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Matches 751 - 800 out of 4,337

Document Document Title
JP2015509496A
It is provided for this specification, The unusually high level, the disease related as it is active, or state of TNF-alpha is treated or prevented. It is a new preparing method of the amino sulfone intermediate for composition of useful...  
JP2015048332A
To provide a compound for optical resolution capable of easily optically resolving the optical isomer mixture of amino acid at high sensitivity, and an optically resolving method using the compound.Provided is a compound for optical reso...  
JP2013528577A5  
JP2015505827A
The present invention provides (*) *2* exo* morpholino iso ボルン *10* チオール and an efficient and economical synthesizing method of the chiral catalyst エナンチオマー (ed) and related. A new molecular entity and an asymm...  
JP2015027979A
To provide a novel optically active α-aminophosphonate derivative, and an efficient method of manufacturing the same.A compound of the general formula (1) is obtained by reacting thionophosphonoyl ketimine and phosphite diester by using...  
JP2015504054A
The present invention provides medical treatment of multiple sclerosis of medical treatment of multiple sclerosis which contains the phenyl carbamate compound as a part for a phenyl carbamate compound and validity and/or a pharmacy const...  
JP5663154B2
Process for optical resolution of (3,4-dimethoxy-bicyclo[4.2.0]octa-1,3,5-trien-7-yl)nitrile (I) comprises separating enriched racemic or enantiomeric mixture of (3,4-dimethoxy-bicyclo[4.2.0]octa-1,3,5-trien-7-yl)nitrile into its two ena...  
JP5662345B2  
JP5656635B2
The present invention relates to the resolution by preferential crystallization of potassium salts of racemic omeprazole which is a solvate of ethanol and/or of ethylene glycol, which consists in converting the omeprazole to the potassiu...  
JP2014516920A5  
JP2015003861A
To easily and efficiently produce (R)-2-amino-2-ethylhexanol that is useful as a pharmaceutical intermediate without carrying out a complicated operation.(R)-2-amino-2-ethylhexanol is produced by subjecting a N-benzylidene-2-amino ester ...  
JP5646606B2
Disclosed is an antitumor agent which has higher antitumor activity than conventional antitumor agents, while having low toxicity. Specifically disclosed is an antitumor agent which is characterized by containing a phosphine transition m...  
JP2014503480A5  
JP2014527534A
The present invention relates to spiro Ben Jill Amin * phosphine, a manufacturing method for the same, and its use. It is a compound which has the structure denoted by formula (I), is here, and is n=0*3;R.1R2R3R4R5R6R7R8R9A の value is ...  
JP5605008B2  
JP5605716B2  
JP2014193895A
To provide a method for purifying lactic acid on an industrial scale.(a) A lactic acid solution having, with respect to the weight of a concentrate lactic acid solution, a total acid content of at least 95 wt.% and a monomeric lactic aci...  
JP5604520B2
The present invention relates to a compound of formula I, in all its isomeric forms and pharmaceutically acceptable salts thereof, their manufacture, pharmaceutical compositions containing them and their use as medicaments for the treatm...  
JP5603627B2  
JP5603884B2  
JP5603626B2  
JP2014525895A
This invention relates to novel compounds which are inhibitors of acyl coenzymeA: diacylglycerol acyltransferase 1 (DGAT-1), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy ...  
JP2014520140A5  
JP5598330B2  
JP2014524885A
The present invention targets [output of a preparing method of Ben Jill [(3aS, R / 4 / and 6S, 6aR) *6* hydroxy *2 and 2* ジメチル tetrahydro *3aH* cyclo ペンタ [d] [1, 3] ジオキソル *4* イル] carbamate (VI), (VI), and the ...  
JP5596134B2
The present invention relates to a resolution process of (±)-methyl phenyl[4-[4-[[[4'-(trifluoromethyl)-2-biphenylyl]carbonyl]am ino]phenyl]-1-piperidinyl]acetate to isolate the MTP (microsomal triglyceride transfer protein) inhibitor m...  
JP5595404B2  
JP2014172839A
To provide a process for producing a tertiary alcohol derivative of high optical purity from a racemic tertiary alcohol derivative or a tertiary alcohol derivative of low optical purity.Provided is a method for producing an optically act...  
