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JP2007271586A |
To provide a method for separating optical isomers, capable of separating the optical isomers having high optical purity with high productivity efficiency, using liquid chromatography which uses packing for the stationary phase and a sol...
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JP3993287B2 |
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JP2007254439A |
To provide a method for purifying a high purity optically active amino acid simply and in a good efficiency from an aqueous optically active amino acid solution containing an ammonium salt. This method for producing the optically active ...
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JP2007527923A |
The invention encompasses processes for making tolterodine tartrate.
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JP2007527404A |
Process for the manufacture of an enantiopure compound comprising at least one functional group capable of reacting with an activated carboxyl group, starting from a mixture of enantiomers of the said compound, in which process: (a) a re...
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JP3982993B2 |
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JP2007524614A |
The present invention provides a method for producing an enantiomerically enriched alpha-(phenoxy)phenylactic acid compound of the formula: from its enantiomeric mixture, where R1 is alkyl or haloalkyl and X is halide.
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JP2007217440A |
To provide a simple purification method for optically active α-trifluoromethyl lactate that is useful as an effective intermediate for optically active medicine or optically active agrochemical. The optically active α-trifluoromethyl l...
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JP3963822B2 |
To provide a method for manufacturing an optical isomer separating agent having both of high optical resolution capacity and satisfactory solvent resistance. This method for manufacturing the optical isomer separating agent comprises a s...
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JP3963531B2 |
To provide a process for producing a packing of a column for the separation of optical isomers, causing little dissolution of material originated from polysaccharide derivative and having improved separation performance compared with con...
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JP2007523031A |
The present invention provides a chiral inorganic-organic composite porous material in which cationic chiral organic molecules are present as charge-balancing cations in a porous material containing charge-balancing cations, as well as a...
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JP2007202563A |
To provide a method for producing optically active α-trifluoromethyllactic acid and its chiral ester, and to provide a method for purifying the compound (method for improving optical purity). This method for producing the optically acti...
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JP3959798B2 |
To provide a method for profitably optically resolving 1-(3- methoxyphenyl)ethylamine. This method for optically resolving 1-(3-methoxyphenyl) ethylamine comprises reacting 1-(3-methoxyphenyl)ethylamine with optically active mandelic aci...
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JP2007522152A |
A process for the resolution of each of the enantiomers of methyl-alpha-5-[4,5,6,7-tetrahydro[3,2-c]thienopyridyl]-(2-c
hlorophenyl)acetate and salts thereof by diastereomeric crystallization comprising the use of a single optically acti...
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JP3955180B2 |
The invention relates to substituted aryl and heteroaryl (R)-Chiral Halogenated 1-Substitutedamino-(n+1)-Alkanol compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, ...
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JPWO2005080300A1 |
An optical resolution agent composed of a bicyclo [3.3.0] -2-oxaoctane compound represented by the formulas [1] to [3], and a mixture of the optical resolution agent and an optically active substance having active hydrogen are reacted to...
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JP2007191470A |
To provide a method of producing an optically active 2-aminobutanamide or its salt in high yield and high optical purity. When producing the optically active 2-aminobutanamide or its salt by optically resolving an (RS)-2-aminobutanamide ...
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JP2007186517A |
To provide an optically active acylated (R)-amine usable as an intermediate for producing pharmaceuticals and crop-protective agents.The optically active acylated (R)-amine is an N-[(R)-1-methyl-ω-(substituted phenyl)methyl, ethyl or pr...
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JP3946954B2 |
A process for racemate resolution of 2-hydroxypropionic acids by reacting the racemic acid with an optically active base and subsequently separating off a diastereomeric salt of acid and base comprises using 1-(4-chlorophenyl)ethylamine ...
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JP3939377B2 |
To provide both a method for producing an optically active N-benzyl-3- aminopyrrolidine good in both chemical and optical purities in good chemical yield by an optical resolution and a simple method for recovering a used resolving agent....
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JP3931361B2 |
To obtain the subject new compound useful as an intermediate for an optically active azetidine-2-carboxylic acid derivative important as a medicine intermediate. The dicarboxylic acid salt of an azetidine carboxylic acid derivative of fo...
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JP3924124B2 |
The invention relates to substituted aryl and heteroaryl (R)-Chiral Halogenated 1-Substitutedamino-(n+1)-Alkanol compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, ...
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JP3926662B2 |
To provide a new polymer responding to the chirality of a wide range of optically active substances in improved sensitivity and provide a monomer for the polymer. The invention relates to a polyaryl acetylene derivative and its monomer h...
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JP3920149B2 |
To provide an optical resolution agent, an optical resolution column, an optical resolution method and a production process for optically active compound for making it possible to produce a high purity optically active compound economica...
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JP2007126460A |
To provide a compound and a composition effective for inhibiting the activity of a CETP [cholesterol ester transfer protein (plasma lipid transfer protein-1)] and useful for treating especially atherosclerosis and other coronary arterial...
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JP2007512222A |
The present invention relates to a process for producing an optically active 3-(4-hydroxyphenyl)propionic acid useful as intermediates for medicines, through short steps in good yield and with high optical purity. More specifically, the ...
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JP2007512239A |
Disclosed is a method for preparing (+)-(2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethyl-2-morpholinol
and pharmaceutically acceptable salts such as the (+)-(2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethyl-2-morpholinol
hydrochloride salt via dyna...
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JP3915002B2 |
To obtain a new compound useful as an intermediate for condensed oxazole and thiazole derivatives each usable as an anti-asthmatic agent. This new compound is shown by formula I ((n) is 2-7), e.g. 2-(1-S-amino-2-cyclohexylethyl)pyridine....
