyl-3,3-diphenylpropylamine) and pharmaceutically acceptable salts thereof by optical resolution of a racemic mixture of terodiline using tartaric acid, c...
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WO/1991/002006A1 |
New polysaccharide derivatives useful for the separation of optical isomers, prepared by substituting at least one atomic group of formula (1), (2) or (3) for part or the whole of hydrogen atoms of the hydroxyl or amino groups of the pol...
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WO/1991/000270A1 |
The invention relates to a novel process for the resolution of an acid mixture (hereinafter: threo acid mixture) containing (+)-threo-3-[(2-aminophenyl)thio]-2-hydroxy-3-(4-methoxyphen
yl)propionic acid [hereinafter: (+)-threo acid] and ...
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WO/1990/009376A1 |
A process for the optical resolution of racemic 1,4-dihydropyridines, containing isothioureido groups. Salification of racemic isothioureas with optically active acids produces diasteroisomeric mixtures of isothiouronium salts, that, usi...
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WO/1990/008126A1 |
The invention relates to a novel process for preparing the optical isomers of 2,2-dimethyl-3-(2,2-disubstituted vinyl)cyclopropanecarboxylic acids of general formula (I), wherein R1 and R2, independently from another, stand for halogen o...
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WO/1990/003962A1 |
A novel process for the preparation of compounds of formula (I), wherein X is -CH2CH2- or -CH=CH-; R1 is an ester group inert to the reaction conditions; and R is an organic radical having groups which are inert under reducing conditions...
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WO/1989/009235A1 |
Substituted cylodextrins of general formula (I), where R2 and R6 are linear-chain or branched-chain alkyl or alkenyl groups with 1 to 8 atoms of carbon or cycloalkyl groups with 5 to 8 atoms of carbon, which can be equal or different, an...
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WO/1988/010249A1 |
Crystallizable pyrethroid isomer or enantiomer pairs are converted to more pesticidally active isomers by contacting a hydrocarbon slurry of the starting isomers with a base and a catalyst, the catalyst being substantially soluble in the...
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WO/1988/007050A1 |
Process for the production of (+)-bicyclo-[3.3.0]octane-3-on-2-carboxylic acid steroid esters having the formula (I), in which X represents oxygen or the -O-(CH2)n-O- or the -O-CH2-C(CH3)2-CH2-O- residue; n represents 2 or 3; R2 represen...
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WO/1988/001614A1 |
A process for the resolution of dl-methyl 3-[4-(2-hydroxy-3-isopropylamino)propoxy]phenylpropionate [(dl-esmolol)] into a dextro (+) and a levo (-) isomer.
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WO/1987/006929A1 |
A new chiral reagent of formula (I), wherein X is halogen, an azide group or a succinimidyl group and wherein R is an alkyl group or a trifluormethyl group. The invention further relates to a method for derivatization, determination and ...
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WO/1987/000165A1 |
The system comprises two immiscible liquid phases and one or more enantioselectively binding chiral components, each of which is substantially in one of said phases. Also disclosed is a method for chiral resolution of racemic mixtures, o...
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WO/1986/004215A1 |
An insecticidal composition containing more than one active ingredients which comprises as active ingredient in an amount of 0.001-99% by weight a synthetic pyrethroide of general Formula (I), (wherein X stands for chlorine or bromine) -...
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WO/1986/004216A1 |
A synergistic insecticidal composition containing more than one active ingredients and being harmless to environment characterized by comprising in an amount of from 0.001 to 99% by weight a synthetic pyrethroide of the formula (I) - nam...
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WO/1986/000066A1 |
New butyramide derivatives corresponding to formula (I), wherein X and Y independently represent hydroxymethyl; cyano; carboxy; functionally modified carboxy selected from esterified carboxy, carbamoyl, and N-substituted carbamoyl; 5-tet...
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WO/1985/003932A1 |
The separation of optically active phenylalanine and N-acyl derivatives thereof and novel diastereomer salts of the said compounds. According to the invention a racemic compound of formula (I), is reacted with an optically active resolvi...
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WO/1985/000661A1 |
A packing for use in liquid chromatography for optical resolution of racemic compounds, which comprises a carrier of silica gel having bound thereto a spacer introduced by reacting with a silane treating agent and having chemically bound...
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WO/1983/004103A1 |
A grafted chromatographic filler comprising an inorganic carrier having hydroxy groups on its surface to which alpha-arylalkylamine derivative is grafted, said alpha-arylalkylamine derivative comprising asymmetric carbon-containing, opti...
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JP6595103B2 |
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JP2019528308A |
The present invention relates to Ally Lu 2, a 2'-tandem Bisch azole system compound, and its manufacturing method and use, Concretely, it is related with the use in manufacture of the antineoplastic-agents thing as Ally Lu 2 to whom stru...
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JP6574572B2 |
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JP2019524875A |
The present invention provides the antivirus prodrug nucleoside cyclic-phosphoric-acid ester compound based on liver specific delivery art (liver delivery) (Liver Specific Delivery (LSD)), and its use. Specifically, the compound denoted ...
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JP2019137656A |
[Subject] optics -- offer of a manufacturing method of an active cyclopentenone derivative. [Means for Solution] A manufacturing method of an optically active substance including optical division of formula (I) by high speed liquid chrom...
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JP2019135249A |
[Subject] Offer of a method which manufactures an optical activity 5-hydroxy 3- Ketoester compound useful as a medical-supplies intermediate by high yield and high solid selectivity. [Means for Solution] 1, 3-diene compound and compound ...
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JP6539749B2 |
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JP2019516736A |
The tetrahydro pyran derivative and thiopyran derivative which have double pharmacologic activity [as opposed to both a sigma (sigma) receptor and mu-opioid receptor in the present invention], In the preparing method of such a compound, ...
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JP2019513124A |
The present invention relates to the medical treatment of a Sulfa mate derivative compound and/or its CNS disease which contains permissible salt as an active ingredient pharmacologically, or the pharmacy constituent for prevention. The ...
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JP6506753B2 |
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JP6491213B2 |
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JP6483332B2 |
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JP2019006793A |
To provide novel compounds that can act as auxiliary groups for asymmetric induction in manufacture of phosphorus atom-modified nucleic acid derivatives.The present invention provides chiral auxiliary groups useful for efficiently manufa...
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JP6452119B2 |
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JP6422871B2 |
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JP2018532718A |
compound 61501b whose purity of compound 61501b of the present invention is 90% or more -- it is related with a rich constituent. Compound S of high purity [constituent / above-mentioned]PIn manufacture of -1, it has a remarkable advanta...
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