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Matches 51 - 100 out of 4,262

Document Document Title
WO/2014/147395A1
The present invention relates to materials, methods and kits for detecting and identifying glycated species, in particular methods in which glycated species are first labelled and then subjected to a separation step, following which the ...  
WO/2014/139086A1
The present invention relates to the field of chemical synthesis, and discloses a preparation method of ambrisentan. In the preparation method, using (S)-phenethylamine as a resolving agent, to form two diastereomers with 2-[(4,6-dimethy...  
WO/2014/128523A1
The present invention relates to a process for the preparation of a key intermediate (as described herein) used in the synthesis of (+)-trans enantiomer of pyrrolidine substituted flavones, represented by the compounds of formula (1) or ...  
WO/2014/126028A1
The present invention pertains to an optically active poly(diphenylacetylene) compound represented by formula (I) (the symbols in the formula are as indicated in the description), a preparation method therefor, an optical isomer separati...  
WO/2014/103998A3
 The objective of the present invention is to provide a tyrosine derivative which is useful as a melatonin receptor MT1 antagonist, and a method for efficiently manufacturing a specific m-tyrosine derivative in which an iodine atom is ...  
WO/2014/125667A1
The present invention provides an optical isomer separating agent and a preparation method therefor. Specifically, the present invention pertains to a single-handed helical poly(diphenylacetylene) compound represented by formula (I) (the...  
WO/2014/119731A1
Provided is a method for producing D-alloisoleucine in a fewer steps and with high yield by an asymmetric transformation reaction of L-isoleucine. A method for producing D-alloisoleucine, involving a step of allowing a tartaric acid deri...  
WO/2014/103998A2
 The objective of the present invention is to provide a tyrosine derivative which is useful as a melatonin receptor 1 MT1 antagonist, and a method for efficiently manufacturing a specific m-tyrosine derivative in which an iodine atom i...  
WO/2014/045046A3
There is described (S)-(+)-2-(2-fluoro-4-biphenylyl) propionic acid, or a salt or ester thereof, having substantially limited amounts of specific impurities associated with the synthesis and purification of the (S)-(+)-2-(2-fluoro-4-biph...  
WO/2014/087937A1
Provided is a separating agent which comprises a carrier and a ligand that is supported on the surface of the carrier by means of a chemical bond. This separating agent is characterized in that: the carrier is a core-shell particle that ...  
WO/2014/046172A1
A method that enables isoxazolidine compounds to be produced at high yields is provided. A compound (1) is converted into a compound (2) in the presence of a tertiary amine catalyst having a hydrogen bond donor site within a molecule. (E...  
WO/2014/034957A1
A method for producing a methanol solvate of a D-tartrate of (R)-1,1,3-trimethyl-4-aminoindane characterized by including the following steps (a), (b), and (c) and by mixing water into the reaction system prior to step (c). Step (a): a s...  
WO/2014/009964A1
The invention discloses a process for enantiomeric enrichment of 2',6'-pipecoloxylidide using a chiral carbamoyl benzoic acid to provide (S)-enantiomer in high yield and high enantiomeric purity. The invention also discloses novel interm...  
WO/2013/160926A1
The invention concerns a procedure for the separation of optical isomers or for the production of an enantiomeric excess from a racemic mixture or from a mixture having any composition of D and L enantiomers, through direct crystallizati...  
WO/2013/154066A1
The problem addressed by the present invention is to efficiently produce an optically active bicyclic compound. The present invention efficiently produces an optically active bicyclic compound using an enzyme.  
WO/2013/057736A3
Provided is a process for the preparation of eptifibatide using a novel non-linear liquid phase peptide synthesis scheme. This invention makes use of combing precursor peptides synthesized separately in high purity and yield over present...  
WO/2013/089189A1
An optically active bicyclic compound is efficiently produced by performing optical resolution using an optically active amine.  
WO/2013/089188A1
An optically active bicyclic compound is efficiently produced by performing optical resolution using an optically active amine.  
