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JP2014172839A |
To provide a process for producing a tertiary alcohol derivative of high optical purity from a racemic tertiary alcohol derivative or a tertiary alcohol derivative of low optical purity.Provided is a method for producing an optically act...
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JP2014172856A |
To produce a high-purity optically active tetrahydrofuran-2-carboxylic acid having optical activity efficiently with high productivity.There is provided a method for producing a high-purity (R)- or (S)-tetrahydrofuran-2-carboxylic acid, ...
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JP2014169252A |
To provide a new method of producing optically active β-formyl-β-hydroxy-α-substituted aldehyde compounds.A method of producing an optically active β-formyl-β-hydroxy-α-substituted aldehyde compound (2) includes the step of making ...
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JP2014523896A |
The present invention relates to the new nitryl compound shown in formulas I and II. (I) Formula I(The inside of a formula and X are *CH (s).)3Or it is *C≡N. (II) Formula II(The inside of a formula and X are *CH (s).)3Or as for R, Y is...
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JP2014169294A |
To provide an optically active piperidine derivative which is excellent in antihistaminic activity and antiallergic activity, has little hygroscopicity and is excellent in physicochemical stability, and a manufacturing method thereof.Thi...
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JP2014523416A |
The present invention relates to the medicine constituent which has the antiviral activity which contains 1, 3* dioxo indene derivative, its salt permitted pharmacologically or an optical isomer, its preparing method, and it as an active...
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JP5585822B2 |
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JP2014152156A |
To provide a method for obtaining an optically active material, when erythro ADPE or MA is used as a reagent for optical resolution, having a sign opposite to the previously obtained one without forming a diastereomeric salt again.To pro...
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JP2014148531A |
To provide, among other things, novel compounds useful for treating bacterial infections, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effe...
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JP2014520077A |
Improved stabilityIt has. (4S, 4aS, 5aR, 12aS) -4-dimethylamino 3, The crystalline mono-chloride salt of 10, 12, and 12a-tetra-hydroxy 7- [(methoxy (methyl) amino) - methyl] -1 and 11-dioxo 1, 4, 4a, 5, 5a, 6, and 11 and 12a-octahydro NA...
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JP2014520140A |
Deuteration 1* piperazino *3* phenyl * Indang where the present invention has activity in dopamine receptors D1 and D2 of a central nervous system, and 5HT2 receptor, and its salt, It is related with a therapeutic method including use of...
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JP2014520126A |
The present invention is a new method for manufacture of ソリフェナシン or its acid addition salt permitted pharmacologically, and is the bottom of existence of acid, and (R) * quinuclidine *3* イル. Reaction of フェネチル ...
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JP5566103B2 |
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JP5563830B2 |
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JP2014133771A |
To provide processes and intermediates for the preparation of 3-benzazepines and salts thereof which can be useful as serotonin (5-HT) receptor agonists for the treatment of, for example, central nervous system disorders such as obesity....
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JP5553911B2 |
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JP5557292B2 |
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JP2014516920A |
The present invention relates to those use as *4* cyano *3 replaced (3R, 4R), 4* diphenyl butanoic acid compounds, those manufacturing methods, a weed killer, and a plant growth regulation agent. The compound of formula (I) in an optical...
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JP5552422B2 |
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JP5544298B2 |
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JP2014122211A |
To provide an GPR40 activator containing a compound having a novel GPR40 agonist effect or a salt thereof or a solvate thereof and the like as an active ingredient, especially an insulin secretion promoter, a prevention and/or therapeuti...
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JP5534460B2 |
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JP5536869B2 |
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JP5531097B2 |
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JP5533654B2 |
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JP5531288B2 |
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JP2014514243A |
2R*2* (N, N dimethylamino) * propionic acid ドデシル (R*DDAIP), The activity unexpectedly improved in passing a biomembrane and an organization and easy-izing transportation of an active compound pharmacologically as compared with S*...
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JP5520077B2 |
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JP5518337B2 |
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JP5513621B2 |
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JP5510040B2 |
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JP5514549B2 |
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JP5503546B2 |
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JP2014088389A |
To provide a diagnostic agent for positron emission tomography, comprising a [F-18]-labeled compound.A diagnostic agent for positron emission tomography (PET) comprises a compound which is a L-glutamic acid or L-glutamic acid derivative ...
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JP5487440B2 |
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JP2014074033A |
To provide methods for isolating from a reaction mixture a salt of a mono-propargylated aminoindane (rasagiline), which is a selective inhibitor of MAO-B and useful in treating Parkinson's disease etc.Disclosed are production methods for...
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JP5476859B2 |
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JP2014509592A |
The present invention provides the compound of formula (I), this salt permitted as medicine, a prodrug, a biological activity metabolite, a stereoisomeric form, and an opposite-sex object, and the variable thing is defined in this specif...
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JP2014509304A |
The present invention experiences the new method for manufacturing Sis *1* ammonium *4* alkoxy cyclohexane カルボ nitril salts, and the manufacturing method by the present invention, or relates to the new intermediate output or the st...
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JP5468003B2 |
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JP5456871B2 |
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JP5455394B2 |
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JP5452165B2 |
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JP5451870B2 |
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JP2014043463A |
To provide alkanoylamino benzamide aniline HDAC inhibitor compounds.The present invention provides a compound of the general formula (I) having histone deacetylase (HDAC) inhibitory activity, a pharmaceutical composition comprising the c...
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JP5437525B1 |
[Subject] The present invention is melatonin MT.1In addition to a tyrosine derivative useful as a receptor antagonist, in a benzene ring of m* tyrosine, an iodine machine is introduced by good site selectivity and quantity 収率 at leas...
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JP5435656B2 |
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JP5436438B2 |
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JP5425806B2 |
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JP5424650B2 |
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