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Matches 651 - 700 out of 4,263

Document Document Title
JP2018531946A
Present invention, The formula whose X is fumarate (I) that5S and (10S) -10-Benji Lu 16-methyls 11 and 14, 18-trio Kiss - 15 and 17, 19-trioxa 2 and 7, and 8-Tori Cheer - -- it is related with the industrial process for manufacture of 12...  
JP2018529697A
The present invention relates to the manufacturing method of beta 2-thienyl Alanine which has optical activity, and is in details more, It is related with the method of manufacturing beta 2-thienyl L- Alanine or beta 2-thienyl D- Alanine...  
JP2018529633A
This indication is useful for the medical treatment of diseases, such as cancer in a mammal, It is related with the many forms of 7S and (R [13]) -11-full Oro - 7, 13- Dimethyl - 6, 7, and 13, 14-tetrahydro 1, and 15- Eteno pyrazolo [4 a...  
JP2018150307A
To provide a compound that is a spleen tyrosine kinase inhibitor, and can be used for treatment of, especially, cancer, articular rheumatism and/or systemic lupus erythematosus.The present invention provides pyridopyrimidine derivatives ...  
JP2018527356A
The present invention provides the compound of formula 1, its stereoisomeric form, the salt permitted pharmacologically and a derivative, and the method of manufacturing and using such a compound. The present invention includes use of th...  
JP2018527355A
The present invention is a compound of formula XXIII. [Formula 1](Inside of a formula, R)1It is Is , hydrogen, a Alkyl machine, an acyl group, or a silyl group, and is R.2It is Is , hydrogen, a Alkyl machine, a benzyl group, an acyl grou...  
JP2018526451A
The present invention relates to a manufacturing method of D-arginine, in detail, using D-3- Bromo camphor 8-sulfonic acid or its salt as an optical resolving agent, carries out optical division of the DL-arginine, and relates to a metho...  
JP2018525395A
The present invention exhibits use of a manufacturing method of compound 5-3 of an orexin receptor antagonist, crystal form I~IV of the compound concerned, a manufacturing method for the same, and the above-mentioned crystal form in manu...  
JP2018523643A
The present invention contains the new method of preparation of a GalNAc derivative of formula I whose n is an integer between 0~10, its salt, its corresponding mirror image isomer, and/or an optical isomer. A GalNAc acid derivative of f...  
JP6379078B2  
JP2018127472A
To provide compounds useful as triple reuptake inhibitors, methods of producing compositions comprising the compounds, and methods of their use.The invention provides compounds represented by formula (I) or pharmaceutically acceptable sa...  
JP6368794B2  
JP2018517768A
a) A compound of a formula (2a) including making the mixture of the Diastereo opposite-sex object of a formula (2a, 2b) react to a basic heterocyclic aldehyde compound and optical activity amine, its salt, or an isolation method of solve...  
JP2018512405A
The present invention is among a formula I [type and Y is C*R.1Come out, and it is and is;R.1'It is Is , hydrogen, F, or Cl, and is;R.1It is Is , F, or Cl and is;R.2It is Is , hydrogen, or low-grade Alkyl , and is;R.3It is phenyl, pillag...  
JP2018043944A
To provide a method for completely separating four optical isomers of nahlsgen.This invention relates to an optical resolution method for DL-2-amino-4-[(RSp)-(3-carboxymethyl phenoxy) (methoxy) phosphoryl] butanoic acid derivative, where...  
JP2018507173A
[Means for Solution] this indication -- for example2* [[5* chloro *2* [[(-- six -- S --) -- * -- six -- * -- [-- four -- * (2* hydroxyethyl) -- Piperazine -- * -- one -- * -- Il --] -- * -- one -- * -- methoxy -- * -- 6, 7, 8 -- nine -- ...  
JP6287836B2  
JP6272250B2  
JP2018502106A
This indication is related with those use as the picoline amide and Fungicide agent of formula I.  