WO/2013/081087A1
A method for preparing trans-{4-[({2-[({1-[3,5-bis(tri- fluoromethyl)phenyl]ethyl}{5-[2-(methylsulfonyl)ethoxy]- pyrimidin-2-yl}amino)methyl]-4-(trifluoromethyl)phenyl}- (ethyl)amino)methyl]cyclohexyl}acetic acid having a high optical pu...  
WO/2013/043009A3
Disclosed are a method for preparing 1-palmitoyl-3-acetylglycerol in a high purity and a high yield without purification by column chromatography, and a method for preparing 1-palmitoyl-2-linoleoyl-3-acetylglycerol in a high purity and a...  
WO/2013/069025A1
The invention discloses a novel process for preparation of dexmedetomidine in higher yield and with enantiomeric purity more than 99%.  
WO/2013/061515A1
[Problem] The present invention provides: a composition for imparting a cooling sensation, which contains 3-menthoxy propanol; and a method for producing 3-menthoxy propanol with high selectivity and high yield using 3-menthoxy-1,2-epoxy...  
WO/2013/058241A1
The present invention makes it possible to produce (R)-2-amino-2-ethylhexanol, which is useful as a pharmaceutical intermediate, easily and efficiently without complicated procedures. (R)-2-amino-2-ethylhexanol is produced by asymmetrica...  
WO/2013/043009A2
Disclosed are a method for preparing 1-palmitoyl-3-acetylglycerol in a high purity and a high yield without purification by column chromatography, and a method for preparing 1-palmitoyl-2-linoleoyl-3-acetylglycerol in a high purity and a...  
WO/2012/153991A3
The present invention relates to a method for preparing chiral α-aminonitrile through a strecker reaction by using a cyanide source under a catalyst having Chemical Formula 1 or Chemical Formula 2 of ethylene glycol derivatives. Accordi...  
WO/2013/010618A1
The invention relates to a method for producing optically pure propane-1,2-diol, comprising the method steps: a. hydrogenation of lactides, metal-catalysed heterogenous catalysis being carried out in the presence of hydrogen, a crude pro...  
WO/2012/169575A1
A method that manufacturers an optically active carboxylic acid ester at high yield and high enantioselectivity is provided. An optically active carboxylic acid ester is manufactured at high yield and high enantioselectivity by reacting ...  
WO/2012/165499A1
In order to provide a compound exhibiting a high controlling effect with respect to a plant disease, this triazole compound is the compound indicated in formula (I), the -OH group, the -R2 group, and the CH2-Ar group bonded to the cyclop...  
WO/2012/158099A1
The present invention is directed to a process for the preparation of benzyl [(3a S,4R,6S,6a R)-6-hydroxy-2,2-dimethyltetrahydro-3a H-cyclopenta[d][1,3]dioxol-4- yl]carbamate (VI), (VI), to products of said process and the use thereof.  
WO/2012/153991A2
The present invention relates to a method for preparing chiral α-aminonitrile through a strecker reaction by using a cyanide source under a catalyst having Chemical Formula 1 or Chemical Formula 2 of ethylene glycol derivatives. Accordi...  
WO/2012/152779A1
The present invention relates to a process of separating chiral isomers of chroman compounds, particularly tocopherols and tocotrienols as well as the esters and intermediates thereof. It has been found that this process allows a separat...  
WO/2012/147020A1
A process for the preparation and purification of Frovatriptan of formula (I) and its enantiomers, particuariy the R- enantiomer is disclosed, comprising formation of the di-p-toluoyltartaric acid salt of Frovatriptan.  
WO/2012/142983A1
Diastereomeric salts of the compound of formula I with D-(-)-mandelic and R-(-)-3- chloromandelic acid, a method of for the preparation thereof and their use in the synthesis of the drug ticagrelor.  
WO/2012/137047A1
The present invention relates to an improved process for the preparation of Fesoterodine and pharmaceutically acceptable salts thereof. The present invention particularly relates to a process for the preparation of fesoterodine and pharm...  
