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Matches 801 - 850 out of 4,296

Document Document Title
JP2014031327A
To easily and efficiently produce an optically active cis-2-amino-cyclohexane carboxylic acid derivative that is important as a raw material of pharmaceutical products from an easily available starting material.An optically active cis-2-...  
JP5421311B2  
JP5422827B2  
JP5417560B2  
JP2014503480A
The present invention provides ジュウテリウム-ized ラサギリン, its salt, and use.  
JP5416928B2  
JP5410749B2  
JP5404655B2  
JP2014502270A
The present invention relates to the method of manufacturing compounds 1a and 1b of the pure following chemical formula 1 optically from the Rasse Mick compound 1 of the following chemical formula 1, respectively. [-izing 1]compounds 1a ...  
JP5404414B2  
JP5399711B2  
JP5398662B2  
JP2014012678A
To provide a novel compound that can be used as a selective mineralocorticoid receptor antagonist for treating disorders in particular cardiovascular disorders, and a medicament containing said compounds for the treatment and/or preventi...  
JP2014012713A
To provide a method of producing optically active trans-2,6-dimethylmorpholine.A method of producing optically active trans-2,6-dimethylmorpholine comprises steps of: (i) reacting racemic trans-2,6-dimethylmorpholine with D-mandelic acid...  
JP5395901B2  
JP2014005252A
To provide (R)-2-[(4,6-dimethoxypyrimidine-2-yl)hydroxymethyl]-6-methox ymethylaniline having a high herbicidal effect.This invention relates to (R)-2-[(4,6-dimethoxypyrimidine-2-yl)hydroxymethyl]-6-methox ymethylaniline or salts thereof...  
JP5387040B2  
JP5380743B2  
JP2013256526A
To provide an optically pure (-)-venlafaxine derivative and a synthesis process thereof; and a composition containing the derivative and usage thereof.Provided is a pharmaceutical composition consisting of a (-)-venlafaxine derivative es...  
JP2013544787A
Disclosed are methods, reagents, and intermediates useful for making azaindazole derivatives, which may be used to modulate Glucokinase. The disclosed methods and materials are generally useful for making halo-esters and sulfonyl-substit...  
JP5366192B2
The invention relates to a method for preparing enantiomerically pure 4-pyrrolidinophenylbenzyl ether derivatives of formula I: wherein R1, R21, R22, R23, R24 and n are as defined in the description and claims and to intermediates useful...  
JP2013241339A
To provide a method for producing an optically active amino acid simply and in good yield without necessitating a special facility.A method for producing an optically active amino acid simply and in good yield includes: making an amino a...  
JP2013241338A
To provide a method for producing an optically active 2-aminobutyric acid simply and in good yield without necessitating a special facility.A method for producing an optically active 2-aminobutyric acid includes: a step of heating 2-amin...  
JP5359348B2
To provide a method for purifying lactic acid from an aqueous lactic acid solution by a crystallization method without passing through a complicated operation, when producing the lactic acid having high purity and high optical purity, be...  
JP2013237675A
To provide a method for optical resolution of (3,4-dimethoxy-bicyclo[4.2.0]octa-1,3,5-trien-7-yl)nitrile, and to provide a method for synthesis of ivabradine, of its addition salts with a pharmaceutically acceptable acid and of their hyd...  
JP5352478B2
A process for the enantioselective preparation of (2 R ,3 S )-3-phenylisoserine methyl ester acetate salt of formula (I) which is an useful building block for the synthesis of taxane derivatives. The process involves the resolution of ra...  
JP5328564B2
To provide a method for obtaining high-purity wine lactone abundantly containing natural wine lactone industrially and in a high yield by a simple method that does not need a dangerous reagent requiring a severe caution in handling, a he...  
JP5326400B2
Disclosed is a purification method of reducing and removing fluoride ions contained in an optically active ±-fluorocarboxylic acid ester represented by formula [1] [in the formula, R 1 represents a C 1-6 alkyl group, R 2 represents a C ...  
