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Matches 851 - 900 out of 4,297

Document Document Title
JP5250205B2  
JP2013144685A
To provide a process for the preparation of enantiomerically pure (S)- or (R)-4-halo-3-hydroxybutyrates.A 4-halo-3-hydroxybutyrates shown by formula (S)-I or (R)-I are obtained by asymmetric hydrogenation of a 4-halo-3-oxobutyric acid es...  
JP2013530209A
What is provided in the present invention is a new preparing method of the phenyl cyclo propylamine derivative which is a useful intermediate in manufacture of a triazolo [4, 5*d] pyrimidine compound. Substantially, the transformer * (R ...  
JP5247699B2  
JP2013529676A
The object of the present invention has high solid selectivity by existence of the benzyl group as a substitution machine of an amino group, It is the new process containing the step which obtains compound (VIII) by alkylation of ketone ...  
JP2013142081A
To provide a process for separating menthol compound isomers.The process includes rectifying and separating a substance composition including 2-isopropyl-5-methylcyclohexanol diastereoisomers by using an ionic liquid as an extracting agent.  
JPWO2011129365A1
本発明の目的は、従来よりも高い抗がん活性 を有し、かつ毒性の低い抗がん剤を提供する こと。本発明の抗がん剤は、下記一般式(1 )で表されるホスフィン遷移金属錯体を...  
JPWO2011129365A
The object of the present invention has anti-cancer activity higher than before, and provide an antineoplastic drug with low toxicity. An antineoplastic drug of the present invention contains a phosphine transition metal complex denoted ...  
JP5236627B2  
JP5236743B2  
JP2013528577A
Impurities in which the present invention has genetic toxicity influence (for example (C))1*C5アルカ nil methanesulfonate and a remains solvent publicly known as the potential precursor (for example (C))1*C5As form A which does not co...  
JP2013136573A
To provide a method for efficiently producing optically-active 1-bromo-1-[3,5-bis(trifluoromethyl)phenyl]ethane in a high yield from otpically-active 1-[3,5-bis(trifluoromethyl)phenyl]ethanol while maintaining high optical purity, and fu...  
JP5235018B2
This invention relates to a process for the preparation of pyrido[2,1-a] isoquinoline derivatives of the formula wherein R1, R2, R3 and R4 are defined in the specification, comprising the optical resolution of an enamine of the formula w...  
JP5233299B2  
JP2013129642A
To easily obtain an optically active 3,4-bis(alkyloxycarbonyl)-1,6-hexanedioic acid derivative in high efficiency.An optically active 3,4-bis(alkyloxycarbonyl)-1,6-hexanedioic acid derivative is produced by precipitating, from a solvent ...  
JP5228166B2  
JP2013526603A
the present invention being a manufacturing method of a hop acid mixture, contacting the racemic compound of tetrahydro alpha-acid to chiral amine, and including forming the hop acid complex in [as a sediment] solution -- andThe hop acid...  
JP5212953B2  
JP5212740B2  
JPWO2011102388A
The object of the present invention is to provide / (R [1], 2S) (1S, 2R) *1* amino *1* alkoxy carbonyl *2* vinyl cyclopropane useful as synthetic intermediate of a hepatitis C curative medicine, and the new manufacturing method of the sy...  
JPWO2011102388A1
本発明の目的は、C型肝炎治療薬の合成中間 体として有用である(1R,2S)/(1S ,2R)−1−アミノ−1−アルコキシカル ボニル−2−ビニルシクロプロパン及び...  
JP2013522273A
(a) 4* oxo *1 and 2* cyclopentane dicarboxylic acid (V) is made to react to ブルシン (brucine), or 1R and (2S) * (*) * ephedrin. Screw * ブルシン of (V) or screw * (R [1], 2S) * (*) * ephedrin salt is manufactured in this way, An...  