WO/2012/121068A1
In this method of producing optically active 1-amino-2-vinylcyclopropane carboxylic acid ester, a 1-amino-2-vinylcyclopropane carboxylic acid ester and an optically active tartaric acid or an optically active camphorsulfonic acid are rea...  
WO/2012/081885A3
The present invention relates to compounds 1, 1a (S-enantiomer) and 1b (R-enantiomer) of the following formula 1, and a method for preparing the same. [formula 1] The novel compound of the formula 1 is used as an important intermediate f...  
WO/2012/116752A1
A process for resolution of a mixture of (R)-and (S)-enantiomers of 1-aminoindan comprising fractional crystallizing one diastereomeric acid addition salt of 1-aminoindan from a solution containing a pair of diastereomeric acid addition ...  
WO/2012/072663A9
The present invention relates to a new process of separation of triazine derivatives enantiomers involving tartaric acid.  
WO/2012/070896A3
The present invention relates to a method for preparing enantiomerically pure compounds 1a and 1b of the following formula 1 from racemic compound 1 of the following formula 1. [formula 1] The compounds 1a and 1b of the above formula 1 r...  
WO/2012/093165A1
The present invention relates to resolution methods for manufacture of 4-((1R,3S)-6- chloro-3-phenyl-indan-1-yl)-1,2,2-trimethyl-piperazine and 1-((1R,3S)-6-chloro-3- phenyl-indan-1-yl)-3,3-dimethyl-piperazine and pharmaceutically accept...  
WO/2012/081885A2
The present invention relates to compounds 1, 1a (S-enantiomer) and 1b (R-enantiomer) of the following formula 1, and a method for preparing the same. [formula 1] The novel compound of the formula 1 is used as an important intermediate f...  
WO/2012/072663A1
The present invention relates to a new process of separation of triazine derivatives enantiomers involving tartaric acid.  
WO/2012/070896A2
The present invention relates to a method for preparing enantiomerically pure compounds 1a and 1b of the following formula 1 from racemic compound 1 of the following formula 1. [formula 1] The compounds 1a and 1b of the above formula 1 r...  
WO/2012/059797A1
Improved process for the synthesis of (S)-pregabalin having more than 99% ee through (S) 3-cyano-5-methyl-hexanoic acid has been developed. In addition to above, a novel process for resolution of (RS) - 3-cyano-5-methyl-hexanoic acid thr...  
WO/2012/033187A1
The present invention pertains to a method for producing optically active 2-aminobutyric acid containing a step for obtaining a diastereometric salt of optically active 2-aminobutyric acid and optically active tartaric acid by combining ...  
WO/2012/033188A1
A method for producing an optically active amino acid, said method comprising heating an amino acid and an optically active carboxylic acid together with an aldehyde in an organic solvent, and then adding an amine to the organic solvent ...  
WO/2012/001571A1
The object of the present invention is a new process for the synthesis of tapentadol, both as free base and in hydrochloride form, which comprises the step of alkylation of the ketone (VII) to yield the compound (VIII), as reported in Di...  
WO/2012/000308A1
A method for resolution of tetrabenazine is disclosed. Racemic tetrabenazine is used as starting material and salified with D- or L-chiral acid to form the corresponding tetrabenazine enantiomer chiral acid salt according to dissolubilit...  
WO/2011/158720A1
Disclosed is a method for efficiently producing a (1R, 2S)-1-amino-2-vinyl cyclopropane carboxylic acid ester, which is useful as a pharmaceutical intermediate, at low cost. Specifically, a (1R, 2S)-1-amino-2-vinyl cyclopropane carboxyli...  
WO/2011/129365A1
Disclosed is an antitumor agent which has higher antitumor activity than conventional antitumor agents, while having low toxicity. Specifically disclosed is an antitumor agent which is characterized by containing a phosphine transition m...  

Matches 51 - 100 out of 4,262