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WO/1992/020334A1 |
The use of S(-)sodium 2-(4-isobutylphenyl)propionate (the sodium salt of S(+)-ibuprofen) in pharmaceutical compositions for the treatment of inflammation, pain and pyrexia is described. Preferred compositions comprise S(-)sodium 2-(4-iso...
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WO/1992/019684A1 |
Pyridone dyes of formula (I), wherein R?1� stands for hydrogen or C�1?-C�4? alkyl, R?2� and R?3� may be identical or different and independently stand for hydrogen, optionally substituted C�1?-C�12? alkyl, C�5?-C�7? cyc...
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WO/1992/018455A1 |
A method for resolving (+)-/alpha/-(3-benzoylphenyl)propionic acid is disclosed. The method comprises: (i) converting said propionic acid with (-)-cinchonidine in a solvent comprising a mixture of an aliphatic ester and an alkyl alcohol;...
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WO/1992/016536A1 |
New racemic, optically active phosphorous compounds have the formula (I), in which R stands for lower alkyl, lower alkoxy or a protected hydroxy group; R1 stands for a 5-membered heteroaromatic compound; R2 stands for lower alkyl or lowe...
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WO/1992/016274A1 |
In a continuously operated counter-current chromatography process, relative displacement between the adsorber, composed of a solid phase, and a liquid movable phase, in successively linked chromatography columns, is obtained by successiv...
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WO/1992/015617A1 |
A novel polysaccharide derivative prepared by replacing part or the whole of the hydroxyl or amino groups of a polysaccharide by two or more different substituents, and a separating agent and a separator both containing this derivative. ...
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WO/1992/015616A1 |
A compound prepared by chemically bonding at least one hydroxyl group of the 2-, 3- and 6-hydroxyl groups of a cyclic oligosaccharide derivative to a carrier through a spacer (except one wherein the 6-hydroxyl group is bonded to a carrie...
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WO/1992/013872A1 |
Compounds of general formula (I) in the form of a 22R and 22S epimer, wherein X1 and X2 are the same or different and each represents a hydrogen atom or a fluorine atom, provided that X1 and X2 are not simultaneously a hydrogen atom, pro...
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WO/1992/013823A1 |
A compound of formula (I), or a salt or solvate thereof, in which R1 and R2 each independently represents hydrogen, alkyl, optionally substituted aryl or optionally substituted aralkyl; R3 represents alkyl, optionally substituted aryl or...
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WO/1992/012152A1 |
Azabicyclo[2.2.2]octan-3-imines of general formula (I), wherein R1, R2 and R3 are as defined herein are prepared by reacting a compound of formula (II) with a compound of formula (III), wherein A is MgCl, MgBr or Li.
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WO/1992/012180A1 |
Novel cyclodextrin and epichlorohydrin based polymers are obtained by adding an epoxy-ammonium salt to a cyclodextrin-epichlorohydrin polycondensate wherein the ratio of cyclodextrin to epichlorohydrin is 1:3 to 1:10 and the proportion o...
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WO/1992/012135A1 |
Optically substantially pure (-) enantiomer of [[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]
hydrazono]propanedinitrile or pharmaceutically acceptable salt thereof, intermediates and a process for the preparation are descr...
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WO/1992/008702A1 |
A method for resolving chiral hydantoins having general formula (I), wherein R1 is a lower alkyl radical having 1-5 carbon atoms in a linear or branched chain; and R2 is a phenyl radical which is optionally mono-, di- or trisubstituted b...
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WO/1992/005151A1 |
This invention relates to salts of formula (I) where, A is 1 and X is 1 or 2; R1 is C8 to C13 alkyl, C7 to C12 alkoxy, C7 to C12 alkylthio, C10 to C12 1-alkynyl, 10-undecynyloxy, 11-dodecynyl, phenyl-C4 to C10 alkyl, phenyl-C3 to C9 alko...
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WO/1992/003404A1 |
Process for transforming (benzoyl-3 phenyl)-2 propionic-R(-) acid into an S(+) isomer through the action of a base either in situ during the splitting of racemic ketoprofen or on the crystallization mother liquor of a (benzoyl-3 phenyl)-...
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WO/1992/002283A1 |
The media is an ether derivative of cyclodextrin such as a permethylated hydroxy ether of cyclodextrin or a dialkyl trifluoroacetyl ether derivative of cyclodextrin and is used in capillary gas chromatographic columns. Particular benefit...
