Login| Sign Up| Help| Contact|

Patent Searching and Data


Matches 651 - 700 out of 4,313

Document Document Title
JP2019182971A
To provide a chiral stationary phase having high separability on an optical active body.There is provided a chiral stationary phase in which a high molecular compound having chiral discrimination performance is physically adsorbed to sur...  
JP6595103B2  
JP2019528308A
The present invention relates to Ally Lu 2, a 2'-tandem Bisch azole system compound, and its manufacturing method and use, Concretely, it is related with the use in manufacture of the antineoplastic-agents thing as Ally Lu 2 to whom stru...  
JP6574572B2  
JP2019524875A
The present invention provides the antivirus prodrug nucleoside cyclic-phosphoric-acid ester compound based on liver specific delivery art (liver delivery) (Liver Specific Delivery (LSD)), and its use. Specifically, the compound denoted ...  
JP2019137656A
To provide a production method of an optically active cyclopentenone derivative.A production method of an optical active material is provided, including optical resolution of a compound of formula (I) by use of a high-speed liquid chroma...  
JP2019135249A
To provide a method for manufacturing an optically active 5-hydroxy-3-ketoester compound having high yield and high stereoselectivity and useful as a pharmaceutical intermediate.By conducting an asymmetric aldol reaction a 1,3-diene comp...  
JP6539749B2  
JP2019516736A
The tetrahydro pyran derivative and thiopyran derivative which have double pharmacologic activity [as opposed to both a sigma (sigma) receptor and mu-opioid receptor in the present invention], In the preparing method of such a compound, ...  
JP2019513124A
The present invention relates to the medical treatment of a Sulfa mate derivative compound and/or its CNS disease which contains permissible salt as an active ingredient pharmacologically, or the pharmacy constituent for prevention. The ...  
JP6506753B2  
JP6491213B2  
JP6483332B2  
JP2019006793A
To provide novel compounds that can act as auxiliary groups for asymmetric induction in manufacture of phosphorus atom-modified nucleic acid derivatives.The present invention provides chiral auxiliary groups useful for efficiently manufa...  
JP6452119B2  
JP6422871B2  
JP2018532718A
compound 61501b whose purity of compound 61501b of the present invention is 90% or more -- it is related with a rich constituent. Compound S of high purity [constituent / above-mentioned]PIn manufacture of -1, it has a remarkable advanta...  
JP2018531946A
Present invention, The formula whose X is fumarate (I) that5S and (10S) -10-Benji Lu 16-methyls 11 and 14, 18-trio Kiss - 15 and 17, 19-trioxa 2 and 7, and 8-Tori Cheer - -- it is related with the industrial process for manufacture of 12...  
JP2018529697A
The present invention relates to the manufacturing method of beta 2-thienyl Alanine which has optical activity, and is in details more, It is related with the method of manufacturing beta 2-thienyl L- Alanine or beta 2-thienyl D- Alanine...  
JP2018529633A
This indication is useful for the medical treatment of diseases, such as cancer in a mammal, It is related with the many forms of 7S and (R [13]) -11-full Oro - 7, 13- Dimethyl - 6, 7, and 13, 14-tetrahydro 1, and 15- Eteno pyrazolo [4 a...  
JP2018150307A
To provide a compound that is a spleen tyrosine kinase inhibitor, and can be used for treatment of, especially, cancer, articular rheumatism and/or systemic lupus erythematosus.The present invention provides pyridopyrimidine derivatives ...  
JP2018527356A
The present invention provides the compound of formula 1, its stereoisomeric form, the salt permitted pharmacologically and a derivative, and the method of manufacturing and using such a compound. The present invention includes use of th...  
JP2018527355A
The present invention is a compound of formula XXIII. [Formula 1](Inside of a formula, R)1It is Is , hydrogen, a Alkyl machine, an acyl group, or a silyl group, and is R.2It is Is , hydrogen, a Alkyl machine, a benzyl group, an acyl grou...  