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JP2007112804A |
To provide substituted aryl and heteroaryl (R)-chiral halogenated 1-substituted amino-(n+1)-alkanol compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and a composition of the com...
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JP3911302B2 |
To provide a method for industrially and advantageously producing optically active 2-methylpiperazine useful as a medicine and an agrochemical by itself or a synthetic raw material for them by using inexpensive racemic-2- methylpiperazin...
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JP3911545B2 |
PCT No. PCT/GB95/02513 Sec. 371 Date Apr. 25, 1997 Sec. 102(e) Date Apr. 25, 1997 PCT Filed Oct. 23, 1995 PCT Pub. No. WO96/12699 PCT Pub. Date May 2, 1996Levobupivacaine or an analogue thereof is prepared by reaction with a tartaric aci...
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JP3913329B2 |
To carry out the optical resolution of (±)-6-hydroxy-2,5,7,8- tetramethylchroman-2-carboylic acid in high efficiency by using a specific resolution agent. For example, (±)-6-hydroxy-2,5,7,8-tetramethylchroman-2- carboxylic acid is mixe...
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JP2007510626A |
A compound of Formula (I); wherein the substituents are as defined in the text for use in modulating insulin-like growth factor 1 receptor activity in a warm blooded animal such as man.
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JP2007510630A |
The present invention relates to a process for preparing optically pure (+)-(2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethyl-2-morpholinol
and pharmaceutically acceptable salts and solvates from a mixture of (+)-(2S,3S)-2-(3-chlorophenyl)-3,5...
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JP2007509922A |
The present invention relates to chiral N-acetyl-alpha-amino acid salts of optically active beta-amino alkylnitriles, and also to a process for preparing optically active beta-amino alkylnitriles by resolving racemic beta-amino alkylnitr...
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JP3905564B2 |
PURPOSE: To obtain a separating agent having no tailing of an objective compound, excellent in separating properties, useful as a separating agent for optical resolution of racemic modification by cleaning a separating agent comprising a...
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JP3900254B2 |
To provide an improved process for preparing the bis- diphenylphosphine oxide set forth in the title by starting from a phosphorus oxide of the type O=P(phenyl)2(Cl) and 5-bromo-2-chloroanisole. This process for preparing the bis-dipheny...
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JP3901093B2 |
An optical resolving reagent comprising at least one of compounds represented by the following formulae (1) and (2) (1) (2) (wherein R<1> to R<8> each represents hydrogen or C1-20 alkyl; R<9> represents optionally substituted C1-20 alkyl...
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JP2007077135A |
To provide a medicine for treating nervous diseases, mood disorder, pain and tobacco withdrawal symptom accompanied by cerebral ageing caused by an agonist of α4β2 type central nicotinic receptor.A compound represented by formula (I) [...
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JP3898220B2 |
PCT No. PCT/GB95/02247 Sec. 371 Date May 30, 1997 Sec. 102(e) Date May 30, 1997 PCT Filed Sep. 22, 1995 PCT Pub. No. WO96/09290 PCT Pub. Date Mar. 28, 1996A process for the racemisation of an optically-enriched piperidine-2-carboxanilide...
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JP3896468B2 |
To obtain a chiral stationary polymer phase advancing a reaction of monomers with a supporting material at a high bonding yield and useful for monomers of expensive in preparing by reacting an inorganic supporting material covered with m...
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JP2007063267A |
To provide a method for producing an optically active diphenylalanine compound.An optically active diphenylalanine compound (e.g., L-2-acetylamino-3,3-diphenylpropanoic acid) is obtained by reacting a diphenylalanine compound (e.g., 2-ac...
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JPWO2005040099A1 |
The present invention is 3-substitution-(2S).*, 3R*)-2,3-Epoxy Propionic Acid 3-Substitution of (1)-(3)-(2R, 3R) -2-Efficient Production of Protected Amino-3-Hydroxypropionic Acid Derivatives Regarding the method. (1) 3-Substitution-(2S*...
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JP3888402B2 |
To obtain the subject compound in a high yield by optically resolving N-carboxy-(RS)-tert-leucine with a specific optically active amine. This method for producing (D) optically active N-carbobenzoxy- tert-leucine comprises reacting (A) ...
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JP3883352B2 |
To provide a method for producing an optically active 4,4,4-trifluoro-3- hydroxybutanoic acid ester derivative being an important intermediate for a functional material including a medicine, an agrochemical and a ferroelectric liquid cry...
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JP3883568B2 |
Substituted phenyl compounds endowed with chain extension activity for formulations such as polyurethanes are disclosed, and which have the general formula: wherein n is 1-1000 and m is 1-100; and R1 and R2 are each independently selecte...
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JP2007502852A |
The invention relates to the 1,5-naphthalene disulfonic acid addition salt of the compound of the formula 1, or a solvate or hydrate thereof. The compound according to the invention is a valuable intermediate for the preparation of thera...
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JP3874306B2 |
A method of making (+/-)-3-(aminomethyl)-5-methylhexanoic acid that comprises condensing isovaleraldehyde with to form primarily reacting the with a cyanide source to form decarboxylating the to form hydrolyzing the with an alkali or alk...
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JP3874035B2 |
To produce an optically active secondary alcohol useful as a raw material for pharmaceuticals and agrochemical and a raw material for functional materials such as liquid crystal in high productivity by asymmetrically transesterifying a r...
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JP3867433B2 |
To provide a method for optically resolving the subject compound useful as an intermediate for synthesizing a chiral ketone compound, by allowing a specified chiral compound to act on a specified racemic compound and then separating and ...
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