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WO/1992/000965A1 |
1R-cis,1'R-cis isomer of a 2',2'-(3,11-dioxo-4,10-dioxatridecylene)-bis-(1,2,3,4-tetrah
ydro-6,7-dimethoxy-2-methyl-1-veratrylisoquinolinium) salt, substantially free from other geometrical and optical isomers thereof. The 1R-cis,1'R-cis...
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WO/1992/000275A1 |
The description relates to a process for producing enantiomer-pure $g(a)-hydroxypropionoaldehyde derivatives of the general formula (I) in which: R¿1? is the substituent Q which may be a hydrocarbon radical interrupted by oxygen atoms, ...
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WO/1991/018878A1 |
Novel processes are disclosed for the preparation and resolution of substituted piperidines of formula (I), wherein R1 and R2 are defined as below, and related compounds, as well as novel intermediates used in such processes.
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WO/1991/018910A1 |
A compound of general formula (I), in which each of R1, R2, R3 and R4 independently represent a hydrogen atom or a group -(CO)nR5 in which n is 0 or 1 and R5 represents an alkyl, aryl, cycloalkyl, alkaryl or aralkyl group, or R1 or R2 to...
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WO/1991/017816A1 |
The invention relates to a process for the high yield, cost efficient means of separating enantiomers. The process utilizes a supported liquid membrane and a chiral carrier which selectively complexes with one of the two enantiomeric opt...
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WO/1991/017977A1 |
Process for the stereoselective preparation of phenylisoserin derivatives of general formula (I) from benzylamine. In the general formula (I), R is a phenyl radical or tert.butoxy and R1 is a hydroxy function protective group.
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WO/1991/017159A1 |
(-)-4-Amino-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(1H)-pyr
imidin-2-one, its pharmaceutically acceptable derivatives, pharmaceutical formulations thereof, methods for its preparation and its use as an antiviral agent are described.
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WO/1991/015471A1 |
A process is disclosed for the isolation of an enantiomerically enriched alcohol from a first mixture of an enantiomerically enriched alcohol and an enantiomerically enriched ester. The process includes the steps of: (a) contacting the m...
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WO1991013066A3 |
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WO/1991/015472A1 |
A process is disclosed for the separation of an enantiomerically enriched 1-tosyloxy-2-acyloxy-3-butene and an enantiomerically enriched 1-tosyloxy-2-hydroxy-3-butene from a first mixture containing both compounds. The process includes t...
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WO/1991/014671A1 |
The new (S)-4-(2-bromobenzoyl)-5-hydroxy-benzocyclobutene-1-carboxyl
ic acid, i.e., the compound of formula (I), in free or salt form, can be used as the active substance in pharmaceutical preparations and can be made by a new process wh...
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WO/1991/013066A2 |
Method for the preparation of beta-phenylglycidic-(2R,3R) acid optionally in the form of salt or ester by precipitation of the salt of the beta-phenylglycidic-(2R,3R) acid with (+)-alpha-methylbenzylamine-(R) in a solution of a mixture o...
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WO/1991/013046A1 |
A process for separating optical isomers in a pseudo-moving bed system, which comprises introducing a solution containing an optical isomer mixture and a desorbing liquid into a packed bed containing an optical resolution packing therein...
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WO/1991/012072A1 |
Disclosed are processes and apparatus for separating a desired solute (A), such as an optically active isomer, from a complex mixture (A, X, Y) using carrier (C) facilitated transport in an immobilized liquid membrane (50) or carrier (C)...
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WO/1991/007366A1 |
A novel process for preparing the R(+)-enantiomer of terodiline (N-tert.butyl-1-methyl-3,3-diphenylpropylamine) and pharmaceutically acceptable salts thereof by optical resolution of a racemic mixture of terodiline using tartaric acid, c...
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WO/1991/002006A1 |
New polysaccharide derivatives useful for the separation of optical isomers, prepared by substituting at least one atomic group of formula (1), (2) or (3) for part or the whole of hydrogen atoms of the hydroxyl or amino groups of the pol...
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WO/1991/000270A1 |
The invention relates to a novel process for the resolution of an acid mixture (hereinafter: threo acid mixture) containing (+)-threo-3-[(2-aminophenyl)thio]-2-hydroxy-3-(4-methoxyphen
yl)propionic acid [hereinafter: (+)-threo acid] and ...
