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JP4130625B2 |
Production of a novel separation agent for separating optical isomers comprises adding a compound (A) having an asymmetric structure and at most 1000 mol. wt. while supporting an optically active polymer (B1) on a carrier (C1).
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JP4126921B2 |
The present application discloses a method for the production of an optically active beta -phenylalanine derivative in which an N-acyl- beta -phenylalanine derivative is made to react with a specific optically resolving agent to conduct ...
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JP4126121B2 |
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JP2008169204A |
To provide a method for safely preparing (1R, 2R)-2-amino-1-cyclopentanol and a hydrochloride thereof in a commercial scale.The method for preparing the (1R, 2R)-2-amino-1-cyclopentanol and a hydrochloride thereof comprises steps (A)-(E).
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JP2008527010A |
The present invention involves use of the compounds narciclasine (2a) and 7-deoxy-narciclasine (2c), which are obtained via isolation from the medicinal plant species Narcissus (Amaryllidaceae), as precursors in a novel synthesis method ...
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JP4122389B2 |
To provide (+)-dihydrokaranone having remarkable and intense woody note and (-)-dihydrokaranone having citrus and mild woody note as useful perfumery materials through industrially producing them in high chemical and optical purity. Opti...
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JP4122648B2 |
Polymerizable and cross-linkable chlorosilane, hydroxysilane and alkoxysilane derivatives, comprising a linear, branched, or cyclic chain of chiral osidic units (Ia)-(Ik), are new. The polymerizable and cross-linkable chlorosilane, hydro...
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JP4117424B2 |
To provide a method for industrially and advantageously producing 1,4-bis(aminomethyl)cyclohexane at >=80% trans-form ratio using the 1,4-bis(aminomethyl)cyclohexane at a low tans-form ratio as a raw material. 1,4-Bis(aminomethyl)cyclohe...
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JP4109446B2 |
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JP2008143786A |
To provide an optical resolution method by which an amino compound can effectively optically be resolved through an amide compound.This optical resolution method for optically resolving an amino compound is characterized by comprising th...
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JP2008143883A |
To provide a new method for producing (Z)-7-chloro-((S)-2,2-dimethylcyclopropanecarboxamide)-2-hep
tenoic acid as the main intermediate for producing cilastatin used as an auxiliary agent for imipenem.The new method for producing (Z)-7-c...
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JP4108611B2 |
A production method of a racemic 3-hydroxy-3-(2-phenylethyl)hexanoic acid ester, which comprises reacting magnesium, haloacetic acid ester and 1-phenyl-3-hexanone.
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JP4104319B2 |
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JP4104871B2 |
To provide a method for obtaining an optically active 1,1'-bi-2-naphthol of high purity from a clathrate compound formed by reaction between a 1,1'-bi- naphthol and an optically active proline. The clathrate compound which is obtained by...
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JP4093608B2 |
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JP4090215B2 |
Production of (R)- and (S)- alpha -hydroxycarboxylic acids (I) of optical and chemical purity comprises recrystallizing crude material in an aromatic hydrocarbon (II), to give (I) of optical purity over 98% enantiomeric excess (ee). The ...
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JP2008516002A |
The present invention provides improved processes for the preparation of atomoxetine hydrochloride under reaction conditions that improve reaction yields and facilitate commercial synthesis. In particular, the invention is directed to th...
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JP4085601B2 |
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JP2008514729A |
A process is provided for preparing spiro-hydantoin compounds of the formula II wherein Z is N or CR4b; K and L are independently O or S; Ar is an optionally substituted aryl or heteroaryl; A2 is a linker, G' is a linker; Q is a linker; ...
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JP2008513371A |
A process for the manufacture of isoquinoline and 1,7-naphthyridine derivatives of formula wherein R1, R2, R3, R4 and X have the meanings as indicated in the specification. The process utilizes readily available starting materials of the...
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JP4081619B2 |
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JP4080570B2 |
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JP4077031B2 |
The invention relates to substantially photochemically cross-linked polysaccharide derivatives that do not contain photopolymerisable functional groups prior to the cross-linking, which can be used as carrier materials for the chromatogr...
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JP4076441B2 |
The present invention provides an aliphatic compound represented by the following formula (I) or pharmacologically acceptable salts thereof: where n denotes an integer of 1 to 11, and l denotes an integer of 1 to 16, the aliphatic compou...