JP2018526451A
The present invention relates to a manufacturing method of D-arginine, in detail, using D-3- Bromo camphor 8-sulfonic acid or its salt as an optical resolving agent, carries out optical division of the DL-arginine, and relates to a metho...  
JP2018525395A
The present invention exhibits use of a manufacturing method of compound 5-3 of an orexin receptor antagonist, crystal form I~IV of the compound concerned, a manufacturing method for the same, and the above-mentioned crystal form in manu...  
JP2018523643A
The present invention contains the new method of preparation of a GalNAc derivative of formula I whose n is an integer between 0~10, its salt, its corresponding mirror image isomer, and/or an optical isomer. A GalNAc acid derivative of f...  
JP6379078B2  
JP2018127472A
To provide compounds useful as triple reuptake inhibitors, methods of producing compositions comprising the compounds, and methods of their use.The invention provides compounds represented by formula (I) or pharmaceutically acceptable sa...  
JP6368794B2  
JP2018517768A
a) A compound of a formula (2a) including making the mixture of the Diastereo opposite-sex object of a formula (2a, 2b) react to a basic heterocyclic aldehyde compound and optical activity amine, its salt, or an isolation method of solve...  
JP2018512405A
The present invention is among a formula I [type and Y is C*R.1Come out, and it is and is;R.1'It is Is , hydrogen, F, or Cl, and is;R.1It is Is , F, or Cl and is;R.2It is Is , hydrogen, or low-grade Alkyl , and is;R.3It is phenyl, pillag...  
JP2018043944A
To provide a method for completely separating four optical isomers of nahlsgen.This invention relates to an optical resolution method for DL-2-amino-4-[(RSp)-(3-carboxymethyl phenoxy) (methoxy) phosphoryl] butanoic acid derivative, where...  
JP2018507173A
[Means for Solution] this indication -- for example2* [[5* chloro *2* [[(-- six -- S --) -- * -- six -- * -- [-- four -- * (2* hydroxyethyl) -- Piperazine -- * -- one -- * -- Il --] -- * -- one -- * -- methoxy -- * -- 6, 7, 8 -- nine -- ...  
JP6287836B2  
JP6272250B2  
JP2018502106A
This indication is related with those use as the picoline amide and Fungicide agent of formula I.  
JP2018501270A
The present invention is (3RS) *3* [(2SR) * (2* cyclopentyl *2* hydroxy *2* phenylacetyl) Oxy ] *1 and 1* Dimethyl pyridinium . Star's picture, It is suitable for production on an industrial scale, is further obtained in quantity yield a...  
JP2018500326A
(R) Anhydride of *2* hydroxy *2* methyl *4* (2, 4, 5* Trimethyl *3, 6* dioxo cyclohexa *1, 4* dienyl) butaneamide, The method of using the constituent for the disposal of the polymorphism form of a hydrate and solvent Japanese food , an ...  
JP6255343B2  
JP6234999B2  
JP6234030B2  
JP6231151B2  
JP6226318B2  
JP2017529323A
The present invention relates to a method for chiral resolution of a chiral kind contained in a fluid arranged in a cell formed of an inner wall and an outer wall surrounding an inner wall over at least one copy of an inner wall, Each of...  
JP6176259B2  
JP2017132793A
To provide a novel process for the synthesis of R-biphenylalaninol and its intermediates useful in the synthesis of pharmaceutically active compounds.The present invention provides a process for obtaining a compound of formula I by Boc-p...  
JP2017128528A
To provide a method for producing an (S)-2-hydroxypropanoic acid derivative and ambrisentan having high optical purity in an industrially advantageous manner.There is provided a method for producing an (S)-2-hydroxypropanoic acid derivat...  
JP2016523241A5  
JP2016528180A5  
JPWO2015118793A1
A manufacturing method of out (R) *1 including following process (A), (B), and (C), 1, and 3* Trimethyl *4* amino in. (A) : Optical division of out 1, 1, and 3* Trimethyl *4* amino in is carried out, (R) Process (B) which obtains out 3 [...  

Matches 651 - 700 out of 4,313