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WO/1990/009376A1 |
A process for the optical resolution of racemic 1,4-dihydropyridines, containing isothioureido groups. Salification of racemic isothioureas with optically active acids produces diasteroisomeric mixtures of isothiouronium salts, that, usi...
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WO/1990/008126A1 |
The invention relates to a novel process for preparing the optical isomers of 2,2-dimethyl-3-(2,2-disubstituted vinyl)cyclopropanecarboxylic acids of general formula (I), wherein R1 and R2, independently from another, stand for halogen o...
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WO/1990/003962A1 |
A novel process for the preparation of compounds of formula (I), wherein X is -CH2CH2- or -CH=CH-; R1 is an ester group inert to the reaction conditions; and R is an organic radical having groups which are inert under reducing conditions...
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WO/1989/009235A1 |
Substituted cylodextrins of general formula (I), where R2 and R6 are linear-chain or branched-chain alkyl or alkenyl groups with 1 to 8 atoms of carbon or cycloalkyl groups with 5 to 8 atoms of carbon, which can be equal or different, an...
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WO/1988/010249A1 |
Crystallizable pyrethroid isomer or enantiomer pairs are converted to more pesticidally active isomers by contacting a hydrocarbon slurry of the starting isomers with a base and a catalyst, the catalyst being substantially soluble in the...
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WO/1988/007050A1 |
Process for the production of (+)-bicyclo-[3.3.0]octane-3-on-2-carboxylic acid steroid esters having the formula (I), in which X represents oxygen or the -O-(CH2)n-O- or the -O-CH2-C(CH3)2-CH2-O- residue; n represents 2 or 3; R2 represen...
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WO/1988/001614A1 |
A process for the resolution of dl-methyl 3-[4-(2-hydroxy-3-isopropylamino)propoxy]phenylpropionate [(dl-esmolol)] into a dextro (+) and a levo (-) isomer.
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WO/1987/006929A1 |
A new chiral reagent of formula (I), wherein X is halogen, an azide group or a succinimidyl group and wherein R is an alkyl group or a trifluormethyl group. The invention further relates to a method for derivatization, determination and ...
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WO/1987/000165A1 |
The system comprises two immiscible liquid phases and one or more enantioselectively binding chiral components, each of which is substantially in one of said phases. Also disclosed is a method for chiral resolution of racemic mixtures, o...
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WO/1986/004215A1 |
An insecticidal composition containing more than one active ingredients which comprises as active ingredient in an amount of 0.001-99% by weight a synthetic pyrethroide of general Formula (I), (wherein X stands for chlorine or bromine) -...
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WO/1986/004216A1 |
A synergistic insecticidal composition containing more than one active ingredients and being harmless to environment characterized by comprising in an amount of from 0.001 to 99% by weight a synthetic pyrethroide of the formula (I) - nam...
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WO/1986/001799A1 |
A novel sequence of highly selective chemical reactions for conversion of 3-Aryl-2-propyn-1-ols into cis-1-Aryl-3-fluoro-1-propene and into D,L-(threo)-1-Aryl-2-acylamido-3-fluoro-1-propanols. Preparation of D-(threo)-1-Aryl-2-acylamido-...
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WO/1986/000066A1 |
New butyramide derivatives corresponding to formula (I), wherein X and Y independently represent hydroxymethyl; cyano; carboxy; functionally modified carboxy selected from esterified carboxy, carbamoyl, and N-substituted carbamoyl; 5-tet...
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WO/1985/003932A1 |
The separation of optically active phenylalanine and N-acyl derivatives thereof and novel diastereomer salts of the said compounds. According to the invention a racemic compound of formula (I), is reacted with an optically active resolvi...
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WO/1985/000661A1 |
A packing for use in liquid chromatography for optical resolution of racemic compounds, which comprises a carrier of silica gel having bound thereto a spacer introduced by reacting with a silane treating agent and having chemically bound...
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WO/1983/004103A1 |
A grafted chromatographic filler comprising an inorganic carrier having hydroxy groups on its surface to which alpha-arylalkylamine derivative is grafted, said alpha-arylalkylamine derivative comprising asymmetric carbon-containing, opti...
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JP6801845B2 |
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