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JP4070608B2 |
The invention relates to a novel method for producing optically active dihydropyrones, novel intermediate products obtained by said synthesis, and the use of the same as parent compounds in the production of pharmaceutically active compo...
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JP4067319B2 |
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JP4068702B2 |
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JP2008056639A |
To provide a method for producing benzylidene glycerol, by which the benzylidene glycerol which has an acetal group between the 1- and 3-hydroxy groups among the three hydroxy groups of the glycerol can preferentially be produced to lowe...
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JP4061293B2 |
PCT No. PCT/US94/10655 Sec. 371 Date Mar. 20, 1996 Sec. 102(e) Date Mar. 20, 1996 PCT Filed Sep. 20, 1994 PCT Pub. No. WO95/08529 PCT Pub. Date Mar. 30, 1995Chiral surfactants, methods for their synthesis and use, and apparatus designed ...
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JP2008506729A |
The present invention is aimed at a process for the preparation of enantiomerically enriched compounds of general formula (I). These are obtained by classical resolution of the corresponding acid using a chiral amino base in organic solv...
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JP4056565B2 |
PCT No. PCT/EP97/06782 Sec. 371 Date Aug. 6, 1999 Sec. 102(e) Date Aug. 6, 1999 PCT Filed Dec. 4, 1997 PCT Pub. No. WO98/24741 PCT Pub. Date Jun. 11, 1998A process for the preparation of carbocyclic stereoisomers of formulae (I), (I'), (...
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JP4049548B2 |
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JP4051314B2 |
This invention relates to a multistep process for the preparation of an L-tartrate salt of formula XX which is an intermediate in the preparation of growth hormone secretagogues.
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JP2008504302A |
The present invention provides improved processes for the preparation of atomoxetine hydrochloride under reaction conditions that improve reaction yields and facilitate commercial synthesis. In particular, the invention is directed to th...
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JP4046691B2 |
The invention relates to pharmaceutical formulations containing exo/exo-tricyclo[5.2.1.02.6]-dec-9-yl-xanthogenate, drugs containing exo/exo-tricyclo[5.2.1.02.6]-dec-9-yl-xanthogenate as active ingredient for the treatment of genital her...
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JP2008024666A |
To provide a practical method for producing an optically active amine having adamantyl group or its salt.This method for producing the optically active amine having the adamantyl group or its salt comprises a process of forming a diaster...
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JP2008019351A |
To provide an efficient and industrial method for the separation of an N-substituted homophenylalanine's optical isomer mixture.The method comprises contacting an optical isomer mixture of N-benzyloxycarbonyl homophenylalanine with a pre...
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JP2008019212A |
To provide a method for efficiently and industrially resolving an optical isomer mixture of N-substituted proline.The method for separating an optically active N-substituted proline comprises bringing a preparative optical-isomer separat...
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JP2008013558A |
To provide a compound represented by formula (I) and usable for treatment of melatoninergic system-associated disorder, and to provide a method for producing the compound and a pharmaceutical composition.The pharmaceutical composition co...
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JP4035856B2 |
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JP4032127B2 |
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JP4032225B2 |
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JP4030195B2 |
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JP4025838B2 |
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JP4027315B2 |
The invention relates to a method for determining the enantiomer ratio of trimethylcyclopentene derivatives of structure (I), wherein Z is an alkyl radical having 1-10 C atoms, can be saturated or olefinically unsaturated, straight-chain...
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JP4012389B2 |
A method including resolution of a diastereomeric mixture represented by the formula wherein R<1> and R<2> are the same or different and each is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group,...
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JP4009697B2 |
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JP4010562B2 |
The present invention relates a process for stereoselective or regioselective chemical synthesis which generally comprises reacting a nucleophile and a chiral or prochiral cyclic substrate in the presence of a non-racemic chiral catalyst...
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JP2007284349A |
To provide a method for producing monatin or a salt thereof wherein the configuration of the 2-position is an R configuration by isomerizing the 2-position of the monatin wherein the 2-position is an S configuration. The method for produ...
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JP3995119B2 |
Preparation of pure trans- and cis-4-hydroxy-2,2,6-trimethylcyclohexan-1-one of formulae (I) and (II) respectively comprises separation of a mixture of these isomers by fractional distillation in a column with 30-80 theoretical plates at...
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