JP2014172856A
To produce a high-purity optically active tetrahydrofuran-2-carboxylic acid having optical activity efficiently with high productivity.There is provided a method for producing a high-purity (R)- or (S)-tetrahydrofuran-2-carboxylic acid, ...  
JP2014169252A
To provide a new method of producing optically active β-formyl-β-hydroxy-α-substituted aldehyde compounds.A method of producing an optically active β-formyl-β-hydroxy-α-substituted aldehyde compound (2) includes the step of making ...  
JP2014523896A
The present invention relates to the new nitryl compound shown in formulas I and II. (I) Formula I(The inside of a formula and X are *CH (s).)3Or it is *C≡N. (II) Formula II(The inside of a formula and X are *CH (s).)3Or as for R, Y is...  
JP2014169294A
To provide an optically active piperidine derivative which is excellent in antihistaminic activity and antiallergic activity, has little hygroscopicity and is excellent in physicochemical stability, and a manufacturing method thereof.Thi...  
JP2014523416A
Disclosed are 1,3-Dioxoindene derivatives of Formula 1, pharmaceutically acceptable salts thereof or enantiomers, a preparation method thereof, and a pharmaceutical composition for the prevention or treatment of viral diseases, comprisin...  
JP5585822B2  
JP2014152156A
To provide a method for obtaining an optically active material, when erythro ADPE or MA is used as a reagent for optical resolution, having a sign opposite to the previously obtained one without forming a diastereomeric salt again.To pro...  
JP2014148531A
To provide, among other things, novel compounds useful for treating bacterial infections, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effe...  
JP2014520077A
A crystalline mono hydrochloride salt of (4S,4aS,5aR,12aS)-4-dimethylamino- 3,10, 12, 12a-tetrahydroxy-7-[(methoxy(methyl)amino)-methyl]- 1, 11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carbox ylic acid amide is disclosed having...  
JP2014520140A
The present invention relates to deuterated 1-piperazino-3-phenyl-indanes and salts thereof with activity at dopamine receptors D 1 and D 2 as well as the 5HT 2 receptors in the central nervous system, for use as a medicament and for the...  
JP2014520126A
The invention provides a new process for the preparation of solifenacin or a pharmaceutically acceptable acid addition salt thereof, comprising reacting (R)-quinuclidin-3-yl phenethylcarbamate with benzaldehyde in the presence of an acid...  
JP5566103B2  
JP5563830B2
The present invention relates to synthesis procedures and intermediates of a compound of formula: and the salts thereof.  
JP2014133771A
To provide processes and intermediates for the preparation of 3-benzazepines and salts thereof which can be useful as serotonin (5-HT) receptor agonists for the treatment of, for example, central nervous system disorders such as obesity....  
JP5553911B2
Provided is a process for preparing Voriconazole represented by Chemical Formula 1. More particularly, the process for preparing Voriconazole of Chemical Formula 1 includes: carrying out the Reformatsky-type coupling reaction between a k...  
JP5557292B2
The problem to be solved is to provide a method for producing a compound having excellent activity as an ± 2 ´ ligand. The solution thereto is a method for producing a compound represented by the general formula (I) or a salt thereof b...  
JP2014516920A
The present invention relates to those use as *4* cyano *3 replaced (3R, 4R), 4* diphenyl butanoic acid compounds, those manufacturing methods, a weed killer, and a plant growth regulation agent. The compound of formula (I) in an optical...  
JP5552422B2
(6S)-N(5)-methyl-5,6,7,8-tetrahydrofolic acid calcium salt aqueous solution production involves methylating (6S)-5,6,7,8-tetrahydrofolic acid with a part of the corresponding (6R)-diastereoisomer in the range of 4-8 wt.% in water. Calciu...  
JP5544298B2
The invention relates to compounds that are vitamin D receptor activators, compositions comprising such compounds, methods of using such compounds and compositions, processes for preparing such compounds, and intermediates obtained durin...  
JP2014122211A
To provide an GPR40 activator containing a compound having a novel GPR40 agonist effect or a salt thereof or a solvate thereof and the like as an active ingredient, especially an insulin secretion promoter, a prevention and/or therapeuti...  
JP5534460B2  
JP5536869B2
A new process for the enantiomeric separation of racemic 3,6-dihydro-1,3,5-triazine derivatives for the treatment of disorders associated with insulin-resistance syndrome, by preferential crystallization.  

Matches 751 - 800 out of 4,337