JPWO2012020724A
A manufacturing method of an amino アダマン tongue carbamate derivative useful as an important intermediate of 11betaHSD*1 inhibitor is provided. Formula (I) :(Inside of a formula, R)1And R2はそれぞれ independence is achieved, a...  
JP5322641B2
The present invention relates to a process for preparing optically active bisphosphinylalkanes from the correspondingly substituted, racemic 1,2-diols. The optically active bisphosphinylalkanes which can be obtained in this way are suita...  
JP5322928B2
The invention relates to a process for the manufacture of enantiomerically enriched or pure compounds of formula I wherein R1, R2, R3, R6, R7 and Q are defined as in claim 1 as well as their crystalline forms for the treatment of prolife...  
JP5323480B2
Crystalline hydrochloric acid salts (A') of 3-((2-dimethylaminomethyl )-cyclohexyl)-phenol (I) with hydrochloric acid are new, where ratio hydrochloric acid : (I) is specifically 1:1. Independent claims are included for: (1) new hydrates...  
JP5322650B2
Salt forms of potent modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.  
JP5319885B2
By simultaneously carrying out an isomerization reaction at position 2 of monatin in different configurations at positions 2 and 4 in the presence of an aldehyde under a condition of pH 4 to 11 in a mixture solvent of water and an organi...  
JP5317907B2
To provide a method for producing optically active mandelic acids having high purity and useful as pharmaceutical and agrochemical raw materials, liquid crystal materials and optical resoluting agents. Crystals of objective optically act...  
JP5312324B2
A method of selectively producing the syn-isomer of a compound having a hydantoin ring, which is important as an optical material, an electronic material, an active ingredient and an intermediate of medicines and pesticides and an active...  
JP2013537527A
The method and intermediate for preparing a formula (Ia) and a phospho ルアミ date prodrug pure as diastereomer of the nucleoside of (Ib) are provided. The compound of formulas Ia and Ib is useful although infection of hepatitis C is ...  
JP5287250B2
A method of producing optically active trans-2-aminocyclohexanol includes allowing racemic trans-2-aminocyclohexanol to react with optically active 2-methoxyphenylacetic acid to produce an optically active 2-methoxyphenylacetic acid salt...  
JP5287719B2
Disclosed is a novel method for producing an optically active form of etodolac. Specifically disclosed is a method for producing an optically active form of etodolac at a high productivity rate, at a low cost and in a simple manner. The ...  
JP2013173677A
To provide a method for inexpensively and efficiently producing a (1R,2S)-1-amino-2-vinyl cyclopropane carboxylic acid ester, which is useful as a pharmaceutical intermediate.A (1R,2S)-1-amino-2-vinyl cyclopropane carboxylic acid ester d...  
JP5279275B2  
JP5278937B2
To provide a method for producing an optically active secondary alcohol useful as a raw material compound for medicines and agrochemicals, a raw material for producing functional material compounds, and the like in high optical purity by...  
JP5277295B2
A method for preparing optically substantially pure (-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phe nyl]hydrazono]propanedinitrile from racemic 6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone intermediate is descri...  
JP5269349B2
The invention provides a process for producing a compound of formula (I), wherein Y is selected from the group consisting of CH3, CH2OH, CH2CH2OH, CH2Br and Br; comprising the steps of: (i) reacting a compound of formula (II), wherein OX...  
JP5271280B2
An optically active 2,2'-biphenol derivative and a production method that enables simple and efficient production of this compound. More specifically, an optically active biphenol derivative represented by the following formulas (1) and ...  
JP2013530977A
The present invention provides an alternative synthesis of N-substituted aminotetralines comprising resolution of N-substituted aminotetralins of formula (II), wherein R1, R2 and R3 are as defined for compound of formula (I).  
JP5249226B2  
JP5249225B2  
JP5250205B2  
JP2013144685A
To provide a process for the preparation of enantiomerically pure (S)- or (R)-4-halo-3-hydroxybutyrates.A 4-halo-3-hydroxybutyrates shown by formula (S)-I or (R)-I are obtained by asymmetric hydrogenation of a 4-halo-3-oxobutyric acid es...  

Matches 801 - 850 out of 4,296