JP2018501270A
The present invention is (3RS) *3* [(2SR) * (2* cyclopentyl *2* hydroxy *2* phenylacetyl) Oxy ] *1 and 1* Dimethyl pyridinium . Star's picture, It is suitable for production on an industrial scale, is further obtained in quantity yield a...  
JP2018500326A
(R) Anhydride of *2* hydroxy *2* methyl *4* (2, 4, 5* Trimethyl *3, 6* dioxo cyclohexa *1, 4* dienyl) butaneamide, The method of using the constituent for the disposal of the polymorphism form of a hydrate and solvent Japanese food , an ...  
JP6255343B2  
JP6234999B2  
JP6234030B2  
JP6231151B2  
JP6226318B2  
JP2017529323A
The present invention relates to a method for chiral resolution of a chiral kind contained in a fluid arranged in a cell formed of an inner wall and an outer wall surrounding an inner wall over at least one copy of an inner wall, Each of...  
JP6176259B2  
JP2017132793A
To provide a novel process for the synthesis of R-biphenylalaninol and its intermediates useful in the synthesis of pharmaceutically active compounds.The present invention provides a process for obtaining a compound of formula I by Boc-p...  
JP2017128528A
To provide a method for producing an (S)-2-hydroxypropanoic acid derivative and ambrisentan having high optical purity in an industrially advantageous manner.There is provided a method for producing an (S)-2-hydroxypropanoic acid derivat...  
JP2016523241A5  
JP2016528180A5  
JPWO2015118793A1
A manufacturing method of out (R) *1 including following process (A), (B), and (C), 1, and 3* Trimethyl *4* amino in. (A) : Optical division of out 1, 1, and 3* Trimethyl *4* amino in is carried out, (R) Process (B) which obtains out 3 [...  
JPWO2015064453A1
the present invention has a thiol group in a side chain -- optics -- it made into a subject to provide a method of manufacturing active D* object and/or L* object amino acid with sufficient yield by a simple method. The present invention...  
JP6086512B2  
JP6087504B2  
JPWO2014157607A1
optics useful as a manufacturing raw material of medicine, agricultural chemicals, and an industrial commodity -- the optical purity improving method of active 2* hydroxycarboxylic acid is provided. Hydroxycarboxylic acid denoted by the ...  
JPWO2014148344A1
The present invention is a manufacturing method of optical activity transformer 1, optical activity transformer 1 which makes it Crystallization from solution of 2* Diamino cyclohexane, and obtains a crystal of optical activity transform...  
JPWO2014125667A1
The present invention provides an optical isomer separating medium and a manufacturing method for the same. That is, the present invention is following formula (I) : Each sign in [type is as given in a specification. A spiral poly (diphe...  
JPWO2014119731A1
By non- A conversion reaction of L* isoleucine, a method of manufacturing D* alloisoleucine by a short process and quantity yield is provided. To the specific system of reaction in the state where L* isoleucine and D* alloisoleucine Epim...  
JP2017502020A
Formula (1) [Formula 1] It is Of compound and they are inside of a formula, and R.1A Is hydrogen , Halo , C1*C4 Alkyl machine, C1*C4 Alkyl halide machine, and C1*C4 alkoxy *C2*C4 Alkyl machine, C2*C4 alkenyl group, C2*C4 alkynyl group, o...  
JP2016539924A
Formula (I) [Formula 1] (The inside of a formula, X, R)1*R7It has a meaning defined as a The book specification. HBV replication inhibitor which is of HBV replication inhibitor and contains the stereochemical opposite-sex form, salt, a h...  
JP6045531B2  
JP6023794B2  
JP2016164191A
To provide a method for producing a high-quality optically active thiazolylalanine derivative and salt thereof, in which the method does not require the use of any unsafe reagent and is economically advantageous, and is suitable for the ...  
JP5986380B2  
JP2016155849A
To provide methods for producing substituted heterocycle fused gamma-carbolines, intermediates useful in producing them, methods for producing such intermediates and such heterocycle fused gamma-carbolines.The invention provides compound...  
JP5981719B2  
JP5968439B2  
JP5951825B2  

Matches 651 - 700 out of 4,263