JP5207518B2  
JP5202519B2  
JP5200245B2  
JP2013519655A
2 - (2-pyridyl methylsulfinyl) - Preparing method of the sodium salt of a benzimidazole derivative compound. a) エソメプラゾール (C)3-C8- ketone or its mixture, and sodium alcoholate -- and (C)1-C5Alcohol or エソメプラゾー...  
JP2013103935A
To provide a method for selectively producing (+)-cis-sertraline represented by formula 1 and usable as an intermediate in the production of sertraline hydrochloride.The method for producing the (+)-cis-sertraline represented by formula ...  
JP2013518876A
The manufacturing method of Voriconazole shown with chemical formula 1 is provided. Especially a manufacturing method of Voriconazole denoted by chemical formula 1, The Reformatsky type coupling reaction of the ketone derivative denoted ...  
JP2013095725A
To provide a method for producing one enantiomer selectively from the racemates of a compound exhibiting a high controlling effect on plant diseases.This method for producing one enantiomer includes reacting an optically active camphor s...  
JP2013091630A
To provide a composition for imparting a cold sensation containing 3-menthoxy propanol, and to provide a method for producing the 3-menthoxy propanol at high selectivity and high yield using 3-menthoxy-1,2-epoxypropane as a starting mate...  
JP2013515683A
A method of preparing a pharmacological active agent and its salt permitted pharmacologically is indicated by this specification.  
JPWO2011078172A
A manufacturing process of optical activity 3* substitution glutaric acid mono-amide is a following formula (2) : (* shows an asymmetric carbon atom among a formula.) Inside of a formula, R1A アルキル machine of は炭素数 1*8, an ...  
JP5191385B2  
JP5185127B2  
JP5182615B2  
JP2013512276A
R [2], (R [3]) *O, and O'* ジベンゾイル 酒石 chiral acid is used for the present invention, and it is the following scheme 2 (V). The stereoisomeric form of (S) *3* (dimethylamino) *2* methyl *1* (3* nitrophenyl) * propane *1* ON...  
JP2013511478A
The theme of the present invention is a manufacturing method of L* carnitine, and it is a process for which solution which contains at least 5% (w/w) of carnitine in the (a) 1st solvent is prepared, A process in which this carnitine is a...  
JPWO2011061934A
It is a manufacturing method of a bicyclo [3.1. 0] hexane derivative shown in formula (I), and its salt, A manufacturing method including a process of changing a process changed into an optically active compound which makes enzyme acting...  
JP5176452B2  
JP2013510885A
It is a compound which modulates a Sphingosine *1* phosphate acceptor alternatively, and the compound containing the compound which modulates subtype 1 of S1P receptor is provided. The asymmetric synthesis method of such a compound is pr...  
JP2013056848A
To provide a new method for producing an optically active alcohol compound.The method for producing the optically active alcohol compound comprises a step of conducting a reaction of a racemic alcohol compound in the presence of oxygen-c...  
JP5164841B2  
JP2013043890A
To provide a method for producing a novel cyclopentenone useful for producing benzindene prostaglandin.There are provided a method for producing a racemic cyclopentenone represented by formula I by which a protected 3-hydroxyphenylacetat...  
JP2011509298A5  
JP2012515142A5  
JP5153631B2  
JP5149238B2  
JP2013505215A
The present invention relates to those use to a medicine constituent aiming at those use in new benzene カルボキサミド compounds which have the structure corresponding to general formula (I), those synthesizing methods and human m...  
JP2013032380A
To provide a simpler preparation method for an enantiomerically and essentially pure compound like levocetirizine or the like by using a novel and enantiomerically and essentially pure intermediate.There is provided a (S)-2-[4-(4-chlorob...  
JP2013504557A
This application is by diimine hydrogenation of CC* double bond outside a ring from アルテ sewing machine acid or アルテ sewing machine acid ester, Respectively, it is related with use of the method for manufacturing (R [2]) * dihy...  

Matches 851 - 900 out of 4,297